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| 1 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 2 | Myomeetomy during cesarean section显示文摘 | Kaymak O Ustunyurt E Okyay RE | 2005 | Int J Gynaecol Obstet2005，89，2： | 1 |
| 3 | Myometomy during cesarean seetion显示文摘 | Kaymak O Usmnyuite Okyay RE | 2005 | Lnt J Gynaeeol Obstet2005，89，： | 1 |
| 4 | Principal causes of mechanical bowel obstruction in surgically treated adults in western turkey显示文摘 | Fuzun M Kaymak E Astarcioglu K | 1991 | British J Surgery1991，78，4： | 1 |
| 5 | Fuzzy clustering with volume prototypes and adaptive cluster merging 显示文摘 | KAYMAK U SETNES M | 2002 | IEEE Trans- actions on Fuzzy Systems2002，10，6： | 1 |
| 6 | Similarity Measures in Fuzzy Rule Base Simplification显示文摘 | Setnes M Babuska R Kaymak U | 1998 | IEEE Trans on Systems Man and Cybernetics1998，28，3： | 1 |
| 7 | Myomectomy during ce- sarean section 显示文摘 | Kaymak O Ustunyurt E Okyay RE | 2005 | Int J Gynecol Obatet2005，89，2： | 1 |
| 8 | Pricipal cause of mechanical bowel obstruction in surgical treatment adults in Western Turkey显示文摘 | Füzün M Kaymak E Astracioglu K | 1991 | Br J Surg1991，78，2： | 1 |
| 9 | Myomectomy during cesareansection显示文摘 | Kaymak O Ustunyurt E Okyay RE | 2005 | Int J Gynaecol Obstet2005，89，2： | 1 |
| 10 | Stable isotope analysis reveals relative influences of seasonal hydrologic variation and impoundment on assimilation of primary production sources by fish in the upper Yeslhrmask River, Turke 显示文摘 | Kaymak N Winemiller K O Akin S Altuner Z Pola F Dal T | 2015 | Hydrobiologia2015，753，1： | 1 |
| 11 | Modelling bulk density, porosity and shrinkage of quince duringdrying: The effect of drying method显示文摘 | Banu Koc Ismail Eren Figen Kaymak Ertekin | 2008 | Journal of Food Engineering2008，85，3： | 1 |
| 12 | Myomectomy during cesarean section 显示文摘 | Kaymak O Ustunyurt E Okyay R E | 2005 | Int J Gynecol Obstet2005，89，2： | 1 |
| 13 | Shortest hop multipath algorithm for wireless sensor networks显示文摘 | YILMAZ O DEMIRCI S KAYMAK Y | 2012 | Computers and Mathematics with Applications2012，63，1： | 1 |
| 14 | Antiproliferative effects of progesterone anlagonists and Progesterone receptor modulators on tendome trium review显示文摘 | Kaymak O Ustunyurt E Okyay RE | 2007 | Stevoids2007，15，6： | 1 |
| 15 | Myomectomy during cesarean section显示文摘 | Kaymak O Ustunyurt E | 2005 | Int J Gynaecol Obstet2005，89，： | 1 |
| 16 | Antiproliferative effects of progesterone anlagonists and Progesterone receptor modulators on tendome trium review显示文摘 | Kaymak O U stunyurt E Okyay RE | 2007 | Stevoids2007，15，6： | 1 |
| 17 | Myomectomy during ce- sarean section 显示文摘 | Kaymak O Ustumyurt E Okyay RE | 2005 | Int J Gynecol Obstet2005，89，2： | 1 |
| 18 | Fuzzy arithmetic-based interpolative reasoning for nonlinear dynamic fuzzy systems显示文摘 | SETNES M VAN NAUTA LEMKE H R KAYMAK U | 1998 | Engineering Applications of Artificial Intelligence1998，11，： | 1 |
| 19 | Genetic algorithms for optimization in predictive control显示文摘 | Onnen C Babuska R Kaymak U | 1997 | Control Engineering Practice1997，5，10： | 1 |
| 20 | Myometomy duringcesarean section显示文摘 | Kaymak O Usmnyuite Okyay RE | 2005 | Int J Gynaecol Obstet2005，89，2： | 1 |
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