|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 2 | Low eradication rate of Helicobacterpyloriwith triple 7-14 days and quadriple therapy in Turkey显示文摘AIM:The eradication rate of Helicobacter pylori (H pylon) shows variation among countries and regimens of treatment.We aimed to study the eradication rates of different regimens in our region and some factors affecting the rate of eradication.METHODS:One hundred and sixty-four Hpylori positivepatients (68 males, 96 females; mean age:48±12 years)with duodenal or gastric ulcer without a smoking history were included in the study. The patients were divided into three groups according to the treatment regimens. Omeprazole 20mg, clarithromycin 500mg, amoxicillin 1g were given twice daily for 1 week (Group I) and 2 weeks (Group Ⅱ).Patients in Group Ⅲ received bismuth subsitrate 300mg,tetracyline 500 mg and metronidazole 500mg four times daily in addition to Omeprazole 20mg twice daily.Two biopsies each before and after treatment were obtained from antrum and corpus, and histopathologically evaluated.Eradication was assumed to be successful if no Hpylorus was detected from four biopsy specimens taken after treatment. The effects of factors like age, sex, Hpyloridensity on antrum and corpus before treatment, the total Hpylori density, and the inflammation scores on the rate of Hpylori eradication were evaluated.RESULTS:The overall eradication rate was 42%. The rates in groups Ⅱ and Ⅲ were statistically higher than that in group I (P<0.05). The rates of eradication were 24.5%,40.7% and 61.5% in groups Ⅰ, Ⅱ and Ⅲ, respectively. The eradication rate was negatively related to either corpus Hpylori density or total Hpyloridensity (P<0.05).The median age was older in the group in which the eradication failed in comparison to that with successful eradication (55yr vs 39yr, P<0.001). No correlation between sex and Hpylori eradication was found.CONCLUSION: Our rates of eradication were significantly lower when compared to those reported in literature.We believe that advanced age and high Hpyloridensity are negative predictive factors for the rate of Hpylorieradication. | Yuksel Gumurdulu Ender Serin Birol zer Fazilet Kayaselcuk Kursat Ozsahin Arif Mansur Cosar Murat Gursoy Gurden Gur Ugur Yilmaz Sedat Boyacioglu | 2004 | World Journal of Gastroenterology2004，10，5： | 4 |
| 3 | Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy显示文摘AIM: To determine whether Helicobacter pylori ( H pylori)infection caused hyperhomocysteinemia by altering serum vitamin B12, serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level.METHODS: The study involved 73 dyspeptic H pylori-positive patients, none of them had gastric mucosal atrophy based on rapid urease test and histology. Out of 73 patients, 41 (56.2%) showed a successful eradication of Hpylori4 wk after the end of treatment. In these 41 patients, fasting serum vitamin B12, folate and homocysteine levels, and erythrocyte folate levels before and 4 wk after Hpylorieradication therapy were compared.RESULTS: The group with a successful eradication of Hpylori had significantly higher serum vitamin B12 and erythrocyte folate levels in the post-treatment period compared to those in pre-treatment period (210±97 pg/mL vs237±94pg/mL, P<0.O01 and 442±212 ng/mL vs 539±304 ng/mL,P = 0.024, respectively), but showed no significant change in serum folate levels (5.6±2.6 ng/mL vs 6.0±2.4 ng/mL,P= 0.341). Also, the serum homocysteine levels in this group were significantly lower after therapy (13.1±5.2 μmol/L vs 11.9±6.2 μmol/L, P = 0.002). Regression analysis showed that serum homocysteine level was positively correlated with age (P = 0.01) and negatively with serum folate level before therapy (P = 0.003).CONCLUSION: Eradication of H pylori decreases serum homocysteine even in patients who do not exhibit gastric mucosal atrophy. It appears that the level of homocysteine in serum is related to a complex interaction among serum vitamin B12, serum folate and erythrocyte folate levels. | Birol Ozer Ender Serin Yuksel Gumurdulu Fazilet Kayaselcuk Ruksan Anarat Gurden Gur Kemal Kul Mustafa Guclu Sedat Boyacioglu | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 4 | PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade显示文摘 | Kayaselcuk F Zorludemir S Gumurduhu D | 2002 | J Neurooncol2002，57，2： | 2 |
| 5 | Halitosis in patients with helicobacter pylori-positive non-ulcer dyspepsia:an indication for eradication therapy显示文摘 | Serin E Gumurdulu Y Kayaselcuk F | 2003 | European J Int Med2003，14，： | 1 |
| 6 | Expression ofsurvivin,PTEN and p27 in normal,hyperplastic,and carcinomatous endometrium显示文摘 | Erkanli S Kayaselcuk F Kuscu E | 2006 | Int J Gynecol Cancer2006，16，3： | 1 |
| 7 | Tear function tests and conjunctival impression cytology before and after hormone replacement therapy in postmenopausal women 显示文摘 | Pelit A Bagis T Kayaselcuk F | 2003 | Eur J Ophthalmol2003，13，4： | 1 |
| 8 | Expression of survivin,PTEN and p27 in normal,hyperplastic,and car-cinomatous endometrium显示文摘 | Erkanli S Kayaselcuk F Kuscu E | 2006 | Int J Gynecol Cancer2006，16，3： | 1 |
| 9 | COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma 显示文摘 | Erkanli S Bolat F Kayaselcuk F | 2007 | Gynecologic Oncology2007，104，2： | 1 |
| 10 | Expression of survivin, Bc1-2, p53 and Bax inbreast carcinoma and ductal intraepithelial neoplasia (DIN la) 显示文摘 | Kayaselcuk F Nursal TZ Polat A | 2004 | J Exp Clin Cancer Res2004，23，1： | 1 |
| 11 | PCNA and Ki 67 in centralnervous system tumors: correlation with the histologi- caltype and grade显示文摘 | Kayaselcuk F Zorludemir S Gumurduhu D | 2002 | J Neurooncol2002，57，2： | 1 |
| 12 | PCNA and Ki-67in central nervous system tumors:correlation with the histological type and grade显示文摘 | Kayaselcuk F Zorludemir S Gumurduhu D | 2002 | J Neurooncol2002，57，2： | 1 |
| 13 | PCNA and Ki-67 in central nervous system tumors:correlation with the his tological ype and grade显示文摘 | KAYASELCUK F ZORLUDEMIR S GUMURDUHU D | 2002 | Neurooncol2002，57，2： | 1 |
| 14 | PCNA and Ki-67 in central nervous system tumors:correlation with the histological type and grade显示文摘 | KAYASELCUK F ZORLUDEMIR S GUMURDUHU D | 2002 | Neurooncol2002，57，2： | 1 |
| 15 | PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade显示文摘 | Kayaselcuk F Zorludemir S Gumurduhu D | 2002 | J Neurooncol2002，57，2： | 1 |
| 16 | Expression of survivin,PTEN and p27 in normal,hyperplastic,and carcinomatous endometrium显示文摘 | Erkanli S Kayaselcuk F Kuscu E | 2006 | Int J Gynecol Cancer2006，16，： | 1 |
| 17 | PCNA and Ki-67 in central nervous system tumors:correlation with the histological type and grade显示文摘 | Zorludemir S Gumurduhu D | 2002 | J Neurooncol2002，，： | 1 |
| 18 | PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade显示文摘 | Kayaselcuk F Zorludemir S Gumurduhu D | 2002 | J Neurooncol2002，57，2： | 1 |
| 19 | Tear function tests and conjunctival impression cytology before and after hormone replacement therapy in postmenopausal women 显示文摘 | Pelit A Bagis T Kayaselcuk F | 2003 | Eur J Ophthalmol2003，13，： | 1 |
| 20 | Micmvessel density,VEGF expression,and tumor-associated macrophages in breast tumors : cor- relations with prognostic Parameters 显示文摘 | Bolat F Kayaselcuk F Nursal TZ | 2006 | J E:cp Clin Cancer Res2006，25，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员