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| 1 | Assessing the host genetic background effects on type 2 diabetes and obesity development in response to mixed–oral bacteria and high-fat diet using the collaborative cross mouse model显示文摘Background: Host genetic background and sex, play central roles in defining the pathogenesis of type 2 diabetes(T2 D), obesity and infectious diseases. Our previous studies demonstrated the utilization of genetically highly diverse inbred mouse lines, namely collaborative cross(CC), for dissecting host susceptibility for the development of T2 D and obesity, showing significant variations following high-fat(42% fat) diet(HFD). Here, we aimed to assessing the host genetic background and sex effects on T2 D and obesity development in response to oral-mixed bacterial infection and HFD using the CC lines.Materials and Methods: Study cohort consists of 97 mice from 2 CC lines(both sexes), maintained on either HFD or Standard diet(CHD) for 12 weeks. At week 5 a group of mice from each diet were infected with Porphyromonas gingivalis(Pg) and Fusobacterium nucleatum(Fn) bacteria(control groups without infection). Body weight(BW) and glucose tolerance ability were assessed at the end time point of the experiment.Results: The CC lines varied(P <.05) at their BW gain and glucose tolerance ability(with sex effect) in response to diets and/or infection, showing opposite responses despite sharing the same environmental conditions. The combination of diet and infection enhances BW accumulation for IL1912, while restraints it for IL72. As for glucose tolerance ability, only females(both lines) were deteriorated in response to infection.Conclusions: This study emphasizes the power of the CC mouse population for the characterization of host genetic makeup for defining the susceptibility of the individual to development of obesity and/or impaired glucose tolerance. | Luna Karkar Hanifa JAbu-Toamih Atamni Asal Milhem Yael Houri-Haddad Fuad A.Iraqi | 2020 | Animal Models and Experimental Medicine2020，3，2： | 5 |
| 2 | Studying host genetic background effects on multimorbidity of intestinal cancer development,type 2 diabetes and obesity in response to oral bacterial infection and high-fat diet using the collaborative cross(CC)lines显示文摘Background:Multimorbidity of intestinal cancer(IC),type 2 diabetes(T2D)and obesity is a complex set of diseases,affected by environmental and genetic risk factors.High-fat diet(HFD)and oral bacterial infection play important roles in the etiology of these diseases through inflammation and various biological mechanisms.Methods:To study the complexity of this multimorbidity,we used the collaborative cross(CC)mouse genetics reference population.We aimed to study the multimorbidity of IC,T2D,and obesity using CC lines,measuring their responses to HFD and oral bacterial infection.The study used 63 mice of both sexes generated from two CC lines(IL557 and IL711).For 12 weeks,experimental mice were maintained on specific dietary regimes combined with co-infection with oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum,while control groups were not infected.Body weight(BW)and results of a intraperitoneal glucose tolerance test(IPGTT)were recorded at the end of 12 weeks,after which length and size of the intestines were assessed for polyp counts.Results:Polyp counts ranged between 2 and 10 per CC line.The combination of HFD and infection significantly reduced(P<.01)the colon polyp size of IL557 females to 2.5 cm 2,compared to the other groups.Comparing BW gain,IL557 males on HFD gained 18 g,while the females gained 10 g under the same conditions and showed the highest area under curve(AUC)values of 40000-45000(min mg/dL)in the IPGTT.Conclusion:The results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance,and this effect is gender related. | Asal Milhem Hanifa J.Abu Toamih-Atamni Luna Karkar Yael Houri-Haddad Fuad A.Iraqi | 2021 | Animal Models and Experimental Medicine2021，4，1： | 4 |
| 3 | Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold显示文摘 | Karkar KM Garcia PA Bateman LM | 2002 | Epilepsia2002，43，： | 1 |
| 4 | Prevention and treatment of experimental crescentic glomeralonephritis by blocking tumour necrosis factor-alpha显示文摘 | Karkar AM Smith J Pusey CD | 2001 | Nephrol Dial Transplant2001，16，3： | 1 |
| 5 | Studies on thermostable antigens, production of species-specific antiadrenal sera and comparison of immunological techniques in meat speciation显示文摘 | Sherikar A T Karkare U D Khot J B et am | 1993 | Meat Sci1993，33，1： | 1 |
| 6 | Promising nucleic acid analogs and mimics:characteristic features and applications of PNA,LNA,and morpholino显示文摘 | KARKARE S BHATNAGAR D | 2006 | Appl Microbiol Biotechnol2006，71，5： | 1 |
| 7 | Modulation of renal inflammation:therapeutic strategies显示文摘 | Karkar A | 2008 | Saudi J Kidney Dis Transpl2008，19，1： | 1 |
| 8 | Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold显示文摘 | Karkar KM Garcia PA Bateman LM | 2002 | Epilepsia2002，43，： | 1 |
| 9 | hnproving artcriove- nous fistula rate : Effect on hemodialysis quality 显示文摘 | Karkar A Chaballout A Ibrahim MH | 2014 | Hemodial Int2014，18，2： | 1 |
| 10 | RNA interference silencing the transcriptional message显示文摘 | Shantanu Karkare Saurabha Daniel Deepak Bhatnagar | 2004 | Applied Biochemistry and Biotechnology2004，，1： | 1 |
| 11 | Ictal magnetoencephalography in temporal and extratemporal lobe epilepsy显示文摘 | Assaf BA Karkar KM Laxer KD | 2003 | Epilepsia2003，44，10： | 1 |
| 12 | The inhibition of growth and down - regulation of gonadotropin releasing hormone (GnRH) recep- tor in alpha T3 - 1 cells by GnRH agonist 显示文摘 | KARKAR S S NATH S BUNN J | 1997 | Anticancer Drugs1997，，4： | 1 |
| 13 | Monitoring i- ron status in end-stage renal disease patients on hemdialysis显示文摘 | RAFI A KARKAR A ABODELRAHMAN M | 2007 | Saudi J Kidney Dis Transpl2007，18，1： | 1 |
| 14 | Hepatitis C in dialysis units: The Saudi experience 显示文摘 | Karkar A | 2007 | Hemodial Int2007，11，3： | 1 |
| 15 | MELAS with A3243G mutation presenting with occipital status epilepticus 显示文摘 | Karkare S Merchant S Solomon G | 2009 | J Child Neurol2009，24，： | 1 |
| 16 | Exploiting bacterial DNA gyrase as a drug target:current state and perspectives显示文摘 | Collin F Karkare S Maxwell A | 2011 | Appl Microbiol Biotechnol2011，92，3： | 1 |
| 17 | Abrogation of glomerular injury in nephrotoxic nephritis by continuous infusion of interleukin-6显示文摘 | Karkar AM Smith J Tam FW | 1997 | Kidney Int1997，52，5： | 1 |
| 18 | Differential expression of macrophage inflammatory protein -2 and monocyte chemoattractant protein-1 in experimental glomerulonephritis显示文摘 | Frederick WK Karkar AM Smith J | 1996 | Kidney Int1996，49，3： | 1 |
| 19 | Interleukin-4 ameliorates experimental glomerulonephritis and up-regulates glomerular gene expression of IL-1 decoy receptor显示文摘 | Tam FW Smith J Karkar AM | 1997 | Kidney Int1997，52，5： | 1 |
| 20 | Use of 30°external ro- tation view for postero-medial tubercle fractures of the talus显示文摘 | Ebraheim NA Karkare N Gehling DJ | 2007 | J Orthop Trauma2007，21，： | 1 |
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