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| 1 | Current concepts in the management of radial head fractures显示文摘Fracture of the radial head is a common injury. Over the last decades, the radial head is increasingly recognized as an important stabilizer of the elbow. In order to maintain stability of the injured elbow, goals of treatment of radial head fractures have become more and more towards restoring function and stability of the elbow. As treatment strategies have changed over the years, with an increasing amount of literature on this subject, the purpose of this article was to provide an overview of current concepts of the management of radial head fractures. | Iza?k F Kodde Laurens Kaas Mark Flipsen Michel PJ van den Bekerom Denise Eygendaal | 2015 | World Journal of Orthopedics2015，6，11： | 9 |
| 2 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 3 | Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration显示文摘Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely understood.Here,we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors,including Dickkopf 1(Dkkl),Dkk3,secreted Frizzled-related protein 1(sFrpl),and sFrp2,in cardiac tissue adjacent to injury sites.Experimental blocking of Wnt activity via Dkkl overexpression enhances CM proliferation and heart regeneration,whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and proliferation.Although Wnt signaling is dampened upon injury,the cytoplasmic β-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound edges.Our analyses indicated that p21-activated kinase 2(Pak2)is induced at regenerating CMs,where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled sarcomeres.Myocardial-specific induction of the phospho-mimeticβ-catenin(S675E)enhances CM dedifferentiation and sarcomere disassembly in response to injury.Conversely,inactivation of Pak2 kinase activity reduces the Ser 675-phosphorylatedβ-catenin(pS675-β-catenin)and attenuates CM sarcomere disorganization and dedifferentiation・Taken together,these findings demonstrate that coordination of Wnt signaling inhibition and Pak2/pS675-βYatenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation. | Xiangwen Peng Kaa Seng Lai Peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin Xiaolei Xu Lujian Liao Jiandong Liu Ethan Lee Kenneth D.Poss Tao P.Zhong | 2021 | Journal of Molecular Cell Biology2021，13，1： | 3 |
| 4 | Dynamic turboFLASH subtraction technique for contrast-enhanced MR imaging of the prostate:correlation with histopathologic results显示文摘 | Jager G J Ruijter E T G Van de Kaa C A | 1997 | Radiology1997，203，： | 1 |
| 5 | Deactivation and reactivation of somatosen- sory cortex after dorsal spinal cord injury显示文摘 | Jain N Catania KC Kaas JH | 1997 | Nature1997，386，6624： | 1 |
| 6 | Subdivisions of audito- ry cortex and ipsilateral cortical connections of the parabelt au- ditory cortex in macaque monkeys显示文摘 | Hackett TA Stepniewska I Kaas JH | 1998 | J Comp Neurol1998，394，： | 1 |
| 7 | Plasticity of sensory and motor maps in adult mammals显示文摘 | | 1991 | Annu Rev Neurosci1991，14，3： | 1 |
| 8 | The prognostic value of a primary inverted papilloma of the urinary tract显示文摘 | Witjes J A van Balken M R van De kaa C A | 1997 | J Urol1997，158，： | 1 |
| 9 | Is Dynamic General Equilibrium A Theory of Everything? 显示文摘 | Azariadis Costas Kaas Leo | 2007 | Economic Theory2007，，32： | 1 |
| 10 | Large-scale reorganization in the so- matosensory cortex and thalamus after sensory loss in macaque monkeys 显示文摘 | Jain N Qi HX Collins CE Kaas JH | 2008 | J Neurosei2008，28，11： | 1 |
| 11 | The incidence of associated fractures of the upper limb in fractures of the radial head 显示文摘 | Kaas L van Riet RP Vroemen JP | 2008 | Strategies Trauma Limb Reconstr2008，，3： | 1 |
| 12 | Reorganization in primary motorcortex of primates with long standing therapeuticamputations显示文摘 | Wu CW Kaas JH | 1999 | J Neurosci1999，19，17： | 1 |
| 13 | Effects of nutrient limitation and irradiance on marine phytoplankton pigments显示文摘 | Henriksen P Riemann B Kaas H | 2002 | Journal of Plankton Research2002，24，： | 1 |
| 14 | Prefrontal connections of the parabelt auditory cortex in macaque monkeys 显示文摘 | Hackett TA Stepniewska I Kaas JH | 1999 | Brain Research1999，，817： | 1 |
| 15 | Dynamic Turbo- FLASH subtraction technique for contrast enhanced MR imaging of the Prostate: correlation with histopathologic resuhs显示文摘 | Jager G J Ruijter E T Van de Kaa C A | 1997 | Radiology1997，203，3： | 1 |
| 16 | Arthroscopic ankle arthrodesis: factors influenciong union in 39 consecutive pa- tients显示文摘 | Collman DR Kaas MH Schuberth JM | 2006 | Foot Ankle Int2006，27，12： | 1 |
| 17 | Prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers:very low risk for subsequent breast cancer显示文摘 | Kaas R Verhoef S Wesseling J | 2010 | Ann Surg2010，251，3： | 1 |
| 18 | Optical properties and signatures of chromophoric dissolved organic matter(CDOM)in Danish coastal waters显示文摘 | STEDMON C A MARKAGER S KAAS H | 2000 | Estuarine Coastal and Shelf Science2000，51，： | 1 |
| 19 | Limits on plasticity in somatosensory cortex of adult rats:hindlimb cortex is not reactivated after dorsal column section显示文摘 | Jain N Florence SL Kaas JH | 1995 | J Neurophysiol1995，73，4： | 1 |
| 20 | Management of radial head fractures:current concepts显示文摘 | Laurens Kaas Jesse B Jupiter C | | 0，，01： | 1 |
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