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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | A frequency-dependent finite-difference time-domain formulation for transient propagation in plasma显示文摘 | Hunsberger F P Kunz K S | 1991 | IEEE Trans AP1991，39，1： | 1 |
| 3 | Effect of grain size on the high cycle fatigue behavior of polycrystalline copper显示文摘 | Lukás P Kunz L | 1987 | Materials Science and Engineering1987，85，： | 1 |
| 4 | 查看详情显示文摘 | Renoncourt A Bauduin P Nicholl E Touraud D Verbavatz J.M Dubois M Drechsler M Kunz W | | 0，，： | 1 |
| 5 | The influence of structure and composition of a reverse SDS microemulsion on enzymatic activities and electrical conductivities显示文摘 | Bauduin P Touraud D Kunz W | 2005 | J Colloid Interface Sci2005，292，： | 1 |
| 6 | Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy显示文摘 | Kunz W S Kudin A P Vielhaber S | 2000 | Ann Neurol2000，48，5： | 1 |
| 7 | Comparison of caudal and intravenous clonidine in the prevention of agitation after sevoflurane in children 显示文摘 | Bock M Kunz P Chreckenberger R | 2002 | Br J Anaesthesia2002，88，6： | 1 |
| 8 | Diffusion-weigh-ted MRI in the characterization of soft-tissue tumors显示文摘 | van Rijswijk CS?Kunz P? Hogendoorn PC | 2002 | J MagnReson Imaging2002，15，3： | 1 |
| 9 | Time-resolved fluorescence imaging of photosensitiser distributions in mammalian cells using a picosecond laser line-scanning microscope 显示文摘 | Connelly J P Botchway S W Kunz L | 2001 | J Photoch Photobio A2001，142，23： | 1 |
| 10 | Highly sensitive triaxial silicon accelerometer with integrated PZT thin film detectors 显示文摘 | Kunz K Enoksson P Stemme G | 2001 | Sensors and Actuators A2001，92，： | 1 |
| 11 | Identification of Ras, MAP kinases, and a GAP protein in Sehistosoma mansoni by immunobloting and their putative involvement in male-female interaction显示文摘 | Schussler P Grevelding C G Kunz W | 1997 | Parasitology1997，115，： | 1 |
| 12 | Effects of UV-filter mixtures on vitellogenin induction and secondary sex characteristics in fathead minnows显示文摘 | Kunz P Y Fent K | 2008 | Marine Environmental Research2008，66，： | 1 |
| 13 | Comparison of caudal and intravenous elonidine in the prevention of agitation after sevoflurane in children显示文摘 | Bock M Kunz P Schreckenberger R | 2002 | Br J Anaesth2002，88，6： | 1 |
| 14 | Thermodynamic investigation of the austenite and the delta ferrite in the system Fe-Cr-Mn-N 显示文摘 | Kunze J Broz P Gruner W | 1996 | Steel Research1996，67，1： | 1 |
| 15 | Comparison of in vitro and in vivo estrogenic activity of UV filters in fish显示文摘 | Kunz P Y Galicia H F Fent K | 2006 | Toxicological Sciences2006，90，2： | 1 |
| 16 | Effects of the UV filter benzophenone-2 on reproduction in fish显示文摘 | Weisbrod CJ Kunz P Y Zenker A K | 2007 | Toxicology and Applied Pharmacology2007，225，3： | 1 |
| 17 | A resonantly excited 2D-micro-scanning-mirror with large deflection显示文摘 | SCHENK H DRR P KUNZE D | 2001 | Sensors and Actuators2001，89，12： | 1 |
| 18 | Assessment of hormonal activity of UV filters in tadpoles of frog Xenopus laevis at environmental concentrations显示文摘 | Kunz P Y Galicia H F Fent K | 2004 | Marine Environ?mental Research2004，58，25： | 1 |
| 19 | TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast 显示文摘 | Helliwell SB Wagner P Kunz J | 1994 | Mol Biol Cell1994，5，1： | 1 |
| 20 | The ultraviolet filter 3-benzylidene camphor adversely affects reproduction in fathead minnow 显示文摘 | Kunz P Y Gries T Fent K | 2006 | Toxicological Sciences2006，93，2： | 1 |
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