|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Modulations of genes related to gut integrity,apoptosis,and immunity underlie the beneficial effects of Bacillus amyloliquefaciens CECT 5940 in broilers fed diets with different protein levels in a necrotic enteritis challenge model显示文摘Background:The ban of in-feed antimicrobial additives has negatively affected the poultry industry by causing necrotic enteritis(NE)to emerge in the flocks.Alternatives such as Bacillus probiotics have shown to be effective on eliminating the negative effects of this disease.Two experiments were conducted to investigate the effect of Bacillus amyloliquefaciens CECT 5940(BA)in broiler chickens under NE challenge and/or fed diets with different protein levels.Methods:In both experiments,480 day-old mix-sexed Ross-308 broilers were arranged in a 2×2 factorial arrangement of treatments.In experiment 1,the factors were NE challenge(yes or no)and probiotic(yes or no).In experiment 2,the factors were dietary crude protein levels(standard or reduced)and probiotic(yes or no)and were used under NE challenge condition.Oral administration of Eimeria oocysts(day 9)followed by inoculation with Clostridium perfringens(day 14 and 15)was used to induce NE challenge.On day 16,two birds from each treatment were gavaged with fluorescein isothiocyanate-dextran(FITC-d)and blood samples were collected for gut integrity evaluation,and jejunal samples were collected for gene expression assay.Results:In experiment 1,BA supplementation decreased caspase-3(CASP3)(P<0.001)and caspase-8(CASP8)(P<0.05)and increased occludin(OCLD)(P<0.05)expression regardless of the challenge.Additionally,BA supplementation downregulated interfron-γ(IFN-γ)expression(P<0.01)and upregulated immunoglobulin-G(IgG)(P<0.01)and immunoglobulin-M(IgM)(P<0.05)only in challenged birds.In experiment 2,the expression of genes encoding mucin-2(MUC2)(P<0.001),tight junction protein-1(TJP1)(P<0.05)and OCLD(P<0.05)were upregulated by the addition of BA in the diet,regardless of the crude protein level.Further,BA supplementation downregulated INF-γ(P<0.01)and upregulated immunoglobulin-A(IgA)(P<0.05),IgM(P<0.05)and IgG(P<0.01)regardless of the crude protein level.Conclusion:These findings suggest that supplementation of BA in broiler diets can improve gut health by modulation of genes related to the mucosal barrier,tight junction,and immunity in broilers challenged by unfavourable conditions such as NE challenge. | Kosar Gharib-Naseri Juliano Cesar de Paula Dorigam Kiran Doranalli Sarbast Kheravii obert A.Swick Mingan Choct Shu-Biao Wu | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 6 |
| 2 | ZnAl_2O_4@SiO_2纳米复合催化剂用于无溶剂条件下乙酸酐与醇、酚和胺的乙酰化反应(英文)显示文摘A ZnAl2O4@SiO2 nanocomposite was prepared from metal nitrates and tetraethyl orthosilicate by the sol-gel process,and characterized by X-ray diffraction,Fourier transform infrared,transmission electron microscopy,and N2 adsorption-desorption measurements.The nanocomposite was tested as a heterogeneous catalyst for the acetylation of alcohols,phenols,and amines under solvent-free conditions.Under optimized conditions,efficient acetylation of these substrates with acetic anhydride over the ZnAl2O4@SiO2 nanocomposite was obtained.Acetylation of anilines and primary aliphatic amines proceeded rapidly at room temperature,while the reaction time was longer for the acetylation of alcohols and phenols,showing that an amine NH2 group can be selectively acetylated in the presence of alcoholic or phenolic OH groups.The catalyst can be reused without obvious loss of catalytic activity.The catalytic activity of the ZnAl2O4@SiO2 nanocomposite was higher than that of pure ZnAl2O4.The method gives high yields,and is clean,cost effective,compatible with substrates having other functional groups and it is suitable for practical organic synthesis. | Saeed Farhadi Kosar Jahanara | 2014 | 催化学报2014，35，3： | 3 |
| 3 | 钢悬链线立管与海底相互作用和疲劳分析显示文摘钢悬链线立管触底段与海底相互作用的复杂特性是工程设计中的一大难题,既要保证悬链线立管的弯曲在弹性范围内又要保证在其使用周期内满足疲劳要求。采用解析法对立管的形态和受力性能进行了初步的分析,将悬链线分为悬链段、边界层段和触地段3个部分,保证各段之间的连续性。同时用解析法和有限元法比较了刚-塑性海床,塑性海床和沟状海床3种不同海底模型,从而验证了理论方法的可靠性并运用理论方法对管道进行了疲劳评估。 | REZAZADEH Kosar 陆钰天 白勇 唐继蔚 | 2014 | 哈尔滨工程大学学报2014，35，2： | 3 |
| 4 | Cost-effectiveness of an integrated'fast track'rehabilitation service for multi-trauma patients involving dedicated early rehabilitation intervention programs:design of a prospective,multi-centre,non-randomised clinical trial显示文摘 | Kosar S Seelen HA Hemmen B | 2009 | J Trauma Manag Outcomes2009，3，1： | 1 |
| 5 | Clinical outcomes of catheter substrate ablation for high-risk patients with atrial fibrillation显示文摘 | Nademanne K Schwab MC Kosar EM | 2008 | J Am Coil Cardiol2008，51，： | 1 |
| 6 | Antioxidant properties and composition of aqueous extracts from Mentha species, hybrids , varieties, and cultivars 显示文摘 | Dorman H J D Kosar M Kahlos K | 2003 | J Agric Food Chem2003，51，： | 1 |
| 7 | A new approach for catheter, ablation of atrial fibrillation: mapping of the electrophysiology substrate显示文摘 | Nndemaneek mckertzie J Kosar E | 2004 | JAM Coil Cardid2004，43，11： | 1 |
| 8 | Clinical outcomes of catheter substrate ablation for high-risk patients with atrial fibrillation显示文摘 | Nademanee K Schwab MC Kosar EM | | Journal of the American College of Cardiology0，，： | 1 |
| 9 | Laminar flow across a bank of low aspect ratio micro pin fins显示文摘 | Kosar A Mishra C Peles Y | 2005 | Journal of Fluids Engineering2005，127，3： | 1 |
| 10 | A new approach for catheter ablation of atrial fibrillation: mapping of the electro- physiologic Substra-te显示文摘 | Nademanee K McKenzie J Kosar E | 2004 | J Am Coll Cardiol2004，43，11： | 1 |
| 11 | A nonfluorscopic catheter based mapping technique to ablate focal ventricular tachycardia显示文摘 | Nademanee K Kosar EM | 1998 | PACE1998，21，： | 1 |
| 12 | A new approach for catheter ablation of atrial fibrillation: Mapping of the electrophysiologic substrate显示文摘 | Nademanee K McKenzie J Kosar E | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 13 | Cytomegalovirus infection after liver transplantation:viral load as a guide to treating clinical infection显示文摘 | NORRIS S KOSAR Y DONALDSON N | 2002 | Transplantation2002，74，： | 1 |
| 14 | A new approach for catheter abhtion of atrial fibrillation:mapping of the electrophysiologic substrate显示文摘 | Nedemanee K McKenzie J Kosar E | 2004 | J Am Coll Cardiol2004，43，11： | 1 |
| 15 | Solid desiccant tech- nology review 显示文摘 | Wurm J Kosar D Clemens T | 2002 | Bulletin of the International Insti- tute of Refrigeration2002，82，3： | 1 |
| 16 | Plasma thrombospondin in immune thrombocytopenic purpura显示文摘 | Ozcebe O I Karakus S Haznedaro-lu I C G-ker H Kosar A Koco-lu H | 2002 | J Int Med Res2002，30，： | 1 |
| 17 | Laminar flow across a bank of low aspect ratio micro pin fins 显示文摘 | KOSAR A MISI-IRA C PELES Y | 2005 | Journal of Fluids Engineering-Transactions of the ASME2005，127，3： | 1 |
| 18 | Anatomical variations in branching pattern of arcus aorta : 64-slice CTA appearance 显示文摘 | Ergun E Simsek B Kosar PN | 2013 | Surg Radiol Anat2013，35，： | 1 |
| 19 | The essential oil composition of Dictamnus albus from Turkey显示文摘 | Baser K Baser KH Kosar M | 1994 | Planta Mad1994，60，5： | 1 |
| 20 | Thermal-hydraulic performance of MEMS-based pin fin heat sink 显示文摘 | KOSAR A PELES Y | 2006 | Journal of Heat Transfer- Transactions of the ASME2006，128，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员