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| 1 | Fiber-enriched diet helps to control symptoms and improves esophageal motility in patients with non-erosive gastroesophageal reflux disease显示文摘AIM To investigate the effect of dietary fiber on symptoms and esophageal function testing parameters in nonerosive gastroesophageal reflux disease(GERD)(NERD) patients.METHODS Thirty-six NERD patients with low(< 20 g/d) dietary fiber intake were enrolled in the study. They were examined with the use of symptom questionnaire(GERD-Q), highresolution esophageal manometry, 24-h esophageal p Himpedance examinations, and food frequency questionnaire before and after 10 d of usual diet supplemented by psyllium 5.0 g TID. Complete data of 30 patients were available to the final analysis. The obtained results were analyzed with the use of non-parametric statistics(Wilcoxon matched pairs test). RESULTS The number of patients experiencing heartburn was less(93.3% at baseline vs 40% at the end of the study, P < 0.001) and the GERD-Q score decreased(mean ± SD: 10.9 ± 1.7 vs 6.0 ± 2.3, P < 0.001) after the treatment period. Minimal resting lower esophageal sphincter(LES) pressure increased from 5.41 ± 10.1 to 11.3 ± 9.4 mm Hg(P = 0.023), but no change in residual LES pressure and mean resting pressure was found. Total number of gastroesophageal refluxes(GER) decreased from 67.9 ± 17.7 to 42.4 ± 13.5(P < 0.001) predominantly by acid and weak acid types of GERs. No significant change in mean esophageal p H and % of time p H < 4 was registered. Maximal reflux time decreased from 10.6 ± 12.0 min to 5.3 ± 3.7 min(P < 0.05). CONCLUSION Fiber-enriched diet led to a significant increase of minimal lower esophageal sphincter resting pressure, a decrease of number of gastroesophageal refluxes, and a decrease of heartburn frequency per week in NERD. | Sergey Morozov Vasily Isakov Mariya Konovalova | 2018 | World Journal of Gastroenterology2018，24，21： | 9 |
| 2 | Genetic diver- sity of the tick-borne encephalitis virus in Ixodes persulcatus ticksin northeastern European Russia 显示文摘 | Mikriukova TP Chausov EV Konovalova SN | 2014 | Parazitologiia2014，48，2： | 1 |
| 3 | Enhanced level of site 2 specific proteolysis of GAP-43 protein during early stages of brain development显示文摘 | Mosevitsky MI Konovalova ES Bichevaya NK | 2000 | Biochemistry2000，65，： | 1 |
| 4 | Spatial sequencing of microbial reduction of chromate and nitrate in membrane bioreactor显示文摘 | KONOVALOVA V DMYTRENKO G POBIGAY G | 2008 | Bioprocess and Biosystems Engineering2008，31，： | 1 |
| 5 | Modified track membranes with antibacterial properties显示文摘 | Vakuliuk P Burban A Konovalova V | 2009 | Desalination2009，235，123： | 1 |
| 6 | Enhanced level of site specific proteolysis of gap-43 protein during early stages of brain development显示文摘 | Mosevitsky MI Konovalova ES Bichevava NK | 2000 | Biochemistry2000，65，10： | 1 |
| 7 | Composite module analyst: identification of transcription factor binding site combinations using genetic algorithm 显示文摘 | Waleev T Shtokalo D Konovalova T | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 8 | Nitric oxide donor increases the efficiency of cytostatic therapy and retards the development of drug resistance 显示文摘 | Konovalova N P Goncharova S A Volkova L M | 2003 | Nitric Oxide2003，8，1： | 1 |
| 9 | Solubility of sebacic acid in water显示文摘 | Tudorovskaya G L Shtol'ts N V Konovalova T P | 1985 | J Appl Chem Ussr1985，58，9： | 1 |
| 10 | Extracellular biology of Myxococcus xanthus显示文摘 | Konovalova A Petters T Sogaard-Andersen L | 2010 | FEMS Microbiol Rev2010，34，2： | 1 |
| 11 | Surface modificalion of TiO2 naopmlicle with carotenoids EPR study 显示文摘 | Konovalova T A Kispert L D Konovalov V V | 1999 | Journal of Physical Chemistry : B1999，10，3： | 1 |
| 12 | Enhanced levelof site- specific proteolysis of GAP- 43 protein during early stages of brain development显示文摘 | MosevitskyMI Konovalova ES Bichevaya NK | 2000 | Biochemistry2000，65，10： | 1 |
| 13 | Quantitative determination of total valepotri- ates显示文摘 | Konovalova 0 A | 1983 | Khim-FarmZh1983，17，7： | 1 |
| 14 | Nitric oxide donor increases the efficiency of cytostatic therapy and retards the development of drug resistance显示文摘 | Konovalova NP Goncharova SA Volkova LM | 2003 | Nitric Oxide2003，8，1： | 1 |
| 15 | Inhibitor of β-Hydroxy-β-Methylglutaryl Coenzyme A Reductase Decreases Energy Supply to the Myocardium in Rats显示文摘 | O. I. Pisarenko I. M. Studneva V. Z. Lankin G. G. Konovalova A. K. Tikhaze V. I. Kaminnaya Yu. N. Belenkov | 2001 | Bulletin of Experimental Biology and Medicine2001，，4： | 1 |
| 16 | Chemical composition of Ledum palustre显示文摘 | N. S. Mikhailova O. A. Konovalova K. S. Rybalko | 1978 | Chemistry of Natural Compounds1978，，1： | 1 |
| 17 | Extracellu- lar biology ofMyxococcus xanthus显示文摘 | KONOVALOVA A PETTERS T SOGAARD-ANDERSEN L | 2010 | FEMSMicrobiolgev2010，34，2： | 1 |
| 18 | Enhanced level of Site specific proteolysis of gap-43 protein during early stages of brain development显示文摘 | Mosevitsky MI Konovalova ES Bichevava NK | 2000 | Biochemistry2000，65，10： | 1 |
| 19 | Chromium(Ⅵ) reduction in a membrane bioreactor with immobilized Pseudomonas cells显示文摘 | Konovalova V V Dmytrenko G M Nigmatullin R R | 2003 | Enzyme and Microbial Technology2003，33，7： | 1 |
| 20 | Radical-induced generation of small silver particles in SPEEK-PVA polymer films and solutions:UV-Vis,EPR,and FT-IR studies显示文摘 | Korchev A S Konovalova T Cammarata V | | 0，，01： | 1 |
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