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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | 8 皮质激素治疗血管瘤对患者的免疫抑制作用显示文摘血管瘤是婴幼儿常见的肿瘤.38%的患者需要积极治疗,而皮质激素是治疗此病的主要药物,但此药对患者免疫系统的抑制作用缺乏前瞻性研究报道。该文旨在评价皮质激素治疗血管瘤时药物对患者的免疫抑制作用。 | Kelly ME Juern AM Grossman WJ | 2010 | 中国口腔颌面外科杂志2010，8，6： | 2 |
| 3 | Development of anterior cingulate functional connectivity from late childhood to early adulthood 显示文摘 | Kelly AM Di Martino A Uddin LQ | 2009 | Cereb Cortex2009，19，： | 1 |
| 4 | Outcomes of emergency department patients treated for primary spontaneous pneumothorax显示文摘 | Kelly AM Kerr D Clooney M | 2008 | Chest2008，134，5： | 1 |
| 5 | Comparison between two methods for estimating pneumothorax size from chest X-rays显示文摘 | Weldon D Tsang AY | 2006 | Respir Med2006，100，8： | 1 |
| 6 | Meta- analysis: effectiveness of drugs for preventing contrast - induced nephropathy显示文摘 | Kelly AM Dwamena B Cronin P | 2008 | Ann Intern Med2008，148，： | 1 |
| 7 | Functional connectivity of default mode network components: correlation, anticorrelation, and causality显示文摘 | Uddin LQ Kelly AM Biswal BB | 2009 | Hum Brain Mapp2009，30，2： | 1 |
| 8 | Fibreoptie endoscopic evaluation of swallowing and videofluomscopy: does examination type influence perception of pharyngeal residue severity? 显示文摘 | Kelly AM Leslie P Beale T | 2006 | Clin Otolaryngo12006，31，5： | 1 |
| 9 | Early experience with endoscopic carpal tunnel release显示文摘 | Kelly CP Pulisteti D Jamieson AM | 1994 | J Hand Surg (Br)1994，19，： | 1 |
| 10 | Multidetector row CT pulmonary angiography and indirect venography for the diagnosis of venous thromboembolic disease in intensive care unit patients 显示文摘 | Kelly AM Patel S Carlos RC | 2006 | Acad Radiol2006，13，4： | 1 |
| 11 | Mapping the functional connectivity of anterior cingulate cortex显示文摘 | Margulies DS Kelly AM Uddin LQ | 2007 | Neuroimage2007，37，2： | 1 |
| 12 | Agreement between arterial and transcu- taneous PCO2 in patients undergoing non-invasive ventilation 显示文摘 | Kelly AM Klim S | 2011 | RespirMed2011，105，2： | 1 |
| 13 | An alternative method for harvest and processing fat grafts: an in vitro study of cell viabili?ty and survival显示文摘 | Gonzalez AM Lobocki C Kelly CP | 2007 | Plast Reconstr Surg2007，120，1： | 1 |
| 14 | Changes in urinary cytokines and soluble intercellular adhension molecule-1 (ICAM-1) in bladder cancer patients after bacillus calmette Gurerin (BCG) immuneotherapy显示文摘 | Alexandroff AB Kelly RW | 1995 | Clin Exp Immunl1995，99，3： | 1 |
| 15 | An alternative method for harvest and processing fat grafts:an in vitro study of cell viabifity and survival显示文摘 | Gonzalez AM Lobocki C Kelly CP | 2007 | Plast Reconstr Surg2007，120，1： | 1 |
| 16 | Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus显示文摘 | Bank A J Kelly AS Thelen AM | 2007 | Am J Hypertens2007，20，： | 1 |
| 17 | An alternative method for harvest and processing fat grafts: an in vitro study of cell via?bility and survival显示文摘 | Gonzalez AM Lobocki C Kelly CP | 2007 | Plast Reconstr Surg2007，120，： | 1 |
| 18 | Fibreoptic endoscopic evalua-tion of swallowing and videofluoroscopy : Does examination typeinfluence perception of pharyngeal residue severity? 显示文摘 | Kelly AM Leslie P Beale T | 2006 | ClinOtolaryngol2006，31，42： | 1 |
| 19 | HRCT appearance of systemic mastocytosis involving the lungs 显示文摘 | Kelly AM Kazerooni EA | 2004 | J Thorac Imaging2004，19，1： | 1 |
| 20 | Nurse-initiated, titrated intravenous opioid analgesia reduces time to analgesia for selected painful condi- tions显示文摘 | Kelly AM Brumby C Barnes C | 2005 | CJEM2005，7，3： | 1 |
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