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| 1 | Sphincter-preserving R0 total mesorectal excision with resection of internal genitalia combined with pre-or postoperative chemoradiation for T4 rectal cancer in females显示文摘AIM: To evaluate the impact of chemoradiation admi- nistered pre- or postoperatively on prognosis in females following R0 extended resection with sphincter- preserving total mesorectal excision (TME) for locally advanced rectal cancer and to assess the association between chemoradiation and intra- and postoperative variables. METHODS: Twenty-one females were treated for locally advanced but preoperatively assessed as primarily resectable rectal cancer involving reproductive organs. Anterior resection with TME and excision of internal genitalia was combined with neo- or adjuvant chemoradiation. Two-year disease-free survival analysis was performed with the Kaplan-Meier method and log- rank test. The association between chemoradiation and other variables was evaluated with the Fisher’s exact test and Mann-Whitney test. RESULTS: Survival rate decreased in anaemic females (51.5% vs 57.4%), in patients older than 60 years (41.8% vs 66.7%) with poorly differentiated cancers (50.0% vs 55.6%) and tumors located ≤ 7 cm from the anal verge (42.9% vs 68.1%) but with the lack of importance. Patients with negative lymph nodes and women chemoradiated preoperatively had significantly favourable prognosis (85.7% vs 35.7%; P= 0.03 and 80.0% vs 27.3%; P = 0.01, respectively). Preoperative chemoradiation compared to adjuvant radiochemotherapy was not significantly associated with the duration of surgery, incidence of intraoperative bowel perforation and blood loss ≥ 1 L, rate of postoperative bladder and anorectal dysfunction, and minimal distal resection margin. It significantly influenced minimal radial margin (mean 4.2 mm vs 1.1 mm; P < 0.01). CONCLUSION: Despite involving internal genitalia, long-term disease-free survival and sphincter preservation may be achieved with combined-modality therapy for females with T4 locally advanced rectal carcinoma. Neoadjuvant chemoradiation does not compromise functional results and may significantly improve oncological outcomes probably due to enhanced radial clearance. | Bartlomiej Szynglarewicz Rafal Matkowski Piotr Kasprzak Daniel Sydor Jozef Forgacz Marek Pudelko Jan Kornafel | 2007 | World Journal of Gastroenterology2007，13，16： | 2 |
| 2 | Inhibition of intercellular communication bynickel(Ⅱ):antagonistic effect of magnesium显示文摘 | Miki H Kasprzak KS Kenney S | 1987 | Carcinogenesis1987，8，： | 1 |
| 3 | Heart type fatty acid binding protein-a rehable marker of myocardial necrosis in a heterogeneous group of patients with acute coronary syndrome without persistent ST elevation 显示文摘 | Figiel L Kasprzak JD Peruga J | 2008 | Kardiol Pol2008，66，3： | 1 |
| 4 | Nickel carcinogenesis显示文摘 | KASPRZAK K S SUNDERMAN F W SALNIKOW K | 2003 | Mutation Research2003，533，： | 1 |
| 5 | On neural blind separation with noise suppression and redundancy reduction 显示文摘 | Karhunen J Cichocki A Kasprzak W | 1997 | Int J Neural Systems1997，，8： | 1 |
| 6 | Investigation of the free radical scavenging activity of Ginkgo biloba L. leaves显示文摘 | M. Ellnain-Wojtaszek Z. Kruczyński J. Kasprzak | 2002 | Fitoterapia2002，，1： | 1 |
| 7 | Heart-type fatty acid binding protein-a reliable marker of myocardial necrosis in a heterogeneous group of patients with acute coronary syndrome without persistent ST elevation显示文摘 | Figiel L Kasprzak JD Peruga J | 2008 | Kardiol Pol2008，66，3： | 1 |
| 8 | Nickel carcinogenesis显示文摘 | Kasprzak KS Sunderman FW Salnikow K | 2003 | Mutat Res2003，533，12： | 1 |
| 9 | Nickel induced lipid peroxidation in the rat: Correlation with nickel effect on antioxidant defense systems 显示文摘 | Misra M Rodriguez RE Kasprzak KS | 1990 | Toxicol1990，64，1： | 1 |
| 10 | ,Role of high endothelial postcapillary venules and selected adhesion molecules in periodontal diseases:a review显示文摘 | Kasprzak A Surdacka A Tomczak M | 2013 | J Periodontal Res2013，48，1： | 1 |
| 11 | Nonlinear learning algorithms for blind separation of natural images显示文摘 | Cichocki A Kasprzak W | 1996 | Neural Network World1996，4，： | 1 |
| 12 | Thermal degradation of commercial fluoropolymer in air显示文摘 | Baker B B Kasprzak D J | 1994 | Polymer Degradation and Stability1994，42，： | 1 |
| 13 | Modelling the gravitational sag of the cornea and the subsequent quality of the refracted image显示文摘 | Henryk Kasprzak Barbara Krystyna Pierscionek | 2002 | Journal of Modern Optics2002，，13： | 1 |
| 14 | A Bax-induced Pro-oxidant State Is Critical for Cytochrome C Release During Programmed Neuronal Death 显示文摘 | Kirkland Rebecca A Windelbom James A Kasprzak Julia M | 2002 | The Journal of Neuroscience2002，22，15： | 1 |
| 15 | Cadmium(Ⅱ), unlike nickel (Ⅱ) inhibits 8-oxo-dGT Pase activity and increases 8-oxo-dG level in DNA of the rat testis,a target organ for Cadmium(Ⅱ) carcinogenesis 显示文摘 | Bialkowski K Bialkowska A Kasprzak KS | 1999 | Carcinogenesis1999，20，8： | 1 |
| 16 | On Neural Blind Separation with Noise Suppression and Redundancy Reduction显示文摘 | Karhunen J Cichocki A Kasprzak W | 1997 | Int J of Neural Systems1997，8，2： | 1 |
| 17 | Time- related changes in determinants of antiplatelet effeet of clopidogrel in patients after myocardial infarction 显示文摘 | Kubica A Kasprzak M Siller-Matula J | 2014 | Eur J Pharmaeol2014，11，5： | 1 |
| 18 | The easy formation of antisperm antibodies in prepubertal boys and the difficult bumoral response in severe - combined immunodeficiency mice显示文摘 | Kurpisz M Kasprzak M Mazurkiewicz I | 1996 | Fertil Steril1996，66，5： | 1 |
| 19 | Cadmium (Ⅱ),unlike nickel (Ⅱ),inhibits 8-oxo-d GT Pase activity and increases 8-oxo-dG level in DNA of the rat testis,a target organ for cadmium(Ⅱ) carcinogcnesis显示文摘 | BIALKOWSKI K BIALKOWSKA A KASPRZAK K S | 1999 | Carcinogenesis1999，20，： | 1 |
| 20 | Restoration of astratified lake(Feldberger Hausee,Germany)by a combina-tion of nutrient load reduction and long-term biomanipula-tion显示文摘 | Mehner T Kasprzak P Wysujack K | 2001 | International Review of Hydrobiology2001，86，： | 1 |
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