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| 1 | 慢性心力衰竭大鼠转化生长因子-β—Smads信号传导通路的调节异常显示文摘目的 探讨慢性缺血性心力衰竭大鼠转化生长因子 (transforminggrowthfactorTGF β) 信号传导蛋白 (Smads)的信号传导通路的变化 ,及与心肌梗死 (MI)后心力衰竭心脏重塑过程的关系。方法 大鼠经冠状动脉结扎 ,5d后经有创性血流动力学监测 ,试验分组 :(1)慢性心力衰竭组 (CHF) :左室舒张末压 (LVEDP)≥ 15mmHg (1mmHg =0 .133kPa) ,n =6 ;(2 )Sham组 :无冠状动脉结扎的手术对照组 ,n =6。 6周末 ,行逆行心脏体外灌流 ,应用胶原酶灌流心脏。分离活的心肌细胞和非心肌细胞。应用Westernblot测定TGF β1、β3 、Smad 2 /3、Smad 6蛋白表达水平。结果 非心肌细胞 :CHF组TGF β1明显增高 (P <0 .0 2 ) ,而TGF β3 明显减少 (P <0 .0 1) ,Smad 6明显下调 ;而Smad 3明显上调 (P <0 .0 2 ) ;心肌细胞 :CHF组TGF β3 明显减少 ,TGF β1明显增高 (P <0 .0 1) ;伴有Smad 2 /3明显下调 (P <0 .0 1) ;而Smad 6明显上调 (P <0 .0 5 )。结论 本研究首次证明了CHF大鼠心肌细胞和非心肌细胞的TGF β1、β3 和它们的信号转导通路特异性调节变化 ,TGF β | 高连如 John Teerlink Joel Karliner | 2001 | 中华心血管病杂志2001，29，3： | 23 |
| 2 | Adenoviral transduction of PTEN induces apoptosis of cultured hepatic steUate cells显示文摘 | HAO Li-sen ZHANG Xiao-lan AN Jun-yan YAO Dong-mei Justin Karlin FANG Shu-ming JIANG Hui-qing BAI Wen-yuan CHEN Shuang | 2009 | Chinese Medical Journal2009，，23： | 3 |
| 3 | Lysophospholipids and the cardiovascular system显示文摘 | KARLINER J S | 2002 | Biochim Biophys Acta2002，1582，13： | 2 |
| 4 | Chronic hypoxia modulates the interleukin-1β-stimulated inducible nitric oxide synthase pathway in cardiac myocytes显示文摘 | LONG C S KARLINER J S | 1997 | Circulation1997，96，6： | 1 |
| 5 | Comparative DNA analysis across diverse genomes显示文摘 | Karlin S Campbell AM Mrazek J | 1998 | Annu Rev Genetics1998，32，： | 1 |
| 6 | Practical network support for IP traceback显示文摘 | Savage S Wetherall D Karlin A | 2000 | ACM SIGCOMM Computer Communication Review2000，30，4： | 1 |
| 7 | Pomalidomide plus low-dose Dexamethasone in relapsed or refractory multiple myeloma (RRMM) with deletion (del)17p and/or translocation t(4;14) 显示文摘 | Leleu X Karlin L Macro M | 2013 | Blood (ASH Annual Meeting Abstracts)2013，122，： | 1 |
| 8 | Dynamic inventory policy with varying sto- chastic demands 显示文摘 | Karlin S | 1960 | Management Science1960，6，3： | 1 |
| 9 | Endothelin-1 Stimulates Cardiac Fibroblast Proliferation Through Activation of Protein Kinase C显示文摘 | Lucia Piacentini Mary Gray Norman Y Honbo Jamila Chentoufi Marina Bergman Joel S Karliner | 2000 | Journal of Molecular and Cellular Cardiology2000，，4： | 1 |
| 10 | Prediction of complete gene structures in human genomic DNA显示文摘 | Karlin S | 1997 | J Mol Biol1997，268，： | 1 |
| 11 | Metalloenzymes,structural motifs and inorganic models显示文摘 | Karlin K D | 1993 | Science1993，261，： | 1 |
| 12 | Applications and statistics for multiple hish scoring segments in molecular sequences显示文摘 | Karlin S Altschul S F | 1993 | Proc Natl Acad1993，90，： | 1 |
| 13 | Prediction of complete gene structures in human genomic DNA显示文摘 | Burge C Karlin S | 1997 | J Mol Biol1997，268，： | 1 |
| 14 | Asian-variant intravascular lymphoma in the African race显示文摘 | Geyer H Karlin N Palen B | 2012 | Rare Tumors2012，4，1： | 1 |
| 15 | BRIDGE: An Open-Label Phase II Trial Evaluating the Safety of Bevacizumab + Carboplatin/Paclitaxel as First-Line Treatment for Patients with Advanced, Previously Untreated, Squamous Non-small Cell Lung Cancer显示文摘 | John D. Hainsworth Liang Fang Jane E. Huang David Karlin Kenneth Russell Leonardo Faoro Christopher Azzoli | 2011 | Journal of Thoracic Oncology2011，，1： | 1 |
| 16 | Finding the genes in genomic DNA显示文摘 | Karlin S | 1998 | Curr Opin Struct Biol1998，8，： | 1 |
| 17 | A novel strong competitive inhibitor of complex I 显示文摘 | KOTLYAR A B KARLINER J S CECCHINI G | 2005 | FEBS Letters2005，579，21： | 1 |
| 18 | Lysophospholipids and the cardiovascular system 显示文摘 | Karliner JS | 2002 | Biochim Biophys Acta2002，1582，： | 1 |
| 19 | Methods for assessing the stastical significance of molecular sequence features by using general scoring schemes显示文摘 | Karlin S Altschul S F | 1989 | Proc Natl Acad1989，87，： | 1 |
| 20 | Network Support for IP Traceback 显示文摘 | Stevan Savagel David Wetherall Anna Karlin | 2001 | ACM/IEEE Transactions on Networking(TON)2001，9，3： | 1 |
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