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| 1 | IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers. | Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez | 2013 | World Journal of Gastroenterology2013，19，2： | 8 |
| 2 | Melatonin and/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats显示文摘The study aimed to explore the prophylactic effect of melatonin, rowatinex; a naturally occurring renal drug, and its combination on diabetic nephropathy in type 2 diabetic rats. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin(50 mg/g body weight). Three days before diabetes induction, rats were daily treated with melatonin, rowatinex and their combination continuously for 8 weeks. Evaluation was done through measuring blood urea nitrogen(BUN), serum uric acid, serum creatinine, urine creatinine, creatinine clearance, nitric oxide(NO), malondialdehyde(MDA), superoxide dismutase(SOD), glutathione(GSH), total antioxidant capacity(TAC),kidney injury molecule-1(KIM-1), heat shock protein-70(HSP-70), caspase-3, transforming growth factor β1(TGFβ1), DNA degradation by the comet assay and total protein contents. Histopathologic study was also done for the kidney and the pancreas. Drastic changes in all measured parameters of the diabetic rats were observed. Treatment with melatonin and rowatinex showed amelioration to variable degrees. In conclusion, melatonin showed the most potent effect on protecting rats from deleterious action of diabetic nephropathy followed by its combination with rowatinex. | Tarek K Motawi Samia A Ahmed Manal A Hamed Shohda A El-Maraghy Wessam M Aziz | 2019 | The Journal of Biomedical Research2019，33，2： | 2 |
| 3 | Significance of sperm characteristics in the evaluation of male infertility 显示文摘 | Nallella K P Sharma R K Aziz N | 2006 | Fertil Steril2006，85，3： | 1 |
| 4 | A homogeneous model for gas-liquid flow in horizontal wells显示文摘 | Ouyang L B Aziz K | 2000 | Journal of Petroleum Science and Engineering2000，27，3： | 1 |
| 5 | Neonatal Resuscitation: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care 显示文摘 | Kattwinkel J Perlman J Aziz K | 2010 | Pediatrics2010，126，5： | 1 |
| 6 | Compositional modeling with an equation of state 显示文摘 | Nghiem L X Fong D K Aziz K | 1981 | Society of Petroleum Engineering Journal1981，21，12： | 1 |
| 7 | Model-checking continuous-time Markov chains显示文摘 | AZIZ A SANWAL K SINGHAL V | 2000 | ACM Transactions on Computational Logic2000，1，1： | 1 |
| 8 | Incidental power morcellation of malignancy:a retrospective cohort study显示文摘 | Graebe K Garcia-Soto A Aziz M | 2015 | Gynecol Oncol2015，136，2： | 1 |
| 9 | Use of Voronoi Grid in Reservoir Sim- ulation显示文摘 | Palagi C L Aziz K | 1994 | SPE Advanced Technology Series1994，2，2： | 1 |
| 10 | Radiographic and CT appearances of the major fissures显示文摘 | Hayashi K Aziz A Ashizawa K | 2001 | Radiographics2001，21，4： | 1 |
| 11 | Thermodynamic analysis of two-component,two-phase flow in solar collectors with applicationto a direct-expamion solar assisted heat pump显示文摘 | Aziz W Chaturvedi S K Kheireddine A | 1999 | Energy1999，24，3： | 1 |
| 12 | Heavy metals removal from water in Malaysia: Post treatment by high quality limestone 显示文摘 | AZIZ H A ADLAN M N ARIFFIN K S | 2008 | Bioresource Technology2008，99，6： | 1 |
| 13 | Properties of Polyimide Snbstrate for Applications in Flexible Solar Cells 显示文摘 | Pakhuruddin M Z Ibrahim K Aziz A A | 2013 | Optoelectronies and Advanced Materials-Rapid Commu- nications2013，7，56： | 1 |
| 14 | High qual- ity biodiesel and its diesel engine application: a review 显示文摘 | ATADASHI I M AROUA M K ABDUL AZIZ A | 2010 | Renew Sustain Energy Rev2010，14，7： | 1 |
| 15 | Effects of sildenafil on myocardial blood flow in humans with ischemic heart disease显示文摘 | Tawakol A Aziz K Migrino R | 2005 | Comn Artery Dis2005，16，7： | 1 |
| 16 | Laser atherectomy for lower extremity revascularization: An adjunctive endovascular treatment option 显示文摘 | Abela GS Aziz K | 2006 | Vasc Endovascular Surg2006，40，4： | 1 |
| 17 | 查看详情显示文摘 | Erlebacher J Aziz M J Karma A Dimitrov N Sieradzki K | | 0，，： | 1 |
| 18 | Octreotide in the management of chemoradio ther-apy induced diarrhea refrantory to loperamide in patients with rectalcarcinoma显示文摘 | Erkan T Aziz K | 2006 | Oncology2006，71，： | 1 |
| 19 | The Kawase approach to retrosellar and upper clival basilar aneurysms 显示文摘 | AZIZ K M VAN LOVEREN H R TEW J M JR | 1999 | Neurosurgery1999，44，6： | 1 |
| 20 | Evolution of nanoporosity in dealloying 显示文摘 | ERLEBACHER J AZIZ M J KARMA A DIMITROV N SIERADZKI K | 2001 | Nature2001，410，： | 1 |
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