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| 1 | Efficacy and safety of endoscopic prophylactic treatment with undiluted cyanoacrylate for gastric varices显示文摘AIM:To evaluate the efficacy and safety of undiluted N-butyl-2 cyanoacrylate plus methacryloxysulfolane(NBCM)as a prophylactic treatment for gastric varices(GV)bleeding.METHODS:This prospective study was conducted at a single tertiary-care teaching hospital between October 2009 and March 2013.Patients with portal hypertension(PH)and GV,with no active gastrointestinal bleeding,were enrolled in primary prophylactic treatment with NBCM injection without lipiodol dilution.Initial diagnosis of GV was based on endoscopy and confirmed with endosonography(EUS); the same procedure was used after treatment to confirm eradication of GV.After puncturing the GV with a regular injection needle,1 mL of undiluted NBCM was injected intranasally into GV.The injection was repeated as necessary to achieve eradication or until a maximum total volume of 3 mL of NBCM had been injected.Patients were followed clinically and evaluated with endoscopy at 3,6 and 12 mo.Later follow-ups were performed yearly.The main outcome measures were efficacy(GV eradication),safety(adverse events related to cyanoacrylate injection),recurrence,bleeding from GV and mortality related to GV treatment.RESULTS:A total of 20 patients(15 male)with PH and GV were enrolled in the study and treated with undiluted NBCM injection.Only 2(10%)patients had no esophageal varices(EV); 18(90%)patients were treated with endoscopic band ligation to eradicate EV before inclusion in the study.The patients were followed clinically and endoscopically for a median of 31 mo(range:6-40 mo).Eradication of GV was observed in all patients(13 patients were treated with 1 session and 7 patients with 2 sessions),with a maximum injected volume of 2 mL NBCM.One patient had GV recurrence,confirmed by EUS,at 6-mo follow-up,and another had late recurrence with GV bleeding after 35 mo of follow-up; overall,GV recurrence was observed in 2 patients(10%),after 6 and 35 mo of follow-up,and GV bleeding rate was 5%(1 patient).Mild epigastric pain was reported by 3 patients(15%).No mortality or major complications,including embolism,or damage to equipment were observed.CONCLUSION:Endoscopic injection with NBCM,without lipiodol,may be a safe and effective treatment for primary prophylaxis of gastric variceal bleeding. | Matheus Cavalcante Franco Gustavo Flores Gomes Frank Shigeo Nakao Gustavo Andrade de Paulo Angelo Paulo Ferrari Jr Ermelindo Della Libera Jr | 2014 | World Journal of Gastrointestinal Endoscopy2014,6,6: | 16 |
| 2 | Post-combustion for the Electric Arc Furnace 显示文摘 | FRANK A VONESH Jr | 1995 | Iron and Steel Engineer1995,72,6: | 1 |
| 3 | Laparoscopic partial nephrectomy for renal tumors显示文摘 | GILL IS COLOMBO JR JR FRANK I | 2005 | J Urol2005,174,3: | 1 |
| 4 | Sclerosing hemangioma of thelung显示文摘 | Keylock JB5Galvin JR Franks TJ | 2009 | Arch Pathol Lab Med2009,133,: | 1 |
| 5 | Kinetic and spectral studies on the redox forms of methanol dehydrogenase from Hyphomicrobium X显示文摘 | FRANK J JR DIjKSTRA M DUINE JA | 1988 | Eur J Biochem1988,174,2: | 1 |
| 6 | Root decomposition across a barrier island chronosequence:Litter quality and environmental controls显示文摘 | Christine E Conn Frank P Day Jr | 1997 | Plant and Soil1997,195,2: | 1 |
| 7 | Acute fibrinous and organizing pneumonia:a histological pattern of lung injury and possible variant of diffuse alveolar damage显示文摘 | Beasley MB Franks TJ Galvin JR | 2002 | Arch Pathol Lab Med2002,126,9: | 1 |
| 8 | Smoking-related lung disease 显示文摘 | Galvin JR Franks TJ | 2009 | J Thorac Imaging2009,24,: | 1 |
| 9 | Synthesis and biological evaluation of c-aminophosphonates as potent, subtype-selectivesphingosine 1-phosphate receptor qagonists and antagonists 显示文摘 | Frank W Foss Jr Ashley H Snyder Michael D Davis | 2007 | Bioorg Med Chem2007,15,2: | 1 |
| 10 | Failures for disorders of syndromes; anterior cervical fixation deovaic by fixation of morscher screw, a biomechanic study显示文摘 | Frank JR Morges PV | 1994 | J Spine Disorder1994,7,2: | 1 |
| 11 | Evaluating damage potential in buildings affected by excavations显示文摘 | FINNO RICHARD J VOSS JR FRANK T ROSSOW EDWIN | 2005 | Journal of Geotechnieal and Geoenvironmental Engineering2005,131,10: | 1 |
| 12 | Competency-based medical education: theory to practice 显示文摘 | Frank JR Snell LS Care OT | 2010 | Med Teach2010,32,8: | 1 |
| 13 | From the archives of the AFIP:pulmonary vasculature-hypertension and infarction显示文摘 | Frazier AA Galvin JR Franks JJ | | 0,,: | 1 |
| 14 | Laparoscopic partial nephrectomy for centrally located renal tumors显示文摘 | Frank I Colombo J R Jr Rubinstein M | 2006 | J Urol2006,175,31: | 1 |
| 15 | Pan DR binding seq uence provides T-cellhelp for induction of protective antibodies against Pla smodium yoelii sporozoites显示文摘 | Franke ED Hoffman SL Sacci Jr JB | 1999 | Vaccine1999,17,: | 1 |
| 16 | Understanding growth-faulted,intraslope subbasins by applying sequence stratigraphic principles:Example from the south Texas Oligocene Frio Formation显示文摘 | L FRANK BROWN JR | 2004 | AAPG Bulletin2004,88,11: | 1 |
| 17 | Alterations in activating protein 1 composition correlate with phenotypic differentiation changes induced by resveratrol in human melanoma 显示文摘 | Sun Yang Frank L Meyskens Jr | 2005 | Mol Pharmacol2005,67,1: | 1 |
| 18 | Modulation of cell cycle Kinetics in human cancer with total parenteral nutrition显示文摘 | Frank JI Lawrence WJR Banks WI JR | 1992 | Cancer1992,69,: | 1 |
| 19 | Laparoscopic partial nephrectomy for hilar tumors显示文摘 | Gill I S Colombo J R Jr Frank I | 2005 | J Urol2005,174,3: | 1 |
| 20 | Missile Defence:Options and Obstacles 显示文摘 | Sietzen Jr Frank | 2002 | Aerospace America2002,40,5: | 1 |