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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | No evidence found thatchildhood onset of psoriasis influences disease severity,future bodymass index or type of treatments used 显示文摘 | de Jager ME de Jong EM Meeuwis KA | 2010 | J Eur Acad Dermatol Vene-reol2010，24，11： | 1 |
| 3 | Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support显示文摘 | Schipper ME van Kuik J de Jonge N | 2008 | J Heart Lung Transplant2008，27，12： | 1 |
| 4 | Pharmacological strategies to decrease excessive blood loss in cardiac surgery:a meta-analysis of clinically relevant endpoints显示文摘 | levi M Cromheecke ME de Jonge E | 1999 | Lancet1999，354，9194： | 1 |
| 5 | Performance of three point-of-care urinalysis test devices for drugs of abuse and thera- peutic drugs applied in the emergency department 显示文摘 | Attema de Jonge ME Peeters SY | 2012 | J Emerg Med2012，42，6： | 1 |
| 6 | A phase II multicenterclinical trial of systemic bexarotene in psoriasis显示文摘 | Smit JV Franssen ME de Jong EM | 2004 | J Am Acad Dermatol2004，51，2： | 1 |
| 7 | Changes in reg ulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support显示文摘 | Schipper ME van Kuik J de Jonge N | 2008 | J Heart Lung Transplant2008，27，12： | 1 |
| 8 | De-tection by polymerase chain reaction of Treponema pallidum DNAin cerebrospinal fluid from neurosyphilis patients before and afterantibiotic treatment显示文摘 | NOORDHOEK GT WOLTERS EC DE JONGE ME | 1991 | J Clin Microbiol1991，29，9： | 1 |
| 9 | A retrospective study of the teratogenicity of dermatological coal tar products显示文摘 | Franssen ME van der Wilt GJ de Jong PC | | 0，，05： | 1 |
| 10 | High exposures to bioactivated eyclophosphamide are related to the occurrence of veno-occlusive disease of the liver following high-dose chemotherapy 显示文摘 | de Jonge ME Huitema AD Beijnen JH | 2006 | Br J Cancer2006，94，9： | 1 |
| 11 | Detection by polymerase chain reaction of Treponema pallidum DNA in cerebrospinal fluid from neurosyphilis patients before and after antibiotic treatment显示文摘 | Wolters EC de Jonge ME | 1991 | J Clin Microbiol1991，29，9： | 1 |
| 12 | Recruitment of the priming protein pTP and DNA binding occur by overlapping Oct-1 POU homeodomain surfaces 显示文摘 | RN de Jong ME Mysiak LA Meijer | 2002 | EMBO J2002，21，4： | 1 |
| 13 | Pharmaco- logical strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints显示文摘 | Levi M Cromheecke ME de Jonge E | 1999 | Lancet1999，354，9194： | 1 |
| 14 | Are there inequalities in choice of birthing position? Sociodemographic and labour factors associated with the supine position during the second stage of labour显示文摘 | de Jonge A Rijnders ME van Diem MT | 2009 | Midwifery2009，25，： | 1 |
| 15 | Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support显示文摘 | Schipper ME van Kuik J de Jonge N | 2008 | J Heart Lung Transplant2008，27，12： | 1 |
| 16 | Detection by polymerase chain reaction of Treponema pallidum DNA in cerebrospinal fluid from reurosyphilis patients before and after antibiotic treatmen显示文摘 | Noordhoek GT Wolters EC de Jonge ME | 1991 | J Clin Microbiol1991，29，9： | 1 |
| 17 | Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism 显示文摘 | de Jonge ME Huitema AD Hohkamp M J | 2005 | Cancer Chemother Pharmacol2005，56，4： | 1 |
| 18 | Systematic literature review and pooled analyses of risk factors for finding adenomas at surveillance colonoscopy 显示文摘 | de Jonge V Sint Nicolaas J van Leerdam ME | 2011 | Endoscopy2011，43，7： | 1 |
| 19 | High exposures to bio- activated cyclophosphamide aa-e related to the occurrence of veno-oc- clusive disease of the liver following high-dose chemotherapy显示文摘 | de Jonge ME Huitema AD Beijnen JH | 2006 | Br J Cancer2006，94，9： | 1 |
| 20 | The significance of plasma membrane transport in the bioavailability of thyroid hormone显示文摘 | Hennemann G Everts ME de Jong M | 1998 | Clin Endocrinol(Oxf)1998，48，1： | 1 |
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