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| 1 | CYP1B1在成年肥胖小鼠巨噬细胞浸润及组织炎症中的作用显示文摘目的探讨CYP1B1(cytochrome P450,family 1,subfamily B,polypeptide 1)缺失对成年小鼠巨噬细胞募集及组织炎症作用。方法选择6 w周龄SPF级CYP1B1基因敲除(KO)和野生型(WT)雄性小鼠,给予低脂肪(LFD)、高脂肪(HFD)饲料,喂养6 w后分别测定各组全血葡萄糖及血清胰岛素水平。利用葡萄糖耐量实验,判断糖耐量损伤情况。HE染色及免疫荧光检测小鼠附睾脂肪组织的巨噬细胞浸润情况。多重实时定量PCR(qRT-PCR)检测附睾脂肪组织及肝脏中巨噬细胞特异性蛋白(Emr1)及肿瘤坏死因子α(TNF-a)的表达水平。结果 CYP1B1敲除可以改善高脂膳食导致的胰岛素敏感性下降;在附睾脂肪组织中,CYP1B1基因缺失与高脂肪膳食均促进巨噬细胞的募集,但CYP1B1缺失抑制高脂膳食对炎症因子的诱导;在肝脏组织中,高脂膳食诱导巨噬细胞的浸润,但CYP1B1基因缺失抑制小鼠巨噬细胞浸润并下调组织炎症因子的表达。结论 CYP1B1基因缺失对高脂膳食诱导的肥胖及相关的胰岛素敏感性下降的保护作用可能是由其对炎症抑制的组织特异性决定的。 | 赵丽华 刘小聪 冯婧 Colin R Jefcoate 王素青 | 2012 | 营养学报2012，34，3： | 3 |
| 2 | Air emissions from foundries: a current survey of literature, suppliers and foundrymen 显示文摘 | McKinley M D Jefcoat I A Herz W J | 1993 | American Foundry Society Transactions1993，101，： | 1 |
| 3 | Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells显示文摘 | Alexander DL Eltom SE Jefcoate CR | 1997 | Cancer Res1997，57，20： | 1 |
| 4 | Evaluation of the adsorptive capacity of peanut hull pellets for heavy metals in solution显示文摘 | BROWN P JEFCOAT I A PARRISH D | | 0，，01： | 1 |
| 5 | Evaluation of the adsorptive capacity of peanut hull pellets for heavy metals in solution显示文摘 | BROWN P JEFCOAT I A PARRISH D | 2000 | Advances in Environmental Research2000，4，1： | 1 |
| 6 | Tissue-specific synthesis and oxidative metabolism of estrogens显示文摘 | Jefcoate CR Liehr JG Santen RJ | 2000 | J Natl Cancer Inst Monogr2000，，27： | 1 |
| 7 | Characterization of pitting corrosion in bare and sol-gel coated aluminum 2024-T3 alloy显示文摘 | VOEVODIN N JEFCOATE C SIMON L | 2001 | Surface and Coatings Technology2001，140，： | 1 |
| 8 | Post-menopausal bone loss and its relationship to oral bone loss 显示文摘 | Jefcoat M Lewis C Reddi M | 2000 | Periodontol2000，23，1： | 1 |
| 9 | Evaluation of the adsorptive capacity of peanut hull pellets for heavy metals in solution 显示文摘 | BROWN P JEFCOAT I A PARRISH D | 2000 | Advances in Environmental Research2000，4，4： | 1 |
| 10 | Tissue-specific synthesis and oxidative metabolism of estrogens 显示文摘 | Jefcoate CR Liehr JG Santen RJ | 2000 | J Natl Cancer Inst Monogr2000，27，： | 1 |
| 11 | Evaluation of the adsorptive capacity of peanut hull pellets forheavy metals in solution 显示文摘 | BROWNP P JEFCOAT I A PARRISH D | 2000 | Advanced Environmental Resources2000，4，1： | 1 |
| 12 | Metabolism, Disposition and Excretion of^ Melamine in Male Fisher 344 Rats 显示文摘 | Mast RW Jefcoat AR Sadler BM | 1983 | Food Chem Toxieol1983，21，： | 1 |
| 13 | Tissue - specific synthesis and oxidative metabolism of estrogens as endogenous carcer in the breast and prostate 显示文摘 | Jefcoate CR Liehr JG Santen RI | 2000 | J Nst Cancer Inst Monograph2000，27，： | 1 |
| 14 | High-flux mitochondrial cholesterol trafficking,aspecialized function of the adrenal cortex显示文摘 | Jefcoate C | 2002 | J Clin Invest2002，110，7： | 1 |
| 15 | Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes显示文摘 | Raggatt LJ Jefcoat SC Jr Choudhury I | 2006 | Osteoarthritis Cartilage2006，14，7： | 1 |
| 16 | Current evidence regarding periodontal disease as a risk factor in preterm birth显示文摘 | Jefcoat MK Geurs NC Reddy MS | 2001 | Ann Periodontal2001，6，1： | 1 |
| 17 | Tissue-specific syn- thesis and oxidative metabolism of estrogens 显示文摘 | Jefcoate C R Liehr J G Santen R J | 2000 | J Natl Cancer Inst Monogr2000，27，： | 1 |
| 18 | 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes:implications for the mechanism of uterine tumorigenesis显示文摘 | Liehr J G Ricci M J Jefcoate C R | 1995 | Proceedings of the National Academy of Sciences of the United States of America1995，92，20： | 1 |
| 19 | Christian Gottlob Heyne and the u- niversity library at Gottingen as 'universalbib- liothek' of the eighteenth century 显示文摘 | Jefcoate G | 1998 | Library History1998，14，2： | 1 |
| 20 | Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates显示文摘 | Halberg RB Larsen MC Elmergreen TL Ko AY Irving AA Clipson L Jefcoate CR | 2008 | Cancer Res2008，68，18： | 1 |
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