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| 1 | 欧洲卒中组织颅内动脉瘤和蛛网膜下腔出血处理指南显示文摘背景伴或不伴蛛网膜下腔出血(subarachnoidhaemorrhage,SAH)的颅内动脉瘤是一个重要的健康问题,其总体发病率约为9/10万,在不同国家存在很大差异,在某些国家可高达20/10万。采用保守治疗时,发病最初数月内病死率为50%~60%。在动脉瘤未经处理的患者中,约1剧寄在初次出血恢复后6个月内死于再次出血。此外,血管痉挛、脑积水、迟发性缺血性神经功能缺损以及其他并发症均会影响预后。本指南旨在为伴和不伴颅内动脉瘤的SAH以及未破裂颅内动脉瘤患者的处理提供全面的推荐意见。方法我们使用Medline和Embase进行广泛的文献检索(时间范围为1960年至2011年)。写作组成员通过面谈和电话会议的形式讨论各条推荐意见。按照欧洲神经科学学会联盟标准对检索结果进行分级。欧洲卒中组织指南委员会成员对本指南进行了审阅。结果本指南为SAH的流行病学、危险因素和预后提供了循证信息,并为破裂和未破裂颅内动脉瘤的诊断和治疗方法提供了循证推荐意见。我们明确了动脉瘤生长和破裂的多种危险因素,并且提供了诊断性检查、监测和一般处理(血压、血糖、体温、血栓预防、抗癫痫治疗和类固醇的使用)的推荐意见。特异性治疗干预需考虑处理时机、夹闭和弹簧圈栓塞。本指南还涉及并发症的处理,如脑积水、血管痉挛和迟发性缺血性神经功能缺损等,并对非动脉瘤性SAH和未破裂动脉瘤的处理提供了推荐意见。结论破裂颅内动脉瘤是一种严重的疾病,具有很高的继发并发症风险,需要在治疗此类患者方面有着丰富经验的医疗中心内及时治疗。本指南为破裂或未破裂颅内动脉瘤患者的处理提供了实用的循证建议。应用这些措施能改善SAH的预后。 | Thorsten Steiner Andreas Unterberg Carla Jung Michael Forsting Seppo Juvela Gabriel Rinkel 吴政政(译) 李政(译) 陈蓓蕾(译) 陈聪(译) 杨卉(译) 徐运(译) | 2013 | 国际脑血管病杂志2013，21，6： | 182 |
| 2 | Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules显示文摘AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related HCC.METHODS: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically analyzed.RESULTS: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic metastasis.CONCLUSION: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis. | Seung Oe Lim Sung Gyoo Park Jun-Hi Yoo Young Min Park Hie-Joon Kim Kee-Taek Jang Jae Won Cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park | 2005 | World Journal of Gastroenterology2005，11，14： | 62 |
| 3 | Hepatolithiasis and intrahepatic cholangiocarcinoma: A review显示文摘Although the incidence of hepatolithiasis is decreasing as the pattern of gallstone disease changes in Asia, the prevalence of hepatolithiasis is persistently high, especially in Far Eastern countries. Hepatolithiasis is an established risk factor for cholangiocarcinoma(CCA), and chronic proliferative inflammation may be involved in biliary carcinogenesis and in inducing the upregulation of cell-proliferating factors. With the use of advanced imaging modalities, there has been much improvement in the management of hepatolithiasis and the diagnosis of hepatolithiasis-associated CCA(HLCCA). However, there are many problems in managing the strictures in hepatolithiasis and differentiating them from infiltrating types of CCA. Surgical resection is recommended in cases of single lobe hepatolithiasis with atrophy, uncontrolled stricture, symptom duration of more than 10 years, and long history of biliaryenteric anastomosis. Even after resection, patients should be followed with caution for development of HL-CCA, because HL-CCA is an independent prognostic factor for survival. It is not yet clear whether hepatic resection can reduce the occurrence of subsequent HL-CCA. Furthermore, there are no consistent findings regarding prediction of subsequent HL-CCA in patients with hepatolithiasis. In the management of hepatolithiasis, important factors are the reduction of recurrence of cholangitis and suspicion of unrecognized HL-CCA. | Hyo Jung Kim Jae Seon Kim Moon Kyung Joo Beom Jae Lee Ji Hoon Kim Jong Eun Yeon Jong-Jae Park Kwan Soo Byun Young-Tae Bak | 2015 | World Journal of Gastroenterology2015，21，48： | 63 |
| 4 | Diagnostic value of AFP-L3 and PIVKA-Ⅱin hepatocellular carcinoma according to total-AFP显示文摘AIM:To evaluate diagnostic value ofα-fetoprotein (AFP)-L3 and prothrombin induced by vitamin K absence-Ⅱ(PIVKA-Ⅱ)in hepatocellular carcinoma(HCC). METHODS:One hundred and sixty-eight patients during routine HCC surveillance were included in this study.Of the 168 patients,90(53.6%)had HCC including newly developed HCC(n=82)or recurrent HCC after treatment(n=8).Sera were obtained during their first evaluation for HCC development and at the time of HCC diagnosis before commencing HCC treatment.HCC was diagnosed by histological examination,appropriate imaging characteristics-computed tomography or magnetic resonance imaging.Control sera were collected from 78 patients with benign liver disease(BLD),which were obtained during routine surveillance with a suspicion of HCC.AFP,AFP-L3 and PIVKA-Ⅱwere measured in the same serum by microchip capillary electrophoresis and liquid-phase binding assay on a micro-total analysis system Wako i30 auto analyzer.The performance characteristics of three tests and combined tests for the diagnosis of HCC were obtained using receiver operating characteristic curves in all populations and subgroups with AFP<20 ng/mL. RESULTS:Of 90 HCC patients,38(42.2%)patients had AFP<20 ng/mL,20(22.2%)patients had AFP 20-200 ng/mL and 32(35.6%)patients had AFP>200 ng/mL.Of the 78 BLD patients,74(94.9%)patients had AFP<20 ng/mL.After adjustment for age and HBV infection status,AFP-L3 levels were higher in HCC than in BLD among patients with low AFP levels(<20 ng/mL)(P<0.001).In a total of 168 patients,areas under the curve(AUC)for HCC were 0.879,0.887,0.801 and 0.939 for AFP,AFP-L3,PIVKA-Ⅱand the combined markers,respectively.The combined AUC for three markers showed higher value than the AUCs of individual marker(P<0.05).AFP-L3 had higher AUC value than PIVKA-Ⅱfor HCC detection in entire patients(P =0.043).With combination of AFP-L3(cut-off>5%) and PIVKA-Ⅱ(cut-off>40 AU/L),the sensitivity were 94.4%and specificity were 75.6%in all patients.In 112 patients with low AFP levels(<20 ng/mL),AUCs of AFP-L3,PIVKA-Ⅱand combine AFP-L3 and PIVKA-Ⅱtests were 0.824,0.774 and 0.939,respectively. AFP-L3 with a cut-off value of 5%showed sensitivity of 71.1%and specificity of 83.8%,and PIVKA-Ⅱwith a cut-off value of 40 AU/L had sensitivity of 57.9%and specificity of 95.9%in patients with low AFP levels. The combination of AFP-L3 and PIVKA-Ⅱincreased the sensitivity and specificity up to 92.1%and 79.7%, respectively,in low AFP group.Combined markers detected 81.8%of early stage HCC(Union for Inter-national Cancer Control stageⅠ),86.7%of small sized tumor(<2 cm)and 91.7%of single tumor of HCC in the low AFP group.In multivariate analysis,AFP-L3 was correlated with AFP and tumor size,and PIVKA-Ⅱwas correlated with laboratory tests including serum aspartate aminotransferase,total bilirubin,platelets and albumin levels.PIVKA-Ⅱhad no correlation with AFP,AFP-L3 or tumor characteristics. CONCLUSION:Combined determination of AFP-L3 and PIVKA-Ⅱcould improve the diagnostic value for HCC detection in patients with or without increased AFP levels. | Jong Young Choi Seung Won Jung Hee Yeon Kim Myungshin Kim Yonggoo Kim Dong Goo Kim Eun-Jee Oh | 2013 | World Journal of Gastroenterology2013，19，3： | 55 |
| 5 | 黄河、长江与韩国Keum、Yeongsan江沉积物常量元素地球化学特征显示文摘运用同样的样品采集和测试方法比较分析了我国的长江和黄河以及韩国的Keum和Yeongsan江的常量元素地球化学特征。韩国河流沉积物中Ca及碳酸盐含量显著低于长江和黄河,而其他元素含量则在二者之间;黄河沉积物以总无机碳(TIC)、Na和Ca含量高为特征,而长江沉积物则显著富集Ti和P。Keum和Yeongsan江沉积物中P、Ca、Fe和Mg在酸溶相中比例可达30%~66%,而K、Al和Ti则富集在残渣相中。韩国河流沉积物极低的Ca含量同流域缺乏碳酸盐源岩密切相关,其沉积物主要由侏罗-晚白垩纪的花岗岩经过中等程度的化学风化而成。虽然Ca在中韩河流沉积物之间含量差异显著,但必须谨慎运用全钙含量来识别海区物源。而沉积物中非碳酸盐态钙(Ca)及相应的K/Ca和Al/Ca比更适合用来示踪黄河及Keum和Yeongsan江沉积物;Ti则可以用来区分长江与其他河流沉积物。 | 杨守业 Jung Hoi-Soo 李从先 LimDong-Il | 2004 | 地球化学2004，33，1： | 55 |
| 6 | Learning curve of laparoscopy-assisted distal gastrectomy with systemic lymphadenectomy for early gastric cancer显示文摘AIM: To evaluate the nature of the 'learning curve' for laparoscopy-assisted distal gastrectomy (LADG) with systemic lymphadenectomy for early gastric cancer. METHODS: The data of 90 consecutive patients with early gastric cancer who underwent LADG with systemic lymphadenectomy between April 2003 and November 2004 were reviewed. The 90 patients were divided into 9 sequential groups of 10 cases in each group and the average operative time of these 9 groups were determined. Other learning indicators, such as transfusion requirements, conversion rates to open surgery, postoperative complication, time to first flatus, and postoperative hospital stay, were evaluated. RESULTS: After the first 10 LADGs, the operative time reached its first plateau (230-240 min/operation) and then reached a second plateau (<200 min/operation) for the final 30 cases. Although a significant improvement in the operative time was noted after the first 50 cases, there were no significant differences in transfusion requirements, conversion rates to open surgery, postoperative complications, time to first flatus, or postoperative hospital stay between the groups. CONCLUSION: Based on operative time analysis, this study show that experience of 50 cases of LADG with systemic lymphadenectomy for early gastric cancer is required to achieve optimum proficiency. | Min-Chan Kim Ghap-Joong Jung Hyung-Ho Kim | 2005 | World Journal of Gastroenterology2005，11，47： | 49 |
| 7 | Long-term result of endoscopic Histoacryl (N-butyl-2-cyanoacrylate)injection for treatment of gastric varices显示文摘AIM:To evaluate the long-term efficacy and safety of endoscopic obliteration with Histoacryl for treatment of gastric variceal bleeding and prophylaxis.METHODS:Between January 1994 and March 2010 at SoonChunHyang University Hospital,a total of 127 patients with gastric varices received Histoacryl injections endoscopically.One hundred patients underwent endoscopic Histoacryl injections because of variceal bleeding,the other 27 patients received such injections as a prophylactic procedure.RESULTS:According to Sarin classification,56 patients were GOV1,61 patients were GOV2 and 10 patients were IGV.Most of the varices were large(F2 or F3,111 patients).The average volume of Histoacryl per each session was 1.7±1.3 cc and mean number of sessions was 1.3±0.6.(1 session-98 patients,2 sessions-25 patients,≥3 sessions-4 patients).Twenty-seven patients with high risk of bleeding(large or fundal or RCS+or Child C) received Histoacryl injection as a primary prophylactic procedure.In these patients,hepatitis B virus was the major etiology of cirrhosis,25 patients showed GOV1 or 2(92.6%)and F2 or F3 accounted for 88.9%(n=24).The rate of initial hemostasis was 98.4%and recurrent bleeding within one year occurred in 18.1%of patients.Successful hemostasis during episodes of rebleeding was achieved in 73.9%of cases.Median survival was 50 mo (95%CI 30.5-69.5).Major complications occurred in 4 patients(3.1%).The rebleeding rate in patients with hepatocellular carcinoma or GOV2 was higher than in those with other conditions.None of the 27 subjects who were treated prophylactically experienced treatment-related complications.Cumulative survival rates of the 127 patients at 6 mo,1,3,and 5 years were 92.1%,84.2%,64.2%,and 45.3%,respectively.The 6 mo cumulative survival rate of the 27 patients treated prophylactically was 75%.CONCLUSION:Histoacryl injection therapy is an effective treatment for gastric varices and also an effective prophylactic treatment of gastric varices which carry high risk of bleeding. | Eun Jung Kang Soung Won Jeong Jae Young Jang Joo Young Cho Sae Hwan Lee Hyun Gun Kim Sang Gyune Kim Young Seok Kim Young Koog Cheon Young Deok Cho Hong Soo Kim Boo Sung Kim | 2011 | World Journal of Gastroenterology2011，17，11： | 41 |
| 8 | Comparison of RECIST version 1.0 and 1.1 in assessment of tumor response by computed tomography in advanced gastric cancer显示文摘Objective:Response Evaluation Criteria in Solid Tumors(RECIST)guideline version 1.0(RECIST 1.0)was proposed as a new guideline for evaluating tumor response and has been widely accepted as a standardized measure.With a number of issues being raised on RECIST 1.0,however,a revised RECIST guideline version 1.1(RECIST 1.1)was proposed by the RECIST Working Group in 2009.This study was conducted to compare CT tumor response based on RECIST 1.1 vs.RECIST 1.0 in patients with advanced gastric cancer(AGC).Methods:We reviewed 61 AGC patients with measurable diseases by RECIST 1.0 who were enrolled in other clinical trials between 2008 and 2010.These patients were retrospectively re-analyzed to determine the concordance between the two response criteria using theκstatistic.Results:The number and sum of tumor diameters of the target lesions by RECIST 1.1 were significantly lower than those by RECIST 1.0(P<0.0001).However,there was excellent agreement in tumor response between RECIST 1.1 and RECIST 1.0(κ=0.844).The overall response rates(ORRs)according to RECIST1.0 and RECIST 1.1 were 32.7%(20/61)and 34.5%(20/58),respectively.One patient with partial response(PR)based on RECIST 1.0 was reclassified as stable disease(SD)by RECIST 1.1.Of two patients with SD by RECIST 1.0,one was downgraded to progressive disease and the other was upgraded to PR by RECIST 1.1.Conclusions:RECIST 1.1 provided almost perfect agreement with RECIST 1.0 in the CT assessment of tumor response of AGC. | Gil-Su Jang Min-Jeong Kim Hong-Il Ha Jung Han Kim Hyeong Su Kim Sung Bae Ju Dae Young Zang | 2013 | Chinese Journal of Cancer Research2013，25，6： | 42 |
| 9 | Study on the removal of NO_x from simulated flue gas using acidic NaClO_2 solution显示文摘从模仿的烟道气体的 NOx 的移动上的学习在起泡的实验室规模被执行了用钠绿泥石的酸的答案的反应堆。实验在各种各样的 pH 和入口被执行在在 45 ° C 的 SO2 气体的缺席或存在的没有集中。没有氧化和 NO2 吸收上的 SO2 的效果非常被检验。钠绿泥石的氧化能力在不同 pH 被调查,是在 pH 的更好的氧化剂被发现不到 4。在酸的媒介,钠绿泥石分解了成 ClO2 气体,它被相信不象在 NO2 吸收一样参予氧化。用酸的钠绿泥石答案的貌似合理的 NOx 移动机制被要求了。大约 81% 的最大的 NOx 移动效率被完成了。 | Bal Rai Deshwal Si Hyun Lee Jong Hyeon Jung Byung Hyun Shon Hyung Keun Lee | 2008 | Journal of Environmental Sciences2008，20，1： | 39 |
| 10 | 黄河沉积物中REE制约与示踪意义再认识显示文摘根据黄河不同地区的20个沉积物全岩样、酸溶相和酸不溶相中的稀土元素(REE)组成分析,并与1999年的研究比较,揭示出黄河沉积物REE组成主要受流域黄土源岩控制,而粒度、化学风化和人类活动等因素影响较弱。磷酸盐和Fe-Mn氧化物是形成酸溶相中的中稀土富集主要因素;而重矿物则明显影响了全岩和酸不溶残渣态REE分异特征。在世界大河中黄河沉积物REE组成非常独特,直接反映了我国上陆壳和陆表沉积物的组成特征,也可以用做标准化物质,用来对比研究世界其他河流的REE分异特征。 | 杨守业 李从先 JUNG Hoi-Soo CHOI Man-Sik | 2003 | 自然科学进展2003，13，4： | 36 |
| 11 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 12 | A Peroxidase Contributes to ROS Production during Arabidopsis Root Response to Potassium Deficiency显示文摘反应的氧种类(ROS ) 玩在对由调整高亲密关系的 K+ transporter 基因 AtHAK5 和另外的基因的表示的钾剥夺的根回答的一个重要角色。包含驾驶酶的 AtHAK5 倡导者的 Arabidopsis 植物的标注激活的线在钾足够的条件下面为生物体之发光被屏蔽。类型 III peroxidase 家庭,的一个成员 RCI3,被孤立,当它是由激活标签的 overexpressed 时,这导致了酶和内长的 AtHAK5 的提高的表示。RCI3 被发现在钾剥夺之上起来调整。而 ROS 生产和 AtHAK5 表示在剥夺 K+ 的条件下面在 rci3-1 被减少,植物 overexpressing RCI3 (RCI3 公牛) 显示出更多的 ROS 生产和 AtHAK5 表示。这些结果建议 RCI3 在钾剥夺下面涉及 ROS 的生产,那调停 RCI3 的 ROS 生产影响 AtHAK5 表示的规定。这 peroxidase 看起来是在 Arabidopsis 根的低钾的信号 transduction 小径的另一个部件。 | Min Jung Kim Silvano Ciani Daniel P. Schachtman | 2010 | Molecular Plant2010，3，2： | 29 |
| 13 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 14 | Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer显示文摘AIM: To analyze predictive factors for lymph node metastasis in early gastric cancer.METHODS: We analyzed 1104 patients with early gastric cancer(EGC) who underwent a gastrectomy with lymph-node dissection from May 2003 through July 2011. The clinicopathologic factors and molecular markers were assessed as predictors for lymph node metastasis. Molecular markers such as microsatellite instability, human mut L homolog 1, p53, epidermal growth factor receptor(EGFR) and human epidermal growth factor receptor 2(HER2) were included. The χ2 test and logistic regression analysis were used to determine clinicopathologic parameters.RESULTS: Lymph node metastasis was observed in 104(9.4%) of 1104 patients. Among 104 cases of lymph node positive patients, 24 patients(3.8%) were mucosal cancers and 80 patients(16.7%) were submucosal. According to histologic evaluation, the number of lymph node metastasis found was 4(1.7%) for well differentiated tubular adenocarcinoma, 45(11.3%) for moderately differentiated tubular adenocarcinoma, 36(14.8%) for poorly differentiated tubular adenocarcinoma, and 19(8.4%) for signet ring cell carcinoma. Of 690 EGC cases, 77 cases(11.2%) showed EGFR overexpression. HER2 overexpression was present in 110 cases(27.1%) of 406 EGC patients. With multivariate analysis, female gender(OR = 2.281, P = 0.009), presence of lymphovascular invasion(OR = 10.950, P < 0.0001), diameter(≥ 20 mm, OR = 3.173, P = 0.01), and EGFR overexpression(OR = 2.185, P = 0.044) were independent risk factors for lymph node involvement.CONCLUSION: Female gender, tumor size, lymphovascular invasion and EGFR overexpression were predictive risk factors for lymph node metastasis in EGC. | Eun Hyo Jin Dong Ho Lee Sung-Ae Jung Ki-Nam Shim Ji Yeon Seo Nayoung Kim Cheol Min Shin Hyuk Yoon Hyun Chae Jung | 2015 | World Journal of Gastroenterology2015，21，2： | 30 |
| 15 | 复合益生素对生长育肥猪生产性能、盲肠菌群及代谢产物的影响显示文摘试验旨在研究饲粮中添加复合益生素(JS菌)对生长育肥猪生产性能、盲肠菌群、挥发性脂肪酸及蛋白质腐败产物的影响。试验选择120头体重10 kg左右的健康DLY仔猪,随机分为对照组、抗生素组、0.1%JS菌组和0.2%JS菌组,每组5个重复。结果表明:与对照组相比,添加0.2%JS菌显著提高试猪30-50 kg阶段的平均日增重和采食量(P〈0.05);添加0.1%JS菌显著提高试猪80-100 kg阶段的平均日增重(P〈0.05);从试验全期来看,抗生素组、0.1%JS菌组和0.2%JS菌组试猪平均日增重和采食量均有所提高,但各组间差异不显著(P〉0.05)。添加JS菌趋于增加盲肠内容物乳酸杆菌数量,减少大肠杆菌数量(P〉0.05),从而提高二者的比值,分析PCR-DGGE图谱发现添加JS菌对菌群多样性和相似性也有一定影响。与对照组相比,0.1%JS菌组和0.2%JS菌组盲肠内容物乙酸含量分别提高2.35倍和2.99倍,丁酸含量分别提高58.87%和62.10%,挥发性盐基氮含量分别降低31.91%和28.53%(P〈0.05)。在本试验条件下,添加JS菌对生长育肥猪的生产性能有一定改善,效果与抗生素基本相当,这可能与其对肠道健康的保护作用有关。 | 毛倩 陈代文 余冰 Jung Sik Choi | 2010 | 中国畜牧杂志2010，46，17： | 27 |
| 16 | Alcohol,inflammation,and gut-liver-brain interactions in tissue damage and disease development显示文摘Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous system contributes to anti-inflammatory regulation through neuroimmunoendocrine actions. Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. The study of these interactions may provide potential new targets for therapeutic intervention. | H Joe Wang Samir Zakhari M Katherine Jung | 2010 | World Journal of Gastroenterology2010，16，11： | 26 |
| 17 | A Comparison of Brain Activity between Healthy Subjects and Stroke Patients on fMRI by Acupuncture Stimulation显示文摘目的将在击病人在针灸期间调查大脑活动模式,并且用功能的磁性的回声成像(fMRI ) 把结果与正常题目作比较。有马达软弱和 10 个健康题目的 11 个击病人全部的方法 A 被学习。fMRI 在点 Quchi (LI11 ) 和 Zusanli (ST36 ) 在左边上在针灸期间被执行。数据用针灸刺激导致的大脑激活的统计参量的地图被分析。结果显示出的结果 LI11 和 ST36 的刺激生产了在二之间的显著地不同的大脑激活模式,这组织。正常的组比击组显示出更大的全面激活。在正常的组,正面的脑叶的部分,顶骨脑叶,亚 lobar,小脑和中脑,区域被针灸在左 LI11 激活。在另一方面,仅仅劣等的顶骨腹片区域的右边在击病人被激活。当左 ST36 在正常的组被刺激时,正面的脑叶,顶骨脑叶,时间的脑叶,和亚 lobar 的双方,和枕骨的脑叶的左边,和小脑和中脑区域的右边被激活。为在击组的一样的刺激,仅仅劣等的顶骨腹片和小脑区域的双方被激活(P < 0.05,簇水平) 。释放模式没在两个组在任何针灸刺激期间被注意。结论大脑信号激活在一样的针灸期间是不同的在之间健康并且击病人,和效果显示出不同针灸点的关联。 | Seung-Yeon Cho Mia Kim Jong Joo Sun Geon-Ho Jahng Hengjun J Kim Seong-Uk Park Woo-Sang Jung Chang-Nam Ko Jung-Mi Park | 2013 | Chinese Journal of Integrative Medicine2013，19，4： | 25 |
| 18 | 中韩河流沉积物微量元素地球化学研究显示文摘长江和黄河以及韩国的Keum和Yeongsan江,具有不同的微量元素地球化学特征。韩国河流沉积物中微量元素含量多介于长江和黄河之间,以Li、Rb和Th较高为特征,粒级效应明显。长江富铁族和铜族元素,黄河则Sr最高,其他元素均低于其他3条河流;韩国河流中Sr主要赋存于长石中,而长江和黄河中则主要赋存于碳酸盐矿物中。根据沉积物中元素的赋存相态及含量,我们认为Ti、Cr/Th、Ti/Nb和Zr/Nb等可以作为判别西太平洋边缘海,尤其是黄海中长江、黄河与韩国河流物质贡献的可靠地球化学参数,但在运用中必须注意粒级效应影响。 | 杨守业 李从先 JUNG Hoi-soo LI M Dong-il CHOI Man-sik | 2003 | 海洋地质与第四纪地质2003，23，2： | 24 |
| 19 | Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization显示文摘AIM: To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS: A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospectively enrolled. HCC was diagnosed based on the diagnostic guidelines issued by the 2005 American Association for the Study of Liver Diseases. HCC rupture was defined as disruption of the peritumoral liver capsule with enhanced fluid collection in the perihepatic area adjacent to the HCC by dynamic liver computed tomography, and when abdominal paracentesis showed an ascitic red blood cell count of > 50000 mm 3 /mL in bloody fluid. RESULTS: Of the 54 patients, 6 (11.1%) underwent surgery, 25 (46.3%) TAE, and 23 (42.6%) supportive care. The 2-, 4and 6-mo cumulative survival rates at 2, 4 and 6 mo were significantly higher in the surgery (60%, 60% and 60%) or TAE (36%, 20% and 20%) groups than in the supportive care group (8.7%, 0% and 0%), respectively (each, P < 0.01), and tended to be higher in the surgical group than in the TAE group. Multivariate analysis showed that serum bilirubin (HR = 1.09, P < 0.01), creatinine (HR = 1.46, P = 0.04), and vasopressor requirement (HR = 2.37, P = 0.02) were significantly associated with post-treatment mortality, whereas surgery (HR = 0.41, P < 0.01), and TAE (HR = 0.13, P = 0.01) were inversely associated with posttreatment mortality. CONCLUSION: Post-treatment survival after surgery or TAE was found to be better than after supportive care, and surgery tended to provide better survival benefit than TAE. | Young-Joo Jin Jin-Woo Lee Seoung-Wook Park Jung Il Lee Don Haeng Lee Young Soo Kim Soon Gu Cho Yong Sun Jeon Kun Young Lee Seung-Ik Ahn | 2013 | World Journal of Gastroenterology2013，19，28： | 23 |
| 20 | Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells显示文摘AIM: The genes were divided into seven categories according to biological function; apoptosis-reiated, immune response-related, signal transduction-related, cell cyclerelated, cell growth-related, stress response-related and transcription-related genes.METHODS: We compared the gene expression profiles of SNU-C4 cells between amygdalin-treated (5 mg/mL,24 h) and non-treated groups using cDNA microarray analysis. We selected genes downregulated in cDNA microarray and investigated mRNA levels of the genes by RT-PCR. RESULTS: Microarray showed that amygdalin downregulated especially genes belonging to cell cycle category: exonuclease 1 (EXO1), ATP-binding cassette, sub-family F, member 2 (ABCF2), MRE11 meiotic recombination 11 homolog A (MRE114), topoisomerase (DNA) I (TOP1), and FK506 binding protein 12-rapamycin-associated protein 1 (FRAP1). RT-PCR analysis revealed that mRNA levels of these genes were also decreased by amygdalin treatment in SNU-C4 human colon cancer cells.CONCLUSION: These results suggest that amygdalin have an anticancer effect via downregulation of cell cycle-related genes in SNU-C4 human colon cancer cells,and might be used for therapeutic anticancer drug. | Hae-Jeong Park Seo-Hyun Yoon Long-Shan Han Long-Tai Zheng Kyung-Hee Jung Yoon-Kyung Uhm Je-Hyun Lee Ji-Seon Jeong Woo-Sang Joo Sung-Vin Yim Joo-Ho Chung Seon-Pyo Hong | 2005 | World Journal of Gastroenterology2005，11，33： | 23 |
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