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| 1 | Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates显示文摘Antibacterial adhesives are promising to inhibit biofilms and secondary caries.The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives,and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time.Six quaternary ammonium methacrylates with chain lengths of 3,6,9,12,16 and 18were synthesized and incorporated into Scotchbond Multi-Purpose.Streptococcus mutans bacteria were cultured on resin to form biofilms.Confocal laser scanning microscopy was used to measure biofilm thickness,live/dead volumes and live-bacteria percentage vs.distance from resin surface.Biofilm thickness was the greatest for Scotchbond control;it decreased with increasing chain length,reaching a minimum at chain length 16.Live-biofilm volume had a similar trend.Dead-biofilm volume increased with increasing chain length.The adhesive with chain length 9 had 37%live bacteria near resin surface,but close to 100%live bacteria in the biofilm top section.For chain length 16,there were nearly 0%live bacteria throughout the three-dimensional biofilm.In conclusion,strong antibacterial activity was achieved by adding quaternary ammonium into adhesive,with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16.Antibacterial adhesives typically only inhibited bacteria close to its surface;however,adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm.Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries. | Han Zhou Michael D Weir Joseph M Antonucci Gary E Schumacher Xue-Dong Zhou Hockin H K Xu | 2014 | International Journal of Oral Science2014，6，2： | 5 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 4 | Late Cenozoic eolian deposition in the North Pacific: Asian drying, Tibetan uplift, and cooling of the northern hemisphere显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，3，： | 3 |
| 5 | Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer 显示文摘 | Elsaleh H Joseph D Grien F | 2000 | Lancet2000，355，9217： | 1 |
| 6 | Late Cenozoic eolian deposition in the North Pacific: Asian drying, Tibetan uplift and cooling of the Northern Hemisphere 显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，13，： | 1 |
| 7 | U- Pb zircon and geochemical evidence for bimodal mid-Paleozoic magmatism and syngenetic base-metal mineralization in the Yukon-Tanana terrane,Alaska显示文摘 | Cynthia D B Joseph L W Melanie J H | | 0，，7： | 1 |
| 8 | Late Cenozoic eolian deposition in the North Pacific: Asian drying, Tibetan uplift, and cooling of the northern hemisphere 显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，13，3： | 1 |
| 9 | Assessing Understanding in Biology 显示文摘 | Joel J Mintzes James H Wandersee Joseph D Novak | 2001 | Journal of Biological Education2001，，3： | 1 |
| 10 | Annual Energy Out- look 2012, DOE/EIA-0383 显示文摘 | John J C Paul D H Joseph A B | 2012 | Energy Information Admin- istration2012，6，： | 1 |
| 11 | Increaees in cardiac,output can reverse flowed,cits from vasospasm independent of blood pressure:a study using xenon computed tomographic measurement of cerebral blood flow显示文摘 | Kim D H Joseph M Ziadi S | 2003 | Neurosurgery2003，53，5： | 1 |
| 12 | 75 keV, 140 mA proton injector显示文摘 | JOSEPH D S TERRY L F LASH D H | 2002 | Review of Scientific Instruments2002，73，2： | 1 |
| 13 | Kinetics and thermody- namics of cadmium ion removal by adsorption onto nano zerov- alent iron particles显示文摘 | Boparai H K Joseph M Carroll D M | 2011 | J Hazard Mater2011，186，3： | 1 |
| 14 | Neural network modeling of coastal algal blooms显示文摘 | JOSEPH H W LEE Y H MIKE D | 2003 | Ecological Modeling2003，159，23： | 1 |
| 15 | Amplitude death solutions for stabilization of DC microgrids with instantaneous constant-power loads 显示文摘 | STANLEY R H JOSEPH D S | 2013 | IEEE Transactions on Power Electronics2013，28，1： | 1 |
| 16 | Purification and characterization of a marine bacterial collagenase显示文摘 | JOSEPH R M JOSEPH H D | 1978 | Biochemistry1978，17，14： | 1 |
| 17 | CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage Ⅲ colorectal cancer显示文摘 | Van Rijnsoever M Elsaleh H Joseph D | 2003 | Clin Cancer Res2003，9，8： | 1 |
| 18 | Late Cenozoic eolian deposition in the North Pacific: Asia drying, Tibetan uplift and cooling of the Northern Hemisphere显示文摘 | Rea D K Snoeckx H Joseph L H | 1998 | Paleoceanography1998，13，： | 1 |
| 19 | Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc显示文摘 | Joseph D H David H B | 1993 | J Anita Sci1993，71，： | 1 |
| 20 | Mode Choice, Commuting Cost, and Urban Household Behavior 显示文摘 | Joseph S D Mobinul H | 2005 | Journal of Regional Science2005，45，3： | 1 |
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