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| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | 未处理或上游法处理后精子的DNA碎片能否预测使用赠卵ICSI后的妊娠?显示文摘本研究比较了未处理的精子和上游法处理后精子中的DNA碎片值(SDF)预测使用赠卵ICSI后妊娠的可能性。总共81例不孕女性接受通过夫精和赠卵ICSI后的胚胎移植。这种方式排除了目前公认的影响精子DNA修复的女方因素。在ICSI受精时,同时使用DNA碎片率检测试剂盒(Halosperm)进行盲法检测未处理的和上游法处理后精液中的精子DNA碎片。经上游法处理后的精液样本中SDF值呈显著下降。有趣的是,未处理的或上游法处理后精液样本中的SDF值均能预测妊娠。通过ROC曲线和其衍生的约登指数计算得出未处理前和上游法处理后精子sDF的临界值分别是24.8%和17.5%。未处理精子SDF预测妊娠的敏感性和特异性分别为75%和69%,而上游法处理后的精子SDF预测妊娠的敏感性和特异性分别是78%和73%。虽然SDF值增高与生育呈负相关,但我们发现在精子筛选降低sDF值后再与赠卵进行ICSI并不能保证获得妊娠。这表明目前的技术手段对于一些DNA损伤仍无法探及,从而相对影响辅助生殖成功的机率。因此,我们认为对目前的“冰山模式”作一些修饰后可以用来解释SDF在生育中的作用。 | Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega José Andrés Guijarro José Luís FernAndez Stephen D Johnston Rocio Nufiez-Calonge | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 3 | 骨髓活检标本中经典型霍奇金淋巴瘤的诊断显示文摘经典型霍奇金淋巴瘤(CHL)是一种通常发生于淋巴结的B细胞肿瘤,具有扩散到结外的潜能,可累及几乎任何器官系统,如肺、肝、骨和骨髓。原发结外CHL不常见,原发骨髓累及的CHL更为罕见(0.25%),其通常发生于HIV阳性患者且通常与EBV相关。 | Laurent C Arber D A Johnston P 陈敏(译) 刘勇(审校) | 2021 | 临床与实验病理学杂志2021，37，4： | 2 |
| 4 | Use of Solid State Carbothermic Reduction in Production of Transition Metals and Their Carbides显示文摘Many transition metals are produced by pyrometallurgical procedures which require very considerable amounts of energy, commonly electrical. On the other hand, some transition metals are obtained by employing very complex hydrometallurgical process routes. Solid state carbothermic reduction offers an alternative route for the production of both the metals and their carbides for energy saving and process step elimination.
Consequently, it seemed worth to review the work carried out in this area The metals covered in this brief review are chromium, tungsten, titanium, manganese, niobium and molybdenum. Silicon is also mentioned although it is not a transition metal. | YANG Yin-dong SOMMERVILLE I D JOHNSTON R F McLEAN A | 2000 | Journal of Iron and Steel Research(International)2000，7，2： | 2 |
| 5 | Adapting to unknown smoothness via wavelet shrinkage显示文摘 | Donoho D L Johnstone I M | 1995 | Journal of the American Statistical Assoc1995，90，432： | 1 |
| 6 | Adapting to Unknown Smoothness via Wavelet Shrinkage显示文摘 | Donoho D L Johnstone I M | 1995 | Journal of the American Statistical Association1995，90，432： | 1 |
| 7 | Ideal spatial adaptation via wavelet shrinkage显示文摘 | Donoho D L Johnstone I M | 1994 | Biometrika1994，81，12： | 1 |
| 8 | lnterventional pulmonary procedures: guidelines from the American College of Chest Physicians显示文摘 | Ernst A Silvestri GA Johnstone D | 2003 | Chest2003，123，： | 1 |
| 9 | Sleep-disordeered breathing,psychiatric distress,and quality of life impairment in sexual assault surviors显示文摘 | Krakow B Melendrez D Johnston L | 2002 | J Nerv Ment Dis2002，190，7： | 1 |
| 10 | Vapor-absent melting at 10 kbar of a biotite- and amphibole-bearing tonalitic gneiss: implication for the generation of A-type granites显示文摘 | Skjerlie K P Johnston A D | 1992 | Geology1992，20，： | 1 |
| 11 | Wavelet shrinkage: asymptotia显示文摘 | DONOHO D L JOHNSTONE I M | 1995 | Journal of the Royal Statistical Society: Series (B)1995，7，2： | 1 |
| 12 | A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma显示文摘 | Johnston P B Inwards D J Colgan J P | 2010 | Am JHematol2010，85，5： | 1 |
| 13 | Adapting to unknownsmoothness via wavelet shrinkage显示文摘 | Donoho D L Johnstone I M | 1995 | Journal of A-merican Statistical Association1995，，90： | 1 |
| 14 | Reappraisal of the 5 centimetre of distal excision for carcinoma of the rectum: a study of distal intramural spread and of patients' survival显示文摘 | Williams NS Dixon MF Johnston D | 1983 | Br J Surg1983，70，： | 1 |
| 15 | Bile acid and lysolecithin concentration in the stomach of patients with gastric ulcer显示文摘 | Dewar P King R Johnston D | 1983 | Br Jsurg1983，73，： | 1 |
| 16 | Temperature acclimatisation of swimming performance in the European Queen Scallop 显示文摘 | Bailey D M Johnston I A | 2005 | J Therm Biol2005，30，： | 1 |
| 17 | Human breast cancer specimens:diffraction-enhanced imaging with histologic correlation-improved conspicuity of lesion detail compared with digital radiography显示文摘 | Pisano E D Johnston R E Chapman D | 2000 | Radiology2000，214，3： | 1 |
| 18 | Thermally induced dynamics of satellite solar panels 显示文摘 | Johnston J D Thornton E A | 2000 | Journal of Spacecraft and Rockets2000，37，5： | 1 |
| 19 | Stress amongst nurses working in a healthcare telephone-advice service: relationship with job satisfaction, intention to leave, sickness absence, and performance 显示文摘 | Farquharson B Allan J Johnston D | 2012 | J Adv Nuts2012，68，7： | 1 |
| 20 | Short-term prognosis after emergency department diagnosis of TIA显示文摘 | Johnston S C Gress D R Browner W S | 2000 | JAMA2000，284，22： | 1 |
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