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| 1 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | Endovascular strategies for vertebrobasilar dissecting aneurysms 显示文摘 | Jin SC Kwon DH Choi CG | 2009 | Am J Neuroradiol2009，30，： | 1 |
| 3 | Analysis of clinical and radiologieal outcomes in mierosurgieal and endovaseular treatment of basilar apex aneurysms显示文摘 | Jin SC Ahn JS Kwun BD | 2009 | J Korean Neurosurg Soe2009，45，4： | 1 |
| 4 | Epilepsy after bypass sur- gery in adult moyamoya disease 显示文摘 | Jin SC Oh CW Kwon OK | 2011 | Neurosurgery2011，68，： | 1 |
| 5 | Char acterization of a novel bioflocculant,p-KG03,from a marine dinoflagellate,Gyrodinium impudicum KGO3显示文摘 | Joung Han Yim Sung Jin Kim Sc Hun Ahn | 2007 | Bioresource Technology2007，98，： | 1 |
| 6 | Development of 'De novo' aneurysm after therapeutic carotid occlusion显示文摘 | Jin SC Choi CG Kwon DH | 2009 | J Korean Neurosurg SCI2009，45，4： | 1 |
| 7 | Epidemic syphilis among homosexually active men in Sydney显示文摘 | Jin F Prestage GP Kippax SC | | 0，，04： | 1 |
| 8 | Multimodal treatment for complex intracranial aneurysms: clinical research 显示文摘 | Jin SC Kwon do H Song Y | 2008 | J Korean Neurosurg2008，44，5： | 1 |
| 9 | Phosphodiesterase 4 and its inhibitors in inflammatory diseases 显示文摘 | JIN SL DING SL LIN SC | 2012 | Chang Gung Med J2012，35，3： | 1 |
| 10 | Pooled-DNA sequencing identifies novel causative variants in PSEN1,GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort显示文摘 | Jin SC Pastor P Cooper B | | 0，，04： | 1 |
| 11 | Rare coding variants in the phospholipase D3 gene confer risk for Alzheimefs disease 显示文摘 | Cruchaga C Karch CM Jin SC | 2014 | Nature2014，505，7484： | 1 |
| 12 | IL28B genetic variants and gender are associated with spontaneous clearance of hepatitis C virus infection 显示文摘 | Rao HY Sun DG Jiang D Yang RF Guo F Wang JH Liu F Zhang HY Zhang HH Du SC Jin Q Qin H Lok AS Wei L | 2012 | J Viral Hepat2012，19，3： | 1 |
| 13 | Epidemic syphilis among homosexually active men in Sydney显示文摘 | Jin F Prestage GP Kippax SC | 2005 | MJA2005，183，4： | 1 |
| 14 | Pooled-DNA sequencing identifies novel causativevariants in PSEN1,GRN and MAPT in a clinical early-onset andfamilial Alzheimer’s disease Ibero-American cohort显示文摘 | Jin SC Pastor P Cooper B | 2012 | Alzheimers Res Ther2012，4，： | 1 |
| 15 | Kinetics of color develop- ment, pH decreasing, and anti-oxidative activity reduction of Maillard reaction in galactose/glycine model systems 显示文摘 | Liu SC Yang DJ Jin SY | 2008 | Food Chemistry2008，108，： | 1 |
| 16 | The impact of intensified supervisory activities on tuberculosis treatment显示文摘 | Jin BW Kim SC Mori T etal | 1993 | Tuber Lung Dis1993，74，： | 1 |
| 17 | A retrieval thrombectomy technique with the Solitaire stent in a large cerebral artery occlusion 显示文摘 | Park H Hwang GJ Jin SC | 2011 | Acta Neurochir ( Wien)2011，153，8： | 1 |
| 18 | Incidental gallbladder cancer at cholecystectomy: when should the surgeon be suspicious?显示文摘 | Pitt SC Jin LX Hall BL | 2014 | Ann surg2014，260，1： | 1 |
| 19 | Up-regμlation of DNA methylt-ransferase 3B expression in endometrial cancers显示文摘 | Jin F Dowdy SC Xiong Y | 2005 | Gynecol Oncol2005，96，2： | 1 |
| 20 | Up-regulation of DNA methyltransferase 3B expression in endometrial cancers显示文摘 | Jin F Dowdy SC Xiong Y | 2005 | Gynecol Oncol2005，96，2： | 1 |
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