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| 1 | Canopy Temperature Depression as a Potential Selection Criterion for Drought Resistance in Wheat显示文摘Field studies were conducted at Bushland, Texas, USA, in 2004 to examine usefulness of canopy temperature depression(CTD), the difference of air-canopy temperature, in screening wheat (Triticum aestivum L.) genotypes for yield underdryland and irrigated. Forty winter wheat genotypes were grown under irrigation and dryland. CTDs were recorded afterheading between 1 330 and 1 530 h on 6 clear days for dryland and 9 days for irrigation. Drought susceptible index (DSI)for each genotype was calculated using mean yield under dryland and irrigated conditions. Genotypes exhibited greatdifferences in CTD under each environment. The dryland CTDs averaged 1.33°C ranging from -0.67 to 2.57°C, and theaverage irrigation CTD were 4.59°C ranging from 3.21 to 5.62°C. A low yield reduction was observed under drylandconditions relative to irrigated conditions for high-CTD genotypes. CTD values were highly negatively correlated withDSI under dryland, and genotypes of CTDs = 1.3°C in dryland condition were identified as drought resistant. For 21genotypes classified as drought resistant by DSI, their CTDs were 1.68°C for dryland and 4.35°C for irrigation on average;for 19 genotypes classified as drought susceptible by DSI, average CTD was 0.94°C in dryland and 4.85°C in irrigation.The high-yield genotypes consistently had high CTD values, and the low-yield ones had low CTD values for allmeasurements in dryland. After heading, genotypes maintained consistent ranking for CTD. Regression results for CTDand yield suggested that the best time for taking CTD measurement was 3-4 weeks after heading in irrigation but any timebefore senescence in dryland. Crop water stress index (CWSI) calculated from CTD data was highly correlated with CWSIcalculated from yield, which suggesting traditional costly CWSI measurement may be improved by using portable infraredthermometers. Most importantly, grain yield was highly correlated with CTD under dryland (R2 = 0.79-0.86) and irrigation(R2 = 0.46-0.58) conditions. These results clearly indicated grain yield and water stress can be predicted by taking CTDvalues in field, which can be used by breeding programs as a potential selection criterion for grain yield and droughtresistance in wheat, but a second study year is needed to confirm further. | FAN Ting-lu Maria Balta Jackie Rudd William A Payne | 2005 | Agricultural Sciences in China2005，4，10： | 35 |
| 2 | 济南市机构养老服务的定性研究:老年护理人员现状显示文摘分析机构养老服务利益相关者对济南市养老机构老年护理人员队伍现状的认识。方法:采用焦点小组访谈的方法,分别对政府官员、养老机构管理人员、养老机构工作人员,入住养老机构的老年人以及社区老年人进行访谈。结果:养老机构中的老年护理人员多为下岗或农村务工人员,普遍缺少专业教育背景,养老机构对老年护理人员的培训还处于'以师带徒'的阶段。人员管理存在诸多困难和问题。结论:养老机构老年护理人员队伍层次较低,职业化和专业化教育滞后,人员管理需进一步加强。 | 吴敏 李士雪 Ning Jackie Zhang 朱嫒嫒 宁博 Thomas Wan Lynn Unruh | 2010 | 中国卫生事业管理2010，27，11： | 32 |
| 3 | 独居老年人生活及精神健康状况调查显示文摘目的分析山东省济南市独居老年人生活现状及精神健康状况。方法采用调查问卷收集160名独居老人和911名非独居老人的生活现状及精神健康状况等,应用2χ检验和秩和检验进行统计分析。结果独居老人中女性99人,占61.88%,男性61人,占38.12%,平均年龄为74.45岁,文化程度小学及以下105人,占65.62%;城乡独居老人的平均月收入分别为1 816.40和274.46元,非独居老人分别为1 911.37和372.59元;城乡独居老人中从不与亲戚、朋友交往的比例分别为20.93%和25.68%;从不参加体育活动的比例为60.47%和94.59%;独居老年人的精神健康得分为45.21分,低于非独居老年人的46.81分。结论与非独居老人相比较,独居老年人尤其是农村独居老人的生活状况较差,精神健康水平较低,需进一步改善。 | 吴敏 李士雪 Ning Jackie Zhang 朱媛媛 宁博 Thomas Wan Lynn Unruh | 2011 | 中国公共卫生2011，27，7： | 24 |
| 4 | Neuropathophysiology of functional gastrointestinal disorders显示文摘The investigative evidence and emerging concepts in neurogastroenterology implicate dysfunctions at the levels of the enteric and central nervous systems as underlying causes of the prominent symptoms of many of the functional gastrointestinal disorders. Neurogastroenterological research aims for improved understanding of the physiology and pathophysiology of the digestive subsystems from which the arrays of functional symptoms emerge. The key subsystems for defecation-related symptoms and visceral hyper- sensitivity are the intestinal secretory glands, the musculature and the nervous system that controls and integrates their activity. Abdominal pain and discomfort arising from these systems adds the dimension of sensory neurophysiology. This review details current concepts for the underlying pathophysiology in terms of the physiology of intestinal secretion, motility, nervous control, sensing function, immuno-neural communication and the brain-gut axis. | Jackie D Wood | 2007 | World Journal of Gastroenterology2007，13，9： | 17 |
| 5 | 特立独行的第二脑--肠神经系统显示文摘肠神经系统(enteric nervous system, ENS)由分布在肠壁的黏膜下及肌间两个神经丛组成,能独立地控制和调节胃肠的消化和吸收功能,被称为机体的第二脑(the second brain)或肠脑(gut brain)。ENS相对于中枢神经系统(central nervous system,CNS),在神经元的性能和环路上有着明显的独特性。ENS和CNS通过交感和副交感神经以及外周初级感觉神经组成反馈环路(脑-肠轴),影响个体的情绪、食欲和行为等其他功能。肠神经功能异常引起的胃肠功能紊乱不仅导致消化功能异常,还引起内脏痛及情绪和行为异常,如肠易激综合征(irritable bowel syndrome, IBS),严重影响病人的生活质量。然而,从世界范围来看,对ENS研究的深入程度和投入规模远低于对CNS的研究,在中国尤其如此。回顾ENS的研究历史,一个突出的问题是忽视了ENS的神经元及其神经网络和功能活动的特异性。本文将简介ENS结构和功能,举例重点阐述ENS独有的特性和重要意义,以期使更多的基础和临床研究领域的同仁们加深对ENS独特性的认识,促进ENS和相关疾病研究的进展。 | 李军华 段睿 李俍 WOOD Jackie D 望西玉 舒友生 王过渡 | 2020 | 生理学报2020，72，3： | 17 |
| 6 | 济南市≥65岁老人身体健康状况及影响因素分析显示文摘目的了解山东省济南市老年人身体健康状况并比较城乡区别。方法采用分层随机抽样方法选取样本,采用问卷调查方法,对济南市1 071名≥65岁老年人进行了入户调查,并拟合广义线性模型进行统计分析。结果 1 071人中,自评身体健康状况很好者143人,占13.40%;自评一般者729人,占68.10%;自评较差者198人,占18.50%;与同龄人比较,自评身体健康状况很好者106人,占9.90%;自评较好者313人,占29.20%;自评一般者522人,占48.70%;自评较差者128人,占12.00%;城市好于农村,差异有统计学意义(u=-4.544,P=0.000);患有慢性病老年人675人,患病率为63.02%,城市老年人慢性病患病率高于农村,差异有统计学意义(u=134.65,P=0.000);常见慢性病患病率前6位为高血压、心脏病、糖尿病、慢性支气管炎、颈椎病、脑血管疾病。结论济南市老年人群健康状况不容乐观,年龄、对所居住社区(村)评价、精神/心理得分、居住地和个人平均月收入对身体健康状况的影响具有统计学意义。 | 朱嫒嫒 李士雪 吴敏 Ning Jackie Zhang 宁博 Thomas Wan Lynn Unruh | 2011 | 中国公共卫生2011，27，4： | 13 |
| 7 | Synthesis of an AIE-active fluorogen and its application in cell imaging显示文摘A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor. | LAM Jacky Wing Yip FAISAL Mahtab NG Ka Ming LUO Kathy Qian | 2009 | Science China Chemistry2009，52，1： | 12 |
| 8 | 济南市老年人自感健康状况调查及其影响因素分析显示文摘目的:了解济南市老年人自感健康状况及影响因素。方法:采用分层随机抽样方法选取样本,采用问卷调查方法,对济南市1071名65岁以上老年人进行了入户调查,并用spss17.0进行Logistic回归模型进行统计分析。结果:1071例调查对象中,觉得现在身体健康状况很好的有143人,占13.40%,一般的有729人,占68.10%,较差的有198人,占18.50%。老年人熟悉朋友的个数、参加集体活动情况、是否患有慢性病、是否需要辅助用具为影响老年人自感健康状况的因素。结论:鼓励老年人多交朋友,积极参加集体活动对提高老年人自感健康状况有重要意义。患有慢性病和需要辅助用具会降低自感健康状况。 | 朱嫒嫒 李士雪 吴敏 Ning Jackie Zhang Thomas Wan Lynn Unruh 宁博 | 2011 | 中国卫生事业管理2011，28，6： | 10 |
| 9 | 济南市65岁以上老年人精神健康状况影响因素研究显示文摘目的了解老年人精神健康状况及其影响因素。方法随机抽取济南市1 071名65岁以上老年人,采用改编后的'社区需要评估工具'进行问卷调查,应用广义线性模型进行统计分析。结果老年人精神健康平均得分为46.57分,男性高于女性(P=0.001),城市高于农村(P=0.009)。与子女相聚的实际频率低于期望,生活部分自理或完全不能自理可能降低老年人的精神健康水平;而朋友人数大于5人、对居住环境较为满意、参加锻炼、身体和经济状况较好可能会提高老年人的精神健康水平。结论老年人精神健康水平总体较好。影响因素主要包括与子女相聚的频率、朋友人数、居住满意度、参加集体活动和体育锻炼、身体健康状况和生活自理能力以及经济状况等。 | 吴敏 李士雪 Ning Jackie Zhang 朱嫒嫒 宁博 Thomas Wan Lynn Unruh | 2011 | 山东大学学报(医学版)2011，49，1： | 10 |
| 10 | 中国推进消灭脊髓灰质炎终结战略计划技术问题:世界卫生组织专家解读显示文摘中国积极推进消灭脊髓灰质炎(脊灰)终结战略计划,分阶段将灭活脊灰病毒疫苗(Inactivated Poliovirus Vaccine,IPV)纳入免疫规划,预期2016年4月与全球同步停服三价(Trivalent)口服脊灰减毒活疫苗(Oral Poliomyelitis Attenuated Live Vaccine,t OPV),开始接种二价(Bivalent)OPV(b OPV)。为澄清对一些技术问题的认识,世界卫生组织驻中国代表处会同国内外相关专家,讨论了中国部分专业人员提出的主要技术和政策问题,包括停用OPV的原因,b OPV替代t OPV使用的步骤,转换前减少风险的准备等,形成专家解读,供相关部门和专业人员在推进消灭脊灰终结战略计划中参考。 | 左树岩 Lance Rodewald Roland Sutter Jackie Fournier-Caruana William Schluter Sergey Diorditsa | 2015 | 中国疫苗和免疫2015，21，4： | 9 |
| 11 | 黄果茄植物提取物对不同寄生虫中间宿主贝类的生物效应测定显示文摘采用常规浸杀灭螺的方法 ,观察黄果茄植物提取物对不同贝类的生物效应。设 8组浓度 ,观察 2 4h、4 8h和 72h不同贝类的死亡率 ,并计算LC50 。结果表明 ,当SX浓度为 8 64 0mg L ,室温在 (2 5± 1 )℃、水温 (2 3± 1 )℃时 ,对湖北钉螺、光滑双脐螺、静水椎实螺浸杀 4 8h ,其死亡率均达 1 0 0 %。 4 8h的LC50 分别为 0 3 3 2、0 858、0 74 7mg L。研究结果显示 ,黄果茄植物提取物是一种灭螺效果好且很有苗头的植物灭螺剂。 | 徐兴建 魏风华 刘建兵 戴裕海 杨先祥 李文新 殷荣华 赵利琴 盛桂莲 Georges Dussart Jackie Trigwell | 2001 | 动物学杂志2001，36，3： | 8 |
| 12 | 硝基苯衍生物结构与其淬灭聚(2,5-二戊氧基对亚苯基亚乙炔基)荧光效率的关系显示文摘The poly(2,5-dipentyloxy-para-phenylene ethynylene)(P) was synthesized by Pd-catalyzed Sonogashira coupling reaction.Due to causing energy transfer between the nitrobenzene’s quenchers and the polymer chains through the charge-transfer interaction,the fluorescence quenched properties of P varied obviously with the para-substituting group’s structure in the nitrobenzene derivatives.The fluorescence quenching efficiency of quenchers improved with increasing of electron repulsion capability of the para-substituting group.The fluorescence quenching efficiency increased nonlinearly with the concentration of the quenchers and had,however,no relation with the quenching time. | 徐宏丽 佟斌 石建兵 刘旸 田旭玲 董宇平 LAM Jacky Wing Yip 唐本忠 | 2007 | 高分子学报2007，17，3： | 8 |
| 13 | A Simple Approach to Bioconjugation at Diverse Levels: Metal-Free Click Reactions of Activated Alkynes with Native Groups of Biotargets without Prefunctionalization显示文摘Te efcient bioconjugation of functional groups/molecules to targeted matrix and bio-related species drives the great development of material science and biomedicine,while the dilemma of metal catalysis,uneasy premodifcation,and limited reaction efciency in traditional bioconjugation has restricted the booming development to some extent.Here,we provide a strategy for metal-free click bioconjugation at diverse levels based on activated alkynes.As a proof-of-concept,the abundant native groups including amine,thiol,and hydroxyl groups can directly react with activated alkynes without any modifcation in the absence of metal catalysis.Trough this strategy,high-efcient modifcation and potential functionalization can be achieved for natural polysaccharide,biocompatible polyethylene glycol(PEG),synthetic polymers,cell penetrating peptide,protein,fast whole-cell mapping,and even quick diferentiation and staining of Gram-positive bacteria,etc.Terefore,current metal-free click bioconjugation strategy based on activated alkynes is promising for the development of quick fuorescence labeling and functional modifcation of many targets and can be widely applied towards the fabrication of complex biomaterials and future in vivo labeling and detection. | Xianglong Hu Xueqian Zhao Benzhao He Zheng Zhao Zheng Zheng Pengfei Zhang Xiujuan Shi Ryan T.K.Kwok Jacky W.Y.Lam Anjun Qin Ben Zhong Tang | 2018 | Research2018，，1： | 7 |
| 14 | HYPERBRANCHED CONJUGATIVE MACROMOLECULES CONSTRUCTED FROM TRIPLE-BOND BUILDING BLOCKS显示文摘Polycyclotrimerization and polycoupling of acetylenic monomers respectively furnish hyperbranched polyarylenes and polyynes with high molecular weights (up to 1 × 106) in high yields (up to 99.9%). The polymers possess low intrinsic viscosities and high thermal stabilities, losing little of their weights when heated to > 400℃. Upon pyrolysis at > 800℃, the polymers graphitize with high char yields (up to 86%). Hyperbranched polyarylenes efficiently emit deep-blue to blue-green lights with fluorescence quantum yields up to 98% and strongly attenuate intense laser pulses with optical power-limiting performances superior to that of C60, a well-known optical limiter. Poly(alkenephenylenes), poly(aroylarylenes) and polyynes are readily cross-linkable by UV irradiation, serving as excellent photoresist materials for the generation of patterns with nanometer resolution. Thin films of hyperbranched polyynes exhibit very high refractive indexes (n up to 1.86). The internal and terminal acetylene moieties of the polyynes readily form complexes with cobalt carbonyls, which can be transformed into soft ferromagnetic ceramics with high magnetic susceptibilities (Ms up to ca. 118 emu/g) and near-zero magnetic losses. | Matthias HaeuBler Hong-chen Dong Jacky Wing Yip Lam Rong-hua Zheng An-jun Qin Ben-zhong Tang | 2005 | Chinese Journal of Polymer Science2005，23，6： | 7 |
| 15 | Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM To characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. METHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular assessments.RESULTS Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance of Adercreutzia, Coprococcus, Dorea, and Ruminococcus and decreased relative abundance of Turicibacter and Anaeroplasma in HFD mice. CONCLUSION Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. | Kandy T Velázquez Reilly T Enos Jackie E Bader Alexander T Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy | 2019 | World Journal of Hepatology2019，11，8： | 6 |
| 16 | A general powder dusting method for latent fingerprint development based on AIEgens显示文摘Powder dusting method is the most practically useful approach for latent fingerprint development in the crime scene. Herein, a general powder dusting method has been explored for latent fingerprint development based on aggregation-induced emission luminogens(AIEgens). A series of tetraphenylethene(TPE) derivatives with multiple diphenylamine(DPA), namely, TPE-DPA,TPE-2 DPA and TPE-4 DPA, were selected as candidates to dope with magnetic powders and applied for latent fingerprint development. After screening, the magnetic powder 3 doped with TPE-4 DPA proves to be the best, in terms of fluorescent intensity, resolution and adhesiveness. Afterwards, the magnetic powder 3 was applied for visualization of latent fingerprint on various smooth and porous substrates, including glass, stainless steel, leaf, ceram, plastic bag, lime wall, wood and paper money.Specific details, such as island, core, termination and bifurcation, can be clearly observed for the fluorescent fingerprint images. | Zijie Qiu Bin Hao Xinggui Gu Zhaoyu Wang Ni Xie Jacky W.Y.Lam Hongxia Hao Ben Zhong Tang | 2018 | Science China Chemistry2018，61，8： | 6 |
| 17 | Hu蛋白作为豚鼠小肠肌间丛神经元标志物的研究显示文摘比较 5种神经元标志物在小肠肌间丛神经元中的特异性。应用新发现的神经元标志物Hu蛋白 ,对豚鼠肠神经系统 (ENS)的小肠肌间丛神经元进行免疫荧光染色研究 ,并与其他神经元标志物MAP 2 ,PGP 9 5 ,NSE ,TUJ 1进行比较。结果表明 :Hu蛋白主要分布于神经元胞浆中 ,神经元核也有较浅的染色 ,尤其在whole mount上 ,每个神经元都清晰可见。MAP 2作为神经元标志物 ,也能显示完好的细胞形态 ,但由于粗大神经纤维的强染色 ,使神经元计数不准确。PGP 9 5 ,NSE和TUJ 1对体外培养的小肠肌间丛神经元染色良好 ,但在whole mount上 ,神经纤维强染色 ,无法计数分析。结果提示在豚鼠肠神经系统小肠肌间丛神经元的计数研究中 ,Hu蛋白是理想的神经元标志物。 | 林中 胡宏镇 Jackie D Wood | 2002 | 基础医学与临床2002，22，3： | 6 |
| 18 | 从单核细胞分化的树突状细胞的低温保存及其临床应用(英文)显示文摘树突状细胞 (dendriticcells,DCs)作为专职的抗原递呈细胞 ,已被广泛地应用于临床的肿瘤疫苗治疗。目前的临床方案大多为分次给病人注射 >10 6 个细胞 /次 ,不同批次培养的DCs,连续 4 - 6周。为了提高疗效 ,简化治疗程序及规范疗程 ,有必要将DCs低温保存 ,使患者在治疗过程中得到同批次的培养的DCs。本实验从患者外周血采取单个核细胞 ,经细胞淘洗分离单核细胞 ,在 80 0U/mlGM CSF + 10 0ng/mlIL 13的培养条件下 ,将单核细胞于Teflon疏水袋中诱导产生DCs。将DCs以 - 1℃梯度降温及不控温两种方式将DCs冻存于 - 80℃及液氮中。 1个月后 ,4 2℃快速复温。检测其免疫表型 (CD1a ,CD14,CD4 0 ,CD80 ,CD83,CD86,CD5 4 ,CD5 8,CD16,CD32 ,CD64,HLA DR)及其对自体及异体淋巴细胞的刺激作用。结果表明 ,2种方式的低温保存及复温过程不改变DCs的免疫表型及对淋巴细胞的刺激功能。结论 :应用Teflon袋 ,能够从外周血单核细胞中诱导出大批量的DCs ,这些DCs可被低温保存而不改变其功能 。 | VERG Véronique MARTINACHE Chantal LEON Anne GORIN Norbert-Claude BERNARD Jacky LOPEZ Manuel | 2000 | 中国实验血液学杂志2000，8，4： | 6 |
| 19 | Cytoprotective Mechanism of the Novel Gastric Peptide BPC157 in Gastrointestinal Tract and Cultured Enteric Neurons and Glial Cells显示文摘Dear Editor,Body protection compound (BPC) 157 is a stable gastric pentadecapeptide. Predrag Sikiric’s team has carried out many investigations of its cytoprotective effects in different organs and tissues (1, 2)Their evidence indicates that BPC157 has potent cytoprotection in neural injury and gastrointestinal (GI) ulcers. Nevertheless. | Xi-Yu Wang Meihua Qu Rui Duan Dengping Shi Ling Jin Jinping Gao Jackie D.Wood Junhua Li Guo-Du Wang | 2019 | Neuroscience Bulletin2019，35，1： | 6 |
| 20 | 企业培训中成人学习策略的质性研究显示文摘企业培训中,成人如何在自定步调的、基于技术的课程中(这些课程与他们的工作或企业现行的任务相关)学习,特别是成人学习者如何使用以下学习策略:先前经验、反思、元认知、对话、生成式学习策略和亲身体验。基于近期开展的博士论文研究,发现元认知仍是最为重要的策略。也就是说,知识建构不仅始于元认知,而且在整个过程中由元认知来维系。本研究也揭示了在诸多学习策略中,学习者使用最多的策略是元认知策略。在自定步调的、基于技术的培训中,经常使用谈话的学习者更喜欢对话和讨论。 | Jackie Dobrovolny 张秀梅 | 2009 | 现代远程教育研究2009，21，2： | 5 |
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