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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Alternatives for large-scale production of cultured beef: A review显示文摘Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today's 2-dimensional(2D) standard technique that was used to make the first cultured hamburger. Options for efficient large-scale production of stem cells are to culture cells on microcarriers, either in suspension or in a packed bed bioreactor, or to culture aggregated cells in suspension. We discuss the pros and cons of these systems as well as the possibilities to use the systems for tissue culture. Either of the production systems needs to be optimized to achieve an efficient production of cultured beef. It is anticipated that the optimization of large-scale cell culture as performed for other stem cells can be translated into successful protocols for bovine satellite cells resulting in resource and cost efficient cultured beef. | Matilda S M Moritz Sanne E L Verbruggen Mark J Post | 2015 | Journal of Integrative Agriculture2015，14，2： | 7 |
| 3 | Percutaneous closure of secundum type atrial septal defects:More than 5-year follow-up显示文摘AIM: To investigate long-term efficacy of two different devices more than five years after percutaneous atrial septal defect(ASD) closure in adults.METHODS: All patients who underwent percutaneous closure of an ASD in the St. Antonius Hospital, Nieuwegein, The Netherlands, between February 1998 and December 2006 were included. Percutaneous closure took place under general anaesthesia and transesophageal echocardiographic moni toring. Transthoracic echocardiography(TTE) was performed 24 h post-procedure to visualize the device position and to look for residual shunting using color Doppler. All complications were registered. All patients were invited for an outpatient visit and contrast TTE more than 5-years after closure. Efficacy was based on the presence of a residual right-to-left shunt(RLS), graded as minimal, moderate or severe. The presence of a residual left-to-right shunt(LRS) was diagnosed using color Doppler, and was not graded. Descriptive statistics were used for patients' characteristics. Univariate analysis was used to identify predictors for residual shunting.RESULTS: In total, 104 patients(mean age 45.5 ± 17.1 years) underwent percutaneous ASD closure using an Amplatzer device(ASO) in 76 patients and a Cardioseal/Starflex device(CS/SF) in 28 patients. The mean follow-up was 6.4 ± 3.4 years. Device migration occurred in 4 patients of whom two cases occurred during the index hospitalization(1 ASO, 1 CS/SF). The other 2 cases of device migration occurred during the first 6 mo of follow-up(2 CS/SF). The recurrent thrombo-embolic event rate was similar in both groups: 0.4% per follow-up year. More than 12 mo post-ASD closure and latest follow-up, new-onset supraventricular tachyarrhythmia's occurred in 3.9% and 0% for the ASO and CS/SF group, respectively. The RLS rate at latest follow-up was 17.4%(minimal 10.9%, moderate 2.2%, severe 4.3%) and 45.5%(minimal 27.3%, moderate 18.2%, severe 0%) for the ASO- and CS/SF groups, respectively. There was no residual LRS in both groups.CONCLUSION: Percutaneous ASD closure has good long-term safety and efficacy profiles. The residual RLS rate seems to be high more than 5 years after closure, especially in the CS/SF. Residual LRS was not observed. | Roel JR Snijder Maarten J Suttorp Jurrien M Ten Berg Martijn C Post | 2015 | World Journal of Cardiology2015，7，3： | 6 |
| 4 | Soil carbon pools and world life zones显示文摘 | POST W M EMANUEL W R ZINKE P J | 1982 | Nature1982，298，： | 1 |
| 5 | Response of northern forests to CO2-induced climate change显示文摘 | Pastor J Post W M | 1988 | Nature1988，334，： | 1 |
| 6 | Patterns of placental pathology in preterm prematurerupture of membranes 显示文摘 | Amstrong W J Post M D Donnelly M | 2013 | J Dev Orig Health dis2013，4，3： | 1 |
| 7 | Electron beam CT versus helical CT scans for assessing coronary calcification: Current utility and future directions显示文摘 | NASIR K BUDOFF M J POST W S | 2003 | Am Heart J2003，146，6： | 1 |
| 8 | Fozest soil carbon inventories and dynamics along an elevation gradient in the southern Appalachian Mountains 显示文摘 | Garten C T Post W M Hanson P J | 1999 | Biogeochemistry1999，45，2： | 1 |
| 9 | Analysis of adult otitis media:polymerase chain reaction versus culture for bacteria and viruses显示文摘 | LIEDERMAN E M POST J C AUL J J | 1998 | Ann Otol Rhinol Laryngol1998，107，： | 1 |
| 10 | Soil carbon pools and world life zones显示文摘 | Post W M Rmanuel W R Zinke P J | 1982 | Nature1982，298，： | 1 |
| 11 | Soil carbon pool and world life zone显示文摘 | Post W M Emanuel W R Zinke P J | 1982 | Nature1982，298，： | 1 |
| 12 | Changes in quality-of-life after pacemaker implantation: responsiveness of the Aquarel questionnaire 显示文摘 | STOFMEEL M A POST M W KELDER J C | 2001 | Pacing Clin Electrophysiol2001，24，3： | 1 |
| 13 | Role of oxidants/inflam- mation in declining renal function in chronic kidney disease and nor- mal aging显示文摘 | Vlassara H Torreggiani M Post J B | 2009 | Kidney Int Suppl2009，，114： | 1 |
| 14 | The 2007 eastern US springfreeze:increased cold damage in a warming world?显示文摘 | GU L H HANSON P J POST W M | 2008 | Bioscience2008，58，3： | 1 |
| 15 | Soil pool and world life zones 显示文摘 | Post W M Emanuel W R Zinke P J | 1982 | Nature1982，298，： | 1 |
| 16 | Effects of lowdose oral and transdermal estrogen replacement therapy on hemostatic factors in healthy postmenopansal women: a randomized placebo-controlled study显示文摘 | Post MS van der Mooren M J van Baal WM | 2003 | Am J Obstet Gyneco12003，189，5： | 1 |
| 17 | Soil car- bon pools and world life zones 显示文摘 | Post W M Emanuel W R Zinke P J | 1982 | Nature1982，298，： | 1 |
| 18 | Standard methods for land-use planning to determine the effects on societal risk显示文摘 | LAHEIJ G M H POST J G ALE B J M | 2000 | Journal of Hazardous Materials2000，71，1： | 1 |
| 19 | Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease,spontaneous myocardial infarctions,severe cardiac dysfunction,and premature death in apolipoprotein E-deficient mice显示文摘 | BRAUN A TRIGATTI B L POST M J | 2002 | Circ Res2002，90，3： | 1 |
| 20 | Soil carbon pools and life zones显示文摘 | Emanuel W R Zinke P J | 1982 | Nature1982，298，： | 1 |
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