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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Postmenopausal hormones and incontinence:The heart and estrogen/progestin replacement study显示文摘 | Grady D Brown J S Vittinshof E | 2001 | Obstet Gynecol2001，97，1： | 1 |
| 3 | Effect of isradipine on in vivo platelet function显示文摘 | O'Grady J Kritz H Schmid P | 1997 | Thrombosis Res1997，86，3： | 1 |
| 4 | The staufen/pumilio path way is involved in Drosophila long-term memory显示文摘 | Dubnau J Chiang AS Grady L | 2003 | Curr Biol2003，13，4： | 1 |
| 5 | Network-based ap- proach to modeling uncertainty in a supply chain显示文摘 | BLACKHURST J WU T GRADY P | 2004 | Interna- tional Journal of Production Research2004，42，8： | 1 |
| 6 | Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression,bipolar disorder and schizophrenia显示文摘 | Webster M J O′Grady J Kleinman J E | 2005 | Neuroscience2005，133，： | 1 |
| 7 | Perylene in basin sediments off southern California显示文摘 | ORR W L GRADY J R | 1967 | Geoehimica et Cosmochimica Acta1967，31，： | 1 |
| 8 | Sub-tenon's injection for local anaesthes'a in posterior segment surgery 显示文摘 | LIHK Abouleish A Grady J | 2000 | Ophthalmolgy2000，107，： | 1 |
| 9 | Power quality disturbance waveform recognition using wavelet-based neural classifier-part 2: application显示文摘 | Santoso S Powers E J Grady W M | 2000 | IEEE Trans on Power Delivery2000，15，1： | 1 |
| 10 | Decreased Ovarian hormones during a soy diet: implications for breast cancer prevention显示文摘 | LU L J ANDERSON K E GRADY J J | 2000 | Cancer Res2000，60，： | 1 |
| 11 | High rates of perinatal group B Streptococcus clindamycin and erythromycin resistance in an upstate New York hospital显示文摘 | Back E E O'Grady E J Back J D | 2012 | Antimicrob Agents Chemother2012，56，： | 1 |
| 12 | Power disturbance classifier using a rule based method and wavelet packet based hidden Markov model显示文摘 | CHUNG J POWERS J E GRADY W M | 2002 | IEEE Trans on Power Delivery2002，17，1： | 1 |
| 13 | Hydroxyl radical production during oxidative deposition of iron in ferritin显示文摘 | Grady J K Chen Y Chasteen N D | 1989 | J Biol Chem1989，264，20： | 1 |
| 14 | Survey of active line conditioning met homologies显示文摘 | Grady W M Samotyi M J Noyola A H | 2000 | 1EEE Transactions on Power Electronics2000，15，4： | 1 |
| 15 | Decreased ovarian hor- mones during a soya diet: implications for breast cancer pre- vention显示文摘 | Lu L J Anderson KE Grady J J | 2000 | Cancer Res2000，60，15： | 1 |
| 16 | 'Postnaenopansal'hormones and incontinence:The heart and estrogen/progestin replacement study 显示文摘 | Grady D Brown J S Vittinshof E | 2001 | Obstet Gynecol2001，97，1： | 1 |
| 17 | Meeting IEEE-519 harmonic voltage and voltage distortion constrains with an active power line conditoner显示文摘 | Chang W K Grady W M Samotyj M J | 1994 | IEEE Transactions on Power Delivery1994，9，3： | 1 |
| 18 | The hidden costs ofemployee turnover显示文摘 | Garman AN Corbett J Grady J | 2005 | Simulation and Gaming2005，36，2： | 1 |
| 19 | Power quality dis-turbance data compression using wavelet transform methods 显示文摘 | SANTOSO S POWERS E J GRADY W M | 1997 | IEEE Trans on Power Delivery1997，12，3： | 1 |
| 20 | Effect of varying the gas headspace to meat ratio on the quality andshelf life of beef steaks packaged in high oxygen modified atmosphere packs 显示文摘 | MURPHY K M O'GRADY M N KERRY J P | 2013 | Meat Science2013，94，4： | 1 |
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