|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 2 | A framework for efficient irregular wave simulations using Higher Order Spectral method coupled with viscous two phase model显示文摘In this paper a framework for efficient irregular wave simulations using Higher Order Spectral method coupled with fully nonlinear viscous,two-phase Computational Fluid Dynamics(CFD)model is presented.CFD model is based on solution decomposition via Spectral Wave Explicit Navier-Stokes Equation method,allowing efficient coupling with arbitrary potential flow solutions.Higher Order Spectrum is a pseudo-spectral,potential flow method for solving nonlinear free surface boundary conditions up to an arbitrary order of nonlinearity.It is capable of efficient long time nonlinear propagation of arbitrary input wave spectra,which can be used to obtain realistic extreme waves.To facilitate the coupling strategy,Higher Order Spectrum method is implemented in foam-extend alongside the CFD model.Validation of the Higher Order Spectrum method is performed on three test cases including monochromatic and irregular wave fields.Additionally,the coupling between Higher Order Spectrum and CFD is validated on three hour irregular wave propagation.Finally,a simulation of a 3D extreme wave encountering a full scale container ship is shown. | Inno Gatin Vuko Vukčević Hrvoje Jasak | 2017 | Journal of Ocean Engineering and Science2017，2，4： | 5 |
| 3 | An image water- marking method based on the wavelet-transform显示文摘 | Innoe H Miyazaki A Katsura T | 1999 | Hoc of KIP1999，，3： | 1 |
| 4 | Skeletal deformity associ?ated with SHOX deficiency显示文摘 | Seki A J inno T Suzuki E | 2014 | Clin Pediatr Endocrinol2014，23，3： | 1 |
| 5 | Supplier selection using a multi-riteria decision aid method显示文摘 | DULM IN R M IN INNO V | 2003 | Purchasing Suppty Manage2003，9，4： | 1 |
| 6 | Viral nervous necrosis in hatch- ery-reared larvae and juvenilse of Japanese parrotfish, Opelgnathusfasciatus(Temminck&Schlegel ) 显示文摘 | YOSHIKOSHI K INNOE K | 1990 | Journal of Fish Diseases1990，13，： | 1 |
| 7 | Different housing condi-tions alter the behavioural phenotype of CCK2 receptor-defi-cient mice 显示文摘 | Abramov U Raud S Innos J | 2008 | Behavioural Brain Research2008，193，1： | 1 |
| 8 | Risk of second primary breast cancers a- mong women with ductal carcinoma in situ of the breast 显示文摘 | Innos K Horn-Ross PL | 2008 | Breast Cancer Res Treat2008，111，3： | 1 |
| 9 | Different housing conditions alter the behavioural phenotype of CCK ( 2 )receptor-deficient mice显示文摘 | Abramov U Raud S Innos J | 2008 | Behav Brain Res2008，193，1： | 1 |
| 10 | Suicides among cancer patients in Estonia: a population-based study显示文摘 | Innos K Rahu K Rahu M | 2003 | Eur J Cancer2003，39，15： | 1 |
| 11 | The effectiveness of primary bipolar arthroplasty in treatment of unstable intertrochante ric fractures in elderly patients显示文摘 | Inno K Sakr M Gira J | 2010 | N Am J Med Sci2010，2，12： | 1 |
| 12 | Effect of leaf age on epicuticular wax alkanes in Rhododendron 显示文摘 | Inno S | 1983 | Phytochemistry1983，22，2： | 1 |
| 13 | Risk of second primary breast cancers a- mong women with ductal carcinoma in situ of the breast显示文摘 | Innos K Horn-Ross PL | 2008 | Breast Cancer Res Treat2008，111，3： | 1 |
| 14 | Therole of neoadjuvant Chemotherapy for breast cancer trearment显示文摘 | Ikeda T J inno H Matsu A | 2002 | Breast Cancer2002，9，1： | 1 |
| 15 | Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice显示文摘 | PLAAS M KARIS A INNOS J | 2008 | J Physiol Pharmacol2008，59，2： | 1 |
| 16 | Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer? 显示文摘 | INNO A DI SALVATORE M CENCI T | 2011 | Clin Colorectal Cancer2011，10，4： | 1 |
| 17 | Viral nervous necrosis in hatchery-reared larvae and juvenilse of Japanese parrotfish, Opelgnathusfasciatus(Temminck& Schlegel) 显示文摘 | Yoshikoshi K Innoe K | 1990 | J Fish Dis1990，13，： | 1 |
| 18 | Is There a Role forIGF1R and c -MET Pathways in Resistance to Cetuximab in Metastatic Colorectal Cancer? 显示文摘 | Inno A Di Salvatore M Cenci T | 2011 | Clinical Colorectal Cancer2011，10，4： | 1 |
| 19 | Effect of leaf age on epieutieular wax alkanes in Rhododendron显示文摘 | INNO S | 1983 | Phytochemistry1983，22，2： | 1 |
| 20 | The implications of R&D offshoring on the innovation capacity of EU firms 显示文摘 | PRO INNO Europe | 2007 | Heisinke School of Economics2007，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员