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| 1 | 中华医学会感染与抗微生物治疗策略高峰论坛:甲氧西林耐药金黄色葡萄球菌感染的治疗策略——专家共识显示文摘中华医学会感染与抗微生物治疗高峰论坛:甲氧西林耐药金葡菌感染的治疗策略于2011年4月17日在长沙举行。60余位来自感染科、呼吸科、血液科、重症医学、皮肤科、普外科、烧伤科、肾病科、儿科等临床学科及医学检验科的资深专家就甲氧西林耐药金葡菌感染的病原诊断和治疗的相关问题进行了广泛深入讨论,拟定了“甲氧西林耐药金葡菌感染的治疗策略一专家共识”的内容纲要。目前国内尚缺少基于充分临床实践(循证医学)证据的治疗耐甲氧西林金葡菌(MRSA)感染的指南或专家共识可供参考。 | Expert panel of Chinese Medical Association Forum on the Strategies for the Management of Methicillinresistant Staphylococcus aureus Infections | 2011 | 中国感染与化疗杂志2011，11，6： | 94 |
| 2 | 中国丙型病毒性肝炎医院感染防控指南显示文摘丙型病毒性肝炎是一种主要经血液传播的疾病,丙型病毒性肝炎病毒(HCV)慢性感染可导致肝脏慢性炎症坏死及纤维化,部分患者可发展为肝硬化甚至肝细胞癌(HCC),对患者的健康和生命危害极大,已成为严重的社会和公共卫生问题。由于丙型病毒性肝炎患者症状隐匿, | Nosocomial Infection Control Branch of Chinese Preventive Medicine Association | 2013 | 传染病信息2013，26，2： | 28 |
| 3 | Plasmacytoid dendritic cells in antiviral immunity and autoimmunity显示文摘Plasmacytoid dendritic cells (pDCs) represent a unique and crucial immune cell population capable of producing large amounts of type I interferons (IFNs) in response to viral infection.The function of pDCs as the professional type I IFN-producing cells is linked to their selective expression of Toll-like receptor 7 (TLR7) and TLR9,which sense viral nucleic acids within the endosomal compartments.Type I IFNs produced by pDCs not only directly inhibit viral replication but also play an essential role in linking the innate and adaptive immune system.The aberrant activation of pDCs by self nucleic acids through TLR signaling and the ongoing production of type I IFNs do occur in some autoimmune diseases.Therefore,pDC may serve as an attractive target for therapeutic manipulations of the immune system to treat viral infectious diseases and autoimmune diseases. | TANG Fei1,2,DU Qiumei1,2 & LIU Yong-Jun3 1 Center for Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 Department of Immunology and Center for Cancer Immunology Research,University of Texas,M.D.Anderson Cancer Center,Houston,Texas 77030,USA | 2010 | Science China(Life Sciences)2010，53，2： | 23 |
| 4 | A new role for T cells in dampening innate inflammatory responses显示文摘The inflammatory response is an attempt by a host to protect itself against injurious stimuli and initiate the tissue healing process [1,2]. Although the production of both pro-and anti-inflammatory mediators which occurs mainly within tissues is a systemic process, | TANG Hong1 & FU YangXin1,2 1 Key Laboratory of Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2 Department of Pathology,Committee of Immunology,University of Chicago,Chicago,IL 60637,USA | 2010 | Science China(Life Sciences)2010，53，2： | 9 |
| 5 | Structural immunology of costimualtory and coinhibitory molecules显示文摘The T cell costimulatory pathways are central to regulating immune responses,and targeting these pathways represents one of the most promising approaches for achieving immunotherapy.The molecular structures of costimulation revealed invaluable mechanistic insights underlying costimulatory receptor/ligand specificity,affinity,oligomeric state,and valency,which provided the bases for better manipulation of these signaling pathways.The incredible growth of this field led to identification of new members and unexpected interactions,revealing a complicated regulatory network of immune responses.The advances in structural biology of costimulation will promise unprecedented opportunities for furthering our understanding and therapeutic application of T cell costimulatory pathways. | WANG ShengDian1 & CHEN LiePing1,2 1Center for Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2Department of Oncology,Johns Hopkins University School of Medicine,Baltimore,Maryland,USA | 2010 | Science China(Life Sciences)2010，53，2： | 8 |
| 6 | On self-nonself discrimination in pattern recognition显示文摘Wide distribution and broad reactivity are cardinal features of pattern recognition receptors that allow rapid mobiliza-tion of large numbers of effectors to deal with pathogens.However, these features come with significant baggage as the receptors have been shown to interact with many intra-cellular components, collectively called | LIU Yang1,2,CHEN GuoYun2,ZHENG Pan2 & TANG Jie11 Key Laboratory of Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2Departments of Surgery,Internal Medicine and Pathology,University of Michigan at Ann Arbor,MI48109,USA | 2010 | Science China(Life Sciences)2010，53，2： | 7 |
| 7 | Expression,purification and immunocharacteristics of recombination UreB protein of H.pylori显示文摘INTRODUCTIONHelicobacter pylori (H . pylori) is associated with the development of chronic gastritis ,peptic ulcer and gastric cancer and gastric MALT lymphoma[1-9],H .pylori has many antigens ,including urease ,heat shock protein and vacuolating cytotoxin and so on ,and urease is an important factor in the colinization of the gastric mucosa and suspected to cause damage to the gastric mucosa[10-14].At the same time ,urdase is also one of the important protective antigens . | Chao Wu~1 Quan Ming Zou~1 Hong Guo~2 Xiao Peng Yuan~1 Wei Jun Zhang~1 Dong Shui Lu~1 Xu Hu Mao~1 ~1Department of Clinical Microbiology,Third Military Medical University,Chongqing 400038,China ~2Department of Gastroenterology,Xinqiao Hospital,Third Military Medical University,Chongqing 40003?,ChinaDr.Chao Wu graduated from Third Military Medical University as a postgraduate in 2000,now a lecturer,specialized in diagnosis,prevention and therapy of Helicobacter pylori infection,having 6 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 5 |
| 8 | Anal cancer in Chinese:human papillomavirus infection and altered expression of p53显示文摘AnalcancerinChinese:humanpapilomavirusinfectionandalteredexpressionofp53LAIMaoDe,LUOMinJie,YAOJianErandCHENPeiHuiSubject... | LAI MaoDe, LUO MinJie, YAO JianEr and CHEN PeiHuiKeywords anus neoplasms papillomavirus infection DNA, viral p53 gene gene expression polymerase chain reaction | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 9 | DNA immune responses induced by codelivery of IL-12 expression vectors with hepatitis C structural antigens显示文摘Objective: To demonstrate the utility of DNA vaccinesfor the tailored methods, the efficacy of enhancedimmune responses, and the types of increased im-mune responses.Methods: Four recombinant plasmids constructed in-cluded the coding regions for the core protein (pC)and for the core, E1 and E2 together (pCE1E2), IL-12 p35 and p40. These plasmids were transfected intomammalian cells to test their protein expression andwere injected into the quadriceps muscles of BALB/C mice for measurement of specific antibodies andcytotoxic T-lymphocyte (CTL) responses.Results: All the recombinant plasmids were shown toexpress specific antigens stably in mammalian cells.Codelivery of pIL-12 expression cassettes with pCand pCE1E2 in mice resulted in the enhancement ofAg-dependent CTL responses and the reduction ofspecific Ab response. The CTL activity was: pC=18.65%±5.71%, pCE1E2=20.07%±11.11%, pC+pIL-12=60.11%±17.37%, pCE1E2+pIL-12=67.48%±15.57%, respectively. The average A val-ues of anti-HCV were pC=0.415±0.127, pCE1E2=0.358±0.096, pC+pIL-12=0.210±0.086, pCE1E2+pIL-12=0.258±0.125.Conclusion: Codelivery of pIL-12 with plasmid DNAcan enhance the efficacy of immune responses andshift the type of immune responses. | Mei-Mei Shan Ke-Zhou Liu Hai-Lin Fang Zhi Chen the Institute of Infections Diseases, Zhejiang Univiersity School of Medicine, Hangzhou 310006, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，4： | 3 |
| 10 | Antimicrobial prophylaxis for surgery:an advisory statement from the National Surgical Infection Prevention Project显示文摘 | Bratzler DW Houck PM Surgical Infection Prevention Guidelines Writers Workgroup | 2004 | Clin Infect Dis2004，38，12： | 1 |
| 11 | Guidelines for the management of adults with hospital-acquired, ventilator-associated, and heahhcare-assoeiated pneumonia 显示文摘 | American Thoracic Society: Infections Diseases Society of America | 2005 | Am J Respir Crit Care Med2005，171，4： | 1 |
| 12 | PediatrInfect显示文摘 | | 1986 | Dis1986，5，1： | 1 |
| 13 | Recommendations for preventing the spread of vancomycin resistance 显示文摘 | Hospital Infection Control Practices Advisory Committee (HICPAC) | 1995 | Infect Control Hosp Epidemiol1995，16，2： | 1 |
| 14 | Guidelines for Preventing Health-Care-Associated Pneumonia显示文摘 | Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee | 2004 | MMWR2004，，53： | 1 |
| 15 | Guidelines for the management of adults with hospital-acquired ventilator -associated and healthcareassociated pneumonia 显示文摘 | American Thoracic Society Infections Diseases Society of America | 2005 | Am J Respir Crit Care Med2005，171，4： | 1 |
| 16 | A population- based study显示文摘 | Uslan D Sohail M St SJ et aL Fermanem pacemaker and implantable cardioverter defibrillator infection | 2007 | Arch Intern Med2007，167，： | 1 |
| 17 | New definition for periprosthetic joint infection 显示文摘 | Workgroup Convened by the Museuloskeletal Infection Society | 2011 | J Arthroplasty2011，26，： | 1 |
| 18 | Report of a WHO Study Group 显示文摘 | Control of foodborne trematode infections | 1995 | World Health Organ Tech Res Ser1995，849，： | 1 |
| 19 | American Academy of Pediatrics Committee on Infectious Diseases 显示文摘 | Reassessment of the indications for ribavirin therapy in respira- tory syncytial virus infections | 1996 | Pediatrics1996，97，1： | 1 |
| 20 | Guidelines for the management of adults with hospital acquired,ventilator-associated,and healthcare-associated pneumonia显示文摘 | American Thoracic Society and the Infections Diseases Society of American | 2005 | Am J Respir Crit Care Med2005，171，4： | 1 |
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