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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | Nanostructures and intermetalliccs, subjected to severe plastic deformation显示文摘 | Valiev R Z Mukherjee unique properties in A K | 2001 | Scr Mater2001，44，： | 1 |
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| 9 | israelensis and development of media for production of protein Crystal endo-toxin显示文摘 | SAKHAROVA Z V RABOTNOVA I L KHOVRYCHEV M E Growth and spore formation in Bacillus thuringiensis var | 1988 | Biotechnology Letters1988，10，7： | 1 |
| 10 | One - step growth of CdTe quantum dots with low cytotox- atmospheric conditions 显示文摘 | Sheng Z Han H high luminescence icity in ambient Hu X | 2010 | Dalton Trans2010，39，30： | 1 |
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| 14 | Recyclable tertaaryphosphonium supported chiral im idazolidin^-one organocatalyst forD iels-A lder reactions显示文摘 | L in Z H L u C F Yang G C e t a l | 2013 | Catal Commun2013，35，： | 1 |
| 15 | elegans显示文摘 | Melendez A Talloczy Z Seaman M :Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C | 2003 | Science2003，301，： | 1 |
| 16 | Rate of CD4 decline and HIV-RNA change fol- lowing HIV seroconversion in men who have sex with men: a comparison between the Beijing PRIMO and CASCADE cohorts 显示文摘 | Huang X Lodi S Fox Z Li W Phillips A Porter K Lut- sar I Kelleher A Li N Xu X Wu H Johnson AM Bei- jing PRIMO cohort study CASCADE Collaboration in EuroCoord | 2013 | J Acquir Immune Defic Syndr2013，62，4： | 1 |
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| 18 | Laboratory Tests to Correlate Galvanic Current with Actual Damage显示文摘 | Yoo J Park Z Kim J Chung L Development of a Galvanic Sensor System for Detecting the Corrosion Damage of the Steel Embedded in Concrete Structures: Part 1 | 2003 | Cement and Concrete Research2003，133，12： | 1 |
| 19 | Diagnosis and treatment 显示文摘 | Yared Z Chiasson JL Ketoacidosis and the hyperosmolar hyperglycemic state in adult diabetic patients | 2003 | Minerva Med2003，94，6： | 1 |
| 20 | Applications of AFLP genetic and phylogenetic analysis of 显示文摘 | Wang Z Y Tsoi technology in penaeid shrimp K H Chu K H | 2004 | Biochemical Systematics and Ecol-ogy2004，32，4： | 1 |
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