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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Randomized Comparison of Strategies for Type B Aortic Dissection: The INvestigation of STEnt Grafts in Aortic Dissection (INSTEAD) Trial显示文摘 | Christoph A. Nienaber Hervé Rousseau Holger Eggebrecht Stephan Kische Rossella Fattori Tim C. Rehders Günther Kundt Dierk Scheinert Martin Czerny Tilo Kleinfeldt Burkhart Zipfel Louis Labrousse Hüseyin Ince | 2009 | Circulation2009，，25： | 2 |
| 3 | Effects of a multimodal exercise program for people with ankylosing spondylitis physical therapy 显示文摘 | INCE G SARPEL T DURGUN B | 2006 | Phys Ther2006，86，7： | 1 |
| 4 | Individual and combined effects of ultrasound, ozone and UV irradiation: a case study with textile dyes显示文摘 | Tezcanli G G Ince N H | 2004 | Ultrasonics2004，42，4： | 1 |
| 5 | Direct observation of the human cerebral microcirculation during aneurysm surgery reveals in- creased arteriolar contractility 显示文摘 | PENNINGS F A BOUMA G J INCE C | 2004 | Stroke2004，35，6： | 1 |
| 6 | Antihypertensive drugs and inflamma- tion in acute ischemic stroke as a predictor factor of future cardiovascular mortality 显示文摘 | Benbir G Ince B Kumral E | 2012 | Inflammation2012，35，1： | 1 |
| 7 | Respirometric kinetic parameter calculations of a batch jet loop bioreactor treating leachate and oxygen uptake rate estimation by DTM显示文摘 | Ince M Yildiz F Engin G O | 2008 | Journal of Hazardous Materials2008，153，3： | 1 |
| 8 | Ultrasound as a eatalyzer of aqueous reaction systems: the state of the art and environmental applications显示文摘 | Ince N H Tezcanli G Belen R K | 2001 | Applied Catalysis B: Environmental2001，29，3： | 1 |
| 9 | An investigation into the pretreatment of dairy wastewater prior to aerobic biological treatment显示文摘 | KASAPGIL B ANDERSON G K INCE O | 1994 | Water Sci Technol1994，29，： | 1 |
| 10 | Assessment of toxic interactions of heavy metals in binary mixtures:A statistical approach显示文摘 | Ince N H Dirilgen N Apikyan I G | 1999 | Archives Environmental Contamination and Toxicology1999，36，： | 1 |
| 11 | Assessment of toxic interactions of heavy metals in binary mixtures: A statistical approach显示文摘 | Ince N H Dirilgen I G Tezcanli A G | 1999 | Arch Environ Contamn Toxicol1999，36，： | 1 |
| 12 | Early forest fire detection using radio-acoustic sounding system显示文摘 | SAHIN Y G INCE T | 2009 | Sensors2009，9，3： | 1 |
| 13 | Ultrasound as a Catalyzer of Aqueous Reaction Systems:The State of the Art and Environmental Applications 显示文摘 | Ince N H Tezcanli G Belen R K | 2001 | Applied Cataly- sis B : Environ2001，，29： | 1 |
| 14 | Polymorphic microsatellite markers transferable across Capsicum species 显示文摘 | INCE A G KARACA M ONUS A N | 2010 | Plant Molecular Biology Reporter2010，28，： | 1 |
| 15 | Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain显示文摘 | Simpson JE Ince PG Lace G | 2010 | Neurobiol Aging2010，31，4： | 1 |
| 16 | Joint 3-D inversion of gravity, magnetic and tensor gravity fields for imaging salt formations in the deepwater Gulf of Mexieo显示文摘 | Jorgensen G J Kisabeth J L Inc C | 2000 | Expanded Abstracts of 70^th Annual International SEG Meeting2000，，： | 1 |
| 17 | Ultrasound as acatalyzer of aqueous reaction systems:the state of the artand environmental applications显示文摘 | Ince N H Tezcanli G Belen R K | 2001 | Applied Catalysis B:En-vironmental2001，，29： | 1 |
| 18 | Further treatment of landfill leachate by nanofiltration and microfiltration - PAC hybrid process显示文摘 | Ince M Senturk E Oakal Engin G | 2010 | Desalination2010，255，1： | 1 |
| 19 | Oxidative damage to protein in sporadic motor neuron disease spinal cord显示文摘 | Shaw PJ Ince PG Falkous G | 1995 | Ann Neurol1995，38，4： | 1 |
| 20 | Conbination of ActivatedCarbon Adsorption with Light-Enhanced ChemicalOxidation via Hydrogen Peroxide 显示文摘 | Ince N H Apikyan I G | 2000 | Water Re-search2000，34，17： | 1 |
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