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| 1 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011,30,1: | 8 |
| 2 | 早发急性心肌梗死的长期结局和风险评估:10年随访研究显示文摘早发急性心肌梗死(acute myocardial infarction,AMI)是一种罕见的疾病,发病率和死亡率很高。该文在再灌注治疗广泛应用的大环境下,纳入前瞻性研究人群进行早发AMI的预后研究。方法:这项前瞻性多中心研究中连续纳入102例AMI存活者(≤40岁),临床预后通过奥地利死亡登记处和维也纳集中患者管理系统进行查询。 | 刘莉 叶鹏 Winter MP Blessberger H Alimohammadi A Pavo N Huber K Wojta J Lang IM Wiesbauer F Goliasch G | 2017 | 中华高血压杂志2017,25,4: | 5 |
| 3 | Successful outcome following resection of a pancreatic liposarcoma with solitary metastasis显示文摘Liposarcomas are rare soft tissue tumors, commonly affecting the lower limbs and less commonly the retroperitoneum. Although other organs can be affected,the pancreas is one of the rarest, and metastasis at presentation has never been reported. We describe the case of a 76-year-old gentleman presenting with abdominal pain and an abdominal mass. Imaging confirmed a primary tumor in the body and tail of the pancreas, with a metastatic deposit in the mesentery adjacent to the second part of the duodenum. Biopsy confirmed a liposarcoma, and subsequently a complete surgical excision was achieved. He then received adjuvant radiotherapy and has remained disease free for the next 26 mo. | IM Dodo JA Adamthwaite P Jain A Roy PJ Guillou KV Menon | 2005 | World Journal of Gastroenterology2005,11,48: | 5 |
| 4 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019,25,48: | 3 |
| 5 | Autologous stern cell transplantation for refractory juvenile idiopathic arthritis : analysis of clinical effects, mortality, and transplant related morbidity 显示文摘 | De Kleer IM Brinkman DM Ferster A | 2004 | Ann Rheum Dis2004,63,10: | 1 |
| 6 | Dendrite cell-based cancer vaccines-clinical application显示文摘 | Svane IM Bemtacn A Trepiakas R | 2006 | Ugeskr Laegnr2006,168,14: | 1 |
| 7 | The diagnosis and management of adult intussusception显示文摘 | Begos DC Sandor A Modlin IM | 1997 | Am J Surg1997,173,1: | 1 |
| 8 | Adult bone marrow-derived cells for cardiac repair: a systematic review and metwanalysis显示文摘 | Abdel-Latif A Bolli R Tleyjeh IM | 2007 | Arch Intern Med2007,167,10: | 1 |
| 9 | Identification of optimal molecular size of modified Aloe polysaecharides with maximum immunomodulatory activity 显示文摘 | IM S A OH S T SONG S | 2005 | Int Immunopharmaeol2005,5,2: | 1 |
| 10 | Effect of nitric oxide synthase inhibition on blood flow after retinal ischemia in cats显示文摘 | Ostwald P Goldstein IM Pachnanda A Roth S | 1995 | Invest Ophthalmol Vis Sci1995,36,12: | 1 |
| 11 | A 4-year follow-up study of the e ffects of calcium supplementation on bone density in elderly postmenopausal wome n显示文摘 | Devine A Dick IM Heal SJ | 1997 | Osteoporos Int1997,7,: | 1 |
| 12 | Efficacy safety and tolerability of quetiapine augmentation in treatment resistant depression:An open-lable pilot study 显示文摘 | Anderson IM Sarsfield A Haddad PM | 2009 | J Affect Disord2009,117,12: | 1 |
| 13 | Evaluation of tibiotalocalcaneal arthrodesis using a retrograde nail as a rescue technique in 15 cases显示文摘 | V Pellicer García Garrido IM Rellán JG | 2011 | Rev esp cir ortop traumatol2011,,02: | 1 |
| 14 | Cognitive performance in asymptomatic patients with advanced carotid disease 显示文摘 | POPOVIC IM LOVRENCIC - HUZJAN A SIMUNDIC AM | 2011 | Cogn Behav Neurol2011,24,3: | 1 |
| 15 | MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2显示文摘 | Foley NH Bray IM Tivnan A | 2010 | Mol Cancer2010,9,: | 1 |
| 16 | 1 Burnou t and Engagement in University Students a Cross - national Study显示文摘 | Schau feliW B M arti IM P into A M eta | 2002 | Journal of Cross - Cultural Psychology2002,33,5: | 1 |
| 17 | Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicityimplications for therapeutic targeting of Nrf2显示文摘 | Olayanju A Copple IM Bryan HK Edge GT Sison RL Wong MW | 2015 | Free Radic Biol Med2015,78,: | 1 |
| 18 | Natural history, diagnosis, treatment and outcome of papillary thyroid mieroeareinoma (PTMC) : a mono-institutional 12-year experience 显示文摘 | Pelizzo MR Boschin IM Toniato A | 2004 | Nucl Med Commun2004,25,6: | 1 |
| 19 | Prognostic impact of clinicopathologic parameters in stage Ⅱ / Ⅲ breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer显示文摘 | Keam B Im S A Kim H J | 2007 | BMC Cancer2007,1,: | 1 |
| 20 | Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer显示文摘 | HANS W OH D Y IM S A | 2009 | Br J Cancer2009,100,2: | 1 |