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| 1 | Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse显示文摘背景雌激素受体 alpha (嗯一)是最重要的内分泌的治疗应答预言者因为有对内分泌的治疗的反应的预言的胸 cancer.The 精确性的女人被认为被包含雌激素受体 coregulatory 蛋白质和串音在之间影响嗯并且另外的生长发信号因素的 networks.Nuclear corepressor 1 ( NCOR1 )是学习客观的抄写 repressor.The 是在蛋白质 le 调查 NCOR1 | ZHANG Zhen-huan Hiroko Yamashita Tatsuya Toyama Yutaka Yamamoto Teru Kawasoe Mutsuko lbusuki Saori Tomita Hiroshi Sugiura Shunzo Kobayashi Yoshitaka Fujii Hirotaka Iwase | 2009 | Chinese Medical Journal2009，，15： | 4 |
| 2 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 3 | Characteristics of alpha-synucleinopathy in centenarians显示文摘 | Ding ZT Wang Y Jiang YP Hashizume Y Yoshida M Mimuro M Inagaki T Iwase T | 2006 | 中国生物学文摘2006，20，8： | 4 |
| 4 | A new technique for the resection of gastric cancer: Modified appleby procedure with reconstruction of hepatic artery显示文摘 | Hiroaki Takenaka M.D. Kazuhiro Iwase M.D. Senya Ohshima M.D. Toshivuki Hiranaka M.D | 1992 | World Journal of Surgery1992，，5： | 2 |
| 5 | Hydrophobic versus double-square-edged hydrophilic foldable acrylic intraocular lens: Effect on posterior capsule opacification显示文摘 | Takeshi Iwase Yutarou Nishi Brian C. Oveson Young-Joon Jo | 2011 | Journal of Cataract & Refractive Surgery2011，，6： | 2 |
| 6 | Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human nantrophils 显示文摘 | Kimura T Iwase M Kondo G | 2003 | int Immunopharmacol2003，3，： | 1 |
| 7 | A new diabetes model induced by neonatal alloxan treament in rats显示文摘 | Iwase M Nunoi K | 1993 | Diab Res Clin Pract1993，20，： | 1 |
| 8 | Clinical significance of the expression of estrogen receptors alpha and beta for endocrine therapy of breast cancer显示文摘 | Zhang Z Omoto Y | 2003 | Cancer Chemother Pharmacol2003，52，1： | 1 |
| 9 | Role of interleukin-8 secreted from human oral squamous cell carcinoma cell lines显示文摘 | Watanabe H Iwase M Ohashi M | 2002 | Oral Oncol2002，38，7： | 1 |
| 10 | Postmortem changes in cytochrome c oxidase activity in various organs of the rat and in human heart显示文摘 | Ikegaya H Iwase H Hatanaka K | 2000 | Forensic Sci Int2000，108，3： | 1 |
| 11 | Determination of eyanoeobalaminin foods by high-performance liquid chromatography with visible detection after solid-phase extraction and membrane filtration for the precolumn separation of lipophilic species显示文摘 | Hiroshi Iwase Iehiro Ono | 1997 | Journal of Chromatography A1997，，771： | 1 |
| 12 | Atherogenic role of lysophosphatidylcholine in low -density lipoprotein modified by phospholipase A2 and in diabetic patients: protection by nitric oxide donor显示文摘 | Sonoki K Iwase M Iiono K | 2003 | Metabolism2003，52，： | 1 |
| 13 | Production of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human breast carcinomas显示文摘 | Iwata H Kobayashi S Iwase H | 1996 | Jpn J Cancer Res1996，87，6： | 1 |
| 14 | Effect of combining epidermal growth factor receptor inhibitors and cisplatin on proliferation and apoptosis of oral squamous cell carcinoma cells显示文摘 | Takaoka S Iwase M Uchida M | 2007 | Int J Oncol2007，30，6： | 1 |
| 15 | Lysophosphatidy-lcholine contents in plasma LDL in patients with type 2 diabetes mellitus:relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment显示文摘 | Iwase M Sonoki K Sasaki N | 2008 | Atherosclerosis2008，196，： | 1 |
| 16 | Concurrent chemoradiotherapy with a novel fluoropyrimidine,S-1,and cisplatin for locally advanced esophageal cancer:long-term results of a phaseⅡtrial显示文摘 | Iwase H Shimada M Tsuzuki T | 2013 | Oncology(Williston Park)2013，84，6： | 1 |
| 17 | Interferon - alpha repressed telomerase along with G1 - accumulation of Daudi cells显示文摘 | Akiyama M Iwase S Horiguchi - Yamada J | 1999 | Cancer Lett1999，142，1： | 1 |
| 18 | Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan 显示文摘 | TERAMURA M KIMURA A IWASE S | 2007 | Blood2007，110，6： | 1 |
| 19 | Mechanism of abnormal postexercise sysolic blood pressure reponse and its diagnostic value in the patients with coronary artery disease显示文摘 | Miyahara T Yokota M Iwase M | 1990 | Am Heart J1990，20，1： | 1 |
| 20 | Enhanced suscepti-bility to tumor necrosis factor-related apoptosis-inducingligand-mediated apoptosis in oral squamous cell carcino-ma cells treated with phosphatidylinositol 3-kinase in-hibitors显示文摘 | Uchida M Iwase M Takaoka S | 2007 | Int J Oncol2007，30，5： | 1 |
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