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| 1 | 伊犁黄土的磁学性质及其与黄土高原对比显示文摘近20多年来黄土高原的黄土磁学性质与古气候研究取得了重要进展,极大地推动了东亚古季风演化、亚洲内陆干旱化及过去全球变化的研究,但对亚洲内陆天山地区的黄土磁学性质知之甚少.选择天山伊犁盆地黄土剖面进行了系统的磁性测量,包括磁化率、无磁滞磁化率、高低温磁化率和磁滞参数等,并与黄土高原进行了对比,开展了伊犁黄土的X射线衍射矿物学分析,初步探讨了伊犁黄土磁化率增强的机制.结果表明,伊犁黄土磁性矿物的总含量要远远低于黄土高原,但磁性矿物类型与黄土高原黄土基本类似,以磁铁矿、磁赤铁矿和赤铁矿为主,部分样品还有钛铁矿等.在磁性矿物中磁赤铁矿占的比例总体上要比黄土高原黄土低,而磁铁矿和赤铁矿占的比例比黄土高原黄土要高.磁性矿物的粒度要比黄土高原粗,以准单畴(PSD)和多畴(MD)为主.成壤作用产生的细粒超顺磁体对磁化率的贡献非常有限,粒径为PSD和MD的磁铁矿和磁赤铁矿为伊犁黄土磁化率的主要贡献者.伊犁黄土磁化率增强既有风速论模式(阿拉斯加或西伯利亚黄土成土模式),又有黄土高原超细颗粒成壤模式,但以前一种模式为主导.伊犁黄土磁化率增强除与源区的原生磁性矿物有关以外,还与当地的地形气候环境和地质背景有关.伊犁黄土磁化率增强的机制十分复杂,将磁化率应用古气候的解释时要慎重. | 宋友桂 史正涛 方小敏 NIE Junsheng NAOTO Ishikawa 强小科 王旭龙 | 2010 | 中国科学(D辑)2010，40，1： | 48 |
| 2 | Analysis of aerodynamic and thermodynamic parameters on the grassy marshland surface of Tibetan Plateau | TSUKAMOTO Osamu ISHIKAWA Hirohiko TAMAGAWA Ichiro | 2002 | Progress in Natural Science:Materials International2002，12，1： | 34 |
| 3 | Clinical features of hepatitis B virus-related hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is a major cause of cancer death,and chronic hepatitis B is a serious worldwide problem.The epidemiology of HCC is distinctive.Hepatitis B virus (HBV) plays a major role in hepatocarcinogenesis.Prevention of HBV-related HCC is a key issue in current hepatology.This paper describes the prevention and clinical features of HBVrelated HCC,along with a short review of the disease. | Toru Ishikawa | 2010 | World Journal of Gastroenterology2010，16，20： | 28 |
| 4 | 藏北高原地区干、雨季大气边界层结构的不同特征显示文摘利用2004年4月预试验期(PIOP)和8月加强期(IOP)的无线电探空仪观测资料,分析了藏北高原地区干、雨季大气边界层结构的不同特征.结果显示:藏北高原地区边界层虚位温、比湿等日变化大,对流混合层高度较高,高度干季在2 211~4 430m之间,雨季在1 006~2 212m之间,干季的对流混合层高度明显高于雨季时的对流混合层高度.干季的比湿明显小于湿季比湿,在干季和雨季都存在逆湿现象;干季时水平风风向基本以偏西风为主,雨季低层2 500m以下基本以偏东风为主,上层以偏西风为主;干季近地层水平风速都较小,随高度增加风速迅速增大,雨季边界层内风速都较小. | 李茂善 马耀明 马伟强 Ishikawa Hirohiko 孙方林 Ogino Shin-Ya | 2011 | 冰川冻土2011，33，1： | 22 |
| 5 | 非梗阻性无精子症患者的手术取精技术显示文摘卵细胞浆内单精子注射(ICSI)的发展开辟了辅助生殖技术的新领域,使男性不育的治疗发生了革命性的变化。除了自然的射精过程,经由生精小管获取的精子也能实现受精和妊娠。睾丸抽吸精子技术(TESA:针/细针抽吸)和睾丸切开取精术(TESE)被广泛应用于非梗阻性无精子症患者(NOA)获取精子的不育治疗当中。最理想的精子提取技术应尽可能地减少侵入性损伤和对睾丸功能的破坏,同时不影响获取足够数量的精子以行ICSI治疗。显微切割睾丸取精技术(micro—TESE)被广泛认为是有效获取NOA患者精子的最佳方法;其在手术显微镜下操作,非常容易辨认出较大的、透明度低的含有正常精曲小管的精子发生活跃区域。NOA患者行micro—TESE获取精子成功率较高,并且睾丸组织损伤最小,术后并发症发生较低。micro-TESE结合IcsI已经成为NOA患者(包括Klinefelter’s综合症患者)常规的辅助生殖方法。伴有血清卵泡刺激素(FSH)升高的NOA患者(包括KS患者)须结合精子缺乏的表型特征来评估外科取精的结果,还需分析手术获取精子的预测参数和治疗结果。最后,考虑用micro—TESE技术治疗NOA和KS患者(46XY)时的短期和长期并发症。 | Tomomoto Ishikawa | 2012 | Asian Journal of Andrology2012，14，1： | 23 |
| 6 | Loess magnetic properties in the Ili Basin and their correlation with the Chinese Loess Plateau显示文摘Over the past two decades, magnetoclimatological studies of loess-paleosol sequences in the Chinese Loess Plateau (CLP) have made outstanding achievements, which greatly promote the understanding of East Asian paleomonsoon evolution, inland aridification of Asia, and past global climate changes. Loess magnetic properties of the CLP have been well studied. In contrast, loess magnetic properties from outside the CLP in China have not been fully understood. We have little knowledge about the magnetic properties of loess in the Ili Basin, an intermontane depression of the Tianshan (or Tien Shan) Mountains. Here, we present the results of rock magnetic measurements of the Ili loess including mass magnetic susceptibility (χ) and anhysteretic remanent magnetization (ARM), high/low temperature dependence of susceptibility (TDS) and hysteresis, as well as X-ray diffraction (XRD) for mineral analysis. Based on the comparison with loess-paleosol sequences in the CLP (hereafter referred to as the Chinese loess), we discuss the possible magnetic susceptibility enhancement mechanism of the Ili loess. The results show that 1) the total magnetic mineral concentration of the Ili loess is far lower than that of the Chinese loess, though they have similar magnetic mineral compositions. The ferrimagnetic minerals in the Ili loess are magnetite and maghemite, and the antiferromagnetic mineral is hematite; XRD analysis also identifies the presence of ilmenite. The ratio of maghemite is lower in the Ili loess than in the Chinese loess, but the ratios of magnetite and hematite are higher in the Ili loess than in the Chinese loess. 2) The granularity of magnetic minerals in the Ili loess, dominated by pseudo-single domain (PSD) and multi-domain (MD) grains, is generally much coarser than that of the Chinese loess. Ultrafine pedogenically-produced magnetic grains have a very limited contribution to the susceptibility enhancement. Rather, PSD and MD particles of magnetite and maghemite are the main contributors to the enhancement of susceptibility in the Ili loess. 3) The susceptibility enhancement mechanism for the Ili loess is complicated and superimposes both a wind velocity/vigor model (Alaskan or Siberian model) and the in situ ultrafine grain pedogenic model; the former might play an important role in the Ili loess. 4) Magnetic susceptibility enhancements of the Ili loess are related not only to the eolian input of the source area, but also to the local climate, landform, and geological background. Therefore, great care should be taken when reconstructing paleoclimate using magnetic susceptibility data from the Ili loess. | NAOTO Ishikawa | 2010 | Science China Earth Sciences2010，53，3： | 21 |
| 7 | Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer显示文摘AIM: To examine the expression of leptin and its receptor, OB-R, in normal gastric mucosa and neoplasia. METHODS: By immunohistochemical staining using specifi c antibodies, we evaluated the expression of leptin and OB-R in 207 gastric carcinomas (100 early and 107 advanced carcinomas) and analyzed their relationship with clinicopathological features. RESULTS: Both normal gastric epithelium and carci- noma cells expressed a significant level of leptin. In cases with OB-R staining, carcinoma cells showed OB-R- positive expression, but the intensity was weaker than that in normal mucosa. The expression of OB-R showed a signifi cant correlation with the level of leptin expres- sion. The expression levels of both leptin and OB-R tend- ed to increase as the depth of tumor invasion or TMN stage increased (P < 0.01). Lymph node metastasis was detected in 49.5% (47/95) of leptin-strong cases and in 50.5% (48/95) of OB-R-positive cases, and the rate was 33% (37/112) in leptin-weak cases and 17% (19/112) in OB-R-negative cases. Both venous and lymphatic inva- sion also tended to be observed frequently in positive tumors as compared with negative tumors. Interestingly, in the 96 leptin- or OB-R-positive tumors, hematogenous metastasis was detected preoperatively in 3 (3.1%) pa- tients. In contrast, none of the carcinomas that lacked expression of leptin and OB-R showed hematogenous metastasis. CONCLUSION: Overexpression of leptin and expres- sion of OB-R may play a positive role in the process of progression in gastric cancer. Functional upregulation of leptin/OB-R may have a positive role in the development and initial phase of progression in gastric cancer. | Makoto Ishikawa Joji Kitayama Hirokazu Nagawa | 2006 | World Journal of Gastroenterology2006，12，34： | 20 |
| 8 | Short term results of endoscopic submucosal dissection in superficial esophageal squamous cell neoplasms显示文摘AIM: To evaluate the efficacy of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms. METHODS: Between July 2007 and March 2009, 27 consecutive superficial esophageal squamous cell neoplasms in 25 enrolled patients were treated by endoscopic submucosal dissection. The therapeutic efficacy, complications, and follow-up results were assessed. RESULTS: The mean size of the lesions was 21 ± 13 mm (range 2-55 mm); the mean size of the resection specimens was 32 ± 12 mm (range 10-70 mm). The enblock resection rate was 100% (27/27), and en block resection with tumor-free lateral/basal margins was 88.9% (24/27). Perforation occurred in 1 patient who was managed by conservative medical treatments. None of the patients developed local recurrence or distant metastasis in the follow-up period. CONCLUSION: Endoscopic submucosal dissection is applicable to superficial esophageal squamous cell neoplasms with promising results. | Kouichi Nonaka Shin Arai Keiko Ishikawa Masamitsu Nakao Yousuke Nakai Osamu Togawa Koji Nagata Michio Shimizu Yutaka Sasaki Hiroto Kita | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，2： | 19 |
| 9 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 10 | Infrequent p53 gene mutation and expression of the cardia adenocarcinomas from a high-incidence area of Southwest China显示文摘INTRODUCTIONAdenocarcinomas of the cardia are the lesionsarising from the proximal stomach or within 3 cm ofthe gastroesophageal junction.These cancerstended to be advanced at the time of presentation,usually with poor prognosis.In recent decade,the incidence of adenocarcinoma of gastric eardiaand esophagus are increasing steadily,while therehas been a decrease in the proportion of the cancersarising from the distal stomach.The | Naoko lida Hideaki Oda Shigetoshi Aiso Takatoshi Ishikawa | 2000 | World Journal of Gastroenterology2000，6，5： | 17 |
| 11 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 12 | 青光眼视网膜神经纤维层厚度的光学相干断层扫描纵向评估显示文摘目的:纵向评估光学相干断层扫描(OCT)视盘周围神经纤维层厚度测量,并将这些检查与临床状态和自动视野计检查作横向比较。
方法:对参与前瞻性纵向研究的青光眼或疑似青光眼患者64只眼(37例)作回顾性评估。所有参与者每6个月作一次全面的临床评估、视野检查和OCT。视野进展按可重复性测量的视野平均偏差至少比基线降低2dB,OCT进展按可重复性测量视网膜神经纤维层平均厚度至少变薄20pro。
结果:每个患者在中位值为4.7年的随访中有5个可使用的OCT扫描。青光眼和疑似青光眼患者之间视网膜神经纤维层厚度线性回归斜度的差异对所有变量均不显著;然而,Kaplan-Meier生存曲线分析显示视野比OCT测量有较高的进展率。在随访期间66%的眼是稳定的。22%只有OCT进展,9%单有视野平均偏差进展。3%视野和OCT都有进展。
结论:OCT比全自动视野计对辨别青光眼进展有更大的可能性。这可能反映OCT的敏感性或在常规方法发现之前其真实损害就能被OCT发现。 | Gadi Wollstein Joel S. Schuman Lori L. Price Ali Aydin Paul C. Stark Ellen Hertzmark Edward Lai Hiroshi Ishikawa Cynthia Mattox James G. Fujimoto Lelia A. Paunescu 刘春(译) 朱志忠(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，4： | 14 |
| 13 | CT-maximum intensity projection is a clinically useful modality for the detection of gastric varices显示文摘AIM: To evaluate the efficacy of CT-maximum intensity projection (CT-MIP) in the detection of gastric varicesand their inflowing and outflowing vessels in patientswith gastric varices scheduled to undergo balloonoccluded retrograde transvenous obliteration (B-RTO). METHODS: Sixteen patients with endoscopicallyconfirmed gastric varices were included in this study. All patients were evaluated with CT-MIP using threedimensional reconstructions, before and after B-RTO. RESULTS: CT-MIP clearly depicted gastric varices in 16 patients (100%), the left gastric vein in 6 (32.5%),the posterior gastric vein in 12 (75.0%), the short gastric veins in 13 (81.3%), gastrorenal shunts in 16 (100%), the hemiazygos vein (HAZV) in 4 (25.0%), the pericardiophrenic vein (PCPV) in 9 (56.3%), and the left inferior phrenic vein in 9 patients (56.3%). Although flow direction itself cannot be determined from CT-MIP,this modality provided clear images of the inflowing and the outflowing vessels. Moreover, in one patient, short gastric veins were not seen on conventional angiographic portography images of the spleen, but were clearly revealed on CT-MIP,CONCLUSION: We suggest that CT-MIP should be considered as a routine method for detecting and diagnosing collateral veins in patients with gastric varices scheduled for B-RTO. Furthermore, CT-MIP is more useful than endoscopy in verifying the early therapeutic effects of B-RTO. | Toru Ishikawa Takashi Ushiki Ken-ichi Mizuno Tadayuki Togashi Kouji Watanabe Kei-ichi Seki Hironobu Ohta Toshiaki Yoshida Keiko Takeda Tomoteru Kamimura | 2005 | World Journal of Gastroenterology2005，11，47： | 13 |
| 14 | Global Wheat Head Detection(GWHD)Dataset:A Large and Diverse Dataset of High-Resolution RGB-Labelled Images to Develop and Benchmark Wheat Head Detection Methods显示文摘The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of awns.Several studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning algorithms.However,these methods have generally been calibrated and validated on limited datasets.High variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer vision.Further,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more complex.Through a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head Detection(GWHD)dataset.It contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of genotypes.Guidelines for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection datasets.The GWHD dataset is publicly available at http://gffzzef49fa24bca249bbhpvpu0wxkwxvf6o6f.ffgz.tsg.suse.edu.cn/and aimed at developing and benchmarking methods for wheat head detection. | Etienne David Simon Madec Pouria Sadeghi-Tehran Helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo | 2020 | Plant Phenomics2020，2，1： | 13 |
| 15 | Utility of linked color imaging for endoscopic diagnosis of early gastric cancer显示文摘BACKGROUND Linked color imaging(LCI) is a method of endoscopic imaging that emphasizes slight differences in red mucosal color.AIM To evaluate LCI in diagnostic endoscopy of early gastric cancer and to compare LCI and pathological findings.METHODS Endoscopic images were obtained for 39 patients(43 lesions) with early gastric cancer. Three endoscopists evaluated lesion recognition with white light imaging(WLI) and LCI. Color values in Commission Internationale de l'Eclairage(CIE)1976 L*a*b* color space were used to calculate the color difference(ΔE) between cancer lesions and non-cancer areas. After endoscopic submucosal dissection,blood vessel density in the surface layer of the gastric epithelium was evaluated pathologically. The identical region of interest was selected for analyses of endoscopic images(WLI and LCI) and pathological analyses.RESULTS LCI was superior for lesion recognition(P < 0.0001), and ΔE between cancer and non-cancer areas was significantly greater with LCI than WLI(29.4 vs 18.6, P <0.0001). Blood vessel density was significantly higher in cancer lesions(5.96% vs4.15%, P = 0.0004). An a* cut-off of ≥ 24 in CIE 1976 L*a*b* color space identified a cancer lesion using LCI with sensitivity of 76.7%, specificity of 93.0%, and accuracy of 84.9%.CONCLUSION LCI is more effective for recognition of early gastric cancer compared to WLI as a result of improved visualization of changes in redness. Surface blood vessel density was significantly higher in cancer lesions, and this result is consistent with LCI image analysis. | Toshihisa Fujiyoshi Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Tsunaki Sawada Keiko Maeda Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Masato Nakaguro Masahiro Nakatochi Yoshiki Hirooka | 2019 | World Journal of Gastroenterology2019，25，10： | 12 |
| 16 | Anti-viral therapy to reduce recurrence and improve survival in hepatitis B virus-related hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common malignancy and the third leading cause of cancer death worldwide.Chronic infection with hepatitis B virus(HBV)and hepatitis C virus accounts for approximately75%-80%of HCC cases worldwide.In particular,chronic HBV infection is a predominant risk factor for HCC in Asia and Africa.Hepatic resection and radiofrequency ablation are increasingly used for the curative treatment of HCC,and good local control can be achieved.However,the high rate of recurrence is a major obstacle to improving prognosis.A high viral load of HBV DNA is the most important correctable risk factor for recurrence.Furthermore,interferon and/or nucleotide analogues may decrease HBV DNA.Therefore,these drugs may decrease recurrence.In this article,treatment strategies for HBV-related HCC are described in order to reduce recurrence and improve survival. | Toru Ishikawa | 2013 | World Journal of Gastroenterology2013，19，47： | 11 |
| 17 | Usefulness of anti-ulcer drugs for the prevention and treatment of peptic ulcers induced by low doses of aspirin显示文摘AIM:To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin- induced peptic ulcer. METHODS:Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin(81 or 100 mg/day).The endoscopic findings were classified according to the Lanza score,and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used.In another study,31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled.The patients were randomly classified into the proton pump inhibitor (PPI)-treated group and the H2 receptor antagonist (H2RA)-treated group.The administration of low-dose aspirin was continued concomitantly,and endoscopic examinations were performed 8 wk later. RESULTS:The Lanza scores(mean±SD)of the gastro-mucosal lesions were 1.0±1.9 and 1.9±2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA,respectively.Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy(4.7±1.0)and in 10 patients receiving cytoprotective anti-ulcer drugs (4.3±1.6).In the prospective study,18 and 13 patients received a PPI and an H2RA,respectively.Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients (92%)in the H2RA-treated group;no significant differences were observed between the groups. CONCLUSION:H2RA therapy was effective for both the prevention and treatment of low-dose aspirin- induced peptic ulcer,similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration. | Sayaka Nakashima Shinichi Ota Shin Arai Kiyoko Yoshino Mie Inao Keiko Ishikawa Nobuaki Nakayama Yukinori Imai Sumiko Nagoshi Satoshi Mochida | 2009 | World Journal of Gastroenterology2009，15，6： | 11 |
| 18 | 藏北高原地表能量和边界层结构的数值模拟显示文摘利用耦合了NCAR LSM陆面过程的中尺度模式MM5V3.7和2002年8月CAMP/Tibet加强期的观测资料,对藏北高原地区地气交换过程进行了48 h模拟研究。模式较好地模拟了该地区的山谷风环流;并将模拟的地表通量在中尺度区域上与NCEP/NCAR全球大气再分析格点资料(NNRP)获得的结果进行了比较,同时也与单站的实测值进行了比较,结果显示:模拟的地表通量与NNRP得到的结果比较吻合,同时可以得到雨季时藏北、藏东地区潜热通量大于感热通量,而高原西部感热通量大于潜热通量,这与观测试验分析结果一致;与单站试验结果比较,模拟的感热通量与实测值一致,潜热通量的模拟值和实测值有一定差别。模拟的边界层位温廓线与实测值比较,模式模拟的对流混合层和夜间残留层都与实测结果吻合,但模拟的混合层高度较实测值高。由此来看,中尺度模式MM5V3.7能够较好地模拟藏北高原的地表能量和边界层结构特征,但还需要进一步完善陆面过程和物理过程参数化方案。 | 李茂善 马耀明 吕世华 胡泽勇 Ishikawa Hirohiko 马伟强 孙方林 宋敏红 | 2008 | 高原气象2008，27，1： | 11 |
| 19 | Treatment strategies for advanced hepatocellular carcinoma:Sorafenib vs hepatic arterial infusion chemotherapy显示文摘Sorafenib is used worldwide as a first-line standardsystemic agent for advanced hepatocellular carcinoma(HCC) on the basis of the results of two large-scale Phase Ⅲ trials. Conversely,hepatic arterial infusion chemotherapy(HAIC) is one of the most recommended treatments in Japan. Although there have been no randomized controlled trials comparing sorafenib with HAIC,several retrospective analyses have shown no significant differences in survival between the two therapies. Outcomes are favorable for HCC patients exhibiting macroscopic vascular invasion when treated with HAIC rather than sorafenib,whereas in HCC patients exhibiting extrahepatic spread or resistance to transcatheter arterial chemoembolization,good outcomes are achieved by treatment with sorafenib rather than HAIC. Additionally,sorafenib is generally used to treat patients with Child-Pugh A,while HAIC is indicated for those with either Child-Pugh A or B. Based on these findings,we reviewed treatment strategies for advanced HCC. We propose that sorafenib might be used as a first-line treatment for advanced HCC patients without macroscopic vascular invasion or Child-Pugh A,while HAIC is recommended for those with macroscopic vascular invasion or Child-Pugh A or B. Additional research is required to determine the best second-line treatment for HAIC non-responders with Child-Pugh B through future clinical trials. | Issei Saeki Takahiro Yamasaki Masaki Maeda Takuro Hisanaga Takuya Iwamoto Koichi Fujisawa Toshihiko Matsumoto Isao Hidaka Yoshio Marumoto Tsuyoshi Ishikawa Naoki Yamamoto Yutaka Suehiro Taro Takami Isao Sakaida | 2018 | World Journal of Hepatology2018，10，9： | 10 |
| 20 | 珠穆朗玛峰北坡地区近地层及土壤微气象要素分析显示文摘利用中国科学院珠穆朗玛峰大气与环境综合观测研究站2005年9月—2006年8月一年的大气与土壤观测资料,初步分析了珠峰地区微气象特征和土壤特征量的变化。结果显示:该地区具有与青藏高原其它地区不同的微气象变化特征,气温在12月最低,6、7月最高,土壤温度呈正弦变化,土壤冻结时间较短等特征。 | 李茂善 马耀明 Hirohiko Ishikawa 马伟强 孙方林 王永杰 朱志鲲 | 2007 | 高原气象2007，26，6： | 10 |
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