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| 1 | Risk factors and urinary biomarkers of non-albuminuric and albuminuric chronic kidney disease in patients with type 2 diabetes显示文摘BACKGROUND A number of recent studies indicate a transformation in the natural course of chronic kidney disease(CKD)in type 2 diabetes(T2D)patients:an increasing prevalence of declined renal function without proceeding to the accompanying elevation of albuminuria.It has been suggested that albuminuric and nonalbuminuric CKD patterns could be different in their phenotypes and pathogenic mechanisms.AIM To identify the risk factors and biomarkers of albuminuric and non-albuminuric patterns of CKD in patients with T2D.METHODS Three hundred sixty patients with T2D duration≥10 years were included in this observational cross-sectional study.The associations of a panel of demographic and clinical characteristics,complications,comorbidities,and metabolic and hematology parameters with albuminuric and non-albuminuric CKD patterns were analyzed.The urinary excretion of nephrin and podocin,two podocytespecific markers,and WAP-four-disulfide core domain protein 2(WFDC-2),a marker of tubulointerstitial fibrosis,was determined by ELISA in comparison with healthy controls.RESULTS Non-albuminuric CKD was associated with age≥65 years(P=0.0001),female sex(P=0.04),diabetes duration≥15 years(P=0.0009),and the use of diuretics(P=0.0005).Male sex(P=0.01),smoking(P=0.01),waist-to-hip ratio>1.0(P=0.01)and hemoglobin A1c(HbA1c)>8.0%(P=0.005)were risk factors for elevated albuminuria not accompanied by a decrease in estimated glomerular filtration rate(eGFR).Duration of diabetes≥15 years and the use of calcium channel blockers were risk factors for albuminuria with decreased eGFR(both P=0.01).In multivariate logistic regression analysis,age,HbA1c,female sex and diuretics were significant predictors for reduced eGFR,while waist-to-hip ratio,HbA1c and male sex were associated with elevated urinary albumin-to-creatinine ratio(UACR).Excretion of nephrin and podocin was increased in patients with albuminuria,regardless of decline in renal function(P<0.001),correlating positively with UACR.The urinary excretion of WFDC-2 was markedly higher in men than in women(P<0.000001).Men with T2D demonstrated increased WFDC-2 levels independently of the CKD pattern(all P<0.05).In T2D women,WFDC-2 excretion was increased in those with reduced renal function(P≤0.01),correlating negatively with eGFR.CONCLUSION The data provide further evidence that albuminuric and non-albuminuric CKD phenotypes correspond to different pathways of diabetic kidney disease progression. | Anton I Korbut Vadim V Klimontov Ilya V Vinogradov Vyacheslav V Romanov | 2019 | World Journal of Diabetes2019，10，11： | 3 |
| 2 | High Performance Top Emitting OLED Devices显示文摘 | All T A Ilyas I Khayrullin el al | 2007 | SID2007，59，： | 1 |
| 3 | Modeling and querying possible repairs in duplicate detection 显示文摘 | Beskales G Soliman M A Ilyas I F | 2009 | Proceedings of the VLDB Endowment2009，2，1： | 1 |
| 4 | Pelvic limb-salvage surgery for malignant tumors 显示文摘 | Pant R Moreau P Ilyas I | 2001 | Int Orthop2001，24，6： | 1 |
| 5 | 查看详情显示文摘 | Becer C R Gibson M I Geng J Ilyas R Wallis R Mitchell D A Haddleton D M | | 0，，43： | 1 |
| 6 | Efficient search for the top-k probable nearest neighbors in uncertain databases 显示文摘 | Bekales G Soliman M A Ilyas I F | 2008 | Proc of the VLDB Endowment2008，1，1： | 1 |
| 7 | Reciprocity between membranous and nuclear expression of beta - catenin in colorectal tumours 显示文摘 | X Hao I Tomlinson M Ilyas | 1997 | Virchows - Arch1997，431，3： | 1 |
| 8 | Letrozole-induced polycystic ovaries in the rat:a new model for cystic ovarian disease显示文摘 | Hasan K Mehmet I Ilyas O | 2004 | ModicalResearch2004，35，2： | 1 |
| 9 | Reciporocity between membranous and nuclear expression of β-catenin in colorectal tumours 显示文摘 | Hao X Tomlison I Ilyas M | 1997 | Virchows Arch1997，431，： | 1 |
| 10 | SP-GiST:An Extensible Database Index for Supporting Space Partitioning Trees显示文摘 | W G Aref and I F Ilyas | 2001 | JIIS2001，17，21： | 1 |
| 11 | Supporting top-k join queries in relational databases显示文摘 | Ilyas I F Aref W G Elmagarmid A K | 2004 | Proceedings of Vldb Conference2004，13，3： | 1 |
| 12 | Reciprocity be tween membranous and nuclear expression of beta-catenin in colorectal tumours 显示文摘 | Hao X Tomlinson I Ilyas M | 1997 | Virchows Arch1997，431，3： | 1 |
| 13 | Probabilistic top k and ranking-aggregate queries 显示文摘 | Soliman M A Ilyas I F Chang K C | 2008 | ACM Trans on Database Systems (TODS)2008，33，3： | 1 |
| 14 | A survey of top-k query processing techniques in relational database systems 显示文摘 | Ilyas I F Beskales G Soliman M A | 2008 | ACM Computing Surveys (CSUR)2008，40，4： | 1 |
| 15 | Letrozole-induced polycystic ovaries in the rat: A new model for cystic ovarian disease 显示文摘 | Hasan K Mehmet I Ilyas O | 2004 | Arch Med Res2004，35，2： | 1 |
| 16 | Locked intramedullary nailing for diffi- cuh nonunions of the humeral diaphysis 显示文摘 | Ilyas I Younge DA | 2003 | lnt Orthop2003，27，5： | 1 |
| 17 | Efficient search for the top-k probable nearest neighbors in uncertain databases 显示文摘 | Beskales G Soliman M Ilyas I F | 2008 | Proc of the VLDB Endowment2008，1，1： | 1 |
| 18 | Supporting ranking queries on uncertain and incomplete data 显示文摘 | Soliman M A Ilyas I F Ben S D | 2010 | The VLDB Journal2010，19，4： | 1 |
| 19 | Reciporocity between membranous and nuclear expression ofβ-catenin in colorectal tumors显示文摘 | HAO X TOMLINSON I ILYAS M | 1997 | Virchows Arch1997，431，3： | 1 |
| 20 | A Generic Model of Equipment Availability under Imperfect Maintenance显示文摘 | Richard C C Ilyas M I | 2005 | IEEE Transaction on Reliability2005，54，4： | 1 |
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