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| 1 | Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy显示文摘AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ:10 mg or 20 mg od,20 mg bid,or 10 mg qid for 14 d. All patients completed a frequency scale for symptoms of gastroesophageal reflux disease questionnaire frequency scale for the symptoms of GERD (FSSG); and underwent 24 h pH monitoring on day 14. RESULTS:With increased dosages and frequency of administration of RPZ,median intragastric pH significantly increased,and FSSG scores significantly decreased. With RPZ 10 mg qid,potent acid inhibition was attained throughout 24 h. However,five subjects were refractory to RPZ 10 mg qid,although the median intragastric pH in these subjects (6.6,range:6.2-7.1) was similar to that in the remaining five responsive subjects (6.5,range:5.3-7.3). With baseline RPZ 10 mg od,FSSG scores in responsive patients improved by > 30%,whereas there was no significant decrease in the resistant group. CONCLUSION:NERD patients whose FSSG score fails to decrease by > 30% after treatment with RPZ 10 mg od for 14 d are refractory to higher dosage. | Mitsushige Sugimoto Masafumi Nishino Chise Kodaira Mihoko Yamade Takahiro Uotani Mutsuhiro Ikuma Kazuo Umemura Takahisa Furuta | 2011 | World Journal of Gastroenterology2011，17，14： | 10 |
| 2 | 结肠直肠癌术前分期:PET并不优于全身多层螺旋CT | Furukawa H. Ikuma H. Seki A. 周智勇 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，11： | 2 |
| 3 | A case of small bowel adenocarcinoma in a patient with Crohn’s disease detected by PET/CT and double-balloon enteroscopy显示文摘Small bowel adenocarcinoma (SBA) in patients with Crohn’s disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis. Here, we report a 48-year-old man with SBA and a 21-year history of CD who was diagnosed by a combination of positron emission tomography/computed tomography (PET/CT) and double-balloon enteroscopy (DBE). Since the age of 27 years, the patient had been treated for ileal CD and was referred to our hospital with persistent melena. Multiple hepatic tumors were found by CT. PET/CT detected an accumulation spot in the small bowel. DBE revealed an ulcerative tumor in the ileum about 100 cm from the ileocecal valve. An endoscopic forceps biopsy specimen showed poorly differentiated adenocarcinoma. There were some longitudinal ulcer scars near the tumor, and the chronic inflammation inthe small bowel appeared to be associated with the cancer development. Previous reports suggest the risk of SBA in patients with CD is higher than in the overall population. Since early diagnosis is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative diagnosis of the development of SBA in CD. | Chise Kodaira Satoshi Osawa Chihiro Mochizuki Yoshihiko Sato Masafumi Nishino Takanori Yamada Yasuhiro Takayanagi Kosuke Takagaki Ken Sugimoto Shigeru Kanaoka Takahisa Furuta Mutsuhiro Ikuma | 2009 | World Journal of Gastroenterology2009，15，14： | 2 |
| 4 | Oxygen self-diffusion in cerium oxide doped with Nd显示文摘 | Kamiya M Shimada E Ikuma Y | | 0，，： | 1 |
| 5 | High-energy extrusion-molded Nd-Fe-B magnets 显示文摘 | Akioka K Shimoda T | 1994 | IEEE Translation Journal on Magnetics in Japan1994，9，5： | 1 |
| 6 | Difficulties in removal of the titanium locking plate in Japan显示文摘 | Maehara T Mofitani S Ikuma H | 2013 | Injury2013，44，8： | 1 |
| 7 | Effect of Pt concentration on the production of hydrogen by a TiO 2 photocatalyst显示文摘 | Yasuro Ikuma Hiroaki Bessho | 2006 | International Journal of Hydrogen Energy2006，，14： | 1 |
| 8 | Preimplantation genetic diagnosis and natural conception: a comparison of live birth rates in patients with recurrent pregnancy loss associated with translocation 显示文摘 | Ikuma S Sato T Sugiura-Ogasawara M | 2015 | PLoS One2015，10，01： | 1 |
| 9 | Incidence and recurrence rates of colorectal adenomas estimated by annually repeated colonosco- pies on asymptomatic Japanese 显示文摘 | Yamaji Y Mitsushima T Ikuma H | 2004 | Gut2004，53，4： | 1 |
| 10 | Neuropeptide FF and FMRF amide potentiate acid-evoked currents from sensor), neurons and proton-gated DEG/ENaC channels 显示文摘 | Askwith CC Cheng C Ikuma M | 2000 | Neuron2000，26，1： | 1 |
| 11 | Improvement in raw meat texture of cultured Eel by feeding of Tochu leaf powder 显示文摘 | Tanimoto S Y Ikuma K Takahashi S | 1993 | Bioscience Biotechnology and Biochemistry1993，57，2： | 1 |
| 12 | Laparoscopic colpopoiesis using sigmoid colon显示文摘 | Ikuma K Ohashi S Koyasu Y | 1997 | Surg Laparosc Endosc1997，7，1： | 1 |
| 13 | Improvement in raw meat texture of cultured eel by feeding of tochu leaf powder 显示文摘 | Tanimoto S Y Ikuma K Takahashi S | 1993 | Bioscience Biotechnology and Biochemistry1993，57，2： | 1 |
| 14 | Preoperative staging of biliary carcinoma using 18 F-fluorodeoxyglucose PET: prospective comparison with PET+CT, MDCT and histopathology显示文摘 | Hiroyoshi Furukawa Hiroki Ikuma Koiku Asakura-Yokoe Katsuhiko Uesaka | 2008 | European Radiology2008，，12： | 1 |
| 15 | Difficulties in removal of the titanium locking plate in Japan显示文摘 | Maehara T Moritani S Ikuma H | | 0，，： | 1 |
| 16 | Difficulties in re- moval of the titanium locking plate in Japan显示文摘 | Maehara T Moritani S Ikuma H | 2013 | Injury2013，44，8： | 1 |
| 17 | Laparoscopic 显示文摘 | Andou M Yoshioka T Ikuma K | 2003 | Obstet Gyneca12003，102，52： | 1 |
| 18 | Laparoscopic ureteroneocys tostomy显示文摘 | Andou M Yoshioka T Ikuma K | | Obstetrics & Gynecology0，102，： | 1 |
| 19 | Effects of work zone configurations and traffic density on performance vari- ables and subjective workload显示文摘 | SHAKOURI M IKUMA L H AGHZADEH F | 2014 | Accident Analysis and Prevention2014，71，： | 1 |
| 20 | The vasopressin injection technique for laparoscopic excision of ovarian endometrioma:a technique to reduce the use of coagulation显示文摘 | Saeki A Matsumoto T Ikuma K | 2010 | J Minim Invasive Gynecol2010，17，2： | 1 |
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