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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 3 | Perspectives on model based integration of process operation显示文摘 | Bassett M H Dave P Doyle F J III | 1996 | Computers & Chem Eng1996，20，67： | 2 |
| 4 | Relative location estimation in wireless sensor networks显示文摘 | Patwari N Hero A O Perkins III M et ac | 2003 | IEEE Transactions on Signal Process2003，51，8： | 1 |
| 5 | Complexing of ac- tin and other nuclear proteins to DNA by platinum(11) and chromium compounds 显示文摘 | MILLER C A III COHENMD COSTA M | 1991 | Carcinogenesis1991，12，： | 1 |
| 6 | Common amino acid se- quence domains among the LEA proteins of higher plants显示文摘 | Dure L III Crouch M Harada J | 1989 | Plant Molecular Biology1989，12，： | 1 |
| 7 | Automated lung nodule classification following automated nodule detection on CT:A serial ap-proach 显示文摘 | Armato III S G Altman M B Wilkie J | 2003 | Medical Physics2003，30，6： | 1 |
| 8 | Optimization of Clamped Circular Piezoelectric Composite Actuators显示文摘 | Papila M Sheptak M Cattafesta N L III | 2008 | Sensors and Actua- tors A : Physical2008，147，1： | 1 |
| 9 | Shared Space: An Augmented Reality Approach for Computer Supported Collabora- tive Work显示文摘 | Billinghurst M Weghorst S Fumess III T | 1998 | Virtual Reality1998，3，1： | 1 |
| 10 | Arctic ice-ocean modeling with and without climate restoring显示文摘 | Zhang J Hibler W D Steele III M | 1998 | Journal of Physical Oceanography1998，28，2： | 1 |
| 11 | Magnetic anomalies in the Pacific and sea floor spreading显示文摘 | Pitman W C III Hen'on E M Heirtzler J R | 1968 | Journal of Geophysical Research1968，73，： | 1 |
| 12 | Alignment by maximization of mutual information显示文摘 | P A Viola W M Wells III | 1997 | International Journal of Computer Vision1997，24，2： | 1 |
| 13 | Effects of elevated dietary arginine on resistance of Channel catfish to exposure to Edwardsiella ictaluri显示文摘 | Buentello A J Gatlin III D M | 2001 | J Aquat Anim Hlth2001，13，： | 1 |
| 14 | Efficacy of electrolyzed oxidizing water against Listeria monocytogenes and Morganella morganii on conveyor belt and raw fish surfaces显示文摘 | Susan M William B III | 2012 | Food Control2012，24，12： | 1 |
| 15 | Relationship of per- sonality traits and counterproductive work behaviors: The mediating effects of job satisfaction 显示文摘 | Mount M IIies R & Johnson E | 2006 | Personal Psychology2006，59，3： | 1 |
| 16 | The topology of complete minimal surfaces of finite total gaussian curvature 显示文摘 | JORGE L P M MEEKS III W H | 1983 | Topology1983，22，2： | 1 |
| 17 | Effects of ultraviolet radiation on primary productivity in a high altitude tropical lake显示文摘 | Kinzie R A III Banaszak A T Lesser M P | 1998 | Hydrobiologia1998，385，： | 1 |
| 18 | An ERP study of the temporal couise of the Stroop color-word interference effect t显示文摘 | Liotti M Woldorff MG Perez III R | 2000 | Neuropsychologia2000，38，5： | 1 |
| 19 | The impact of meteorological parameters on urban air quality显示文摘 | RAMSEY N R KLEIN P M MOORE III B | 2014 | Atmos- pheric Environment2014，86，4： | 1 |
| 20 | L13a-dependent translational control in macrophages imits the pathogenesis of colitis显示文摘 | Darshana Poddar Ravinder Kaur William M Baldwin III Barsanjit Mazumder | 2016 | Cellular & Molecular Immunology2016，13，6： | 1 |
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