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| 1 | A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile显示文摘 | Yuan, KL Kong, HW Guan, YF Yang, J Xu, GX | 2007 | 中国生物学文摘2007，21，11： | 26 |
| 2 | Effect of PA-MSHA vaccine on plasma phospholipids metabolic profiling and the ratio of Th2/Thl cells within immune organ of mouse IgA nephropathy显示文摘 | Jia, LW Wang, C Kong, HW Yang, J Li, FL Lv, S Xu, GW | 2007 | 中国生物学文摘2007，21，11： | 19 |
| 3 | 球铁激光表面重熔组织热处理制备新型铁基耐磨材料显示文摘对球墨铸铁激光表面重熔/快速凝固组织进行热处理,使亚稳相快速凝固共晶渗碳体部分转变为石墨,成功地制得了既含快速凝固共晶渗碳体又含弥散石墨的新型多相铁基耐磨材料其中渗碳体及石墨相的体积分数可以通过调节退火时间严格控制由于集中了快速凝固共晶渗碳体的优异耐磨性与弥散石墨相的优异自润滑、传热及减振性能。 | 王华明 Berg.,HW | 1998 | 材料研究学报1998，12，1： | 18 |
| 4 | Defects in Mesenchymal Stem Cell Self-Renewal and Cell Fate Determination Lead to an Osteopenic Phenotype in Bmi-1 Null Mice(摘要)显示文摘 | Zhang, HW Ding, J Jin, JL Guo, J Liu, JN Karaplis, A Goltzman, D Miao, DS | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 13 |
| 5 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 6 | 儿童期应用吸入性糖皮质激素治疗对成年身高的影响显示文摘背景在青春期前儿童中,应用吸入性糖皮质激素治疗持续性哮喘可引起生长速度暂时减慢。目前认为开始吸入性糖皮质激素治疗后1~4年所致的身高降低不会降低成年后所达到的身高。方法在儿童哮喘管理计划(试验)的1 041名受试者中,我们测量了943名(90.6%)受试者的成年身高,测量成年身高时的平均年龄为(24.9±2.7)岁。从5~13岁时开始,受试者被随机分配接受每日布地奈德400μg、奈多罗米16 mg或者安慰剂治疗4~6年。我们采用对(受试者在)试验入选时人口学特性、哮喘特点以及身高进行校正的多因素线性回归方法,计算了每个治疗组的成年身高(分别)与安慰剂组相比的差异。结果布地奈德组成年平均身高较安慰剂组低1.2 cm〔95%CI(-1.9,-0.5)〕,奈多罗米组成年平均身高较安慰剂组低0.2cm〔95%CI(-0.9,0.5),P=0.61〕。最初2年内吸入性糖皮质激素的日剂量较大,与成年身高较低相关(剂量每增大1 mg/kg体质量,身高就降低0.1 cm,P=0.007)。布地奈德组与安慰剂组相比成年身高降低与治疗了2年后的身高降低情况相似〔-1.3 cm,95%CI(-1.7,-0.9)〕。在最初的2年内,布地奈德组的生长速度减慢主要发生在青春期前的受试者中。结论青春期前儿童中最初出现的、与应用吸入性糖皮质激素治疗相关的身高降低在成年时仍持续存在,不过身高的降低不是进行性的,也不具有累积性。 | Kelly HW Sternberg AL Lescher R | 2012 | 中国全科医学2012，15，36： | 9 |
| 7 | IVF过程受精失败的预测显示文摘在发明和常规应用卵胞浆内单精子注射(ICSI)之前,十多年的临床体外受精(IVF)治疗实践中,受精率低下很常见,大约有20%~35%的IVF患者受精率很低(〈35%的卵子受精)和受精完全失败(所有卵子都不受精)。虽然受精失败与精子或卵子的质量有关,但相当一部分患者受精失败与精液质量或精子功能低下有很密切相关性。最常见的是严重的少精,弱精和畸形精子症患者。 | 刘德一 HW Gordon Baker | 2009 | 生殖医学杂志2009，18，3： | 6 |
| 8 | 脂蛋白a水平与冠状动脉粥样硬化性心脏病患者复发事件的关系显示文摘脂蛋白a是否是冠状动脉粥样硬化性心脏病(冠心病)患者复发性心血管事件(recurrent cardiovascular events,RCVEs)的预测因子尚未确定。本研究旨在探讨脂蛋白a对一个真实世界、大规模首诊心血管事件(cardiovascular event,CVE)患者队列中RCVEs的潜在影响。方法:本实验为多中心的前瞻性研究,纳入经血管造影诊断的冠心病并经历首次CVE的患者7562例。入院时测量所有患者的脂蛋白a浓度. | 周卫(译) 叶鹏(校) Liu HH Cao YX Jin JL Zhang HW Hua Q Li YF Guo YL Zhu CG Wu NQ Gao Y Xu RX Hong LF | 2020 | 中华高血压杂志2020，28，5： | 5 |
| 9 | Colorectal mucosal histamine release by mucosa oxygenation in comparison with other established clinical tests in patients with gastrointestinally mediated allergy显示文摘瞄准:评估的这研究作为一个新诊断过程响应挑战积极的使失明的食物和否定食物抗原渲染表面的粘膜组织安版本。方法:受不了胃肠地调停的过敏症由使失明的口头的挑衅证实了的 19 个病人在他们的病历,皮肤刺测试,浆液 IgE 察觉和颜色的根据上被调查由前 vivo 粘膜氧化的表面的粘膜组织安版本。未经触动的织物粒子为 30 min 与不同食物抗原在一种氧化文化被孵化 / 刺激。与反人的免疫球蛋白 E 并且没有任何刺激质问的标本分别地用作积极、否定的控制。粘膜组织安版本(全部的活体检视组织安内容的 %) 被认为成功(积极) ,从响应抗原的活体检视的组织安版本的率什么时候到达了多于两次自发的版本的。组织安测量被放射性免疫测定执行。结果:从全部的活体检视组织安内容的表面的粘膜被发现是 3.2 的颜色(0.1%-25.8%) 的自发的组织安版本的 median (范围) 。食物抗原由口头的挑衅容忍了没得到桅杆房间去粒 3.4 (0.4%-20.7% , P = 0.4 ) 当 anti-IgE 和原因的食物变应原导致了 5.4 的一个重要组织安版本时(1.1%-25.6% , P = 0.04 ) 并且 8.1 (1.5%-57.9% , P = 0.008 ) 分别地。19 个病人(63.1%) 中的 12 个显示出积极颜色根据对一样的抗原(s) 作出回应的使失明的口头的挑战的表面的粘膜组织安版本,当功能的组织安版本的特性容忍了精确地认出时,食品被发现是 78.6% 。与历史(30.8% 和 57.1%) 的使失明的食物挑战测试,敏感和特性的结果比较,皮肤试验(47.4% 和 78.6%) 或抗原特定的浆液 IgE 决心(57.9% 和 50%) 被发现具有在胃肠地调停的过敏症的更低的诊断精确性。结论:颜色的反应的功能的测试在在有胃肠地调停的过敏症的病人的遗传因子的刺激具有更高诊断的功效的反之上的表面的粘膜。 | M Raithel M Weidenhiller R Abel HW Baenkler EG Hahn | 2006 | World Journal of Gastroenterology2006，12，29： | 4 |
| 10 | Endoscopic options in children: experience with 134 procedures显示文摘 | Oertel JM Baldauf J Schroeder HW Gaab MR | 2009 | 中国神经肿瘤杂志2009，7，1： | 4 |
| 11 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 12 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 13 | Routine defunctioning stoma after chemoradiation and total mesorectal excision:A single-surgeon experience显示文摘AIM:To investigate the 10-year results of treating low rectal cancer by a single surgeon in one institution.METHODS:From Oct 1998 to Feb 2009,we prospectively followed a total of 62 patients with cT2-4 low rectal cancer with lower tumor margins measuring at 3 to 6 cm above the anal verge.All patients received neoadjuvant chemoradiation(CRT) for 6 wk.Among them,85% of the patients received 225 mg/m2/d 5-fluorouracil using a portable infusion pump.The whole pelvis received a total dose of 45 Gy of irradiation in 25 fractions over 5 wk.The interval from CRT completion to surgical intervention was planned to be approximately 6-8 wk.Total mesorectal excision(TME) and routine defunctioning stoma construction were performed by one surgeon.The distal resection margin,circumferential resection margin,tumor regression grade(TRG) and other parameters were recorded.We used TRG to evaluate the tumor response after neoadjuvant CRT.We evaluated anal function outcomes using the Memorial Sloan-Kettering Cancer Center anal function scores after closure of the defunctioning stoma.RESULTS:The median distance from the lower margin of rectal cancer to the anal verge was 5 cm:6 cm in 9 patients,5 cm in 32 patients,4 cm in 10 patients,and 3 cm in 11 patients.Before receiving neoadjuvant CRT,45 patients(72.6%) had a cT3-4 tumor,and 21(33.9%) patients had a cN1-2 lymph node status.After CRT,30 patients(48.4%) had a greater than 50% clinical reduction in tumor size.The final pathology reports revealed that 33 patients(53.2%) had a ypT3-4 tumor and 12(19.4%) patients had ypN1-2 lymph node involvement.All patients completed the entire course of neoadjuvant CRT.Most patients developed only Grade 1-2 toxicities during CRT.Thirteen patients(21%) achieved a pathologic complete response.Few post-operative complications occurred.Nearly 90% of the defunctioning stomas were closed within 6 mo.The local recurrence rate was 3.2%.Pathologic lymph node involvement was the only prognostic factor predicting disease recurrence(36.5% vs 76.5%,P = 0.006).Nearly 90% of patients recovered sphincter function within 2 year after closure of the defunctioning stoma.CONCLUSION:Neoadjuvant CRT followed by TME,combined with routine defunctioning stoma construction and high-volume surgeon experience,can provide excellent surgical quality and good local disease control. | Shao-Chieh Lin Po-Chuan Chen Chung-Ta Lee Hong-Ming Tsai Peng-Chan Lin Helen HW Chen Yuan-Hwa Wu Bo-Wen Lin Wen-Pin Su Jenq-Chang Lee | 2013 | World Journal of Gastroenterology2013，19，11： | 3 |
| 14 | Can the rat donor liver tolerate prolonged warm ischemia?显示文摘INTRODUCTIONThe last two decades of the twentieth century havewitnessed increasingly successful rates of livertransplantation.The number of liver transplantations hasincreased steadily while the number of organ donors | Yan JQ Li HW Cai WY Zhang MJ Yang WP | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 15 | Study on incisional implantation of tumor cells by carbon dioxide pneumoperitoneum in gastric cancer of a murine model显示文摘 | Wang H Zheng MH Zhang HB Zhu J He JR Lu AG Ji YB Zhang MJ Jiang Y Yu BM Li HW | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 16 | Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation显示文摘 | Hoontrakoon R Chu HW Gardai SJ | 2002 | Am J Respir Cell Mol Biol2002，26，： | 2 |
| 17 | Relationship between seminal plasma zinc concentration and spermatozoa-zona pellucida binding and the ZP-induced acrosome reaction in subfertile men显示文摘 | De-Yi Liu Boon-Shih Sie Ming-Li Liu Franca Agresta HW Gordon Baker | 2009 | Asian Journal of Andrology2009，11，4： | 2 |
| 18 | 全球地下煤气化技术综述显示文摘 | Gude.,HW 马玉平 | 1990 | 冶金科技译丛1990，，2： | 2 |
| 19 | Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus:an algorithm for glycemic control显示文摘 | Rodbard HW Jellinger PS Davidson JA | | Endocrine Practice0，，： | 2 |
| 20 | 根据皮肤光型和皮肤疾病进行光防护:来自专家小组的实用性建议显示文摘一、引言研究表明,在使用防晒霜时,应足量涂抹以达到2 mg/cm^(2)的推荐用量,这可以通过“茶匙法则(teaspoon rule)”或使用后1h内再次补涂的方法来实现。防晒霜的配方和质地需要根据个体的皮肤光型和皮肤疾病作出调整,然而大多数消费者仅依据SPF数值来选择防晒霜。 | Passeron T Lim HW Goh CL | 2021 | 中华皮肤科杂志2021，54，7： | 2 |
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