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| 1 | Current progress in epigenetic research for hepato-carcinomagenesis显示文摘Hepatocellular carcinoma is the main type of primary liver cancer,and also one of the most malignant tumors.At present,the pathogenesis mechanisms of liver cancer are not entirely clear.It has been shown that inactivation of tumor suppressor genes and activation of oncogenes play a significant role in carcinogenesis,caused by the genetic and epigenetic aberrance.In the past,people generally thought that genetic mutation is a key event of tumor pathogenesis,and somatic mutation of tumor suppressor genes is in particular closely associated with oncogenesis.With deeper understanding of tumors in recent years,increasing evidence has shown that epigenetic silencing of those genes,as a result of aberrant hypermethylation of CpG islands in promoters and histone modification,is essential to carcinogenesis and metastasis.The term epigenetics refers to heritable changes in gene expression caused by regulation mechanisms,other than changes in the underlying DNA sequence.Specific epigenetic processes include DNA methylation,genome imprinting,chromotin remodeling,histone modification and microRNA regulations.This paper reviews recent epigenetics research progress in the hepatocellular carcinoma study,and tries to depict the relationships between hepatocellular carcinomagenesis and DNA methylation as well as microRNA regulation. | HUANG Jian National Human Genome Research Center at Shanghai-Ministry of Science and Technology to build a healthy and disease Ge-nomics Laboratory,Shanghai 201203,China | 2009 | Science China(Life Sciences)2009，52，1： | 9 |
| 2 | 2显示文摘 | EVANS H K WYLIE A A MURPHY S K et akThe neuronatin gene resides in a micro-imprinted domain on human chromosome 20ql 1 | 2001 | Genomics2001，77，12： | 1 |
| 3 | Differential tissue distribution and subcellular localization of PDE9A variants显示文摘 | WANG P WU P EGAN RW Identification and characterization of a new human type 9 cGMP-specifie phosphodiesterase splice variant (PDE9A5) | 2003 | Gene2003，314，： | 1 |
| 4 | storage time, and temperature on DNA yield and quality显示文摘 | LAHIRI D K SCHUABEL B DNA isolation by a rapid method from human blood samples: Effects of MgCl2 EDTA | 1993 | Biochem Genet1993，31，： | 1 |
| 5 | 显示文摘 | Yun MH Kwang KL High-performance liquid chromatography method for determining alendronate sodium in human plasilia by detecting fuorescence:Application to a pharmaeokineticstudy in humans | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，40，1： | 1 |
| 6 | 显示文摘 | Paul P Cabestre FA Ibrahim EC :Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of the HLA-G mRNA and expression of soluble HLA-G5 HLA-G6 and-G7 transcripts in human transfected cells | 2000 | Hum Immunol2000，61，11： | 1 |
| 7 | The relationship between electrochemical behaviour and in-service corrosion of WC based cemented carbides 显示文摘 | HUMAN A M EXNER H E | 1997 | International Journal of Refractory Metals and Hard Materials1997，15，13： | 1 |
| 8 | Communication Engineering & Technology (UECET) 显示文摘 | Gaikwad A N Humane B | 2012 | Journal Impact Factor2012，3，1： | 1 |
| 9 | Comprehensive seven animal coronavirus 229E with a microarray hybridization assay显示文摘 | Chen detection Q Li J and coronaviruses and Deng Z R et identification of human respiratory a l | 2010 | Intervirology2010，，53： | 1 |
| 10 | Agriculture, Ecosystems and Environment 显示文摘 | Jjemba Patrick K The Potential Impact of Veterinary and Human Therapeutic Agents in Manure and Bisolids on Plants Grown on Arable land: A Review | 2002 | 93:267--2782002，93，： | 1 |
| 11 | Purification and characterization of limonoate dehydrogenase from Rhodococcus fascians显示文摘 | Humanes L Lopez-Ruiz A Merino MT | 1997 | Applied and Environmental Microbiology1997，63，9： | 1 |
| 12 | Inotropic effect of triiodothyronine following myocardial ischemia and cardiopulmonary bypass: an experimental study in pigs显示文摘 | NOVITZKY D HUMAN P A COOPER P K C | 1988 | Ann Thorac Surg1988，45，： | 1 |
| 13 | Mod Rheumatol 显示文摘 | Hirano T Ohguro N Hohki S et ab A case of Behcetg disease treated with a humanized anti-interleukin-6 receptor antibody toeilizumab | 2012 | 22(2) :298-3022012，22，2： | 1 |
| 14 | Vanadium haloperoxidases from brown algae of the Laminariaceae family显示文摘 | Almeida M Filipe S Humanes M Maia M F Melo R Severino N Da Silva J A L Da Silva J J R F Wever R | 2001 | Phytochemistry2001，57，： | 1 |
| 15 | ATP channelopathies:diseases of metabolichomeostasis显示文摘 | Olson TM Terzic A Human K | 2010 | Pflugers Arch2010，460，2： | 1 |
| 16 | Avian influenza A (H5N1) infection in humans 显示文摘 | The Writing Committee of the World Health Organization on Human influenza A/H5 | 2005 | N Engl J Med2005，353，13： | 1 |
| 17 | Tn-AT1,by cDNA microarray显示文摘 | KAWAMATA H FURIHATA T OMOTEHARA F Identification of genes differentially expressed in a newly isolated human metastasizing esophageal cancer cell line T | 2003 | Cancer Sci2003，94，8： | 1 |
| 18 | 1, 2 and 3 to the anti -HIV- 1,activity of CD8 antiviral factor显示文摘 | Zhang L Contribution of human a - defensi | 2002 | Science2002，298，： | 1 |
| 19 | Response to a bo- lus of conivaptan in patients with acute hyponatremia after brain injury 显示文摘 | Human T Onuoha A Diringer M | 2012 | J Crit Care2012，27，6： | 1 |
| 20 | Carcinogenesis显示文摘 | Michael P Waalkes Bhalchandra A Diwan Cadmium-induced inhibition of the growth and metastasis of human lung carcinoma xenografts:Role of apoptosi | 1999 | 20(1):65-701999，20，1： | 1 |
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