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| 1 | Characterization of the Formation of Branched Short-Chain Fatty Acid:CoAs for Bitter Acid Biosynthesis in Hop Glandular Trichomes显示文摘痛苦的酸,作为啤酒香料并且为他们的多样的生物活动为他们的使用知道,主要 formedin 跳跃(Humulus lupulus ) 腺的毛状体。分叉的短链的 acyl-CoAs (例如 isobutyryl-CoA, isovaleryl-CoA 和 2-methylbutyryl-CoA ) , derivedfrom 分支链氨基酸(BCAA ) 的降级,为痛苦的 acidsin 的生合成的必要积木跳跃。然而,很少关于部件被需要生产并且维持分叉的 short-chainacyl-CoAs 的水池在的被知道跳跃毛状体。这里,我们在场 CoA ligases 和 thioesterases 是在痛苦的酸生合成的 likelyinvolved 的证据的几根线。蛋白质有的 Recombinant HlCCL2 ( carboxyl CoA ligase )为象底层酸的 isovaleric 的高特定的活动( K 猫 /K m = 4100 s 1 M 1),而 recombinant HlCCL4 明确地利用了 isobutyric 酸( K 猫 /K m = 1800 s 1 M 1)并且 2-methylbutyric 酸( K 猫 /K m = 6900 s 1 M 1)作为底层。两 HlCCLs 跳跃 valerophenone synthase (HlVPS ) ,在腺的毛状体强烈被表示并且对细胞质局部性。有在酵母的 HlVPS 的 HlCCL2 和 HlCCL4 的合作表示导致了 acylphloroglucinols (为痛苦的酸生合成的直接先锋) 的重要生产, whichfurther 在 vivo 证实了这二 HlCCLs 的生物化学的功能。在线粒体催化 CCL 的反向的反应的 thioesterase 的功能的鉴定,和 thecomprehensive,基因的分析包含了 BCAA 分解代谢,支持了 cytosolic CoA ligases 在腺的毛状体为 linkingBCAA 降级和痛苦的酸生合成被要求的想法。进化和另外的可能的生理的 rolesof 分叉短链的丰满的酸: 在 planta 的 CoA ligases 也是 discussed.Key 词: | Haiyang Xu Fengxia Zhang Baoxiu Liu David V. Huhman Lloyd W. Sumner Richard A. Dixon Guodong Wang | 2013 | Molecular Plant2013，6，4： | 9 |
| 2 | Growth, structure and microhardness of epitaxial TiN/NbN superlattices显示文摘 | Shinn M Huhman L Barnett S A | 1992 | J Mater Res1992，7，4： | 1 |
| 3 | Metabolic profiling of Medicago tnmcatula cell cultures reveals the effects of biotic and abiotic elicitors on metabolism 显示文摘 | Broeckling C D Huhman D V Farag M A | 2004 | JExp Bot2004，56，410： | 1 |
| 4 | Diet, muscle glycogen, and physica performance 显示文摘 | Bergstrom J Hermansen L Huhman E | 1967 | Ac- taPhysiol Scand1967，，1： | 1 |
| 5 | Air embolism and the cause of death in blast injury 显示文摘 | Clemedson C J Huhman HI | 1954 | Milit Surg1954，114，6： | 1 |
| 6 | Strategies for improvement of sludge quality and process performance of sequencing batch reactor plant treating municipal and tannery wastewater 显示文摘 | Kabacinski M Huhman B Plaza E | 1998 | Wat Sci Tech1998，38，45： | 1 |
| 7 | Effects of deviating the thresponse in murine mercury induced autoimmunity towards a thresponse 显示文摘 | Haggqvist B Huhman P | 2003 | Clin Exp Im- munol2003，134，2： | 1 |
| 8 | Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula 显示文摘 | Naoumkina M A Modolo L V Huhman D V | 2010 | Plant Cell2010，22，3： | 1 |
| 9 | Efects of deviating the TH2-response in- murine mercury-induced autoimmunity towards a TH1 respons 显示文摘 | Haqqqvist B Huhman P | 2003 | Clin Exp Immuno2003，134，20： | 1 |
| 10 | A WD40 repeat protein from Medicago truncatula is necessary for tissue-specific anthocyanin and proanthocyanidin biosynthesis but not for trichome development 显示文摘 | Pang Y Wenger J P Saathoff K Peel G J Wen J Huhman D Allen S N Tang Y Cheng X Tadege M Ratct P Mysore K S Sumner L W Marks M D Dixon R A | 2009 | Plant Physiology2009，151，3： | 1 |
| 11 | Mercury induced antinuelear antibodies in mice:characterzation and correlation with renal immune coplex deposit' s显示文摘 | Huhman P Enestyom S | 1988 | Clin Lap Immunol1988，71，2： | 1 |
| 12 | Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for productionof the low-calorie sweetener and flavor enhancer NHDC 显示文摘 | Frydman A Weisshaus O Huhman D V | 2005 | Journal of Agricultural and Food Chemistry2005，53，： | 1 |
| 13 | Meta- bolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for pro- duction of the low-calorie sweetener and flavor enhan- cer NHDC显示文摘 | Frydman A Weisshaus O Huhman D V | 2005 | J Agric Food Chem2005，53，25： | 1 |
| 14 | Mechanical properties and machining performance of Ti1 -x AlxN-coated cutting tools 显示文摘 | Horling A Huhman L Od6n M | 2005 | Surface & Coatings Technology2005，191，23： | 1 |
| 15 | Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using HPLC coupled to an electrospray ion-trap mass spectrometer显示文摘 | Huhman DV Sumner LW | 2002 | Phytochem2002，59，3： | 1 |
| 16 | Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using HPLC coupled to an electrospray ion-trap mass spectrometer显示文摘 | HUHMAN D V SUMNER L W | 2002 | Phytochem2002，59，3： | 1 |
| 17 | Ge- nomics-based selection and functional characteriza- tion triterpene glycosyltransferases from the model legume Medicago truncatula 显示文摘 | Achnine L Huhman D V Farag M A | 2005 | The Plant Jour- nal2005，41，6： | 1 |
| 18 | Perinatal and neonayal risk factors for schizophrenia 显示文摘 | Huhman CM Ohman A Cnattingius S | 1997 | Br J Psychiatry1997，，170： | 1 |
| 19 | Perinatal risk factors for infantile autism显示文摘 | Huhman C M Sparen P Cnattingius S | 2002 | Epidemiology2002，13，4： | 1 |
| 20 | Growth and Characterization of MAX phase Thin Films显示文摘 | Hogberg H Huhman L Emmerlich J | 2005 | Surface & Coatings Technology2005，193，： | 1 |
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