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| 1 | Impact of hypoglycemic agents on myocardial ischemic preconditioning显示文摘Murry et al in 1986 discovered the intrinsic mechanism of profound protection called ischemic preconditioning. The complex cellular signaling cascades underlying this phenomenon remain controversial and are only partially understood. However, evidence suggests that adenosine, released during the initial ischemic insult, activates a variety of G protein-coupled agonists, such as opioids, bradykinin, and catecholamines, resulting in the activation of protein kinases, especially protein kinase C(PKC). This leads to the translocation of PKC from the cytoplasm to the sarcolemma, where it stimulates the opening of the ATP-sensitive K+ channel, which confers resistance to ischemia. It is known that a range of different hypoglycemic agents that activate the same signaling cascades at various cellular levels can interfere with protection from ischemic preconditioning. This review examines the effects of several hypoglycemic agents on myocardial ischemic preconditioning in animal studies and clinical trials. | Rosa Maria Rahmi Garcia Paulo Cury Rezende Whady Hueb | 2014 | World Journal of Diabetes2014，5，3： | 4 |
| 2 | Conservative strategy for treatment of stable coronary artery disease显示文摘Patients with coronary artery disease vary widely in terms of prognosis, which is mainly dependent on ventricular function. In relation to the major outcomes of death and myocardial infarction, it is not clear in the literature if an invasive strategy of myocardial revascularization is superior to a conservative strategy of optimized medical therapy. Moreover, with the exception of patients with left main coronary disease, this similarity in prognosis also occurs in different subgroups of patients. | Paulo Cury Rezende Thiago Luis Scudeler Leandro Menezes Alves da Costa Whady Hueb | 2015 | World Journal of Clinical Cases2015，3，2： | 3 |
| 3 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 4 | Impact of diabetes on 10 - year outcomes of patients with multivessel coronary artery disease in the Medicine, Angioplasty, or Surgery Study II (MA S S 11 ) trial 显示文摘 | Lima EG Hueb W Garcia RM | 2013 | Am Heart J2013，166，2： | 1 |
| 5 | A young worn an with granu lore atous mastitis: a corynebacte riam ay be invo lved in the pathogenesis of these disease显示文摘 | K ieffer P Dukic R Huebe rM | 2006 | Rev Med Interne2006，27，7： | 1 |
| 6 | Quality of life in patients with coronary artery disease:Comparison between the gcn - ders显示文摘 | Favarato ME Favarato D Hueb WA | 2006 | Rev Assoc Med Bras2006，52，4： | 1 |
| 7 | Coronary revaularization (surgical or percutaneous) decreases mortality after the first year in diabetic subjects but not in nondiabetic subjects with multivessel disease: an analysis from the Medicine, Angioplasty, or Surgery Study (MASS Ⅱ)显示文摘 | Soarers PR Hueb WA Lemos PA | 2006 | Circulation2006，114，1： | 1 |
| 8 | Long-term analysis of leftventricular ejection fraction in patients with stable multivesselcoronary disease undergoingmedicine, angioplasty or surgery: 10-yearfollow-up of the MASS II trial显示文摘 | Garzillo CL Hueb W Gersh BJ | 2013 | Euro Heart J2013，34，43： | 1 |
| 9 | Quality of life in patients with sympto- matic multierssel coronary artery disease: a comoarative post hoc analyses of medi-cal, angioplasty or surgical strategies- MASS II trial显示文摘 | Favarato ME Hueb W Boden WE | 2007 | Int J Cardiol2007，116，3： | 1 |
| 10 | The Medicine, Angioplasty, or Surgery Study (MASS-Ⅱ ): A randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease:One-year resuhs显示文摘 | Hueb W Soares PR Gersh BJ | 2004 | J Am Coil Cardiol2004，43，： | 1 |
| 11 | The medicine,angioplasty,or surgery study (MASS-Ⅱ):A randomized,controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease:one-year results显示文摘 | Hueb W Soares PR Gersh BJ | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 12 | Ventricular remodeling and mitral valve modifications in dilated cardiomyopathy:new insights from anatomic study显示文摘 | Hueb AC Jatene FB Moreira LF | 2002 | J Thorac Cardiovasc Surg2002，124，6： | 1 |
| 13 | Quality of life in patients with coronary artery disease: comparison between the genders显示文摘 | Favarato ME Favarato D Hueb WA | 2006 | Rev Assoc Med Bras2006，52，4： | 1 |
| 14 | Mobilization of arsenic and iron from Red River floodplain sediments, Vietnam显示文摘 | Postma D Jessena S Hueb N T M | 2010 | Geochimica et CosmochimicaActa2010，74，12： | 1 |
| 15 | Effect of complete revaseularization on 10 - year survial of patients with stable multivessel coronary artery dis- ease : MASS II trial 显示文摘 | Vieria R D Hueb W Gersh B J | 2012 | Circulation2012，126，11： | 1 |
| 16 | Five-year follow-up of the Medicine,Angioplasty,or Surgery Study (MASS Ⅱ):a randomized controlled clinical trial of 3 therapeutic strategies for multivessel coronary artery disease显示文摘 | Hueb W Lopes NH Gersh BJ | 2007 | Circulation2007，115，9： | 1 |
| 17 | Impact of diabetes on lO-year outcomes of patients with muhivessel coronary artery disease in the Medicine, Angioplasty, or Surgery Study II (MASS II) trial显示文摘 | Lima EG Hueb W Garcia RM | 2013 | Am Heart J2013，166，2： | 1 |
| 18 | Quality of life in patients with symptomatic muhivessel coronary artery disease: a comparative post hoe analyses of medical, angioplasty or surgical strategies--MASS Ⅱ trial 显示文摘 | Favarato ME Hueb W Boden WE | 2007 | 116 (3): 364--3702007，116，3： | 1 |
| 19 | Effect of complete re- vascularization on 10-year survival of patients with stable multivessel coronary artery disease: MASS Ⅱ trial 显示文摘 | Vieira RD Hueb W Gersh BJ | 2012 | Circulation2012，126，1： | 1 |
| 20 | Two-Dimensional Simulation of Two Viscous Debris Flows in Austria显示文摘 | Hueb J Steinwendtner H | 2001 | Phys Chem Earth (C)2001，26，9： | 1 |
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