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	题名	作者	年代	出处	被引量
1	Molecular architecture of mouse and human pancreatic zymogen granules: protein components and their copy numbers显示文摘A molecular model of pancreatic zymogen granule (ZG) is critical for understanding its functions. We haveextensively characterized the composition and membrane topology of rat ZG proteins. In this study, wereport the development of targeted proteomics approaches to quantify representative mouse and humanZG proteins using LC-SRM and heavy isotope-labeled synthetic peptides. The absolute quantities of mouseRab3D and VAMP8 were determined as 1242 ± 218 and 2039±151 (mean ± SEM) copies per ZG. Thesize distribution and the averaged diameter of ZGs 750 ±23 nm (mean ± SEM) were determined byatomic force microscopy. The absolute quantification of Rab3 D was then validated using semi-quantitativeWestern blotting with purified GST-Rab3D proteins as an internal standard. To extend our proteomicsanalysis to human pancreas, ZGs were purified using human acini obtained from pancreatic islet trans-plantation center. One hundred and eighty human ZG proteins were identified for the first time includingboth the membrane and the content proteins. Furthermore, the copy number per ZG of human Rab3 D andVAMP8 were determined to be 1182 ± 45 and 485 ± 15 (mean ± SEM). The comprehensive proteomicanalyses of mouse and human pancreatic ZGs have the potential to identify species-specific ZG proteins.The determination of protein copy numbers on pancreatic ZGs represents a significant advance towardsbuilding a quantitative molecular model of a prototypical secretory vesicle using targeted proteomicsapproaches. The identification of human ZG proteins lays a foundation for subsequent studies of altered ZGcompositions and secretion in pancreatic diseases.	Jin-sook Lee Joseph A. Caruso Garrett Hubbs Patricia Schnepp Jlames Woods Jingye Fang Chunying Li Kezhong ghang Paul M. Stemmer Bhanu P. Jena Xuequn Chen	2018	Biophysics Reports2018，4，2：	2
2	KIT mutation portends poor prognosis in gastrointestinal stromal/smooth muscle tumors显示文摘	Ernst S I Hubbs A E Przygodzki R M	1998	Lab Invest1998，78，12：	1
3	Error analysis in cranial neuronavigation显示文摘	Spetzger U Hubbe U Struffert T	2002	Minim Invasive Neurosurg2002，45，1：	1
4	Heat stable antigen ( mouse CD24) supports myeloid cell binding to endothelial and platelet Pselectin 显示文摘	Aigner S Ruppert M Hubbe M	1995	Int Immunol1995，7，10：	1
5	Timing of local and distantfailure in resected lung cancer: implications for reported rates of localfaiiure显示文摘	Boyd JA Hubbs JL Kim DW		J Thorac Oncol0，5，2：	1
6	Control of tacky deposits on paper machines-A review 显示文摘	Hubbe M A Rojas O J Venditti R A	2006	Nordic Pulp & Paper Research Journal2006，21，2：	1
7	Promotion of experiment liver metastasis by tumor necrosis factor显示文摘	OROSZ P KRUGER A HUBBE M	1995	Int J Cancer1995，60，6：	1
8	Limit of detec- tion(LOD) limit of quantitation (LOQ): comparison of the empirical and the statistical methods exemplified with GC MS assays of abused drug显示文摘	ARMBRUSTER D TILLMAN M HUBBS L	1994	Clinical Chemistry1994，40，7：	1
9	Factors associated with the develop- ment of brain metastases : analysis of 975 patients with early stage nons- mall cell lung cancer显示文摘	Hubbs JL Boyd JA Hollis D	2010	Cancer2010，116，21：	1
10	Timing of local and distant failure in reseeted lung cancer:implications for re- ported rates of local failure显示文摘	Boyd JA Hubbs JL Kim DW	2010	J Thorac Oncol2010，5，2：	1
11	Retention aid polymer inter-actions with cellulosic surfaces and suspensions: a review显示文摘	Hubbe M A Nanko H Mc Neal M R	2009	BioResources2009，4，2：	1
12	Progression of lung In- flammation and damage in rats after cessation of silica inhalation 显示文摘	Porter D W Hubbs A F Mercer R	2004	Toxicol Sci2004，79，2：	1
13	Isolation and identification of six mansonones from Ulmus americana infected with Ceratocystis ulmi 显示文摘	Dumas M T Strunz G M Hubbes M	1983	Experientia1983，39，10：	1
14	Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosis显示文摘	Zeidler P Hubbs A BatteUi L	2004	Toxieol Environ Health A2004，67，13：	1
15	Waterborne outbreaks of cryptosporidiosis显示文摘	Craun GF Hubbs SA Frost F	1998	JAWWA1998，90，9：	1
16	Mansonone E and F accumulation in Ulmus pumila resistant to Dutch elm disease 显示文摘	Duchesne L C Hubbes M Jeng R S	1986	Canadian J Forest Res1986，16，2：	1
17	Accumulation of mansonones E and F in elm callus cultures inoculated with Ophiostoma ulmi 显示文摘	Duchesne L C Jeng R S Hubbes M	1994	Canadian J Plant Pathol1994，16，2：	1
18	Water and papermaking 2:whitewater components显示文摘	Hubbe M A	2007	Paper Technology2007，，2：	1
19	The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement 显示文摘	Schlaier A Hubbe U Ziyeh S	2000	AJNR Am J Neuroradiol2000，21，6：	1
20	Control of Tacky Deposits on Paper Machines--A Review 显示文摘	Hubbe M A Rojas O J Venditti R A	2006	Nordic Pulp and Paper Research Journal2006，21，2：	1

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