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| 1 | Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology显示文摘AIM: To evaluate ATP-binding cassette(ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer(CRC) development. METHODS: Literature search was conducted on Pub Med using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohns disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein(P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2(MRP2) and ABCG2/breast cancer resistance protein(BCRP), Abcb1/Mdr1 a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function. RESULTS: Recently, human studies reported thatchanges in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The finding that colitis was preceded by altered gut bacterial composition suggests that deletion of Abcb1 leads to fundamental changes of hostmicrobiota interaction. Also, high fat diet increases the frequency and severity of colitis in specific pathogenfree Abcb1 KO mice. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Potential molecular mechanisms include defective transport of inflammatory mediators and/or phospholipid translocation from one side to the other of the cell membrane lipid bilayer by ABC transporters affecting inflammatory response and/or function of tight junctions, phagocytosis and vesicle trafficking. Also, diet and microbes give rise to molecules which are potential substrates for the ABC transporters and which may additionally affect ABC transporter function through nuclear receptors and transcriptional regulation. Another critical role of ABCB1 was suggested by the finding that ABCB1 expression identifies a subpopulation of pro-inflammatory Th17 cells which were resistant to treatment with glucocorticoids. The evidence for the involvement of ABCC2 and ABCG2 in colonic pathophysiology was weak. CONCLUSION: ABCB1, diet, and gut microbes mutually interact in colonic inflammation, a well-known risk factor for CRC. Further insight may be translated into preventive and treatment strategies. | Vibeke Andersen Katrine Svenningsen Lina Almind Knudsen Axel Kornerup Hansen Uffe Holmskov Allan Stensballe Ulla Vogel | 2015 | World Journal of Gastroenterology2015，21，41： | 10 |
| 2 | Collectins and collectin receptors in innate immunity 显示文摘 | Holmskov U L | 2000 | APMIS Supplementum2000，100，： | 1 |
| 3 | Surfactant protein A and surfaetant protein D variation in pulmonary disease显示文摘 | Sorensen G L Husby S Holmskov U | 2007 | Immunobi- ology2007，212，45： | 1 |
| 4 | The Concentration of the Ctype lectin,mannose-binding protein,in human plasma increases during an acute phase response显示文摘 | Holmskov U Hviid L | 1992 | Clin Exp Immunol1992，90，1： | 1 |
| 5 | Collections and ficolins: humoral lectins of the innate imrrmne defense显示文摘 | Holmskov U Thiel S Jensenius J C | 2003 | Annu Rev Immunol2003，21，： | 1 |
| 6 | Collectins: col- lagenous C -type lectins of the innate immune defense system显示文摘 | HOLMSKOV U MALHOTRA R SIM R B | 1994 | Immunol Today1994，15，2： | 1 |
| 7 | DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer显示文摘 | Mollenhauer J Herbertz S Holmskov U | 2000 | Cancer Res2000，60，： | 1 |
| 8 | The conserved scavenger receptor cysteine-rich supeffamily in therapy and diag- nosis显示文摘 | Martinez VG Moestrup SK Holmskov U | 2011 | Pharmacol Rev2011，63，4： | 1 |
| 9 | Interaction of calreticulin with CO40 ligand, TRAIL and Fas ligand显示文摘 | Duus K Pagh RT Holmskov U | 2007 | Scand J Immunol2007，66，5： | 1 |
| 10 | Collectins:collagenous C-type lectins of the innate immune defense system显示文摘 | Malhotra R Sim RB | 1994 | Immunol Today1994，15，2： | 1 |
| 11 | Collections and ficolins: humoral lectins of the innate immune defense 显示文摘 | Holmskov U Thiel S Jensenius JC | 2003 | Annu Rev Immunol2003，21，1： | 1 |
| 12 | DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer显示文摘 | MOLLENHAUERJ HERBETZ S HOLMSKOV U | 2000 | Cancer Res2000，60，： | 1 |
| 13 | Collections and ficolins: humoral lectins of the innate immune defense 显示文摘 | Holmskov U Thiel S Jensenius JC | 2003 | Annu Rev Immunol2003，21，： | 1 |
| 14 | Collections and ficolins:humoral lectins of the innate immune defense显示文摘 | Holmskov U Thiel S Jensenius JC | 2003 | Annu Rev Immunol2003，21，： | 1 |
| 15 | The concentration of the Ctype lectin,mannan-binding protein,in human plasma increases during an acute phase response显示文摘 | Thiel S Holmskov U Hviid L | 1992 | Clin Exp Immunol1992，90，： | 1 |
| 16 | Surfactant protein A and surfactant protein D variation in pulmonary disease 显示文摘 | Sorensen GL Husby S Holmskov U | 2007 | Immunobiology2007，212，45： | 1 |
| 17 | Collections and ficolins:humoral lectins of the innate immune defense显示文摘 | Holmskov U Thiel S Jensenius JC | 2003 | Annu Rev Immunol2003，21，： | 1 |
| 18 | The homologue of mannose-binding leetin in the carp family Cyprinidae is expressed at high level in spleen, and the deduced primary structure predicts affinity for galactose 显示文摘 | Vitved L Holmskov U Koch C | 2000 | Immunogenetics2000，51，： | 1 |
| 19 | Surfactant protein Aand surfactant protein D variation in pulmonary disease显示文摘 | Sorensen GL Husby S Holmskov U | 2007 | Immunobiology2007，212，45： | 1 |
| 20 | Collectins:collagenous C-type lectins of the innate immune defense system显示文摘 | Holmskov U Malhotra R Sim R B | 1994 | Immunol Today1994，，15： | 1 |
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