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| 1 | 大同盆地砷中毒病区沉积物中砷的吸附行为和影响因素分析显示文摘沉积物对砷的吸附-解吸作用是控制砷在地下水中的迁移和转化的决定性因素。对砷中毒重病区大同盆地山胡县沉积物中砷的吸附行为和影响因素研究结果表明,沉积物对砷的吸附符合Freundlich吸附等温模式,吸附量主要与沉积物颗粒大小、黏土矿物质量分数和类型、铁铝氧化物质量分数以及沉积物中As的质量分数有关,有机质质量分数对砷的吸附量影响需进一步深入研究。铝硅酸盐、铁铝氧化物质量分数较高且颗粒较细的黏土和亚黏土类沉积物对砷的吸附性较强;而铝硅酸盐、铁铝氧化物质量分数较低且颗粒较粗的细砂和粉砂类沉积物对砷的吸附性较差,其所处的含水层也是形成高砷地下水的主要含水层。pH值为5.5~8.0时,砷的吸附量最大。大同盆地高砷地下水pH条件非常不利于沉积物中砷的吸附,易形成高砷地下水。该区地下水10℃左右的温度条件非常有利于沉积物对砷的吸附,但由于影响因素较多,且地下水的温度在不同季节会发生一定的变化,其产生的影响还有待进一步研究。 | 苏春利 Win hlaing 王焰新 徐芬 张随成 | 2009 | 地质科技情报2009，28，3： | 17 |
| 2 | Future prospectives for the management of chronic hepatitis B显示文摘Chronic hepatitis B virus infection affects about 400 million people around the globe and causes approximately one million deaths a year. Since the discovery of interferon-α as a therapeutic option the treatment of hepatitis B has evolved fast and management has become increasingly complicated. The amount of viral replication reflected in the viral load (HBV-DNA) plays an important role in the development of cirrhosis and hepatocellular carcinoma. The current treatment modalities for chronic hepatitis B are immunomodulatory (interferons) and antiviral suppressants (nucleoside and nucleotide analogues) all with their own advantages and limitations. An overview of the treatment efficacy for both immunomodulatory as antiviral compounds is provided in order to provide the clinician insight into the factors influencing treatment outcome. With nucleoside or nucleotide analogues suppression of viral replication by 5-7 log10 is feasible, but not all patients respond to therapy. Known factors influencing treatment outcome are viral load, ALT levels and compliance. Many other factors which might influence treatment are scarcely investigated. Identifying the factors associated with response might result in stopping rules, so treatment could be adapted in an early stage to provide adequate treatment and avoid the development of resistance. The efficacy of compounds for the treatment of mutant virus and the cross- resistance is largely unknown. However, genotypic and phenotypic testing as well as small clinical trials provided some data on efficacy in this population. Discontinuation of nucleoside or nucleotide analogues frequently results in viral relapse; however, some patients have a sustained response. Data on the risk factors for relapse are necessary in order to determine when treatment can be discontinued safely. In conclusion: chronic hepatitis B has become a treatable disease; however, much research is needed to tailor therapy to an individual patient, to predict the sustainability of response and determine thebest treatment for those failing treatment. | WF Leemans HLA Janssen RA de Man | 2007 | World Journal of Gastroenterology2007，13，18： | 14 |
| 3 | Thermodynamic analysis of mixed and dry reforming of methane for solar thermal applications显示文摘Thermodynamic analysis of the reforming of methane with carbon dioxide alone ('dry reforming') and with carbon dioxide and steam together ('mixed reforming') is performed as part of a project which investigates the suitability of these endothermic reactions for the storage of solar thermal energy. The Gibbs free energy minimization method was employed to identify thermodynamically optimal operating conditions for dry reforming as well as mixed reforming with a desired H2/CO molar ratio of 2. The non-stoichiometric equilibrium model was developed using FactSage software to conduct the thermodynamic calculations for carbon formation, H2/CO ratio, CH4 conversion and H2 yield as a function of reaction temperature, pressure and reactant molar ratios. Thermodynamic calculations demonstrate that in the mixed reforming process, optimal operating conditions in a carbon-free zone are under H2O/CH4 /CO2 =1.0/1.0/0.5, p = 1 to 10 bar and T = 800 to 850℃ for the production of syngas with a H2 /CO molar ratio of 2. Under the optimal conditions, the maximum H2 yield of 88.0% is achieved at 1 bar and 850℃ with a maximum CH4 conversion of 99.3%. In the dry reforming process, a carbon formation regime is always present at a CO2/CH4 molar ratio of 1 for T = 700 1000℃ and p = 1-30 bar, whereas a carbon-free regime can be obtained at a CO2/CH4 molar ratio greater than 1.5 and T≥800℃. | Y. Sun T. Ritchie S. S. Hla S. McEvoy W. Stein J. H. Edwards | 2011 | Journal of Natural Gas Chemistry2011，20，6： | 4 |
| 4 | HLA分型实验室的室内质量控制显示文摘目的建立标准化HLA分型实验室对提高HLA分型检测质量和实验室能力的全面提升,满足临床移植配型需求,对接国际HLA实验室质量标准开展国际合作,具有无可替代的作用。方法依据ISO15189、欧洲免疫遗传联合会组织相容性和免疫遗传检测认证标准以及美国组织相容性和免疫遗传联合会的实验室认证标准,探索建立HLA分型实验室的室内质控方法。结果通过建立HLA分型实验室的室内质控方法,有效提高了实验室检测工作的标准化。结论 HLA分型实验室标准化建设,有力促进了实验室检测水平、管理水平、工作人员能力的提高。 | 于卫建 安万新 梁晓华 周世航 中国输血协会血站管理委员会HLA学组 | 2015 | 中国输血杂志2015，28，11： | 2 |
| 5 | 缅甸掸邦地块二叠纪-三叠纪灰岩的岩石磁学初步研究结果显示文摘对缅甸东部掸邦地块二叠纪-三叠纪灰岩样品进行了饱和等温剩磁获得曲线及反向场退磁曲线、三轴等温剩磁的系统热退磁、磁化率-温度曲线等岩石磁学测试分析,试图通过岩石磁学方法识别缅甸掸邦地块二叠纪和三叠纪灰岩样品中的磁性矿物种类、含量等信息,为研究样品中主要磁性矿物所携带的特征剩磁分量的磁化年龄等性质提高可靠的基础,从而为进一步研究掸邦地块及滇缅泰地块晚古生代-早中生代的古地理位置等提供有力的证据.结果表明缅甸掸邦地块二叠纪和三叠纪灰岩样品中的主要磁性矿物为磁铁矿,或磁铁矿和针铁矿的组合,少部分三叠纪灰岩样品显示有赤铁矿、磁赤铁矿和针铁矿的组合. | 柏千惠 闫永刚 黄宝春 赵杰 Zaw Win Hla Hla Aung | 2015 | 地球物理学进展2015，30，3： | 2 |
| 6 | Hepatitis C virus therapy with peg-interferon and ribavirin in Myanmar: A resource-constrained country显示文摘AIM To investigate peg-interferon(peg-IFN) and ribavirin(RBV) therapy in Myanmar and to predict sustained virologic response(SVR).METHODS This single-center, open-label, study was conducted in Myanmar between 2009 and 2014. A total of 288 patients infected with HCV genotypes 1, 2, 3 and 6 were treated with peg-IFN alpha-2a(180 μg/wk) or alpha-2b(50 to 100 μg as a weight-based dose) and RBV as a weight-based dose(15 mg/kg/d). Treatment duration was 48 wk for genotypes 1 and 6, 24 wk for genotype 2, and 24 or 48 wk for genotype 3 based on rapid virologic response(RVR). Those co-infected with hepatitis B received 48 wk of therapy.RESULTS Overall, SVR was achieved for 82% of patients and the therapy was well tolerated. All patients achieved SVR at equivalent rates regardless of HCV genotype(P = 0.314). Low fibrosis scores(P < 0.001), high baseline albumin levels(P = 0.028) and low baseline viral loads(P = 0.029) all independently predicted SVR. On the other hand, IL-28 B TT and CC genotypes were not found to significantly predict SVR(P = 0.634; P = 0.618). Among those who completed treatment, the occurrence of RVR showed a > 96% positive predictive value for achieving SVR. Treatment duration did not significantly impact the likelihood of achieving SVR for patients infected with genotype 3 HCV(P = 0.371). The most common adverse events were fatigue(71%) and poor appetite(60%). Among patients with genotype 3 HCV, more patients in the 48-wk treatment group required erythropoietin than in the 24-wk treatment group(61.1% vs 49.2%).CONCLUSION SVR rates were high with peg-IFN and RBV therapy in Myanmar. Fibrosis scores, baseline albumin, HCV RNA levels and RVR independently predicted SVR. | Naomi Khaing Than Hlaing Debolina Banerjee Robert Mitrani Soe Htet Arker Kyaw San Win Nyan Lin Tun Zaw Thant Khin Maung Win K Rajender Reddy | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 7 | HLA抗体检测中重点问题的专家共识显示文摘从2003年起,洛杉矶Terasaki基金会实验室最早将纯化抗原法检测HLA抗体的技术大规模应用于器官移植,并逐渐推广到人类白细胞抗原(HLA)不合异基因造血干细胞移植、和血小板输注等临床应用领域[1,2]。近20年来的临床研究进一步确认了HLA抗体是引起抗体介导排斥反应(AMR)的主要病因之一[3,4]。该类检测技术自2010年前后逐渐在我国推广应用,最近几年在我国大多数移植中心和血液中心得到了普及。但是,随着该类技术在国内的广泛应用,各实验中心发现,在检测方法的选择、试剂的质量确认、实验操作方法和结果判读等方面,还存在很多疑惑和亟需解决的问题。 | 中国输血协会HLA专委会 中国医药生物技术协会移植技术分会 蔡俊超 戴红霞 赵晨红 张胜南 张雷 朱兰 郑瑾 沈捷 叶欣 何军 朱冬 | 2022 | 中华器官移植杂志2022，43，3： | 2 |
| 8 | Gene regulation by RNA binding proteins and microRNAs in angiogenesis显示文摘 | Sung-Hee Chang Timothy Hla | 2011 | Trends in Molecular Medicine2011，，11： | 2 |
| 9 | 玉郎伞多糖对抗结核药诱导肝细胞损伤的保护作用显示文摘目的研究玉郎伞多糖(YLSPS)对抗结核药诱导的肝细胞损伤的保护作用。方法将不同浓度的利福平、异烟肼及吡嗪酰胺合用(RFP+INH+PZA)作用于人张氏肝细胞,用MTT法检测肝细胞的存活率,以80%~85%存活率的药物浓度为最佳浓度建立肝细胞损伤模型;给予YLSPS处理后,检测细胞培养上清液中丙氨酸氨基转移酶(ALT)、天门冬氨酸转移酶(AST)和乳酸脱氢酶(LDH)和细胞内丙二醛(MDA)和超氧化物歧化酶(SOD)的浓度。结果与模型组比较,YLSPS各剂量可明显降低肝细胞培养上清液中的AST、ALT、LDH水平及肝细胞中MDA的含量,升高SOD的水平,且呈剂量依赖性。结论YLSPS对RFP+INH+PZA合用诱导张氏肝细胞损伤具有保护作用,其机制可能与抗氧化和清除自由基的作用有关。 | SHWE HLA 黄仁彬 何巧玲 汤小军 黄建春 | 2015 | 华西药学杂志2015，30，3： | 2 |
| 10 | Bleb needling outcomes for failed trabeculectomy blebs in Asian eyes: a 2-year follow up显示文摘·AIM: To describe the outcomes of bleb needling in primary glaucoma in an Asian tertiary eye centre over a2 y period. To compare the success rates between primary angle-closure glaucoma(PACG) and primary open angle glaucoma(POAG). Lastly, to identify factors associated with success of bleb needling.·METHODS: This was a retrospective review of 227 patients who underwent bleb needling between June2009 and June 2011 in Singapore National Eye Centre.The 5-fluorouracil(5-FU) augmented bleb needling was performed either at the slit lamp or in the operating theatre. Repeat bleb needlings were performed as necessary. Complete success was defined as maintenance of intraocular pressure(IOP) ≥6 mm Hg and ≤21 mm Hg, in the absence of further surgery or use of antiglaucoma medication. Qualified success met the above criteria with or without use of antiglaucoma medications.· RESULTS: One hundred and seventy-five eyes completed the two-year follow up. Sixty-nine percent of participants had POAG and 31% had PACG. The mean interval between filtering surgery and bleb needling was299.9 ±616.4d for POAG and 167.1 ±272.2d for PACG.Mean needling attempts were 1.9±1.4 and 2±1.6 for POAG and PACG respectively. In general, there was a statistically significant reduction of IOP ranging from21.9% to 26.8% from month 1 through to month 24. The complete success rates at month 6 were 70.0% for POAG and 65.7% for PACG. At month 12, this decreased to62.2% for POAG and PACG and at month 24, 57.9% for POAG and 63.0% for PACG respectively. The qualified success rates at month 6 for POAG and PACG were23.8% and 29.9% respectively, 32.2% and 29.2% at month12, and 34.7% and 29.6% at month 24. The success ratesbetween POAG and PACG were not significantly different(P >0.05 for complete and qualified success at months 6,12 and 24). An increased number of needlings and higher pre-needling IOP were associated with failure.·CONCLUSION: The 5-FU augmented bleb needling within one year of trabeculectomy in Asian eyes can provide clinically significant IOP lowering of more than20% for 2y. POAG and PACG had similar complete success rates(58% and 63% respectively). Factors associated with greater risk of procedure failure included increased number of needlings and higher pre-needling IOP. Asian eyes have a greater propensity for scarring but bleb needling, if performed in a timely manner can rescue bleb function. | Andrew S.H.Tsai Pui Yi Boey Hla M Htoon Tina T Wong | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 2 |
| 11 | Orthogonal polarization spectral imaging of the microcirculation during acute hypervolemic hemodilution and epidural lidocaine injection显示文摘 | Van den Oever HLA Dzoljic M Inee C | 2006 | Anesth Analg2006，103，2： | 1 |
| 12 | Orthogonal polarization spectral imaging of the microcirculation during acute hypervolemic hemodilution and epidural lidocaine injection显示文摘 | Van den Oever HLA Dzoljic M Ince C | 2006 | Anesth Analg2006，2，： | 1 |
| 13 | Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition显示文摘 | Simmons DL Botting RM Hla T | 2004 | Pharmacol Rev2004，56，3： | 1 |
| 14 | Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(1) , G(q) , and G(12) families of heterotrimeric G pro- teins显示文摘 | Windh RT Lee M J Hla T | 1999 | J Biol Chem1999，274，27： | 1 |
| 15 | Lysophospholipids-receptor revelations 显示文摘 | Hla T Lee M J Ancellin N | 2001 | Science2001，294，： | 1 |
| 16 | Inhibitory role of sphingosine l- phosphate receptor 2 in macrophage recruitment during inflammation 显示文摘 | Michaud J Im DS Hla T | 2010 | J Immunol2010，184，： | 1 |
| 17 | Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition 显示文摘 | Simmons DL Botting RM Hla T | 2004 | Pharmacol Rev2004，56，3： | 1 |
| 18 | A study on a multi-stage hybrid gasifier-engine system 显示文摘 | Bhattacharya S C San Shwe Hla and Pham H-L | 2001 | Bio- mass & Bioenergy2001，21，： | 1 |
| 19 | FTY720:sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function显示文摘 | Bripkmann V Cyster JG Hla T | 2004 | Am J Transplant2004，4，7： | 1 |
| 20 | Cyclooxygenase-1 and-2 isoenzymes 显示文摘 | Hla T Bishop-Bailey D Liu CH | 1999 | Int J Biochem Cell Biol1999，31，5： | 1 |
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