|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of prolonged cryptorchidism on germ cell apoptosisand testicular sperm count显示文摘Aim:To evaluate the long term effect of experimental cryptorchidism on germ cell apoptotic rate and testicular sperm content in adult rats.Methods:Bilateral cryptorchidism was created in 40 adult male Sprague-Dawley rats by surgically manipulating the testes into the abdominal cavity and closing the internal inguinal ring.The rats were sacrificed and the testes removed 6 hours and 2,4,7,21,28 and 56 days after cryptorchidism.Germ cell apoptosis was quantified by means of TUNEL assay and apoptosis was confirmed using transmission electron microscopy.Results:The rate of apoptosis peaked at 4 days of cryptorchidism and then progressively declined to a nadir at 14 days of cryptorchidism.At 56 days of cryptorchidism,the germinal epithelium was largely depleted by the apoptotic process and only a few mature sperm were seen within the testis.At this point,a few tubules were seen to be repopulating with primary spermatocytes and the level of germ cell apoptosis began to increase marginally.Testicular sperm count (TSC) began to decline rapidly at day 7 of cryptorchidism.Only a few mature sperm were found in the testes of rats following 56 days of cryptorchidism.Multinucleated giant cells (MGC) were most numerous within the seminiferous tubules at day 4.At day 7,35% of MGCs were TUNEL positive.At all subsequent time points,however,MGCs fail to stain positive for apoptosis.This resumption of increased apoptosis coincided with the appearance of a population of primary spermatocytes in some seminiferous tubules.Moreover,there was not a corresponding increase in the number of mature sperm after 56 days of cryptorchidism.Conclusion:The decline in germ cell apoptosis after 4 days of cryptorchidism can be attributed to be the result of an overall depletion of germ cells.It appears that after a prolonged cryptorchidism (56 days),there is a limited resumption of spermatogenesis presumably as a result of a decrease in the maturing germ cells undergoing programmed cell death.(Asian JAndrol2004 Mar;6:47-51) | Albaha Barqawi Herald Trummer Randall Meacham | 2004 | Asian Journal of Andrology2004，6，1： | 7 |
| 2 | Pulmonary alveolar microlithiasis: an interesting case report with systematic review of Indian literature显示文摘肺的牙槽的 microlithiasis 是 microliths 的 intra 牙槽的存在描绘的稀罕疾病。这研究报导肺的牙槽的 microlithiasis 的一个有趣的案例并且提供从印度报导的案例的系统的评论。与咳嗽,喘息,胸疼痛,和阵发性的喘息的历史介绍五个月的 23 岁的女性。肺的功能测试表明了一个妨碍的模式,并且胸 X 射线显示出主要包含两个肺的中间、更低的地区的好 micronodular 暗。Transbronchial 肺活体检视揭示了诊断。她对吸入的类固醇治疗作出回应很好。文学的系统的评论被执行并且鉴别肺的牙槽的 microlithiasis 的 73 个案例从印度报导了。病人的平均数(SD ) 年龄是 28.8 (14.9 ) 年,与几乎相等的 male:female 比率。许多病人在表示是无征状的。呼吸急促和咳嗽是最普通的症状,并且疾病进行了进与英国管 pulmonale 联系的呼吸失败。大约三分之一个个案例开始被误诊并且对待同样肺的肺结核。额外肺的表明和 comorbidities 在我们的系列也是明显的。这系统的评论帮助决定肺的牙槽的 microlithiasis 的流行病学、临床的特征。进一步的研究被需要阐明 etiopathogenesis,诊断,和治疗学的选择,它在为肺的牙槽的 microlithiasis 开发并且识别 costeffective 治疗是有益的。 | Nidhya Ganesan Marie Moses Ambroise Anita Ramdas King Herald Kisku Kulwant Singh Renu G' Boy Varghese | 2015 | Frontiers of Medicine2015，9，2： | 2 |
| 3 | Halichondrin B andhomohalichondrin B, marine natural products binding in the vincadomain of tubulin 显示文摘 | BAI R L PAULL K D HERALD C L | 1991 | J Biol Chem1991，266，15： | 1 |
| 4 | Rituximab added to first - line mitoxantrone, chlorambucil, and prednisolone chemotherapy followed by interferon maintenance prolongs survival in patients with advanced follicular lymphoma:an East German Study Group Hematology and Oncology Study显示文摘 | Herald M Haas A Stuck S | 2007 | J Clio Oncol2007，25，15： | 1 |
| 5 | Rheological study of xanthan and locust bean gum interaction in dilute solution: Effect of salt 显示文摘 | Higiro J Herald T J Alavi S Bean S | 2007 | Food Research International2007，40，： | 1 |
| 6 | Rheological character- ization of rice flour-based batters显示文摘 | Mukprasir A Herald T J Flores R A | 2000 | Journal of Food Science2000，65，7： | 1 |
| 7 | Isolation of dolastatins 10-15 from the marine molluscdolabella auricularia显示文摘 | Pettit G R Kamano Y Herald C L | 1993 | Tetrahedron1993，49，41： | 1 |
| 8 | Genetics, pathogenesis and clinical interventions in type 1 diabetes 显示文摘 | Bluestone JA Herald K Eisenbarth G | 2010 | Nature2010，464，7293： | 1 |
| 9 | E- valuation of mechanical and barrier properties of protein coatings on shell eggs 显示文摘 | WONG Y C HERALD T ] HACHMEISTER K A | 1996 | Poultry Science1996，75，3： | 1 |
| 10 | Evaluation of mechanical and barrier properties of protein coatings on shell eggs显示文摘 | Wong Y C Herald T J Hachmeister K A | 1996 | Poultry Science1996，75，3： | 1 |
| 11 | The dolastatins ; 17 : Synthesis of dolaproine and related diastereoisomers 显示文摘 | Pettit G R Singh S B Herald D L | 1994 | J Org Chem1994，59，21： | 1 |
| 12 | The isolation and structure ofa remarkable marine animal antineoplastic constituent: dolastatin 10显示文摘 | Pettit GR Kamano Y Herald CL | 1987 | J Am Chem Soc1987，109，22： | 1 |
| 13 | 显示文摘 | Herald T J Gnanasambandam R Mcguire B H | 1995 | J Food Sci1995，60，： | 1 |
| 14 | Physicochemical and microbiological properties of selected rice flour-based bat ters for fried chicken drumsticks显示文摘 | Mukprasirt A Herald T J Boyle D L | 2001 | Poultry Science2001，80，7： | 1 |
| 15 | Degwadable wheat gluten films: preparation, properties and applications显示文摘 | Herald T J Gnanasambandam R McGuire BH | 1995 | Journal of Food Science1995，60，5： | 1 |
| 16 | Isolation and structure of bryostatin I 显示文摘 | Herald C L Doubek D L | 1982 | J Am Chem Soc1982，104，： | 1 |
| 17 | The isolation and struc- ture of dolatriol 显示文摘 | Pettit G R Ode R H Herald L | 1976 | J Am Chem Soe1976，98，15： | 1 |
| 18 | Characterization of β-conglycinin and glycinin soy protein fractions from four selected soybean genotypes显示文摘 | Riblett A L Herald T J Schmidt K A | 2001 | Agric Food Chem2001，49，： | 1 |
| 19 | Applied Technology Workshop-Progressing Cavity Pumping Systems显示文摘 | James F L Herald WW | 2002 | SPE2002，，4： | 1 |
| 20 | What's new in art ificial lift显示文摘 | James F Lea Herald W W inker Robert E Snyder | 1999 | World Oil1999，220，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员