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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | A very long-chain acyl- coa synthetase--deficient mouse and its relevane to X-linked adrenolenkodystrophy显示文摘 | Heinzer Ak Watkins PA Jyh-Feng L et ai | 2003 | Hum Mol Genet2003，12，10： | 1 |
| 3 | Very long-chain acyl-Co A synthetases:human“bubblegum”represents a new family of proteins capable of activating very longchain fatty acids显示文摘 | STEINBERG S J MORGENTHALER J HEINZER A K | 2000 | Biological Chemistry2000，275，35： | 1 |
| 4 | A comparison of systemic versus inhaled recombinant IL-2 administration for the treatment of metastatic ren al cell carcinoma显示文摘 | Heinzer H Huland H | 2000 | Folia Biol (Krakow)2000，46，6： | 1 |
| 5 | Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study显示文摘 | Heinzer R Vat S Marques-Vidal P | 2015 | Lancet Respir Med2015，3，4： | 1 |
| 6 | Trazodone increases arousal threshold in obstructive sleep apnoea 显示文摘 | Heinzer RC White DP Jordan AS | 2008 | Eur Respir J2008，31，： | 1 |
| 7 | Full functional?length urethral sphincter preservation during radical prostatec?tomy显示文摘 | Schlomm T Heinzer H Steuber T | 2011 | EurUrol2011，60，： | 1 |
| 8 | Interleukin-2 inhalation therapy temporarily induces asthma-like airway inflammation 显示文摘 | Loppow D Huland E Heinzer H | 2007 | Eur J Med Res2007，12，11： | 1 |
| 9 | Full functionallength urethral sphincter preservation during radical prostatectomy显示文摘 | Schlomm T Heinzer H Steuber T | 2011 | Eur Urol2011，60，2： | 1 |
| 10 | Managing Side Effects of Angiogenesis Inhibitors in Renal Cell Carcinoma显示文摘 | Grunwald V Heinzer H Fiedler W | 2007 | Onkolo gie2007，30，10： | 1 |
| 11 | Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea显示文摘 | Heinzer RC Stanchina ML Malhotra A | 2005 | Am J Respir Crit Care Med2005，172，1： | 1 |
| 12 | Full functional-length urethral sphincter preservation during radical prostatectomy 显示文摘 | Sehlomm T Heinzer H Steuber T | 2011 | Eur Urol2011，60，2： | 1 |
| 13 | A comparison of systemic versus inhaled recombinant IL-2 administration for the treatment of metastatic renal cell carcinoma显示文摘 | Huland E Heinzer H Huland H | 2000 | Folia Biol2000，46，： | 1 |
| 14 | Slow-wave activity in sleep apnea patients before and after continuous positive airway pressure treatment:contribution to daytime sleepiness显示文摘 | Heinzer R Gaudreau H | 2001 | Chest2001，119，6： | 1 |
| 15 | Therapeutic approaches in metastatic renal cell carcinoma:local immunotherapy显示文摘 | Huland E Heinzer H Jorres RA | 2004 | Urologe A2004，43，： | 1 |
| 16 | Mouse very long-chain acyl-CoA synthetase in X-linked adrenoleukodystrophy显示文摘 | Heinzer AK Kemp S Lu J F | 2002 | J Biol Chem2002，277，28： | 1 |
| 17 | Trazodone increases arousal threshold in obstructive sleep apnoea显示文摘 | Heinzer RC White DP Jordan AS | 2008 | Eur Respir J2008，31，6： | 1 |
| 18 | Overview of interleukin-2 inhala- tion therapy显示文摘 | Huland E Heinzer H Huland H | 2000 | Cancer J Sci Am2000，6，1： | 1 |
| 19 | 显示文摘 | Haba-Rubio J de Seigneux S Heinzer R | 2012 | Nephrologie & therapeutique2012，8，2： | 1 |
| 20 | Full functional-length urethral sphincter preservation during: radical prostatectomy显示文摘 | Schlomm T Heinzer H Steuher T | 2011 | Eur Urol2011，60，2： | 1 |
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