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| 1 | Importance of intellectual property generated by biomedical research at universities and academic hospitals显示文摘Biomedical research has many different facets.Researchers and clinicians study disease biology and biochemistry to discover novel therapeutic targets,unravel biochemical pathways and identify biomarkers to improve diagnosis,or devise new approaches to clinically manage diseases more effectively.In all instances,the overall goal of biomedical research is to ensure that results thereof(such as a therapy,a device,or a method which may be broadly referred to as“inventions”)are clinically implemented.Most of the researchers’efforts are centered on the advance of technical and scientific aspects of an invention.The development and implementation of an invention can be arduous and very costly.Historically,it has proven to be crucial to protect intellectual property rights(IPR)to an invention(i.e.,a patent)to ensure that companies can obtain a fair return on their investment that is needed to develop an academic invention into a product for the benefit of patients.However,the importance of IPR is not generally acknowledged among researchers at academic institutions active in biomedical research.Therefore this paper aims to(1)raise IP awareness amongst clinical and translational researchers;(2)provide a concise overview of what the patenting trajectory entails;and(3)highlight the importance of patenting for research and the researcher.Importance for patients:Adequate patent protection of inventions generated through biomedical research at academic institutions increases the probability that patients will benefit from these inventions,and indirectly enables the financing of clinical studies,mainly by opening up funding opportunities(e.g.specific grants aimed at start-ups,pre-seed and seed capital)that otherwise would not be accessible.As a consequence,patented inventions are more likely to become clinically tested and reach the market,providing patients with more treatment options. | Joris J.Heus Elmar S.de Pauw Mirjam Leloux Margherita Morpurgo Michael R Hamblin Michal Heger | 2017 | Journal of Clinical & Translational Research2017，3，2： | 3 |
| 2 | Electrospun poly (varepsilon- caprolactone) scaffold for suture-free solder-mediated laser-assisted vessel repair 显示文摘 | Pabittei DR Heger M Balm R | 2011 | Photomed Laser Surg2011，29，1： | 1 |
| 3 | On-line measurement of chlorobenzene in waste incineration flue gas as a surrogate for the emission of polychlorinated dibenzo-p-dioxins/furans(I-TEQ)using mobile resonance laser ionization time-of-flight mass spectrometry显示文摘 | ZIMMERMANN R HEGER H J BLUMENSTOCK M | 1999 | Rapid Communications in Mass Spectrometry1999，13，5： | 1 |
| 4 | Glia to neuron signaling and the neuroendocrine control of female puberty显示文摘 | Ojeda S R Prevot V Heger S | 2003 | Ann Med2003，35，： | 1 |
| 5 | On-line measurement of chlorobenzene in waste incineration flue gas as a surrogate for the emission of polychlorinated dibenzo-pdioxins/furans(I-TEQ)using mobile resonance laser ionization time-of-flight mass spectrometry显示文摘 | ZIMMERMANN R HEGER H J BLUMENSTOCK M | 1999 | Rapid Communications in Mass Spectrometry1999，13，5： | 1 |
| 6 | On-line real-time measurements at incineration plants: PAHs and a PCDD/F surrogate compound at stationary combustion conditions and during transient emission puffs 显示文摘 | Heger H J Zimmermann R Blumenstock M | 2001 | Chemosphere2001，42，57： | 1 |
| 7 | Role of endosomes in simian virus 40 entry and infection显示文摘 | Engel S Heger T Mancini R | | 0，，09： | 1 |
| 8 | Neutron and x-ray single-crystal study of the AlPdMn icosahedral phase显示文摘 | Boudard M de Bosissieu M Janot C Heger G Beeli C Nissen H U Vincent H Ibberson R Audier M Dubois J M | 1992 | J Phys:Condens Matter1992，4，10： | 1 |
| 9 | High potassium, calc-alkaline I-type plutonism in the European Variscides: northern Vosges (France) and northern Schwarzwald (Germany) 显示文摘 | Ahherr R Holl A Heger E | 2000 | Lithos2000，50，： | 1 |
| 10 | Ruptured,intracranial dermoid cyst-A visual diagnosis?显示文摘 | Heger D Scheer F Andresen R | 2016 | J Clin Diagn Res2016，10，4： | 1 |
| 11 | On-line real-time measurements at incineration plants:PAHs and a PCDD/F surrogate compound at a stationary combustion conditions and during transient emission puffs显示文摘 | Heger H J Zimmermann R Blumenstock M | 2001 | Chemosphere2001，42，5： | 1 |
| 12 | The molec- ular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites inrelation to cancers显示文摘 | Heger M van Golen R F Broekgaarden M etal | 2014 | Pharma- cological Reviews2014，66，1： | 1 |
| 13 | IT Support for clinicalpathways-lessons learned显示文摘 | Lenz R Blaser R Beyer M Heger O | 2007 | International Journal of medical infor-matics2007，76，3： | 1 |
| 14 | On-line real-time measurements at incineration plants: PAHs and a PCDD/F surrogate compound at a stationary combustion conditions and during transient emission puffs显示文摘 | Heger H J Zimmermann R Blumenstock M | 2001 | Chemosphere2001，42，5： | 1 |
| 15 | On-line measurement of chlorobenzene in waste incineration flue gas as a surrogate for the emission of polychlorinated dibenzo-p-dioxins/furans (I-TEQ) using mobile resonance laser ionization time-of-flight mass spectrometry 显示文摘 | Zimmermann R Heger H J Blumenstock M | 1999 | Rapid Commun Mass Spectrom1999，13，5： | 1 |
| 16 | Production of Molybdenum-99 Using Solution Reactors 显示文摘 | Glenn D E Heger A S Ball R M | 1996 | Trans Am Nucl Soc1996，74，： | 1 |
| 17 | Activation of a-type gamma-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons显示文摘 | DeFazio R A Heger S Sergio R | 2002 | Mol Endocrinol2002，16，： | 1 |
| 18 | Transgenic overexpression of heart- specific adenine nueleotide translocase 1 positively affects contractile function in cardiomyocytes 显示文摘 | Vogelpohl I Vetter R Heger J | 2011 | Cell Physiol Biochem2011，27，2： | 1 |
| 19 | Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains显示文摘 | Heger M Salles II Bezemer R | 2011 | J Dermatol Scij2011，63，3： | 1 |
| 20 | On-line real-time measurements at incineration plants: PAHs and a PCDD/F surrogate compound at stationary combustion conditions and during transient emission puffs 显示文摘 | HEGER H J ZIMMERMANN R BLUMENSTOCK M | 2001 | Chemosphere2001，42，57： | 1 |
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