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| 1 | Liver cirrhosis and diabetes:Risk factors,pathophysiology,clinical implications and management显示文摘About 30% of patients with cirrhosis have diabetes mellitus(DM).Nowadays,it is a matter for debate whether type 2 DM in the absence of obesity and hypertriglyceridemia may be a risk factor for chronic liver disease.DM,which develops as a complication of cirrhosis,is known as 'hepatogenous diabetes'.Insulin resistance in muscular and adipose tissues and hyperinsulinemia seem to be the pathophysiologic bases of diabetes in liver disease.An impaired response of the islet β-cells of the pancreas and hepatic insulin resistance are also contributory factors.Non-alcoholic fatty liver disease,alcoholic cirrhosis,chronic hepatitis C(CHC) and hemochromatosis are more frequently associated with DM.Insulin resistance increases the failure of the response to treatment in patients with CHC and enhances progression of fibrosis.DM in cirrhotic patients may be subclinical.Hepatogenous diabetes is clinically different from that of type 2 DM,since it is less frequently associated with microangiopathy and patients more frequently suffer complications of cirrhosis.DM increases the mortality of cirrhotic patients.Treatment of the diabetes is complex due to liver damage and hepatotoxicity of oral hypoglycemic drugs.This manuscript will review evidence that exists in relation to:type 2 DM alone or as part of the metabolic syndrome in the development of liver disease;factors involved in the genesis of hepatogenous diabetes;the impact of DM on the clinical outcome of liver disease;the management of DM in cirrhotic patients and the role of DM as a risk factor for the occurrence and exacerbation of hepatocellular carcinoma. | Diego Garcia-Compean Joel Omar Jaquez-Quintana Jose Alberto Gonzalez-Gonzalez Hector Maldonado-Garza | 2009 | World Journal of Gastroenterology2009，15，3： | 112 |
| 2 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 3 | ABO incompatible renal transplants:Good or bad?显示文摘ABO incompatible kidney transplantation(ABOi-KT) was previously considered to be an absolute contraindication for patients with end-stage kidney disease(ESKD) due to hyperacute rejection related to blood type barrier. Since the first successful series of ABOi-KT was reported, ABOi-KT is performed increasingly all over the world. ABOi-KT has led to an expanded donor pool and reduced the number of patients with ESKD awaiting deceased kidney transplantation(KT). Intensified immunosuppression and immunological understanding has helped to shape current desensitization protocols. Consequently, in recent years, ABOi-KT outcome is comparable to ABO compatible KT(ABOc-KT). However, many questions still remain unanswered. In ABOi-KT, there is an additional residual immunological risk that maylead to allograft damage, despite using current diverse but usually intensified immunosuppressive protocols at the expense of increasing risk of infection and possibly malignancy. Notably, in ABOi-KT, desensitization and antibody reduction therapies have increased the cost of KT. Reassuringly, there has been an evolution in ABOiKT leading to a simplification of protocols over the last decade. This review provides an overview of the history, outcome, protocol, advantages and disadvantages in ABOi-KT, and focuses on whether ABOi-KT should be recommended as a therapeutic option of KT in the future. | Masaki Muramatsu Hector Daniel Gonzalez Roberto Cacciola Atsushi Aikawa Magdi M Yaqoob Carmelo Puliatti | 2014 | World Journal of Transplantation2014，4，1： | 18 |
| 4 | 精子尾部和头部疼痛的传奇:影响精子头部、颈部和尾部的精子病理学预后意义的观念转变显示文摘本文对精子形态和活力问题导致的严重男性不育的各种精子病理学的最新预后意义研究进行了综述。严重的弱精症是男性不育症的主要原因之一,即精子不能到达卵母细胞和/或正常穿透。在卵胞浆内单精子注射(ICSI)之前确定精子无动力的结构因素是非常重要的,因为精子无动力是治疗这些病人的关键因素。治疗这些患者时,要用体外培养的方法挑选有活力的精子或激发精子的活力,以免使用的是坏死的精子细胞。这种改进之后,受精和妊娠结果会显著改善。治疗弱精症患者时,需要提前鉴定遗传显型,并充分告知患者治疗结果和风险。畸形精子症是严重影响生育预测的一个精子特征,主要表现为精子头部和颈部异常。染色质凝聚缺陷和顶体发育不全是两种最常见的严重畸形精子症的表现。显微选择精子和ICSI之前评估精子质量的新方法的开发和应用,确保了对精子病理学超微结构的鉴定,不仅仅只是学术兴趣,同时也是选择治疗方法的一种重要途径。本文回顾了精子各部分在正常受精和早期胚胎发育过程中所发挥的不同作用,探讨了辅助生殖技术如何转变了我们对不正常精子头部、颈部、中片和尾部的病理学的预后意义的认识。 | Hector E Chemes Cristian Alvarez Sedo | 2012 | Asian Journal of Andrology2012，14，1： | 16 |
| 5 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 6 | Small for size syndrome following living donor and split liver transplantation显示文摘The field of liver transplantation is limited by the availability of donor organs. The use of living donor and split cadaveric grafts is one potential method of expanding the donor pool. However, primary graft dysfunction can result from the use of partial livers despite the absence of other causes such as vascular obstruction or sepsis. This increasingly recognised phenomenon is termed 'Small-for-size syndrome' (SFSS). Studies in animal models and humans have suggested portal hyperperfusion of the graft combined with poor venous outflow and reduced arterial flow might cause sinusoidal congestion and endothelial dysfunction. Graft related factors such as graft to recipient body weight ratio < 0.8, impaired venous outflow, steatosis > 30% and pro- longed warm/cold ischemia time are positively predictive of SFSS. Donor related factors include deranged liver function tests and prolonged intensive care unit stay greater than five days. Child-Pugh grade C recipients are at relatively greater risk of developing SFSS. Surgi- cal approaches to prevent SFSS fall into two categories: those targeting portal hyperperfusion by reducing inflow to the graft, including splenic artery modulation and portacaval shunts; and those aiming to relieve paren-chymal congestion. This review aims to examine thecontroversial diagnosis of SFSS, including current strate-gies to predict and prevent its occurrence. We will also consider whether such interventions could jeopardize the graft by compromising regeneration. | Hector Daniel Gonzalez Sophia Cashman Giuseppe K Fusai | 2010 | World Journal of Gastrointestinal Surgery2010，2，12： | 13 |
| 7 | 饲用抗生素在家禽生产中的应用进展显示文摘在畜禽饲料中加入亚治疗量抗生素来提高动物生产性能的做法已有60多年历史,然而,抗生素添加剂的安全性问题一直是争论焦点。支持和反对使用抗生素添加剂都还未有足够证据。但考虑到抗生素'潜在'或'可能'对人类健康存在危害性,许多国家或地区正在着手限制甚至完全禁止抗生素添加剂的使用。最近,美国食品和药物管理中心颁布一系列'产业指导文件'以解决耐药性和药物残留问题。事实上,如果对抗生素添加剂进行良好控制,促生长类抗生素以亚治疗剂量应用于动物饲料,可以预防和控制肠道疾病、改善动物营养状况、促进动物生长、提高饲料效率、加强食品安全和提高动物福利。美国佐治亚大学Hector M.Cervantes在第24届世界家禽大会上对此进行了概述。 | Hector M. Cervantes 曹玉娟 | 2013 | 中国家禽2013，35，4： | 10 |
| 8 | Pregnancies established through intracytoplasmic sperm injection (ICSI) using spermatozoa with dysplasia of fibrous sheath显示文摘Aim: Dysplasia of the fibrous sheath (DFS) is an anomaly found in asthenozoospermic patients with extremely low or absent motility. In order to determine the efficacy of ICSI in these patients, a retrospective analysis of ICSI results in DFS patients has been done. Methods: Ten ICSI attempts were performed in 6 patients with diagnosis of Dysplasia of the Fibrous Sheath studied by transmission and scanning electron microscopy. Results: In the cases studied, sperm concentration was (29.62 _+ 18.05) x 106/mL, total motility was 1.14 _+ 1.31%. Progressive motility was 0% except for one case with 0.1%. One hundred and three preovulatory oocytes were obtained and 94 metaphase 11 oocytes were injected. Sixty-nine of them showed two pronuclei (fertilization rate: 73.4% ). Forty-nine embryos were obtained and 34 were transferred (mean: 3.4 embryos per transfer). Five pregnancies were diagnosed by β-hCG plasma level determinations that resulted to be one preclinical abortion, one clinical abortion and three deliveries. Another pregnancy (ongoing) was achieved from a cryopreserved embryo transfer. Conclusion: These results showed that ICSI provides a suitable solution for patients suffering from irreversible sperm defects such as DFS. Nevertheless, it is mandatory to inform couples of possible transmission risks to offspring, which are unknown at present. Only when the etiology of this problem is disclosed, it will be possible to assess the real genetic risk. | Santiago Brugo Olmedo Vanesa Y.Rawe Florencia N.Nodar German D.Galavema Anibal A.Acosta Hector E.Chemes | 2000 | Asian Journal of Andrology2000，2，2： | 7 |
| 9 | Recurrent anal fistulae:Limited surgery supported by stem cells显示文摘AIM:To study the results of stem-cell therapy under a Compassionate-use Program for patients with recurrent anal fistulae.METHODS:Under controlled circumstances,and approved by European and Spanish laws,a Compassionate-use Program allows the use of stem-cell therapy for patients with very complex anal fistulae.Candidates had previously undergone multiple surgical interventions that had failed to resolve the fistulae,and presented symptomatic recurrence.The intervention consisted of limited surgery(with closure of the internal opening),followed by local implant of stem cells in the fistula-tract wall.Autologous expanded adipose-derived stem cells were the main cell type selected for implant.The first evaluation was performed on the 8th postoperative week;outcome was classified as response or partial response.Evaluation one year after the intervention confirmed if complete healing of the fistula was achieved.RESULTS:Ten patients(8 male)with highly recurrent and complex fistulae were treated(mean age:49years,range:28-76 years).Seven cases were nonCrohn’s fistulae,and three were Crohn’s-associated fistulae.Previous surgical attempts ranged from 3to 12.Two patients presented with preoperative incontinence(Wexner scores of 12 and 13 points).After the intervention,six patients showed clinical response on the 8th postoperative week,with a complete cessation of suppuration from the fistula.Three patients presented a partial response,with an evident decrease in suppuration.A year later,six patients(60%)remained healed,with complete reepithelization of the external opening.Postoperative Wexner Scores were 0 in six cases.The two patients with previous incontinence improved their scores from12 to 8 points and from 13 to 5 points.No adverse reactions or complications related to stem-cell therapy were reported during the study period.CONCLUSION:Stem cells are safe and useful for treating anal fistulae.Healing can be achieved in severe cases,sparing fecal incontinence risk,and improving previous scoring. | Damian Garcia-Olmo Hector Guadalajara Ines Rubio-Perez Maria Dolores Herreros Paloma de-la-Quintana Mariano Garcia-Arranz | 2015 | World Journal of Gastroenterology2015，21，11： | 7 |
| 10 | Current protective strategies in liver surgery显示文摘During liver resection surgery for cancer or liver transplantation,the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow),which results in liver injury [ischemiareperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways. These include hypothermia,ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response),ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion),pharmacological agents to decrease IR injury,genetic modulation of IR injury,and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces IR injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC,ischaemic postconditioning,various pharma-cological agents,gene therapy,and machine perfusion decrease IR injury,none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning,gene therapy,and machine perfusion. Randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection. | Kurinchi S Gurusamy Hector D Gonzalez Brian R Davidson | 2010 | World Journal of Gastroenterology2010，16，48： | 7 |
| 11 | Oral allopurinol to prevent hyperamylasemia and acute pancreatitis after endoscopic retrograde cholangiopancreatography显示文摘AIM:To assess the efficacy of allopurinol to prevent hyperamylasemia and pancreatitis after endoscopic retrograde cholangiopancreatography(PEP).METHODS:One hundred and seventy patients were enrolled and randomized to two groups:a study group(n=85)who received 300 mg of oral allopurinol at 15 h and 3 h before endoscopic retrograde cholangiopancreatography(ERCP)and a control group(n=85)receiving an oral placebo at the same times.Main Outcome Measurements included serum amylase levels and the number severity of the episodes of pancreatitis.Serum amylase levels were classified as normal(<150 IU/L)or hyperamylasemia(>151 IU/L).Episodes of PEP were classified following Ranson's criteria and CT severity index.RESULTS:Gender distribution was similar between groups.Mean age was 53.5±18.9 years for study group and 52.8±19.8 years for controls.Also,the distribution of benign pathology was similar between groups.Hyperamylasemia was more common in the control group(P=0.003).Mild PEP developed in two patients from the study group(2.3%)and eight(9.4%) from control group(P=0.04),seven episodes were observed in high-risk patients of the control group(25%) and one in the allopurinol group(3.3%,P=0.02).Risk factors for PEP were precut sphincterotomy(P=0.02),pancreatic duct manipulation(P=0.002)and multiple procedures(P=0.000).There were no deaths or side effects.CONCLUSION:Oral allopurinol before ERCP decreased the incidences of hyperamylasemia and pancreatitis in patients submitted to high-risk procedures. | Hector Martinez-Torres Xochilt Rodriguez-Lomeli Carlo Davalos-Cobian Jesus Garcia-Correa Juan Manue Maldonado-Martinez Fabiola Medrano-Muoz Clotilde Fuentes-Orozco Alejandr Gonzalez-Ojeda | 2009 | World Journal of Gastroenterology2009，15，13： | 7 |
| 12 | 先天性长QT综合征的新进展显示文摘先天性长QT综合征(LQTS)是发病率在1/2 500左右的恶性遗传性心脏疾病。LQTS的典型心脏表现包括可导致心脏骤停和心脏猝死的晕厥发作,以及包括QT间期延长和T波异常在内的心电图异常。90年代中期,LQTS的治病基因被首次发现,至今已有13型被确认。致病基因主要是离子通道和转运相关蛋白。对于具有典型特征的患者,医生并无诊断困难。对于模棱两可的病例,需要参照特殊诊断标准,比如心电图,病史和家族史等等。此外,基因扫描正日益成为诊断过程的一部分。除非有明确的禁忌证,治疗上还是要首选β受体阻滞剂。若在接受足量β受体阻滞剂期间,还有1次以上的晕厥,需立即采取左侧交感神经切除术,并根据病人特征(年龄、性别、临床病史、24 h Holter在内的心电图特征、基因表型等)考虑安装埋藏式心脏转复除颤器。病人接受适当治疗后,一般预后较好。但是LQTS8(Timothy综合征)病人,携带KCNQ1突变的Jervel Lange-Nielsen综合征患者,以及伴有2∶1房室传导阻滞,病窦综合征或Brugada综合征的LQT3病患的预后极其不容乐观。 | 胡丹 阮磊 张存泰 白融 Hector M.Barajas-Martinez Charles Antzelevitch | 2011 | 中国心脏起搏与心电生理杂志2011，25，5： | 7 |
| 13 | Secreted protein acidic and rich in cysteine(SPARC)induces epithelial-mesenchymal transition,enhancing migration and invasion,and is associated with high Gleason score in prostate cancer显示文摘Secreted protein acidic and rich in cysteine(SPARC)is a matricellular protein highly expressed in bone tissue that acts as achemoattractant factor promoting the arrival of prostate cancer(PCa)cells to the bone marrow.However,the contribution of SPARCduring the early stages of tumor progression remains unclear.In this study,we show that SPARC is highly expressed in PCa tissueswith a higher Gleason score.Through stable knockdown and overexpression of SPARC in PC3 and LNCaP cells,respectively,here wedem on strate that en doge nous SPARC induces the epithelial-mesenchymal tran sition(EMT),decreasing E-cadheri n and cytokeratin18 and increasing N-cadheri n and vime ntin.Moreover,SPARC in duces the expression of EMT regulatory tran scription factors Snailfamily transcriptional repressor 1(Snail),Snail family transcriptional repressor 2(Slug),and zinc finger E-box binding homeobox 1(Zeb1).In addition,SPARC knockdown in PC3 cells decreases migration and invasion in vitro,without modifying cell proliferation.Our results indicate that SPARC might facilitate tumor progression by modifying the cellular phenotype in cancer cells. | Fernanda Lopez-Moncada Maria Jose Torres Enrique A Castellon Hector R Contreras | 2019 | Asian Journal of Andrology2019，21，6： | 5 |
| 14 | Biodiversity effects and transgressive overyielding显示文摘Aims The potential for mixtures of plant species to produce more biomass than every one of their constituent species in monoculture is still controversially discussed in the literature.Here we tested how this socalled transgressive overyielding is affected by variation between and within species in monoculture yields in biodiversity experiments.Methods We use basic statistical principles to calculate expected maximum monoculture yield in a species pool used for a biodiversity experiment.Using a real example we show how between-and withinspecies variance components in monoculture yields can be obtained.Combining the two components we estimate the importance of sampling bias in transgressive overyielding analysis.Important Findings The net biodiversity effect(difference between mixture and average monoculture yield)needed to achieve transgressive overyielding increases with the number of species in a mixture and with the variation between constituent species in monoculture yields.If there is no significant variation between species,transgressive overyielding should not be calculated using the best monoculture,because in this case the difference between this species and the other species could exclusively reflect a sampling bias.The sampling bias decreases with increasing variation between species.Tests for transgressive overyielding require replicated species’monocultures.However,it can be doubted whether such an emphasis on monocultures in biodiversity experiments is justified if an analysis of transgressive overyielding is not the major goal. | Bernhard Schmid Andy Hector Prasenjit Saha Michel Loreau | 2008 | Journal of Plant Ecology2008，1，2： | 5 |
| 15 | 遗传性短QT综合征的研究进展显示文摘短QT综合征是以QT间期缩短、心脏性猝死高风险为特征的遗传性心脏离子通道病。它属于常染色体显性遗传,发病罕见,与编码钾通道和钙通道的基因突变有关,基因突变导致的IKr、IKs、IK1增大和ICa,L功能丢失,使净外向电流增加或内向电流减少,复极加速,动作电位时程缩短和复极离散度增加,最终触发室性心动过速/心室颤动(VT/VF)。植入式心脏复律除颤器是唯一有效的防治心脏性猝死的手段,奎尼丁和索他洛尔通过延长有效不应期和QT间期,可有效预防VT/VF。 | 石少波 Hector Barajas-Martinez 胡丹 | 2019 | 中华心血管病杂志2019，47，5： | 5 |
| 16 | The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines显示文摘One of the factors promoting tumoral progress is the abnormal activation of the epithelial-mesenchymal transition(EMT)program which has been associated with chemoresistance in tumoral cells.The transcription factor zinc finger E-box-binding homeobox 1(ZEB1),a key EMT activator,has recently been related to docetaxel resistance,the main chemotherapeutic used in advanced prostate cancer treatment.The mechanisms involved in this protective effect are still unclear.In a previous work,we demonstrated that ZEB1 expression induced an EMT-like phenotype in prostate cancer cell lines.In this work,we used prostate cancer cell lines 22Rvl and DU145 to study the effect of ZEB1 modulation on docetaxel resistance and its possible mechanisms.The results showed that ZEB1 overexpression conferred to 22Rvl cell resistance to docetaxel while its silencing made DU145 cells more sensitive to it.Analysis of resistance markers showed no presenee of ATP-binding cassette subfamily B member 1(MDR1)and no changes in breast cancer resistance protein(BCRP)or ATP-binding cassette subfamily C member 10(MRP7).However,a correlation between ZEB1,multidrug resistance-associated protein 1(MRP1),and ATP-binding cassette subfamily C member 4(MRP4)expression was observed.MRP4 inhibition,using MK571,resensitized cells with ZEB1 overexpression to docetaxel treatment.In addition,modulation of ZEB1 and subsequent change in MRP4 expression correlated with a lower apoptotic response to docetaxel,characterized by lower B-cell lymphoma 2(Bcl2),high BCL2-associated X protein(Bax),and high active caspase 3 expression.The response to docetaxel in our model seems to be mediated mainly by activation of the apoptotic death program.Our results showed that modulation of MRP4 could be a mediator of ZEBl-related resistance to docetaxel in prostate cancer,making it a possible marker for chemotherapy response in patients who do not express MDR1. | Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon Hector R Contreras | 2019 | Asian Journal of Andrology2019，21，5： | 5 |
| 17 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 18 | Organic electrode materials for fast-rate,high-power battery applications显示文摘The development of new battery materials with fast charging/discharging capabilities is necessary to meet the growing demands of modern technologies.While counter ion transport in inorganic materials(generally by de/intercalation)currently limits charge/discharge rates in lithium-ion batteries,the weak intermolecular forces in organic materials result in flexible,spacious structures that offer improved ion transport capabilities.Herein,we present the principles which enable fast rate capabilities in organic electrode materials,accompanied by specific literature examples illustrating exceptional rate performances.We discuss approaches to material design which support electron and/or ion transport and the limitations associated with each approach.This review aims to highlight the unique characteristics of organic materials as high-power density electrodes and inspire continued work in the field. | Cara N.Gannett Luis Melecio-Zambrano Monica Jo Theibault Brian M.Peterson Brett P.Fors Hector D.Abruna | 2021 | Materials Reports(Energy)2021，1，1： | 4 |
| 19 | Our experience in sperm morphology assessment显示文摘 | Julia Irene Ariagno Susana Mercedes Curi Patricia Chenlo Herberto Ernesto Hector Repetto Mercedes Norma Pugliese Luis Alberto Palaoro Melba Sardi Gabriela Ruth Mendeluk | 2011 | Asian Journal of Andrology2011，13，2： | 4 |
| 20 | The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines显示文摘 | Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon Hector R Contreras | 2018 | Asian Journal of Andrology2018，20，3： | 4 |
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