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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma显示文摘 | Hector A Montgomery EA Karikari C | | 0，，10： | 1 |
| 3 | Plant diversity and productivity experiments in European grasslands显示文摘 | HECTOR A SCHMID B BEIERKUHNLEIN C | 1999 | Science1999，286，： | 1 |
| 4 | Plant diversity and productivity experiments in European grasslands显示文摘 | Hector A Schmid B Beierkuhnein C | | 0，，5442： | 1 |
| 5 | Effects of Specific Versus Cross-training on Running Performance 显示文摘 | FOSTER C HECTOR L L WELSH R | 1995 | Eur J Appl Physiol Occup Physiol1995，，70： | 1 |
| 6 | Genetic content of wild-type human eytomegalovirus显示文摘 | Dolan A Cnnningham C Hector RD | 2004 | J Gen Virol2004，85，5： | 1 |
| 7 | Genetic variation in Taenia solium显示文摘 | Gillian C Hector HG Minoru N | 2006 | Parasitology International2006，55，1： | 1 |
| 8 | Role of the human immunodeficiency virus type 1 envelope gene in viral fitness 显示文摘 | Hector R Rangel JW Bikram C | 2003 | J Virol2003，77，16： | 1 |
| 9 | Plant diversity and productivity experiments in European grassland显示文摘 | Hector A B Schmid C | 1999 | Science1999，286，： | 1 |
| 10 | Environmental pollutants and type 2 diabetes:a review of mechanisms that can disrupt beta cell function显示文摘 | Hectors T Vanparys C Van Der Ven K | 2011 | Diabetologia2011，54，6： | 1 |
| 11 | The Axl receptor tyrosine kinase is anadverse prognostic factor and a thera- peutic target in esophageal adenocarcinoma 显示文摘 | Hector A Montgomery EA Karikari C | 2010 | Cancer Biol Ther2010，10，10： | 1 |
| 12 | Development of an horizontal interferometric dilatometer for gauge blocks显示文摘 | Marcos M R | 2005 | Proceedings of SPIE2005，5576，： | 1 |
| 13 | Plant diversity and productivity experiments in European grasslands显示文摘 | HECTOR A SCHMID B BEIERKUHNLEIN C | 1999 | Science1999，286，： | 1 |
| 14 | Heavy metal accumula- tion and tolerance in plants from mine tailings of the semiarid Cartagena-La Union mining district (SE Spain)显示文摘 | HECTOR M C ANGEL F RAQUEL A | 2006 | Sci Total Environ2006，366，： | 1 |
| 15 | Effect of high fiber products on blood lipids and lipoproteins in hamsters 显示文摘 | Hector E M F Yoon K C Fernando M B | 2004 | Nutrition Research2004，24，： | 1 |
| 16 | Production of butanol(abiofuel)from agricultural residues:PartⅡ--Use of corn stover andswitchgrass hydrolysates显示文摘 | Qureshi N Saha B C Hector R E | 2010 | Biomass and Bioenergy2010，34，4： | 1 |
| 17 | Butanol production from wheat straw by simultaneous saccharification and fermentation using Clostridium beijerinckii : Part Ⅰ- Batch fermentation显示文摘 | Qureshi N Saha B C Hector R E | 2008 | Biomass Bioenergy2008，32，2： | 1 |
| 18 | Melasma in men:a clinical and histologic study显示文摘 | Hector M Benmaman C | 1988 | Int J Dermatol1988，27，： | 1 |
| 19 | Epoxidation of cyclooctene and cyclohexene by bis diselenide: recyclable catalyst-containing phases through the use of glycerol-derived solvents显示文摘 | Hector Garcia-Marin John C van der Toorn Jose A Mayoral | 2011 | Journal of Molecular Catalysis A: Chemical2011，334，： | 1 |
| 20 | Molecular evolution of hepatitis A virus:a New classification based on the complete VP1protein显示文摘 | Mauro C M Juan Cristina Hector Romero Raoul Perez-Bercof Didier Casane Rodney Colina Laura Garcia Ines Vega Graciela Glikman Victor Romanowsky Alejandro Castello Elisabeth Nicand | 2002 | J Virol2002，76，18： | 1 |
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