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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | The campaign to DNA barcode all fishes,FISH-BOL显示文摘 | WARD R D HANNER R HEBERT P D N | 2009 | Journal of Fish Biology2009，74，2： | 1 |
| 3 | Barcoding animal life : cytechmme c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S de Waard J R | 2003 | Proceedings of the Royal Society of London B : Biolocal Sciences2003，270，1： | 1 |
| 4 | Identifying spiders through DNA barcodes显示文摘 | Barrett R D H Hebert P D N | 2005 | Canada Journal of Zoology2005，83，3： | 1 |
| 5 | The promise of DNA barcoding for taxon- omy显示文摘 | Hebert P D N Gregory T R | 2005 | Systematic Biology2005，54，5： | 1 |
| 6 | Bar coding animal life:Cytoehrome c oxidase subunit 1 di vergences among closely related species显示文摘 | Hebert P D N Ratnasingham S de Waard J R | 2003 | Proceed ings of the Royal Society of London Series B:Biologi cal Sciences2003，270，： | 1 |
| 7 | Implementation of functional autonomy measurement system: barriers and facilitators in PISE-Dordogne project显示文摘 | Gervais P Hebert R Lamontagne J | 2011 | Geriatric et psychol- ogic neuropsychiatrie du vieillissement2011，9，： | 1 |
| 8 | Barcoding animal life:eytochrome coxidase subunit I divergences amonge losely related species显示文摘 | HEBERT P RATNASINGHAM S JEREMY R | 2003 | Proeeedinngs of the Royal Soeiety Biological Seienees2003，270，： | 1 |
| 9 | The modulation of DNA content:preximate causes and altimate conse-quences显示文摘 | GREGORY T R HEBERT P D | 1999 | Genome Res1999，9，： | 1 |
| 10 | Barcoding animal life: cytochrome c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S Dewaard J R | 2003 | Proc R Soc Lond B ( Suppl )2003，270，： | 1 |
| 11 | Barcoding animal life:cytochrome coxidase subunit 1 divergences among closely related species显示文摘 | Hebert P D Ratnasingham S Waard J R | 2003 | Proc Biol Sci2003，270，1： | 1 |
| 12 | The campaign to DNA barcode all fishes, FISH-BOL显示文摘 | Ward R D Harmer R Hebert P D N | 2009 | J Fish Biol2009，74，2： | 1 |
| 13 | Modulation of lens epithelial cell proliferation by enhanced pros- taglandin synthesis after UVB exposure 显示文摘 | Andley U P Hebert J S Morrison A R | 1994 | Invest Ophthalmol Vis Sci1994，35，2： | 1 |
| 14 | Barcoding animal life: cytochrome coxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S de Ward J R | 2003 | Proc R Soc B Biol Sci2003，270，1： | 1 |
| 15 | Genderspecific correlations of plasminogen activator inhibitor - 1 and tissue plasminogen activator levels with cardiovascular disease - related traits显示文摘 | F W Asselbergs S M Williams P R Hebert | 2007 | J Thromb Haemost2007，5，2： | 1 |
| 16 | Barcoding animal life: cytochrome c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S Waard J R | 2003 | Proc R Soc Eond Ser B2003，270，1： | 1 |
| 17 | DNA barcoding of commercially important salmon and trout spe- cies (Oncorhynchus and Salmo) from North America显示文摘 | Rasmussen R S Morrissey M T Hebert P D N | 2009 | Food Chem2009，57，： | 1 |
| 18 | Education attainment and cognitive decline in old age显示文摘 | Wilson R S Hebert L E Scherr P A | 2009 | Neurology2009，72，： | 1 |
| 19 | The campaign to DNA barcode all fishes 显示文摘 | WARD R D HANNER R HEBERT P D N | 2009 | Journal of Fish Biology2009，74，2： | 1 |
| 20 | Barcoding animal life:cytochrome c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S deWaard J R | 2003 | Proc Biol Sci2003，270，1： | 1 |
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