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| 1 | Volar locking distal radius plates show better short-term results than other treatment options: A prospective randomised controlled trial显示文摘AIM To compare the outcomes of displaced distal radius fractures treated with volar locking plates and with immediate postoperative mobilisation with the outcomes of these fractures treated with modalities that necessitate 6 wk wrist immobilisation.METHODS A prospective, randomised controlled single-centre trial was conducted with 56 patients who had a displaced radius fracture were randomised to treatment either with a volar locking plate(n = 29), or another treatment modality(n = 27; cast immobilisation with or without wires or external fixator). Outcomes were measured at 12 wk. Functional outcome scores measured were the Patient-Rated Wrist Evaluation(PRWE) Score; Disabilities of the Arm, Shoulder and Hand and activities of daily living(ADLs). Clinical outcomes were wrist range of motion and grip strength. Radiographic parameters were volar inclination and ulnar variance.RESULTS Patients in the volar locking plate group had significantly better PRWE scores, ADL scores, grip strength and range of extension at three months compared with the control group. All radiological parameters were significantly better in the volar locking plate group at 3 mo. CONCLUSION The present study suggests that volar locking plates produced significantly better functional and clinical outcomes at 3 mo compared with other treatment modalities. Anatomical reduction was significantly more likely to be preserved in the plating group. Level of evidence: Ⅱ. | Herwig Drobetz Lidia Koval Patrick Weninger Ruth Luscombe Paula Jeffries Stefan Ehrendorfer Clare Heal | 2016 | World Journal of Orthopedics2016，7，10： | 18 |
| 2 | Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury显示文摘AIM: Previous studies showed that exogenous basic fibroblast growth factor (bFGF or FGF-2) could improve physiological dysfunction after intestinal ischemia/reperfusion (I/R) injury. However, the mechanisms of this protective effect of bFGF are still unclear. The present study was to detect the effect of bFGF on the activities of mitogen-activated protein kinase (MAPK) signaling pathway in rat intestine after I/R injury, and to investigate the protective mechanisms of bFGF on intestinal ischemiain jury.METHODS: Rat intestinal I/R injury was produced by clamping the superior mesenteric artery (SMA) for 45 minutes and followed by reperfusion for 48 hours. Seventy-eight Wistar rats were used and divided randomly into sham-operated group (A), normal saline control group (B),bFGF antibody pre-treated group (C), and bFGF treated group (D). In group A, SMA was separated without occlusion. In groups B, C and D, SMA was separated and occluded for 45 minutes, then, released for reperfusion for 48 hours. After the animals were sacrificed, blood and tissue samples were taken from the intestine 45 minutes after ischemia in group A and 2, 6, 24, and 48 hours after reperfusion in the other groups. Phosphorylated forms of p42/p44 MAPK, p38 MAPK and stress activated protein kinase/C-Jun N-terminal kinase (SAPK/JNK) were measured by immunohistochemistry. Plasma levels of D-lactate were examined and histological changes were observed under the light microscope.RESULTS: Intestinal I/R injury induced the expression of p42/p44 MAPK, p38 MAPK, and SAPK/JNK pathways and exogenous bFGF stimulated the early activation of p42/p44 MAPK and p38 MAPK pathways. The expression of phosphorylated forms of p42/p44 MAPK was primarily localized in the nuclei of crypt cells and in the cytoplasm and nuclei of villus cells. The positive expression of p38 MAPK was localized mainly in the nuclei of crypt cells, very few in villus cells. The activities of p42/p44 MAPK and p38 MAPK peaked 6 hours after reperfusion in groups B and C,while SAPK/JNK peaked 24 hours after reperfusion. The activities of p42/p44 MAPK and p38 MAPK peaked 2 hours after reperfusion in group D and those of SAPK/JNK were not changed in group B. D-lactate levels and HE staining showed that the intestinal barrier was damaged severely 6 hours after reperfusion, however, histological structures were much improved 48 hours after reperfusion in group D than in the other groups.CONCLUSION: The results indicate that intestinal I/R injury stimulates the activities of MAPK pathways, and that p42/p44 MAPK and p38MAPK activities are necessary for the protective effect of exogenous bFGF on intestinal I/R injury.The protective effect of bFGF on intestinal dysfunction may be mediated by the early activation of p42/p44 MAPK and p38 MAPK signaling pathways. | Xiao-Bing Fu Yin-Hui Yang Tong-Zhu Sun Wei Chen Jun-You Li Zhi-Yong Sheng Wound Healing and Cell Biology Laboratory,Burns Institute,304 Hospital,Trauma Center of Postgraduate Medical College,Beijing 100037,China | 2003 | World Journal of Gastroenterology2003，9，6： | 11 |
| 3 | Activation of phosphorylating-p38 mitogen-activated protein kinase and its relationship with localization of intestinal stem cells in rats after ischemia-reperfusion injury显示文摘AIM: To investigate the expression of phosphorylating p38mitogen-activated protein kinase (MAPK) in rat small intestine after ischemia-reperfusion (I/R) insult and its relationship with the localization of intestinal stem cells.METHODS: Forty-eight Wistar rats were divided randomly into three groups, namely intestinal ischemia-reperfusion group (R), intestinal ischemia group (Ⅰ) and sham-operated control group (C). In group I, the animals were killed 45minutes after superior mesenteric artery (SMA) occlusion,while in group R the rats sustained SMA occlusion for 45 minutes and reperfusion for 2, 6, 12 or 24 hours respectively. In shamoperated control group, SMA was separated, but without occlusion. The activity of plasma diamine oxidase (DAO)was determined. Intestinal tissue samples were also taken for histological analysis and immunohistochemical analysis of MAPK p38 detection and intestinal stem cell localization.RESULTS: The changes in histological structure and plasma DAO levels indicated that the intestinal barrier was damaged after intestinal I/R injury. In group C and I, each crypt contained 5-6 p38 MAPK positive cells, which were mainly located in the lower region of the crypts. This was consistent with the distribution of intestinal stem cells. The presence of positive cells in crypts increased with the time of reperfusion and reached its peak at 12 hours after reperfusion (35.6%).CONCLUSION: After intestinal T/R injury, the expression of phosphorylating-p38 MAPK in small intestine increased with the duration of reperfusion, and its distribution coincided with that of intestinal stem cells and their daughter cells,indicating that phosphorylating-p38 might be a possible marker of intestinal stem cells. | Xiao-Bing Fu Feng Xing Yin-Hui Yang Tong-Zhu Sun Bao-Chen Guo Wound Healing and Cell Biology Laboratory,Institute of Burns,304 Hospital,Trauma Center of Postgraduate Medical College,Beijing 100037,China | 2003 | World Journal of Gastroenterology2003，9，9： | 10 |
| 4 | A potato late blight resistance gene protects against multiple Phytophthora species by recognizing a broadly conserved RXLR-WY effector显示文摘Species of the genus Phytophthora,the plant killer,cause disease and reduce yields in many crop plants.Although many Resistance to Phytophthora infestans(Rpi)genes effective against potato late blight have been cloned,few have been cloned against other Phytophthora species.Most Rpi genes encode nucleotide-binding domain,leucine-rich repeat-containing(NLR)immune receptor proteins that recognize RXLR(Arg-X-Leu-Arg)effectors.However,whether NLR proteins can recognize RXLR effectors from multiple Phytophthora species has rarely been investigated.Here,we identified a new RXLR-WY effector AVRamr3 from P.infestans that is recognized by Rpi-amr3 from a wild Solanaceae species Solanum americanum.Rpi-amr3 associates with AVRamr3 in planta.AVRamr3 is broadly conserved in many different Phytophthora species,and the recognition of AVRamr3 homologs by Rpi-amr3 activates resistance against multiple Phytophthora pathogens,including the tobacco black shank disease and cacao black pod disease pathogens P.parasitica and P.palmivora.Rpi-amr3 is thus the first characterized resistance gene that acts against P.parasitica or P.palmivora.These findings suggest a novel path to redeploy known R genes against different important plant pathogens. | Xiao Lin Andrea Olave-Achury Robert Heal Marina Pais Kamil Witek Hee-Kyung Ahn He Zhao Shivani Bhanvadia Hari S.Karki Tianqiao Song Chih-hang Wu Hiroaki Adachi Sophien Kamoun Vivianne G.A.A.Vleeshouwers Jonathan D.G.Jones | 2022 | Molecular Plant2022，15，9： | 2 |
| 5 | The use of cultures for studying test( protozoa: rhizopoda ) in soil 显示文摘 | Stout J D Heal O W | 1964 | Pedobiologia1964，4，： | 1 |
| 6 | How far do prawns and fish move into mangrove? Distribution of juvenile banana prawns Penaeus merguiensis and fish in a tropical mangrove forest in northern Australia显示文摘 | Haywood M D E Heales D S | 1996 | Marine ecology progress series1996，131，： | 1 |
| 7 | Nitric oxide,mitochondria and neurological disease显示文摘 | Heals SJ Bolanos JP Stewart VC Brookes PS Land JM Clark JB | 1999 | Biochim Biophys Acta1999，1410，2： | 1 |
| 8 | A 4-year follow-up study of the e ffects of calcium supplementation on bone density in elderly postmenopausal wome n显示文摘 | Devine A Dick IM Heal SJ | 1997 | Osteoporos Int1997，7，： | 1 |
| 9 | Glutamate neurotoxicity is associate with nitric oxide-mediated mitochondrial dysfunction and glutalhione depletion显示文摘 | Almeida A Heales SJ Bolanos JP | 1998 | Brain Res1998，790，12： | 1 |
| 10 | WBC reduction of RBC transfusions is associated with a decreased incidence of RBC alloimmunization显示文摘 | HEAL JM GETTINGS KF | 2003 | Transfusion2003，43，： | 1 |
| 11 | An improved method for the calculation of pore size distribution from adsorption data显示文摘 | Heal G R | 1964 | J Appl Chem1964，14，3： | 1 |
| 12 | A retrospective analysis显示文摘 | Mandracchia VJ Sanders SM Frerichs JA The use of becaplermin (rhPDGF BB) gel for chronic no healing ulcers | 2001 | Clin Podiatr Med Surg2001，18，1： | 1 |
| 13 | A randomized trial of washed red blood cell and platelet transfusions in adult acute leukemia显示文摘 | BLUMBERG N HEAL J M ROWE J M | 2004 | BMC Blood Disord2004，4，： | 1 |
| 14 | Platelet washing to prevent recurrent febrile reactions to leukocyte-reduced transfusions显示文摘 | Vo TD Cowles J Heal JM | 2001 | Transfusion Med2001，11，1： | 1 |
| 15 | Soluble transition metals cause the pro-inflammatory effects of welding fumes in vitro 显示文摘 | MeNeilly JD Heal MR Beverland IJ | 2004 | Toxicol Appl Pharmacol2004，196，1： | 1 |
| 16 | An improved method foe the calculation of pore-size distribution from adsorption data显示文摘 | Dollimore D Heal G R | 1964 | J Appl Chem1964，14，： | 1 |
| 17 | Investment and emission control under technology and pollution exteroalities显示文摘 | GEOFFREY HEAL NORI TARUI | | 0，，32： | 1 |
| 18 | WBC reduction of RBC transfusions is associated with a decreesed incidence of RBC alloimmunodel显示文摘 | Blumber GN Heal JM Gettings KF | 2005 | Blood2005，105，2： | 1 |
| 19 | Hydrology and the Ec-ological Quality of Scottish River Ecosystems显示文摘 | D J Gilvear K V Heal A Stephen | 2002 | TheScience of the Total Environment2002，294，6： | 1 |
| 20 | Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration 显示文摘 | Brown GC Bolanos JP Heals SJR | 1995 | Neurosic Lett1995，193，3： | 1 |
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