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| 1 | Characterization of the receptor-binding domain(RBD)of 2019 novel coronavirus:implication for development of RBD protein as a viral attachment inhibitor and vaccine显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Wanbo Tai Lei He Xiujuan Zhang Jing Pu Denis Voronin Shibo Jiang Yusen Zhou Lanying Du | 2020 | Cellular & Molecular Immunology2020，17，6： | 35 |
| 2 | Agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetlands: A case study in the Yellow River wetland in China显示文摘Riparian wetland is the major transition zone of matter, energy and information transfer between aquatic and terrestrial ecosystems and has important functions of water purification and non-point pollution control. Using the field experiment method and an isotope tracing technique, the agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetland was studied in the Kouma Section of the Yellow River. The results showed that the retention of agricultural non-point nitrogen pollution by riparian wetland soil occurs mainly in top 0-10 cm layer. The amount of nitrogen retained by surface soils associated with three types of vegetation are 0.045 mg/g for Phragmites communis Trin Linn, 0.036 mg/g for Scirpus triqueter Linn, and 0.032 mg/g for Typha angustifolia Linn, which account for 59.21%, 56.25%, and 56.14% of the total nitrogen interception, respectively. Exogenous nitrogen in 0-10 cm soil layer changes more quickly than in other layers. One month after adding K15NO3 to the tested vegetation, nitrogen content was 77.78% for P. communis Trin, 68.75% for T. angustifolia, and 8.33% for S. triqueter in the surface soil. After three months, nitrogen content was 93.33% for P. communis Trin, 72.22% for S. triqueter, and 37.50% for T. Angustifolia. There are large dierences among vegetation communities respecting to purification of agricultural non-point nitrogen pollution. The nitrogen uptake amount decreases in the sequence: new shoots of P. communis Trin (9.731 mg/g) > old P. communis Trin (4.939 mg/g) > S. triqueter (0.620 mg/g) > T. angustifolia (0.186 mg/g). Observations indicated that the presence of riparian wetlands as buers on and adjacent to stream banks could be recommended to control agricultural non-point pollution. | ZHAO Tongqian XU Huashan HE Yuxiao TAI Chao MENG Hongqi ZENG Fanfu XING Menglin | 2009 | Journal of Environmental Sciences2009，21，7： | 29 |
| 3 | Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury显示文摘瞄准:高血压蛋白原酶血管收缩素系统(地岬) 在血压控制和身体液体和电解质动态平衡起一个关键作用。在过去几年里,血管收缩素(Ang )(1-7 ) 被报导了抵抗 Ang II 的效果并且甚至在地岬被看作一个新 therapeutical 目标。现在的学习试图在本地地岬上在一个糖尿病的动物模型和调整上调查 Ang (1-7 ) 管理的效果。方法:Streptozotocin (STZ ) 导致注射的糖尿病的老鼠在实验被使用。动物被划分成 3 个组:(1 ) 控制;(2 )导致 STZ 的糖尿病;并且(3 ) 有长期的 Ang (1-7 ) 处理的导致 STZ 的糖尿病[D+Ang (1-7 )] 。在 D+Ang (l-7 ) 组, 25 μ g · k g~ 的剂量(Ang (1-7 ) 的 -1) · h^(-1) 被嵌入微型渗透的泵 6 个星期不断地通过颈部的静脉注射。血浆葡萄糖,到体重的肾的比率,和 24 h 尿蛋白质和浆液肌酸酐被常规测量监视。血浆和肾的 Ang II 层次被放射性免疫测定测量。Ang-con-verting 酶(王牌) , ACE2, Ang II 打 1 (AT1 ) 受体, Ang II 打 2 (AT2 ) 受体, Ang (1-7 ) 妈受体,和 TGF-β 1 niRNA 层次被实时 PCR 测量;王牌, ACE2,和 TGF-β 1 蛋白质层次被西方的弄污分析。结果:当时,糖尿病的老鼠的肾的函数显著地被倒退与控制老鼠的相比。在由为 6 个星期的经常的 Ang (1-7 ) 静脉注射的处理以后,肾的功能被发现平比糖尿病的老鼠,和两 TGF-β 1 更坏 mRNA 和蛋白质层次与糖尿病的老鼠相比在 D+Ang (l-7 ) 组被提高。即时 PCR 结果也在 D+Ang (1-7 ) 组在 ACE2 mRNA 水平在王牌 mRNA 表示和减少看了增加是否与糖尿病的老鼠相比。受体在 Ang (1-7 ) 增加了的 ATI 的数字注射了组,当 AT2 和妈受体的数字减少了时。结论:外长的 Ang (1-7 ) 注射没改善导致 STZ 的糖尿病的老鼠肾损伤;相反,它加速了进步糖尿病的 nephropathies。 | Ying SHAO Ming HE Li ZHOU Tai YAO Yu HUANG Li-min LU | 2008 | Acta Pharmacologica Sinica2008，29，7： | 12 |
| 4 | TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury显示文摘AIM: To characterize high-mobility group protein 1-toll-like receptor 4(HMGB1-TLR4) and downstream signaling pathways in intestinal ischemia/reperfusion(I/R) injury.METHODS: Forty specific-pathogen-free male C57BL/6 mice were randomly divided into five groups(n = 8 per group): sham, control, anti-HMGB1, anti-myeloid differentiation gene 88(My D88), and anti-translocatingchain-associating membrane protein(TRIF) antibody groups. Vehicle with the control Ig G antibody, antiHMGB1, anti-My D88, or anti-TRIF antibodies(all 1 mg/kg, 0.025%) were injected via the caudal vein 30 min prior to ischemia. After anesthetization, the abdominal wall was opened and the superior mesenteric artery was exposed, followed by 60 min mesenteric ischemia and then 60 min reperfusion. For the sham group, the abdominal wall was opened for 120 min without I/R. Levels of serum nuclear factor(NF)-κB p65, interleukin(IL)-6, and tumor necrosis factor(TNF)-α were measured, along with myeloperoxidase activity in the lung and liver. Inaddition,morphologic changes that occurred in the lung and intestinal tissues were evaluated. Levels of m RNA transcripts encoding HMGB1 and NF-κB were measured by real-time quantitative PCR, and levels of HMGB1 and NF-κB protein were measured by Western blot. Results were analyzed using one-way analysis of variance.RESULTS: Blocking HMGB 1, MyD 8 8, and TRIF expression by injecting anti-HMGB1, anti-My D88, or anti-TRIF antibodies prior to ischemia reduced the levels of inflammatory cytokines in serum; NF-κB p65: 104.64 ± 11.89, 228.53 ± 24.85, 145.00 ± 33.63, 191.12 ± 13.22, and 183.73 ± 10.81(P < 0.05); IL-6: 50.02 ± 6.33, 104.91 ± 31.18, 62.28 ± 6.73, 85.90 ± 17.37, and 78.14 ± 7.38(P < 0.05); TNF-α, 43.79 ± 4.18, 70.81 ± 6.97, 52.76 ± 5.71, 63.19 ± 5.47, and 59.70 ± 4.63(P < 0.05) for the sham, control, anti-HMGB1, anti-My D88, and anti-TRIF groups, respectively(all in pg/m L).Antibodies also alleviated tissue injury in the lung and small intestine compared with the control group in the mouse intestinal I/R model. The administration of antiHMGB1, anti-My D88, and anti-TRIF antibodies markedly reduced damage caused by I/R, for which anti-HMGB1 antibody had the most obvious effect.CONCLUSION: HMGB1 and its downstream signaling pathway play important roles in the mouse intestinal I/R injury, and the effect of the TRIF-dependent pathway is slightly greater. | Jie Wang Gui-Zhen He Yu-Kang Wang Qian-Kun Zhu Wei Chen Tai Guo | 2015 | World Journal of Gastroenterology2015，21，27： | 10 |
| 5 | Correlation between BRAF^(V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma显示文摘In adults, the presence of the BRAF^(V600E) mutation in papillary thyroid cancer(PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF^(V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF^(V600E) mutation in48 pediatric patients with PTC, aged 3–13 years. Of these patients, 41 were diagnosed with classic PTC, five were found to have a follicular variant of PTC, and two to exhibit a diffuse sclerosing PTC variant. The BRAF^(V600E) mutation was identified to be present in 35.4% of the 48 analyzed patients, and in 41.5% of the patients diagnosed with classical PTC. Furthermore, the presence of the BRAF^(V600E) mutation was found to be associated with a patient age at diagnosis of less than ten years(P=0.011), the performance of a thyroidectomy(P=0.03), exhibited tumor multifocality(P=0.02) and/or extra-thyroidal invasion(P=0.003), and both a low MACIS(Metastases, Age, Completeness of resection, Invasion, Size)(P=0.036) and AMES(Age, Metastasis, Extent of tumor,Size)(P=0.001)score. Together, these data suggest that the presence of the BRAF^(V600E) mutation may be negatively correlated with partial aggressive clinicopathological features of pediatric PTC. | Jiangqiao Geng Huanmin Wang Yuanhu Liu Jun Tai Yaqiong Jin Jie Zhang Lejian He Libing Fu Hong Qin Yingluan Song Jinzhu Su Aiying Zhang Xin Wen Yongli Guo Xin Ni | 2017 | Science China(Life Sciences)2017，60，7： | 9 |
| 6 | All-trans retinoic acid inhibited angiotensin Ⅱ-induced increase in cell growth and collagen secretion of neonatal cardiac fibroblasts显示文摘瞄准:为了决定 all-trans retinoic 酸(atRA ) 是否行动调制血管收缩素, II (Ang II ) 导致了心脏的成纤维细胞房间生长和骨胶原分泌物。方法:有教养的新生的老鼠心脏的成纤维细胞(CF ) 在实验被使用。A 3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyl tetrazolium 溴化物(MTT ) 试金被用来检测 CF 的细胞生长;并且免疫细胞化学并且西方的弄污被用来测量骨胶原的生产和由 CF 转变生长 factor-beta1 (TGF-beta1 ) 的表示。结果:atRA (10 (到 10 的 -7)(-5) mol/L ) 禁止了 Ang CF (P<0.05 ) 的房间生长的导致 II 的增加。Ang II 刺激了骨胶原类型的分泌物我和由 CF 的 III。这效果被堵住由在(1 ) 受体对手 losartan (10 (-6) mol/L ) ,然而并非由 AT2 受体对手 PD123319 (多达 10 (-6) mol/L ) 。到 atRA 的 CF 的暴露((-5) mol/L ) 10 稀释了骨胶原的分泌物的导致 II 的增加打的 Ang 我和 III (P<0.05 ) 。atRA ((-5) mol/L ) 10 也堵住了 Ang TGF-beta1 的表示的导致 II 的增加。结论:atRA 禁止 Ang 细胞生长和新生的老鼠 CF 的骨胶原分泌物的导致 II 的增加。atRA 的效果被降低 TGF-beta1 水平可能调停。这些观察支持 atRA 是心脏的改变的预防和治疗的一个潜在的候选人的观点。 | Yan HE Ying HUANG Li ZHOU Li-min LU Yi-chun ZHU Tai YAO | 2006 | Acta Pharmacologica Sinica2006，27，4： | 8 |
| 7 | Basaloid squamous carcinoma of esophagus:a clinicopathological,immunohistochemical and electron microscopic study of sixteen cases显示文摘INTRODUCTIONThetermbasaloidsquamouscarcinoma(BSC)wasfirstproposedbyWainetalin1986todescribearare,aggresiveneoplasmwithapredil... | ZHANG Xin Hua, SUN Gui Qin, ZHOU Xiao Jun, GUO Hui Fang and ZHANG Tai He | 1998 | World Journal of Gastroenterology1998，4，5： | 8 |
| 8 | A review of rockburst:Experiments,theories,and simulations显示文摘Rockburst is becoming a huge challenge for the utilization of deep underground space.Extensive efforts have been devoted to investigating the rockburst behavior and mechanism experimentally,theoretically,and numerically.The aim of this review is to discuss the novel development and the state-of-the-art in experimental techniques,theories,and numerical approaches proposed for rockburst.The definition and classification of rockburst are first summarized with an in-depth comparison among them.Then,the available laboratory experimental technologies for rockburst are reviewed in terms of indirect and direct approaches,with the highlight of monitoring technologies and data analysis methods.Some key rockburst influencing factors(i.e.size and shape,rock types,stress state,water content,and temperature)are analyzed and discussed based on collected data.After that,rockburst theories and mechanisms are discussed and evaluated,as well as the microscopic observation.The simulation approaches of rockburst are also summarized with the highlight of optional novel numerical methods.The accuracy,stability,and reliability of different experimental,theoretical and numerical approaches are also compared and assessed in each part.Finally,a summary and some aspects of prospective research are presented. | Manchao He Tai Cheng Yafei Qiao Hongru Li | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，5： | 6 |
| 9 | Analysis of microscopic pore structures of rocks before and after water absorption显示文摘岩石的吸水的特征被他们的显微镜的毛孔结构影响,它清楚地在水吸收以后变化。水吸收测试和扫描电子显微镜(SEM ) 在岩石上试验样品,在西藏在一个地点定位了,中国,被执行。在水吸收前后的岩石毛孔结构的变化与毛孔尺寸的分发和毛孔的分数维的特征被学习。因为新小毛孔的数字生产了,表面孔,毛孔的分数维的尺寸和毛孔结构的复杂性增加了的结果表演增加了或在岩石吸收了水以后,原来的 macropore 流动隧道被扩展。有他们的水吸收曲线上的变化的点。在另外的岩石的水吸收以后,当原来的毛孔流动隧道变得充满,表面孔和毛孔的分数维的尺寸和毛孔结构的复杂性减少了。水吸收曲线没变化。表面孔和岩石的毛孔分数维图形尺寸在水吸收前后有好线性关系。 | Li Dejian Wang Guilian Han Liqiang Liu Peiyu He Manchao Yang Guoxing Tai Qimin Chen Cheng | 2011 | Mining Science and Technology2011，21，2： | 6 |
| 10 | Steroid elimination within 24 hours after orthotopic liver transplantation:effectiveness and tolerability显示文摘BACKGROUND:Steroids have been the mainstay of immunosuppressive regimen in liver transplantation.However,the use of steroids is associated with various post-transplant complications.This study evaluated the efficacy and safety of reduced immunosuppressive regimen with steroids(steroid elimination within 24 hours post-transplant) in a cohort of Chinese liver transplant recipients.METHODS:Seventy-six patients in line with the selection criteria were enrolled in this prospective study.All patients received anti-IL-2 receptor antibody induction and tacrolimusbased maintenance therapy.The recipients were divided into two groups according to the duration of steroid use:40 transplant in a 3-month withdrawal group and the remaining 36 in a 24-hour elimination group.Recipient survival,postoperative infections,biopsy-proven acute rejection and steroidresistant acute rejection,non-healing wound,recurrence of hepatitis B virus(HBV) and hepatocellular carcinoma(HCC),de novo diabetes,hyperlipidemia and hypertension were assessed in the two groups.RESULTS:There was no significant difference in patient survival,incidence of acute rejection episodes and hyperlipidemia,and recurrence of HBV and HCC between the two groups.However,the incidence rates of post-transplant infection,non-healing wound,de novo diabetes and hypertension were significantly lower in the 24-hour elimination group than in the 3-month withdrawal group(all P values <0.05).CONCLUSION:Under anti-IL-2 receptor antibody induction and tacrolimus-based maintainance,steroid elimination within 24 hours post-transplant is associated with reduced steroidrelated complications without increasing the risk of rejection. | Lin-Wei Wu,Zhi-Yong Guo,Qiang Tai,Wei-Qiang Ju,Dong-Ping Wang,An-Bin Hu,Xiao-Feng Zhu and Xiao-Shun He Organ Transplantation Center, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 4 |
| 11 | Liver transplantation using organs from deceased organ donors: a single organ transplant center experience显示文摘BACKGROUND: In 2011, a pilot program for deceased organ donation was initiated in China. We describe the first successful series of liver transplants in the pilot program.METHODS: From July 2011 to August 2012, our center performed 26 liver transplants from a pool of 29 deceased donors. All organ donation and allograft procurement were conducted according to the national protocol. The clinical data of donors and recipients were collected and summarized retrospectively.RESULTS: Among the 29 donors, 24 were China Category II donors(organ donation after cardiac death), and five were China Category III donors(organ donation after brain death followed by cardiac death). The recipients were mainly the patients with hepatocellular carcinoma. The one-year patient survival rate was 80.8% with a median follow-up of 422(2-696) days. Among the five mortalities during the follow-up,three died of tumor recurrence. In terms of post-transplant complications, 9 recipients(34.6%) experienced early allograft dysfunction, 1(3.8%) had non-anastomotic biliary stricture,and 1(3.8%) was complicated with hepatic arterial thrombosis.None of these complications resulted in patient death. Notably,primary non-function was not observed in any of the grafts.CONCLUSION: With careful donor selection, liver transplant from deceased donors can be performed safely and plays acritical role in overcoming the extreme organ shortage in China. | Ming Han Zhi-Yong Guo Qiang Zhao Xiao-Ping Wang Xiao-Peng Yuan Xing-Yuan Jiao Chun-Hua Yang Dong-Ping Wang Wei-Qiang Ju Lin-Wei Wu An-Bin Hu Qiang Tai Yi Ma Xiao-Feng Zhu Xiao-Shun He | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 3 |
| 12 | Greenhouse gas emissions from a constructed wetland for municipal sewage treatment显示文摘The fluxes of greenhouse gases (methane and nitrous oxide) emission from a constructed wetland in the Eastern China as municipal sewage treatment were measured from June 1999 to August 2000 by the closed chamber method. The constructed wetland for municipal sewage treatment is a significant source of methane, up to 976 6×10 6 g CH 4/a, which was emitted from the constructed wetland with the area of 495000 m 2 and wastewater loading rate of 12000 m 3/d. Its daily mean methane flux reached 5 22 g CH 4/(m 2·d), 250 times as much as that in natural wetland in the same latitude region. 227 8 mg CH 4 was produced from the treatment of 1 liter wastewater, up to 700—1000 times as much as that in the secondary treatment. The emission of nitrous oxide from the constructed wetland is not higher than that from secondary treatment of wastewater, only 0 07 mgN 2O/L. | TAI Pei dong 1, LI Pei jun 1 , SUN Tie heng 1, HE Yao wu 1, ZHOU Qi xing 1 GONG Zong qiang 1, Motoyuki Mizuochi 2, Yuhei Inamori 2 (1 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110015, China. 2 National Insti | 2002 | Journal of Environmental Sciences2002，14，1： | 3 |
| 13 | Agronomical selection on loss-of-function of GIGANTEA simultaneously facilitates soybean salt tolerance and early maturity显示文摘Salt stress and flowering time are major factors limiting geographic adaptation and yield productivity in soybean(Glycine max).Although improving crop salt tolerance and latitude adaptation are essential for efficient agricultural production,whether and how these two traits are integrated remains largely unknown.Here,we used a genome-wide association study to identify a major salt-tolerance locus controlled by E2,an ortholog of Arabidopsis thaliana GIGANTEA(GI).Loss of E2 function not only shortened flowering time and maturity,but also enhanced salt-tolerance in soybean.E2 delayed soybean flowering by enhancing the transcription of the core flowering suppressor gene E1,thereby repressing Flowering Locus T(FT)expression.An E2 knockout mutant e2^(CR) displayed reduced accumulation of reactive oxygen species(ROS)during the response to salt stress by releasing peroxidase,which functions in ROS scavenging to avoid cytotoxicity.Evolutionary and population genetic analyses also suggested that loss-of-function e2 alleles have been artificially selected during breeding for soybean adaptation to high-latitude regions with greater salt stress.Our findings provide insights into the coupled selection for adaptation to both latitude and salt stress in soybean;and offer an ideal target for molecular breeding of early-maturing and salt-tolerant cultivars. | Lidong Dong Zhihong Hou Haiyang Li Zhaobo Li Chao Fang Lingping Kong Yongli Li Hao Du Tai Li Lingshuang Wang Milan He Xiaohui Zhao Qun Cheng Fanjiang Kong Baohui Liu | 2022 | Journal of Integrative Plant Biology2022，64，10： | 3 |
| 14 | Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression. | Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，2： | 2 |
| 15 | Proximate causes of dispersal for female Yunnan snub-nosed monkeys显示文摘DEAR EDITOR,Individual dispersal trends, unquestionably important for species ecology and evolution, are affected by multiple factors. Understanding the factors that influence female dispersal strategies offers important insight into primate dispersal mechanisms and female choice. To investigate the proximate causes of dispersal in female Yunnan snub-nosed monkeys (Rhinopithecus bieti), we observed and analyzed nine years of detailed dispersal and demographic data from a population of R. bieti in Xiangguqing, Baimaxueshan Nature Reserve, Yunnan Province, China. Results showed that females who lived long-term in a one-male unit (OMU), without giving birth and with few or no relatives, were more likely to leave that OMU. In addition, an OMU led by an outgroup male and containing more female relatives was significantly more likely to be chosen for immigration. Conversely, greater male age, longer male tenure, and more potentially fertile females discouraged immigration into an OMU. These results suggest that reproduction, male quality, and kin cooperation play the largest roles in female Yunnan snub-nosed monkey dispersal. | Wan-Cai Xia Sheng-Nan Ji Bao-Ping Ren Xin-Ming He Tai Zhong Ali Krzton Yun Tang Da-Yong Li | 2020 | Zoological Research2020，41，1： | 2 |
| 16 | 小鼠鼻咽部组织相对特异基因调控区的克隆与分析显示文摘通过RT -PCR证实PLUNC基因在小鼠鼻咽部具有相对特异性表达。进一步用染色体步移的方法克隆该基因 5′端旁侧序列 847bp ,网上分析结果提示此序列具有调控活性 ,体外报道基因的研究亦证实这一结果。进一步的研究表明 ,其核心调控区位于转录起始位点上游 2 0 0bp之内。这一工作将为构建鼻咽癌转基因动物提供良好的前提。 | 张玲 李虹 谢鹭 蓝轲 韩为农 冯湘玲 何志巍 姚开泰 He Zhi YAO Kaitai | 2001 | 遗传2001，23，3： | 2 |
| 17 | Characterization of patients and its relationship with medical complaints显示文摘 | NI Xin TAI Jun ZHAO Xiao-lan ZHAO Qiong-shu RAO Yuan-sheng HE Jie XU Jian-li GUO Fu-yong FAN Li-hua | 2012 | Chinese Medical Journal2012，，10： | 2 |
| 18 | Performance analysis of a block-neighborhood-based self-recovery fragile watermarking scheme 显示文摘 | HE Hongjie CHEN Fan TAI H M | 2012 | IEEE Transactions on Information Forensics and Security2012，7，1： | 1 |
| 19 | The cytotoxicity of cadmium-based quantum dots显示文摘 | Nan Chen Yao He Yuanyuan Su Xiaoming Li Qing Huang Haifeng Wang Xiangzhi Zhang Renzhong Tai Chunhai Fan | 2011 | Biomaterials2011，，5： | 1 |
| 20 | Synthesis of 3-(R)-(Adenin-9'-yl)-4-(R)-Hydroxy-5-(R)-Hydroxymethyltetrahydrofuran显示文摘Synthesisof3-(R)-(Adenin-9'-yl)-4-(R)-Hydroxy-5-(R)Hydroxymethyltetrahydrofuran￥HuYiZHANG;XueJunWU;HongWuYU;LingTaiMA;LiHeZHA... | Hu Yi ZHANG Xue Jun WU Hong Wu YU Ling Tai MA Li He ZHANG(School of Pharmaceutical Sciences,Beijing Medical UuiversityBeijing 100083) | 1996 | Chinese Chemical Letters1996，7，12： | 1 |
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