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| 1 | Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer显示文摘Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer(CRC),and the importance of angiogenesis in cancer progression has been established.Computed tomography(CT)perfusion(CTP)based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics.CTP has been reported to characterize tumor angiogenesis,and to be a sensitive marker for predicting recurrence or survival in CRC.In this review,we will discuss the biomarker value of CTP in the management of CRC patients. | Koichi Hayano Takeshi Fujishiro Dushyant V Sahani Asami Satoh Tomoyoshi Aoyagi Gaku Ohira Toru Tochigi Hisahiro Matsubara Kiyohiko Shuto | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 2 | New approaches for precise response evaluation in hepatocellular carcinoma显示文摘With the increasing clinical use of cytostatic and novel biologic targeted agents,conventional morphologic tumor burden assessments,including World Health Organization criteria and Response Evaluation Criteria in Solid Tumors,are confronting limitations because of their difficulties in distinguishing viable tumor from necrotic or fibrotic tissue.Therefore,the investigation for reliable quantitative biomarkers of therapeutic response such as metabolic imaging or functional imaging has been desired.In this review,we will discuss the conventional and new approaches to assess tumor burden.Since targeted therapy or locoregional therapies can induce biological changes much earlier than morphological changes,these functional tumor burden analyses are very promising.However,some of them have not gone thorough all steps for standardization and validation.Nevertheless,these new techniques and criteria will play an important role in the cancer management,and provide each patient more tailored therapy. | Koichi Hayano Jorge M Fuentes-Orrego Dushyant V Sahani | 2014 | World Journal of Gastroenterology2014，20，12： | 4 |
| 3 | Arterio-biliary fistula as rare complication of chemoradiation therapy for intrahepatic cholangiocarcinoma显示文摘Significant hemobilia due to arterio-biliary fistula is a very rare complication of chemoradiation therapy(CRT) for unresectable intrahepatic cholangiocarcinoma(ICC).Here we report a case of arterio-biliary fistula after CRT for unresectable ICC demonstrated by angiographic examinations.This fistula was successfully treated by endovascular embolization.Hemobilia is a rare complication,but arterio-biliary fistula should be considered after CRT of ICC. | Koichi Hayano Fumihiko Miura Hodaka Amano Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Takehide Asano | 2010 | World Journal of Radiology2010，2，9： | 3 |
| 4 | Polysomnographic assessment of respiratory disturbance during deep propofol sedation for endoscopic submucosal dissection of gastric tumors显示文摘AIM To investigate that polysomnographic monitoring can accurately evaluate respiratory disturbance incidence during sedation for gastrointestinal endoscopy compare to pulse oximetry alone.METHODS This prospective observational study included 10 elderly patients with early gastric cancer undergoing endoscopic submucosal dissection(ESD) under propofol sedation. Apart from routine cardiorespiratory monitoring, polysomnography measurements were acquired. The primary hypothesis was tested by comparing the apnea hypopnea index(AHI), defined as the number of apnea and hypopnea instances per hour during sedation, with and without hypoxemia; hypoxemia was defined as the reduction in oxygen saturation by ≥ 3% from baseline.RESULTS Polysomnography(PSG) detected 207 respiratory disturbances in the 10 patients. PSG yielded a significantly greater AHI(10.44 ± 5.68/h) compared with pulse oximetry(1.54 ± 1.81/h, P < 0.001), thus supporting our hypothesis. Obstructive AHI(9.26 ± 5.44/h) was significantly greater than central AHI(1.19 ± 0.90/h, P < 0.001). Compared with pulse oximetry, PSG detected the 25 instances of respiratory disturbances with hypoxemia 107.4 s earlier on average.CONCLUSION Compared with pulse oximetry, PSG can better detect respiratory irregularities and thus provide superior AHI values, leading to avoidance of fatal respiratory complications during ESD under propofol-induced sedation. | Ryuma Urahama Masaya Uesato Mizuho Aikawa Yukiko Yamaguchi Koichi Hayano Tomoaki Matsumura Makoto Arai Reiko Kunii Shiroh Isono Hisahiro Matsubara | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 3 |
| 5 | Is pancreatectomy with arterial reconstruction a safe and useful procedure for locally advanced pancreatic cancer?显示文摘 | Hodaka Amano Fumihiko Miura Naoyuki Toyota Keita Wada Ken-ichirou Katoh Kouichi Hayano Susumu Kadowaki Makoto Shibuya Sawako Maeno Tomoaki Eguchi Tadahiro Takada Takehide Asano | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 2 |
| 6 | Long-term submergence of non-methanogenic oxic upland field soils helps to develop the methanogenic archaeal community as revealed by pot and field experiments显示文摘The community structure of methanogenic archaea is relatively stable,i.e.,it is sustained at a high abundance with minimal changes in composition,in paddy field soils irrespective of submergence and drainage.In contrast,the abundance in non-methanogenic oxic soils is much lower than that in paddy field soils.This study aimed to describe methanogenic archaeal community development following the long-term submergence of non-methanogenic oxic upland field soils in pot and field experiments.In the pot experiment,a soil sample obtained from an upland field was incubated under submerged conditions for 275 d.Soil samples periodically collected were subjected to culture-dependent most probable number(MPN)enumeration,polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE)analysis of archaeal 16 S r RNA gene,and quantitative PCR analysis of the methyl-coenzyme M reductase alpha subunit gene(mcr A)of methanogenic archaea.The abundance of methanogenic archaea increased from 102 to 103 cells g-1 dry soil and 104 to 107 copies of mcr A gene g-1 dry soil after submergence.Although no methanogenic archaeon was detected prior to incubation by the DGGE analysis,members from Methanocellales,Methanosarcinaceae,and Methanosaetaceae proliferated in the soils,and the community structure was relatively stable once established.In the field experiment,the number of viable methanogenic archaea in a rice paddy field converted from meadow(reclaimed paddy field)was monitored by MPN enumeration over five annual cycles of field operations.Viability was also determined simultaneously in a paddy field where the plow layer soil from a farmer’s paddy field was dressed onto the meadow(dressed paddy field)and an upland crop field converted from the meadow(reclaimed upland field).The number of viable methanogenic archaea in the reclaimed paddy field was below the detection limit before the first cultivation of rice and in the reclaimed upland field.Then,the number gradually increased over five years and finally reached 103–104 cells g-1 dry soil,which was comparable to that in the dressed paddy field.These findings showed that the low abundance of autochthonous methanogenic archaea in the non-methanogenic oxic upland field soils steadily proliferated,and the community structure was developed following repeated and long-term submergence.These results suggest that habitats suitable for methanogenic archaea were established in soil following repeated and long-term submergence. | Takeshi WATANABE Susumu ASAKAWA Koichi HAYANO | 2020 | Pedosphere2020，30，1： | 2 |
| 7 | Imaging biomarkers for the treatment of esophageal cancer显示文摘Esophageal cancer is known as one of the malignant cancers with poor prognosis.To improve the outcome,combined multimodality treatment is attempted.On the other hand,advances in genomics and other“omic”technologies are paving way to the patient-oriented treatment called“personalized”or“precision”medicine.Recent advancements of imaging techniques such as functional imaging make it possible to use imaging features as biomarker for diagnosis,treatment response,and prognosis in cancer treatment.In this review,we will discuss how we can use imaging derived tumor features as biomarker for the treatment of esophageal cancer. | Koichi Hayano Gaku Ohira Atsushi Hirata Tomoyoshi Aoyagi Shunsuke Imanishi Toru Tochigi Toshiharu Hanaoka Kiyohiko Shuto Hisahiro Matsubara | 2019 | World Journal of Gastroenterology2019，25，24： | 2 |
| 8 | Population dif- ferentiation in the Pacific white-sided dolphin Lageno- rhynchus obllquidens inferred from mitochondrial DNA and microsatellite analyses 显示文摘 | Hayano A Yoshioka M Tanaka M | 2004 | Zoological Science2004，21，9： | 1 |
| 9 | Properties of protease extracted from tea-field soil 显示文摘 | KA MIMURA Y HAYANO K | 2000 | Biology and Fertilily of Soils2000，30，： | 1 |
| 10 | Thin film transformer and its analysis by integral equation method显示文摘 | Midorikawa Y Hayano S and Saito Y | 1995 | IEEE Transactions on Magnetics1995，31，4： | 1 |
| 11 | Peptidyl-prolyl cistrans isomerase is the eyclosporin A-binding protein cyclophilin显示文摘 | Takahashi N Hayano T Suzuki M | 1989 | Nature1989，337，： | 1 |
| 12 | rnteractive associations of depression and sleep apnea with adverse clinical outcomes after acute myocardial infarction 显示文摘 | Hayano J Carney RM Watanabe E | 2012 | Psychosom Med2012，74，8： | 1 |
| 13 | Seasonal variation of soil protease activities and their relation to proteolytic bacteria and bacillus spp in paddy field soil 显示文摘 | WATANABE K HAYANO K | 1995 | Soil Biology and Biochemistry1995，27，2： | 1 |
| 14 | Magnetiza- tion curve plotting from the magnetic domain images 显示文摘 | ENDO H HAYANO S SAITO Y | 2001 | IEEE Transactions on Magnetics2001，37，4： | 1 |
| 15 | Aging of complex heart rate dynamics显示文摘 | Struzik ZR Hayano J Soma R | 2006 | IEEE Trans Biomed Eng2006，53，： | 1 |
| 16 | A Novel Method of Dissolving Chitosan in Water for Indurstral Application显示文摘 | Yasuo SAKAI Koiehi HAYANO Hiroe YOSHIOKA | 2001 | Polymer Journal2001，33，8： | 1 |
| 17 | Cesium-137 deposition and contamination of Japanese soils due to the Fukushima nuclear accident显示文摘 | Yasunaria T J Stohl A Hayano R S | 2011 | PNAS2011，108，49： | 1 |
| 18 | Chitosan coating of Cellulosic Material Using an Aqueous Chitosan-CO2 Solution 显示文摘 | Yasuo SAKAI Koichi HAYANO Hiroe YOSHIOKA | 2001 | Polymer Journal2001，34，3： | 1 |
| 19 | Decreased Magnitude of Heart Rate Spectral Components in Coronary Artery Disease Its Relations to Antiographic Severity显示文摘 | Sakakibara Y Yamada M | 1990 | Circulation1990，81，： | 1 |
| 20 | Chitosancoating of Cellulosic Materials Using an Aqueous Chitosan-CO2 Solution显示文摘 | Yasuo SAKAI Koichi HAYANO Hime YOSHIOKA | 2002 | Polymer Journal2002，34，3： | 1 |
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