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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Extending path summary and region encoding for efficient structural query processing in native XML databases 显示文摘 | Haw S C Lee C S | 2009 | Journal of Systems and Software2009，82，6： | 1 |
| 3 | Efect ofpectinmethylesterase gene expression on pea root development显示文摘 | WEN F ZHU Y HAWES M C | 1999 | Plant Cell1999，11，： | 1 |
| 4 | Structural and mechanistic investigation of a phosphatemodified HZSM-5 catalyst for methanol conversion显示文摘 | Abubakar S M Marcus D M Lee J C Ehresmann J O Chen C Y Kletnieks P W Guenther D R Hayman M J Pavlova M Nicholas J B Haw J F | | 0，，10： | 1 |
| 5 | Prospects and pitfalls: use of the rai-hc assessment by the department of veterans affairs for home care clients 显示文摘 | Hawes C Fries BE James ML | 2007 | Gerontologist2007，47，3： | 1 |
| 6 | Fate and effects of enrofloxacin in aquatic systems under different light conditions 显示文摘 | Knapp C W Cardoza L A Hawes J N | 2005 | Environmental Science & Technology2005，39，23： | 1 |
| 7 | Arable plant com- munities as indicators of farming practice显示文摘 | Hawes C Squire G R Hallett P D | 2010 | Agric Ecosyst Environ2010，138，12： | 1 |
| 8 | Antipsychotics for BPSD:an audit of prescribing practice in a specialist psychiatric inpatient unit 显示文摘 | Haw C Stubbs J Yorston G | 2008 | Int Psychogeriatr2008，29，4： | 1 |
| 9 | Investigation of the ther-mal performance of a passive solar test-room with wall latent heat storage显示文摘 | Athienitis A K Liu C Hawes D | 1997 | Building and Environment1997，32，5： | 1 |
| 10 | The carbon footprints of food crop production 显示文摘 | Hillier J Hawes C Squire G | 2009 | International Journal of Agricultural Sustainability2009，7，2： | 1 |
| 11 | Data storage practices and query pro?cessing in XML databases: a survey显示文摘 | Haw S C Lee C S | 2011 | Knowledge-Based Systems2011，24，8： | 1 |
| 12 | Does open reduction increase the chance of infection during intramedullary nailing of closed tibial shaft fractures显示文摘 | Tang P Gates C Hawes J | 2006 | J Orthop Trauma2006，5，： | 1 |
| 13 | Effects of carbon black types on treadwear of radial and bias tires at variable test severities显示文摘 | Wilder C R Haws J R Cooper W T | 1981 | RCT1981，，54： | 1 |
| 14 | Characterization of multilayered piezoelectric ceramics for high power transducers显示文摘 | DUBUS B HAW G GRANGER C | 2002 | Ultrasonics2002，40，： | 1 |
| 15 | Possible role of root border cells in detection and avoidance of aluminum toxicity显示文摘 | MIYASAKA S C HAWES M C | 2001 | Plant physiol2001，125，： | 1 |
| 16 | Association between HLA- DQB1 and cervical dysplasia in Vietnamese women 显示文摘 | Lema C Fuessel - Haws AL Lewis LR | 2006 | Int J Gynecol Cancer2006，16，3： | 1 |
| 17 | Characterization of multilayered piezoelectric ceramics for high power transducers显示文摘 | DUBUS B HAW G GRANGER C | 2002 | Ultrasonics2002，40，： | 1 |
| 18 | Investigation of the thermal performance of a passive solar test room with wall latent heat storage 显示文摘 | Athienitis A K Liu C Hawes D W | 1997 | Buliding and Environment1997，32，5： | 1 |
| 19 | Coatings reduce the fouling of microfiltration membranes显示文摘 | AKHTAR S Hawes C | 1995 | J Membr Sci1995，107，3： | 1 |
| 20 | LatePleistocence Raised Beaches of Coastal Estremadura,Central Portugal 显示文摘 | Benedetti M M Haws J A Funk C L | 2009 | Quaternary Science Reviews2009，28，： | 1 |
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