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| 1 | Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy显示文摘AIM To compare the effectiveness and safety of vonoprazan-based therapy with proton pump inhibitor(PPI)-based therapies to treat Helicobacter pylori(H. pylori).METHODS We retrospectively analysed data from first-line(vonoprazan or PPI with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 d)(n = 1353) and second-line(vonoprazan or PPI with 250 mg metronidazole and 750 mg amoxicillin twice daily for 7 d)(n = 261) eradication treatments for H. pylori- positive patients with associated gastrointestinal diseases from April 2014 to December 2015 at Hattori Clinic, Japan. The primary endpoint was the eradication rate, which was assessed with a full analysis set. The secondary endpoints were adverse events and related factors.RESULTS After the first-line treatments, the eradication rates for vonoprazan, esomeprazol, rabeprazole, and lansoprazole were 87.9%(95%CI: 84.9%-90.5%), 71.6%(95%CI: 67.5%-75.5%), 62.9%(95%CI: 52.0%-72.9%), and 57.3%(95%CI: 50.4%-64.1%), respectively. The vonoprazan eradication rate was significantly higher than that of the PPIs(P < 0.01). Interestingly, smoking did not affect the H. pylori eradication rate in the vonoprazan group(P = 0.34), whereas it decreased the rates in the PPI groups(P = 0.013). The incidence of adverse events in the vonop-razan group was not different from the PPI group(P = 0.054), although the vonoprazan group exhibited a wider range of adverse events. Vonoprazan-based triple therapy was highly effective as a second-line treatment, with an eradication rate similar to that of PPI-based therapy.CONCLUSION Vonoprazan might be superior to PPIs in first-line H. pylori therapy, particularly for smokers. However, caution is required due to possible adverse events. | Kouichi Sakurai Hiroko Suda Yumi Ido Takayuki Takeichi Ayako Okuda Kiwamu Hasuda Masahiro Hattori | 2017 | World Journal of Gastroenterology2017，23，4： | 16 |
| 2 | Postoperative outcome and sites of recurrence in patients following curative resection of gastric cancer显示文摘 | Maehara Y Hasuda S Koga T | 2000 | Br J Surg2000，，87： | 1 |
| 3 | Postoprative outcome and sites of recurrence in patients following curative resection of gastric cancer 显示文摘 | Machara Y Hasuda S Koga T | 2000 | British Journal of Surgery2000，87，3： | 1 |
| 4 | Postoperative outcome andsites of recurrence in patients following curative resection of gastriccancer显示文摘 | Maehara Y Hasuda S Koga T | 2000 | Br J Surg2000，87，3： | 1 |
| 5 | The benefit of laparoscopy-assisted distal gastrectomy compared with conventional open distal gastrectomy:a case-matched control study显示文摘 | Migoh S Hasuda K Nakashima K | 2003 | Hepatogastroenterology2003，50，： | 1 |
| 6 | Clincal application of hyperthermia combined with anticancer drugs for the treatment of solid tumors 显示文摘 | Takahashi L Emi Y Hasuda S | 2002 | Surgery2002，131，1： | 1 |
| 7 | Prognostic value of p53 protein expression for patients with gastric cancer - amultivariate analysis 显示文摘 | Maehara Y Tomoda M Hasuda S | 1999 | Br J Cancer1999，79，78： | 1 |
| 8 | Hyperproduction of extracellular lowmolecular weight protein A by Staphylococcus aureus显示文摘 | Kusunoki H Hasuda K | 1988 | Nippon Nogeikagaku Kaishi1988，，62： | 1 |
| 9 | A novel therapy for internal hemorrhoids:ligation of the hemorrhoidal artery with a newly devised instrument (Moricorn) in conjunction with a Doppler flowmeter显示文摘 | MORINAGA K HASUDA K IKEDA T | 1995 | The American Journal of Gastroenterology1995，90，4： | 1 |
| 10 | Fluorina-tion of triptolide and its analogues and their cytotoxicity显示文摘 | Aoyagi Y Hitotsuyanagi Y Hasuda T | 2008 | Bioorg Med Chem Lett2008，18，7： | 1 |
| 11 | The contribution of lac-tic acid to acidification of tumours:Studies of variant cells lackinglactate dehydrogenase显示文摘 | Yamagata M Hasuda K Stamato T | 1998 | British J Cancer1998，77，11： | 1 |
| 12 | A novel therapy for internal hemor- rhoids: ligation of the hemorrhoidal artery with a newly devised in- strument (Moricorn) in conjunction with a doppler flowmeter显示文摘 | Morinaga K Hasuda K Ikeda T | 1995 | Am J Gastroenterol1995，90，4： | 1 |
| 13 | A novel therapy for internal hemorrhoids: ligation of the hemorrhoidal artery with a newly devised instrument (Moricorn) in oniunetion with a Doppler flowmeter显示文摘 | Morinaga K Hasuda K Ikeda T | 1995 | Am J Gastroenterol1995，90，： | 1 |
| 14 | Prognostic value ofP53protein expression for patients with gastric cancer:amulti-variate analysis显示文摘 | Maehara Y Tomoda M Hasuda S | 1999 | Br J Cancer1999，79，12： | 1 |
| 15 | New Epoxy-imide resins cured with bis(hydroxylphthalimide) s 显示文摘 | Toshihiro Ichino Yoshonori Hasuda | 1987 | J Appl Polym Sci1987，34，： | 1 |
| 16 | Prognostic value of P53 protein expression for patients with gastric cancer-a multivariate analysis显示文摘 | Tomoda M Hasuda S | 1999 | Br J Cancer1999，79，： | 1 |
| 17 | Prognostic value of p53 protein expression for patients with gasrric cancer-a multivariate analysis显示文摘 | Maehara Y Tomoda M Hasuda S | 1999 | Br J Cancer1999，79，10： | 1 |
| 18 | Cutting and grinding of glass-like carbon显示文摘 | Hasuda Y | 1996 | Progress of Cutting and Grinding(Japan)1996，，： | 1 |
| 19 | A novel therapy for internal hemorrhoids:ligation of the hemorrhoidal artery with a newly devised instrument (Moricorn) in conjunction with a Doppler flowmeter显示文摘 | Morinaga K Hasuda K Ikeda T | 1995 | Am J Gastroenterol1995，90，4： | 1 |
| 20 | Clinical application of hyperthermia combined with anticancer drugs for the treatment of solid tumors显示文摘 | Takahashi I Emi Y Hasuda S | 2002 | Surgery2002，131，1： | 1 |
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