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| 1 | 镉胁迫对不同水稻基因型植株生长和抗氧化酶系统的影响显示文摘以籽粒镉积累水平不同的两种品种 (丙 972 5 2 ,低积累型 ;秀水 6 3,高积累型 )为材料 ,研究了镉胁迫对水稻植株生长和抗氧化酶系统的影响。采用水培试验 ,镉处理设 0 .0、0 .1、1.0和 5 .0 μmol/L 4个水平。结果表明 ,镉胁迫抑制植株生长和叶绿素合成 ,改变植株丙二醛 (MDA)含量和超氧物歧化酶 (SOD)、过氧化氢酶 (CAT)、过氧化物酶 (POD)活性。在抗氧化酶活性上 ,根和地上部对镉胁迫的反应存在着差异。总体上 ,SOD、CAT和POD活性随镉水平的提高而减少 ,而MDA含量则表现相反。根和地上部MDA含量随着培养液中镉浓度提高而增加 ,且增加幅度秀水 6 3明显大于丙 972 5 2。与对照相比 ,生长在 5 .0 μmol/LCd处理下的植株 ,SOD活性在孕穗期下降 4 6 %~ 5 2 % ,在分蘖期仅下降 13%~ 19%。高浓度镉胁迫下 ,两品种在MDA含量的增加幅度和叶绿素含量的降低幅度上表现不同 ,显示出它们对镉的耐性存在着差异。 | 邵国胜 MUHAMMAD Jaffar Hassan 章秀福 张国平 | 2004 | 中国水稻科学2004，18，3： | 107 |
| 2 | Current status and future strategies of cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis显示文摘This article is to offer a concise review on the use of cytoreductive surgery (CRS) plus intraperitoneal hyperthermic chemotherapy (IPHC) for the treatment of peritoneal carcinomatosis (PC). Traditionally, PC was treated with systemic chemotherapy alone with very poor response and a median survival of less than 6 mo. With the establishment of several phase Ⅱ studies, a new trend has been developed toward the use of CRS plus IPHC as a standard method for treating selected patients with PC, in whom sufficient cytoreduction could be achieved. In spite of the need for more high quality phase Ⅲ studies, there is now a consensus among many surgical oncology experts throughout the world about the use of this new treatment strategy as standard care for colorectal cancer patients with PC. This review summarizes the current status and possible progress in future. | Hassan Alaa Hammed al-Shammaa Yan Li Yutaka Yonemura | 2008 | World Journal of Gastroenterology2008，14，8： | 50 |
| 3 | GRADE指南:Ⅵ.证据质量评价--不精确性(随机误差)显示文摘GRADE建议通过检查95%可信区间(CI)为决定不精确性的最佳方法。在指南实际运用中,如果CI的上、下限值代表了真实效应,而临床实际情况与之不符时,必须降低证据质量级别(即对效应估计值的把握度)。除外当效应值很大且可信区间提示效应稳健,而总样本量不大且事件数很少的情况,其他应考虑因不精确性而降低证据质量级别。作此决定时,可计算有足够检验效能的单个试验所需的病例数(定义为'最优信息样本量',即optimal information size,OIS)。对连续型变量,我们建议用类似方法,首先考虑可信区间上、下限值,再计算OIS。系统评价(SR)所需方法略有不同。如果95%CI不包括相对危险度(RR)为1,且总事件发生数或病例数超过OIS标准,则精确性良好。如果95%CI包括了明显获益或危害(我们建议以RR值<0.75或>1.25作粗标准),即使达到OIS要求,因不精确性而降低证据质量级别较恰当。 | Gordon Guyatt Andrew D.Oxman Regina Kunz Jan Brozek Pablo Alonso-Coello David Rind PJ Devereaux Victor M.Montori Bo Freyschuss Gunn Vist Roman Jaeschke John W.Williams Jr. Mohammad Hassan Murad David Sinclairk Yngve Falck-Ytter Joerg Meerpohl Craig Whittington Kristian orlund Je Andrews Holger J.Schünemann 代表GRADE工作组 李幼平 王莉 陈尹 高霑 | 2011 | 中国循证医学杂志2011，11，12： | 43 |
| 4 | Accuracy of urea breath test in Helicobacter pylori infection: Meta-analysis显示文摘AIM: To quantitatively summarize and appraise the available evidence of urea breath test(UBT) use to diagnose Helicobacter pylori(H. pylori) infection in patients with dyspepsia and provide pooled diagnostic accuracy measures.METHODS: We searched MEDLINE, EMBASE, Cochrane library and other databases for studies addressing the value of UBT in the diagnosis of H. pylori infection. We included cross-sectional studies that evaluated the diagnostic accuracy of UBT in adult patients with dyspeptic symptoms. Risk of bias was assessed using QUADAS(Quality Assessment of Diagnostic Accuracy Studies)-2 tool. Diagnostic accuracy measures were pooled using the random-effects model. Subgroup analysis was conducted by UBT type(13C vs 14C) and by measurement technique(Infrared spectrometry vs Isotope Ratio Mass Spectrometry).RESULTS: Out of 1380 studies identified, only 23 met the eligibility criteria. Fourteen studies(61%) evaluated 13 C UBT and 9 studies(39%) evaluated 14 C UBT. There was significant variation in the type of reference standard tests used across studies.Pooled sensitivity was 0.96(95%CI: 0.95-0.97) andpooled specificity was 0.93(95%CI: 0.91-0.94). Likelihood ratio for a positive test was 12 and for a negative test was 0.05 with an area under thecurve of 0.985. Meta-analyses were associated with a significant statistical heterogeneity that remained unexplained after subgroup analysis. The included studies had a moderate risk of bias.CONCLUSION: UBT has high diagnostic accuracy for detecting H. pylori infection in patients with dyspepsia. The reliability of diagnostic meta-analytic estimates however is limited by significant heterogeneity. | Mazen Ferwana Imad Abdulmajeed Ali Alhajiahmed Wedad Madani Belal Firwana Rim Hasan Osama Altayar Paul J Limburg Mohammad Hassan Murad Bandar Knawy | 2015 | World Journal of Gastroenterology2015，21，4： | 45 |
| 5 | 颈动脉粥样硬化疾病的处理美国血管外科学会临床实践指南显示文摘美国血管外科学会(SVS)任命了一个专家委员会制定颈动脉狭窄处理的循证临床指南。在制定临床实践推荐意见过程中,该委员会使用系统评价对当前最件的证据进行了总结,采用GRADE标准对推荐意见的强度(强烈推荐为GRADEI级,一般推荐为GRADEⅡ级)和证据的质量(高、中、低和极低)进行了分级。对于轻度颈动脉狭窄患者(有症状患者狭窄程度〈50%和无症状患者狭窄程度〈60%),推荐进行最佳的内科治疗而非血管重建术(I级推荐,高质量证据)。对于有症状中到重度狭窄患者(狭窄程度≥50%),推荐行颈动脉内膜切除术(CEA)+最佳的内科治疗(I级推荐,高质量证据)。对于围手术期风险高的有症状巾到重度狭窄患者(狭窄程度≥50%),建议采用颈动脉支架置入术作为其替代治疗手段(Ⅱ级推荐,低质量证据)。对于中到重度狭窄的无症状患者(狭窄程度≥60%),只要围手术期风险较低,就推荐行CEA+内科治疗(I级推荐,高质量证据)。对于中到重度狭窄的尢症状患者(狭窄稗度≥60%),不推荐行颈动脉支架置入术(I级推荐,低质量证据)。颈动脉狭窄≥80%但存在CEA高危解剖学风险的患者可能是一个例外。 | Robert W. Hobson, Ⅱ William C. Mackey Enrico Ascher M. Hassan Murad Keith D. Calligaro Anthony J. Comerota Victor M. Montori Mark K. Eskandari Douglas W. Massop Ruth L. Bush Brajesh K. Lal Bruce A. Perler 刘德志(译) 徐格林(译) 刘新峰(译) | 2008 | 国际脑血管病杂志2008，16，12： | 35 |
| 6 | 可变速抽水蓄能发电技术应用与进展显示文摘可变速抽水蓄能可成为电网负荷频率控制、平衡可再生能源发电出力波动的有效手段。论文在介绍可变速抽水蓄能整体结构的基础上,重点介绍了交交方式和交直交方式变频励磁单元的拓扑和构成。说明了交交方式具有器件少、可靠性高、易于大容量化等优点,但存在频率只能整数倍减小、无法实现大范围连续调节、响应速度较慢等缺点。而交直交方式具有频率可大范围连续调节、响应速度较快等特点,其性价比呈快速上升趋势。分析了机组在发电方式和电动方式时运行的变速原理和调节过程。通过发电出力与转速的关系曲线说明通过转速控制实现最佳出力的过程。通过泵类负荷输入功率与转速的关系,描述了电动方式下调节转速对电网功率调节的作用。综合考虑能量平衡、波动负荷与可再生能源发电出力跟踪控制及电压稳定控制的需求,形成参考功率。在此基础上,采用d-q解耦方法实现可变速机组有功与无功功率的控制。最后,通过电网功率调节、电压波动控制及风电功率波动抑制示例,阐述了可变速机组对电网运行的控制作用。 | 韩民晓 Othman Hassan ABDALLA | 2013 | 科技导报2013，31，16： | 37 |
| 7 | Nonalcoholic fatty liver disease:A comprehensive review of a growing epidemic显示文摘Nonalcoholic fatty liver disease(NAFLD)is quickly becoming one of the most prominent causes of liver disease worldwide.The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it.Current efforts to elucidate the mechanism and causes of the disease have answered some questions,but much remains unknown about NAFLD.The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease,as well as the current and future diagnostic,preventative,and therapeutic options available to clinicians for the management of NAFLD. | Kareem Hassan Varun Bhalla Mohammed Ezz El Regal H Hesham A-Kader | 2014 | World Journal of Gastroenterology2014，20，34： | 36 |
| 8 | Follow-up of intestinal metaplasia in the stomach: When, how and why显示文摘Gastric cancer remains the second most frequent cause of cancer-related mortality in the world. Screening programs in some Asian countries are impractical in the majority of other countries worldwide. Therefore, follow-up of precancerous lesions is advisable for secondary gastric cancer prevention. Intestinal metaplasia (IM) is recognized as a precancerous lesion for gastric cancer, increasing the risk by 6-fold. IM is highly prevalent in the general population, being detected in nearly 1 of every 4 patients undergoing upper endoscopy. The IM prevalence rate is significantly higher in patients with Helicobacter pylori (H. pylori) infection, in first-degree relatives of gastric cancer patients, in smokers and it increases with patient age. IM is the 'breaking point' in the gastric carcinogenesis cascade and does not appear to regress following H. pylori eradication, although the cure of infection may slow its progression. Gastric cancer risk is higher in patients with incomplete-type IM, in those with both antral and gastric body involvement, and the risk significantly increases with IM extension over 20% of the gastric mucosa. Scheduled endoscopic control could be cost-effective in IM patients, depending on the yearly incidence of gastric cancer in IM patients, the stage of gastric cancer at diagnosis discovered at surveillance, and the cost of endoscopy. As a pragmatic behavior, yearly endoscopic control would appear justified in all IM patients with at least one of these conditions: (1) IM extension > 20%; (2) the presence of incomplete type IM; (3) first-degree relative of gastric cancer patients; and (4) smokers. In the remaining IM patients, a less intensive (2-3 years) could be proposed. | Angelo Zullo Cesare Hassan Adriana Romiti Michela Giusto Carmine Guerriero Roberto Lorenzetti Salvatore MA Campo Silverio Tomao | 2012 | World Journal of Gastrointestinal Oncology2012，4，3： | 25 |
| 9 | Personal Review:Sources of sulfide in waste streams and current biotechnologies for its removal显示文摘Sulfide-containing waste streams are generated by a number of industries. It is emitted into the environment as dis- solved sulfide (S2- and HS-) in wastewaters and as H2S in waste gases. Due to its corrosive nature, biological hydrogen sulfide removal processes are being investigated to overcome the chemical and disposal costs associated with existing chemically based removal processes. The nitrogen and sulfur metabolism interacts at various levels of the wastewater treatment process. Hence, the sulfur cycle offers possibilities to integrate nitrogen removal in the treatment process, which needs to be further optimized by appropriate design of the reactor configuration, optimization of performance parameters, retention of biomass and optimization of biomass growth. The present paper reviews the biotechnological advances to remove sulfides from various environments. | MAHMOOD Qaisar ZHENG Ping CAI Jing HAYAT Yousaf HASSAN Muhammad Jaffar WU Dong-lei HU Bao-lan | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，7： | 22 |
| 10 | AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men显示文摘瞄准:第一次评估 Y 染色体的频率,并且讨论 AZF 删除的临床的意义微删除和在摩洛哥的人的 AZFc 区域的部分删除的出现。方法:我们屏蔽了 Y 染色体微删除和不肥沃的人的一个连续的组的 AZFc 区域的部分删除(n = 149 ) 并且控制(100 个肥沃的人, 76 个 normospermic 人) 。AZFa, AZFb, AZFc 和 AZFc 区域的部分删除被聚合酶链反应(PCR ) 根据确定的协议分析。结果:在为微删除屏蔽的 127 个不肥沃的人之中,四个题目被发现有微删除:二 AZFc 删除和二 AZFb+AZFc 删除。所有删除仅仅在 azoospermic 题目被发现(4/48, 8.33%) 。全面 AZFc 删除频率是低的(4/127, 3.15%) 。AZF 微删除没在 oligoasthenoteratozoospermia (燕麦) 或控制被观察。AZFc (gr/gr ) 的部分删除总共部分 AZFc 删除(gr/gr ) 在控制组被发现的 149 个不肥沃的人(4.70%) 中的 7 个和 7 的被观察(7/176, 3.98%) 。另外,二 b2/b3 删除在二个 azoospermic 题目被识别(2/149, 1.34%) 然而并非在控制组。结论:我们的结果建议 Y 染色体 AZF 微删除的频率与严重 spermatogenic 失败在个人被提高并且 gr/gr 删除没与 spermatogenic 失败被联系。 | Laila Imken Brahim El Houate Abdelaziz Chafik Halima Nahili Redouane Boulouiz Omar Abidi Elbakkay Chadli Noureddine Louanjli Abdelouhab Elfath Mohammed Hassar Ken McElreavey Abdelhamid Barakat Hassan Rouba | 2007 | Asian Journal of Andrology2007，9，5： | 22 |
| 11 | Nosocomial infections:Epidemiology,prevention,control and surveillance显示文摘Nosocomial infections or healthcare associated infections occur in patients under medical care.These infections occur worldwide both in developed and developing countries.Nosocomial infections accounts for 7% in developed and 10% in developing countries.As these infections occur during hospital stay,they cause prolonged stay,disability,and economic burden.Frequently prevalent infections include central line-associated bloodstream infections,catheter-associated urinary tract infections,surgical site infections and ventilator-associated pneumonia.Nosocomial pathogens include bacteria,viruses and fungal parasites.According to WHO estimates,approximately 15% of all hospitalized patients suffer from these infections.During hospitalization,patient is exposed to pathogens through different sources environment,healthcare staff,and other infected patients.Transmission of these infections should be restricted for prevention.Hospital waste serves as potential source of pathogens and about 20%–25% of hospital waste is termed as hazardous.Nosocomial infections can be controlled by practicing infection control programs,keep check on antimicrobial use and its resistance,adopting antibiotic control policy.Efficient surveillance system can play its part at national and international level.Efforts are required by all stakeholders to prevent and control nosocomial infections. | Hassan Ahmed Khan Fatima Kanwal Baig Riffat Mehboob | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，5： | 22 |
| 12 | Gastric low-grade mucosal-associated lymphoid tissue-lymphoma: Helicobacter pylori and beyond显示文摘The stomach is the most frequently involved site for extranodal lymphomas,accounting for nearly two-thirds of all gastrointestinal cases.It is widely accepted that gastric B-cell,low-grade mucosal-associated lymphoid tissue(MALT)-lymphoma is caused by Helicobacter pylori(H.pylori)infection.MALT-lymphomas may engender different clinical and endoscopic patterns.Often,diagnosis is confirmed in patients with only vague dyspeptic symptoms and without macroscopic lesions on gastric mucosa.H.pylori eradication leads to lymphoma remission in a large number of patients when treatment occurs at an early stage(Ⅰ-Ⅱ1).Neoplasia confined to the submucosa,localized in the antral region of the stomach,and without API2-MALT1 translocation,shows a high probability of remission following H.pylori eradication.When both bacterial infection and lymphoma recur,further eradication therapy is generally effective.Radiotherapy,chemotherapy and,in selected cases,surgery are the available therapeutic options with a high success rate for those patients who fail to achieve remission,while data on immunotherapy with monoclonal antibodies (rituximab)are still scarce.The 5-year survival rate is higher than 90%,but careful,long-term follow-up is required in these patients since lymphoma recurrence has been reported in some cases. | Angelo Zullo Cesare Hassan Francesca Cristofari Francesco Perri Sergio Morini | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 21 |
| 13 | 真空-堆载预压作用下软土蠕变特性试验研究显示文摘采用改进的、可施加负压的三轴仪开展了真空预压、堆载预压以及真空-堆载联合预压作用下软土的固结蠕变试验,描述了加载率、应力比和时间等对软土蠕变特性的影响,分析了轴向应变(率)、体积应变(率)及偏应变(率)与应力比和时间之间的关系。结果表明:轴向应变率和体积应变率与时间的对数关系并非线性,但经过若干天以后可近似认为是线性关系;在不同应力比n下,体应变与时间的关系可用双曲线方程来表示;偏应变、偏应变率与时间的关系符合双曲线方程,通过温州软黏土样的蠕变试验结果验证了其有效性。 | 刘汉龙 扈胜霞 Ali Hassan | 2008 | 岩土力学2008，29，1： | 21 |
| 14 | Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury,both in vivo and in vitro显示文摘Neural stem cells have great potential for the development of novel therapies for nervous system diseases.However,the proliferation of endogenous neural stem cells following brain ischemia is insufficient for central nervous system self-repair.Ginkgolide B has a robust neuroprotective effect.In this study,we investigated the cell and molecular mechanisms underlying the neuroprotective effect of ginkgolide B on focal cerebral ischemia/reperfusion injury in vitro and in vivo.Neural stem cells were treated with 20,40 and 60 mg/L ginkgolide B in vitro.Immunofluorescence staining was used to assess cellular expression of neuron-specific enolase,glial fibrillary acid protein and suppressor of cytokine signaling 2.After treatment with 40 and 60 mg/L ginkgolide B,cells were large,with long processes.Moreover,the proportions of neuron-specific enolase-,glial fibrillary acid protein-and suppressor of cytokine signaling 2-positive cells increased.A rat model of cerebral ischemia/reperfusion injury was established by middle cerebral artery occlusion.Six hours after ischemia,ginkgolide B(20 mg/kg) was intraperitoneally injected,once a day.Zea Longa's method was used to assess neurological function.Immunohistochemistry was performed to evaluate the proportion of nestin-,neuron-specific enolase-and glial fibrillary acid protein-positive cells.Real-time quantitative polymerase chain reaction was used to measure m RNA expression of brain-derived neurotrophic factor and epidermal growth factor.Western blot assay was used to analyze the expression levels of brain-derived neurotrophic factor and suppressor of cytokine signaling 2.Ginkgolide B decreased the neurological deficit score,increased the proportion of nestin-,neuron-specific enolase-and glial fibrillary acid protein-positive cells,increased the m RNA expression of brain-derived neurotrophic factor and epidermal growth factor,and increased the expression levels of brain-derived neurotrophic factor and suppressor of cytokine signaling 2 in the ischemic penumbra.Together,the in vivo and in vitro findings suggest that ginkgolide B improves neurological function by promoting the proliferation and differentiation of neural stem cells in rats with cerebral ischemia/reperfusion injury. | Pei-Dong Zheng Rajneesh Mungur Heng-Jun Zhou Muhammad Hassan Sheng-Nan Jiang Jie-Sheng Zheng | 2018 | Neural Regeneration Research2018，13，7： | 21 |
| 15 | Photocatalysts for degradation of dyes in industrial effluents:Opportunities and challenges显示文摘Discharging dye contaminants into water is a major concern around the world.Among a variety of methods to treat dye-contaminated water,photocatalytic degradation has gained attention as a tool for treating the colored water.Herein,we review the recent advancements in photocatalysis for dye degradation in industrial effluents by categorizing photocatalyst materials into three generations.First generation photocatalysts are composed of single-component materials (e.g.,TiO2,ZnO,and CdS),while second generation photocatalysts are composed of multiple components in a suspension (e.g.,WO3/NiWO4,BiOl/ZnTiOa,and C3N4/Ag3VO4).Photocatalysts immobilized on solid substrates are regarded as third generation materials (e.g.,FTO/WO3-ZnO,Steel/TiO2-WO3,and Glass/P-TiO2).Photocatalytic degradation mechanisms,factors affecting the dye degradation,and the lesser-debated uncertainties related to the photocatalysis are also discussed to offer better insights into environmental applications.Furthermore,quantum yields of different photocatalysts are calculated,and a performance evaluation method is proposed to compare photocatalyst systems for dye degradation.Finally,we discuss the present limitations of photocatalytic dye degradation for field applications and the future of the technology. | Hassan Anwer Asad Mahmood Jechan Lee Ki-Hyun Kim Jae-Woo Park Alex C.K.Yip | 2019 | Nano Research2019，12，5： | 21 |
| 16 | Study of Helicobacter pylori genotype status in saliva,dental plaques,stool and gastric biopsy samples显示文摘AIM:To compare genotype of Helicobacter pylori(H.pylori) isolated from saliva,dental plaques,gastric biopsy,and stool of each patient in order to evaluate the mode of transmission of H.pylori infection.METHODS:This cross-sectional descriptive study was performed on 300 antral gastric biopsy,saliva,dental plaque and stool samples which were obtained from patients undergoing upper gastrointestinal tract endoscopy referred to endoscopy centre of Hajar hospital of Shahrekord,Iran from March 2010 to February 2011.Initially,H.pylori strains were identified by rapid urease test(RUT) and polymerase chain reaction(PCR) were applied to determine the presence of H.pylori(ureC) and for genotyping of voculating cytotoxin gene A(vacA) and cytotoxin associated gene A(cagA) genesin each specimen.Finally the data were analyzed by using statistical formulas such as Chi-square and Fisher's exact tests to find any significant relationship between these genes and patient's diseases.P < 0.05 was considered statistically significant,RESULTS:Of 300 gastric biopsy samples,77.66% were confirmed to be H.pylori positive by PCR assay while this bacterium were detected in 10.72% of saliva,71.67% of stool samples.We were not able to find it in dental plaque specimens.The prevalence of H.pylori was 90.47% among patients with peptic ulcer disease(PUD),80% among patients with gastric cancer,and 74.13% among patients with none ulcer dyspepsia(NUD) by PCR assay.The evaluation of vacA and cagA genes showed 6 differences between gastric biopsy and saliva specimens and 11 differences between gastric and stool specimens.94.42% of H.pylori positive specimens were cagA positive and all samples had amplified band both for vacA s and m regions.There was significant relationship between vacA s1a/m1a and PUD diseases(P = 0.04),s2/m2 genotype and NUD diseases(P = 0.05).No statically significant relationship was found between cagA status with clinical outcomes and vacA genotypes(P = 0.65).The evaluation of vacA and cagA genes showed 6 differences between gastric biopsy and saliva specimens and 11 differences between gastric and stool specimens,CONCLUSION:Regard to high similarity in genotype of H.pylori isolates from saliva,stomach and stool,this study support the idea which fecal-oral is the main route of H.pylori transmission and oral cavity may serve as a reservoir for H.pylori,however,remarkable genotype diversity among stomach,saliva and stool samples showed that more than one H.pylori genotype may exist in a same patient. | Hassan Momtaz Negar Souod Hossein Dabiri Meysam Sarshar | 2012 | World Journal of Gastroenterology2012，18，17： | 21 |
| 17 | Effect of Bainite Morphology on Mechanical Properties of the Mixed Bainite-martensite Microstructure in D6AC Steel显示文摘The effect of bainite morphology on mechanical properties of the mixed bainite-martensite microstructure in D6AC low alloy ultra-high strength steel has been studied in the present work. For this purpose, samples austenitized at 910 C for 40 min were quenched in three different ways. Some of the samples were directly oil-quenched, some others were quenched in salt bath at 330 C and the remaining samples were quenched in salt bath at 425 C for various holding times. All samples were tempered at 200 C for 2 h. Microstructures were examined by optical microscopy (OM) and scanning electron microscopy (SEM). Fracture surfaces also were studied by SEM. Results showed that the mixed microstructure containing martensite and 28 vol.% of the lower bainite exhibited higher yield and tensile strengths than the fully martensitic microstructure. This could be mainly attributed to the partitioning of the prior austenite grains by the lower bainite and enhancing the strength of lower bainite in the mixed microstructure by plastic constraint. Charpy V-notch (CVN) impact energy and ductility were improved by increasing the volume fraction of the lower bainite. This is not the case about the mixed microstructure containing the upper bainite and martensite. As a result, the tensile and CVN impact properties of mixed upper bainite-martensite microstructure are lower than those of the fully martensitic microstructure. Finally, fractography studies showed cleavage fracture at the surface of CVN impact specimens with martensitic and upper bainitic microstructures confirming the tendency to brittle behavior. | Khodamorad Abbaszadeh Hassan Saghafian Shahram Kheirandish | 2012 | Journal of Materials Science & Technology2012，28，4： | 20 |
| 18 | Platelet-to-lymphocyte ratio in the setting of liver transplantation for hepatocellular cancer: A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio(PLR) as a risk factor for post-transplant hepatocellular cancer(HCC) recurrence. METHODS A systematic literature search was performed using PubM ed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria:(1) studies comparing pre-transplant low vs high PLR values;(2) studies reporting post-transplant recurrence rates; and(3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measure was set for HCC recurrence after transplantation. RESULTS A total of 5 articles, published between 2014 and 2017, fulfilled the selection criteria. As for the quality of the reported studies, all the investigated articles presented an overall high quality. A total of 899 cases were investigated: 718 cases(80.0%) were males. Three studies coming from European countries and one from Japan presented HCV as the main cause of cirrhosis. On the opposite, one Chinese study presented a greater incidence of HBV-related cirrhotic cases. In all the studies apart one, the PLR cut-off value of 150 was reported. At meta-analysis, high PLR value was associated with a significant increase in recurrence after transplantation(OR = 3.33; 95%CI: 1.78-6.25; P < 0.001). A moderate heterogeneity was observed among the identified studies according to the Higgins I^2 statistic value.CONCLUSION Pre-transplant high PLR values are connected with an increased risk of post-operative recurrence of hepatocellular cancer. More studies are needed for better clarify the biological mechanisms of this results. | Quirino Lai Fabio Melandro Zoe Larghi Laureiro Francesco Giovanardi Stefano Ginanni Corradini Flaminia Ferri Redan Hassan Massimo Rossi Gianluca Mennini | 2018 | World Journal of Gastroenterology2018，24，15： | 19 |
| 19 | Circulating micro RNA, mi R-122 and mi R-221 signature in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma显示文摘AIM: To explore the potential usefulness of serum miR-122 and miR-221 as non-invasive diagnostic markers of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS: This prospective study was conducted on 90 adult patients of both sex with HCV-related chronic liver disease and chronic hepatitis C related HCC. In addition to the 10 healthy control individuals, patients were stratified into; interferon-na?ve chronic hepatitis C(CH)(n = 30), post-hepatitis C compensated cirrhosis(LC)(n = 30) and treatment-naive HCC(n = 30). All patients and controls underwent full clinical assessment and laboratory investigations in addition to the evaluation of the level of serum miR NA expression by RT-PCR.RESULTS: There was a significant fold change in serum mi RNA expression in the different patient groups when compared to normal controls; mi R-122 showed significant fold increasing in both CH and HCC and significant fold decrease in LC. On the other hand, mi R-221 showed significant fold elevation in both CH and LC groups and significant fold decrease in HCC group(P = 0.01). Comparing fold changes in miR NAs in HCC group vs non HCC group(CH and Cirrhosis), there was non-significant fold elevation in miR-122(P = 0.21) and significant fold decreasing in miR-221 in HCC vs non-HCC(P = 0.03). ROC curve analysis for miR-221 yielded 87% sensitivity and 40% specificity for the differentiation of HCC patients from non-HCC at a cutoff 1.82. CONCLUSION: Serum miR-221 has a strong potential to serve as one of the novel non-invasive biomarkers of HCC. | Hassan El-Garem Ayman Ammer Hany Shehab Olfat Shaker Mohammed Anwer Wafaa El-Akel Heba Omar | 2014 | World Journal of Hepatology2014，6，11： | 18 |
| 20 | Position Control of Electro-hydraulic Actuator System Using Fuzzy Logic Controller Optimized by Particle Swarm Optimization显示文摘The position control system of an electro-hydraulic actuator system (EHAS) is investigated in this paper. The EHAS is developed by taking into consideration the nonlinearities of the system: the friction and the internal leakage. A variable load that simulates a realistic load in robotic excavator is taken as the trajectory reference. A method of control strategy that is implemented by employing a fuzzy logic controller (FLC) whose parameters are optimized using particle swarm optimization (PSO) is proposed. The scaling factors of the fuzzy inference system are tuned to obtain the optimal values which yield the best system performance. The simulation results show that the FLC is able to track the trajectory reference accurately for a range of values of orifice opening. Beyond that range, the orifice opening may introduce chattering, which the FLC alone is not sufficient to overcome. The PSO optimized FLC can reduce the chattering significantly. This result justifies the implementation of the proposed method in position control of EHAS. | Daniel M. Wonohadidjojo Ganesh Kothapalli Mohammed Y. Hassan | 2013 | International Journal of Automation and computing2013，10，3： | 17 |
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